• Tuberculosis and Respiratory Diseases
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• v.55 no.5
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• pp.499-505
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• 2003

Background : The brain is a common site of a metastasis in lung cancer patients. If left untreated, the patients succumb to progressive neurological deterioration with a lower survival rate than with other metastases sites. Contrast-enhanced MR imaging in the absence of symptoms or clinical signs is not recommended for identifying a cerebral metastasis in lung cancer patients because of management effectiveness. This pilot study was performed to estimate whether or not limited brain MR imaging, which has a lower cost, could be used to replace conventional brain MR imaging. Method : Between April 1999 and March 2001, 43 patients with a primary lung cancer and the others (breast cancer, stomach cancer, colon cancer, malignant melanoma etc), who had neurological symptoms and signs, were examined using conventional brain MR imaging to examine brain metastases. The control group involved four patients who had no evidence of brain metastases the sensitivity, specificity and correlation of limited brain MR imaging were compared with conventional brain MR imaging. Results : All the 43 patients who were examined with conventional brain MR imaging showed evidence of brain metastases, whereas limited brain MR imaging indicated that 42 patients had brain metastases(sensitivity=97.67%). One patient in whom limited brain MR imaging showed no brain metastasis had a metastasis in the cerebellum, as shown by the contrast-enhanced T1 weighted axial view using conventional brain MR imaging. The conventional brain MR imaging and the limited brain MI imaging of the 4 control patients both indicated no brain metastases (specificity=100 %). The Pearson Correlation of the two groups was 0.884(Confidence Interval : 99%) observed. Conclusion : Limited brain MR imaging can detect a brain metastasis with the same accuracy. In addition, it is cost-effective (229,000 won, 180$) compared to conventional brain MR imaging(529,000 won, 480$) when patients had neurological symptoms and signs or staging.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.9 no.3
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• pp.695-701
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• 2008

This study has been made to research on the brain wave characteristics of baduk expert by BCI(Brain Computer Interface). The test was based on the researches from 1th September, 2005 to 30th December, 2005, compared with the ones of the standardized general public. The number of the general public are 695 (elementary school students 423, middle and high school students 161, adults 111) and the number of the baduk players are 57 (researchstudents 15, Korean baduk club students 16, professional baduk players 26). The research data show that the baduk players have the higher indexes than the general public in Self Regulation quotient p=.002, Attention Quotient(left) p=.002, Emotion Quotient p=.027, Stress Quotient(left) p=.002 and Brain Quotient p=.006. There are some differences in brain functions between baduk players and the ordinary people. Difference in functions of the brain among baduk experts is also analyzed. That result shows that there is no different brain function between professional baduk player.

• Journal of the Korean Society of Radiology
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• v.14 no.7
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• pp.947-956
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• 2020

The human body becomes vulnerable to various diseases due to deterioration in structure and function as it ages. In particular, changes in brain structure weaken the immune system against diseases such as vascular and metabolic neuropsychiatric diseases. In this study, we used a magnetic resonance imaging technique that allows non-invasive observation of brain structures and measurement of how the volumes of the brain, gray matter, white matter, and subcortical regions changes with aging in women aged 65 to 85 years. As a result of our investigation, we observed a significant linear decrease in subcortical regions with age. These results suggest that the changes due to aging in the brain structure area are closely related to neuropsychiatric diseases in old age, and can provide information in understanding the vulnerability of the brain in old age.

• Proceedings of the KAIS Fall Conference
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• 2009.12a
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• pp.558-561
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• 2009

본 연구는 2008년 1월부터 2008년 12월까지 B. 뇌훈련 센타에 자기조절 능력 및 학업 성취도 향상을 위하여 방문한 내담자 52명(실험군 26명, 대조군 26명)의 뇌파를 검사하여 뉴로피드백 훈련 전과 훈련후의 뇌 기능과 자기 조절 능력 변화를 보고자 하였다. 자기조절 능력에 영향을 미치는 특정한 뇌 기능의 훈련 전과 후의 결과를 시계열 선형분석으로 비교하였으며, 자기조절 능력 반응 측정 변화를 보기 위하여 5점 척도 설문지를 이용하였다. 연구의 결과로는 자기조절지수, 훈련모드, 최대편차에서 집단 간에 유의미한 차이가 나타났다. 또한 자기조절 능력 반응 설문지에서도 두 집단이 유의미한 차이를 나타냈다. 이는 전전두엽 뉴로피드백의 기술을 적용한 뇌 훈련은 자기조절지수와 자기조절 능력에 긍정적인 영향을 미친다고 볼 수 있겠다.

• Proceedings of the KAIS Fall Conference
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• 2010.11b
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• pp.846-849
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• 2010

본 연구는 2010년 2월부터 2010년 7월까지 B. 뇌 훈련 센터에 자기주도학습 능력 향상을 위하여 방문한 내담자 60명(실험군 30명, 대조군 30명)의 뇌파를 검사하여 뉴로피드백 훈련 전과 훈련 후의 뇌기능과 자기주도학습 능력 변화를 보고자 하였다. 자기주도학습 능력에 영향을 미치는 특정한 뇌 기능의 훈련 전과 후의 결과를 시계열 선형분석으로 비교하였다. 연구의 결과로는 자기조절지수, 훈련모드, 자기주도학습 능력에서 집단 간에 유의미한 차이가 나타났다. 이는 뉴로피드백의 기술을 적용한 뇌 훈련은 자기조절지수와 자기주도학습 능력에 긍정적인 영향을 미친다고 볼 수 있겠다.

