• Korean Journal of Food Science and Technology
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• v.50 no.2
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• pp.225-237
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• 2018

This study was conducted to compare nutritional analysis and neuroprotective effect of 5 cultivars of Diospyros kaki (Dungsi, Godongsi, Gojongsi, Gabjubaekmok, and Bansi). In nutritional analysis, three free sugars: sucrose, glucose, and fructose, and six fatty acids: tartaric acid, hexadecanoic acid, palmitic acid, oleic acid, octadecenamide, and octadecane, were detected. Potassium and phosphorus levels were the highest in inorganic component analysis, and glutamic acid and aspartic acid were the highest contents in amino acid analysis. Vitamin C was detected in all cultivars. Total phenolic content was the highest in Dungsi. Antioxidant activities such as ABTS (3-ethylbenzothiazoline-6-sulfonic acid), DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activities, FRAP (ferric reducing/antioxidant power), and MDA (malondialdehyde) inhibitory effect were the highest in Gabjubaekmok. Acetylcholinesterase inhibitory activity, cell viability, intracellular reactive oxygen species (ROS) accumulation, and lactate dehydrogenase (LDH) release were measured to confirm the neuroprotective effect in MC-IXC cells. Gabjubaekmok showed significant acetylcholinesterase (AChE) inhibition and neuroprotection.

• Journal of Chest Surgery
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• v.39 no.6 s.263
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• pp.440-448
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• 2006

Background: Surgery of descending thoracic or thoracoabdominal aorta has the potential risk of causing neurological injury including spinal cord damage. This study was designed to find out the risk factors leading to spinal cord and brain damage after surgery of descending thoracic and thoracoabdominal aorta. Material and Method: Between October 1995 and July 2005, thirty three patients with descending thoracic or thoracoabdominal aortic disease underwent resection and graft replacement of the involved aortic segments. We reviewed these patients retrospectively. There were 23 descending thoracic aortic diseases and 10 thoracoabdominal aortic diseases. As an etiology, there were 23 aortic dissections and 10 aortic aneurysms. Preoperative and perioperative variables were analyzed univariately and multivariately to identify risk factors of neurological injury. Result: Paraplegia occurred in 2 (6.1%) patients and permanent in one. There were 7 brain damages (21%), among them, 4 were permanent damages. As risk factors of spinal cord damage, Crawford type II III(p=0.011) and intercostal artery anastomosis (p=0.040) were statistically significant. Cardiopulmonary bypass time more than 200 minutes (p=0.023), left atrial vent catheter insertion (p=0.005) were statistically significant as risk factors of brain damage. Left heart partial bypass (LHPB) was statistically significant as a protecting factor of brain (p=0.032). Conclusion: The incidence of brain damage was higher than that of spinal cord damage after surgery of descending thoracic and thoracoabdominal aorta. There was no brain damage in LHPB group. LHPB was advantageous in protecting brain from postoperative brain injury. Adjunctive procedures to protect spinal cord is needed and vigilant attention should be paid in patients with Crawford type II III and patients who have patent intercostal arteries.

• Neonatal Medicine
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• v.18 no.1
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• pp.59-69
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• 2011

Purpose: Current studies have demonstrated the neuroprotective effects of 6-cyano-7-nitroquinoxalin-2,3-dione (CNQX) in many animal models of brain injury, including hypoxic-ischemic (HI) encephlopathy, trauma and excitotoxicity, but limited data are available for those during the neonatal periods. Here we investigated whether CNQX can protect the developing rat brain from HI injury via mediation of nitric oxide synthase. Methods: In an in vivo model, left carotid artery ligation was done in 7-day-old Sprague-Dawley (SD) rat pups. The animals were divided into six groups; normoxia (N), hypoxia (H), hypoxia with sham-operation (HS), hypoxia with operation (HO), HO treated with vehicle (HV), and HO treated with CNQX at a dose of 10 mg/kg (HC). Hypoxia was made by exposure to a 2 hr period in the hypoxic chamber (92% $N_2$, 8% $O_2$). In an in vitro model, embryonic cortical neuronal cell culture of SD rats at 18-day gestation was done. The cultured cells were divided into three groups: normoxia (N), hypoxia (H), and hypoxia treated with CNQX (HC). The N group was prepared in 5% $CO_2$ incubators and the other groups were placed in 1% $O_2$) incubators (94% $N_2$, 5% $CO_2$) for 16 hr. Results: In the in vitvo and in vivo models, the expressions of iNOS and eNOS were reduced in the hypoxia group when compared to the normoxia group, whereas they were increased in the CNQX-treated group compared to the hypoxia group. In contrast, the expression of nNOS was showed reversely. Conclusion: CNQX has neuroprotective property over perinatal HI brain injury via mediation of nitric oxide synthase.