• Proceedings of the KSMRM Conference
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• 2003.10a
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• pp.26-26
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• 2003

목적： 본 연구의 목적은 미각자극에 대한 인간 뇌의 활성화 영역을 측정하고 가시화하여 미각의 뇌 활성화 부위에 대한 기초자료를 마련하는데 있다. 대상 및 방법： 5명의 남자 대학생 (평균 24.8세)을 뇌기능 연구의 실험 대상자로 선정하였고, 대상자들은 미각에 이상이 없고 구강수술 경험이 없는 오른손잡이를 대상으로 3번에 걸쳐 EPI 혈액산 소농도의존(blood oxygen level dependent)법을 이용하여 미각자극에 의한 기능적 자기공명영상 실험을 수행하였다. 미각 자극을 위하여 5％의 saline을 사용하였으며 자체적으로 제작한 Stimulator를 사용하여 자극하였다. 자극은 3회의 휴식기간과 2회의 자극기간에 걸쳐 시행하였으며, 각 자극기간은 30초씩 5초 간격으로 이스 당 42개의 영상을 획득했다. Post-processing은 SPM99 (Statistical Parametric Mapping 99, The Wellcome Department of Cognitive Neurology, Oxford 1999)의 correlation법을 사용하여 threshold 0.4∼0.7의 범위에서 통계처리 하였으며, 활성화 영상은 EPI영상과 같은 부위의 T1 강조영상에 overlapping시켰다. 이렇게 얻어진 fMRI 영상으로 활성 영역의 위치를 분석하였다.

• Korean Journal of Cognitive Science
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• v.24 no.1
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• pp.1-24
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• 2013

The elderly population continues to increase in Korea and there has been a growing interest in understanding normal aging. In response to this public interest, the present paper reviewed human aging research focusing on recently published neuroimaging studies. For the first half of the paper, I reviewed the effects of aging on the brain and cognition. In normal aging, structural changes in the brain include atrophy and volume reduction in the prefrontal and temporal cortices. Functional changes are exhibited in the form of overactivation of the brain. Moreover, age-related cognitive decline is particularly observed in inhibition and memory, which are also associated with the age-related structural changes in the brain. For the second half of the paper, I introduced physical exercise studies showing that exercise played a protective role in the age-related neurocognitive decline. More specifically, engaging in physical exercise (particularly, aerobic exercise) for a relatively long period of time (e. g., > 6 mon.) protected older adults from volume loss in the prefrontal cortex and the hippocampus, and induced better inhibition and memory. These exercise-induced benefits appear to be associated with changes in neuronal levels, indicating that the aging brain is still plastic and this plasticity can be enhanced by physical exercise.

• The Korean Journal of Applied Statistics
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• v.29 no.6
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• pp.1129-1145
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• 2016

Functional neuro-connectivity is one of the main issues in brain science in the sense that it is closely related to neurodynamics in the brain. In the paper, we choose fMRI as a main form of response data to brain activity due to its high resolution. We review methods for analyzing functional neuro-connectivity assuming that measurements are made on physiological responses to neuron activation. This means that we deal with a state-space and measurement model, where the state-space model is assumed to represent neurodynamics. Analysis methods and their interpretation should vary subject to what was measured. We included analysis results of real fMRI data by applying a high-dimensional autoregressive model, which indicated that different neurodynamics were required for solving different types of geometric problems.

• Journal of Practical Engineering Education
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• v.12 no.1
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• pp.41-47
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• 2020

This study aims to investigate effects of brain-based learning. 27 primary studies were selected through rigorous search process and analyzed through meta-analytic methods. Research findings are as follows. First, the total effect size was .67. Second, the effect of dependent variables was academic achievement, cognitive domain, and affective domain in order. Third, with respect to types of cognitive domain, the effect was self-regulation, creativity, competence, communication, and research ability in order. Fourth, the effect of affective domains was sociality, learning interest, and subject attitude in order. Fifth, regarding development of cognitive ability, the effect size was combined, brain training, learning environments, and right brain activities in order. Sixth, the effect of learning activities was memory improvement and attention enhancement in order.

• Korean Journal of Cognitive Science
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• v.33 no.1
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• pp.51-75
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• 2022

Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation that is able to alter neuronal activity in particular brain regions. Many studies have researched how tDCS modulates neuronal activity and reorganizes neural networks. However it is difficult to conclude the effect of brain stimulation because the studies are heterogeneous with respect to the stimulation parameter as well as individual difference. It is not fully in agreement with the effects of brain stimulation. In particular few studies have researched the reason of variability of brain stimulation in response to time so far. The study investigated individual variability of brain stimulation based on circadian rhythm and chronotype. Participants were divided into two groups which are morning type and evening type. The experiment was conducted by Zoom meeting which is video meeting programs. Participants were sent experiment tool which are Muse(EEG device), tdcs device, cell phone and cell phone holder after manuals for experimental equipment were explained. Participants were required to make a phone in frount of a camera so that experimenter can monitor online EEG data. Two participants who was difficult to use experimental devices experimented in a laboratory setting where experimenter set up devices. For all participants the accuracy of 98% was achieved by SVM using leave one out cross validation in classification in the the effects of morning stimulation and the evening stimulation. For morning type, the accuracy of 92% and 96% was achieved in classification in the morning stimulation and the evening stimulation. For evening type, it was 94% accuracy in classification for the effect of brain stimulation in the morning and the evening. Feature importance was different both in classification in the morning stimulation and the evening stimulation for morning type and evening type. Results indicated that the effect of brain stimulation can be explained with brain state and trait. Our study results noted that the tDCS protocol for target state is manipulated by individual differences as well as target state.