• Proceedings of the Korean Society for Quality Management Conference
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• 2006.11a
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• pp.51-56
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• 2006

이 연구에서는 의료서비스 품질 향상을 위하여 제안된 뇌 전위적 영상안내에 의한 개두술 방법과 옥틸 시안화 아크렬산염 (2-octylcyanoacrylate: 2-0CA)을 드레싱 재료로 사용한 조사군과, 전통적 개두술 방법과 봉합사 및 아이오다인을 사용했던 대조군과 비교를 실시하여 의료품질 향상 효과를 분석하였다. 연구방법으로는 특정 의료기관에서 26 례 조사군과, 38례 대조군을 대상으로, 임상적 특성, 감염균, 두피접착의 열개(裂開)성 및 기타 위험 인자를 조사하였다. 연구결과 새롭게 제안된 의료용 재료인 2옥틸시안화 아크릴산염은 피부조직 속으로 외부 액체가 유입되는 것을 억제하거나 제한하였으며, 외피 접착기능으로 창상보호 특히, 평균감염률과 감염빈도에 있어서 상대적으로 대조군보다 우수하였다. 한편 뇌 전위적 영상 안내에 의한 개두술 방법으로 수술시간의 단축과 수술 복잡성의 경감 및 위험성이 감소되었으며, 상처 부위 흔적이 적게 남는 등 미용적인 측면에서도 우수한 것으로 나타났다.

• Proceedings of the KIEE Conference
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• 2008.04b
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• pp.6-8
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• 2008

기상이변과 온난화 현상으로 인한 낙뢰의 발생빈도가 높아졌으며, 이로 인한 인적, 경제적 피해가 중가하고 있다. 또한 낙뢰 및 각종 서지에 약한 고도의 첨단 정보화 기기의 사용 증가로 인적, 경제적 피해가 광범위해져 피뢰설비의 적절한 설치가 현대사회에서 매우 중요한 부분이 되었다. 이에 WTO의 TBT협약에 의한 기술 부합화 차원에서 경제적이고 효율적인 피뢰설비 규격인 IEC 62305를 2007년 11월 30일에 KS C IEC 62305로 제정하였다. 그러나 실제 적용시 문제점이 드러났다. 본 논문에서는 KS C IEC 62305의 문제점을 파악하고 이를 해결하기 위한 방안에 대하여 설명하고자 한다.

• 전기의세계
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• v.29 no.5
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• pp.315-320
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• 1980

It has been appeared and widely used today SF6 Gas Insulated Substation(Hereafter called GIS) for the power supply to the densely populated area due to the superior insulation withstand ability of SF6 Gas. And to maximize the compact effect of this substation, it is normal practice to connect underground cables. If it is possible to elieminate the redundant lightning arresters using the physical characterestics of travelling waves in underground cables, economical advantages can be obtained together with easy maintenances. It is presented in this paper the possiblity of eliminating the transformer protection lightning arresters under some conditions for the 154kV GIS's (BIL:750kV) which Korea Electric Co. plans to construct using the general purpose digital computer program.

• Proceedings of the KIEE Conference
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• 2006.10a
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• pp.194-195
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• 2006

This study evaluated the impedance characteristics of earth termination system and developed a variable frequency-typed inverter (measuring tool) for the utilization in ground design for lightning protection. The variable-frequency-typed inverter were composed of rectification part, voltage adjuster, IGBT controller and measuring part. Meanwhile, the square wave signal of variable frequency converted its frequency up to lightning surge band by using an IGBT after rectifying an alternating current (AC). It conducted performance evaluation of ground impedance of actual earth termination system by using the developed measuring tool for ground impedance and confirmed that such impedance-oriented performance evaluation was effective in the design of lightning protection.

• The Transactions of the Korean Institute of Electrical Engineers C
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• v.53 no.5
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• pp.253-257
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• 2004

In order to analyze the frequency dependance of ground impedance in grounding grids for lightning and surge protection, a novel method for measuring the ground impedance as a function of frequency were experimentally investigated. The experiments were carried out in rectangular grounding grids with $6{\times}8$ conductors of 22 $mm^2$ buried at a depth of 0.5 m. The test current was injected by the variable frequency inverter whose frequency is linearly controlled for the established period in the range of 5∼500 KHz. The amplitude and phase of ground impedance were calculated from the waveforms of the test current and ground potential rise measured by the band-pass filter tuned in a specific frequency. The frequency dependence of ground impedance was mainly caused by the inductive current flowing through grounding conductors over the frequency of 100 KHz. The proposed measurement method of ground impedance would be applicable to evaluate the transient response characteristics in lightning protection grounding systems.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.22 no.10
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• pp.118-125
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• 2008

The outages of transmission lines give big damages to the industrial world Lightning outages occupy above 50[%] among the outages of transmission lines. To decrease the lightning outage rates, it is necessary to try countermeasures considering economical points. For the lightning protection of power transmission lines, it is very important to accurately predict the lightning outage rate because the reliability criterion for transmission line is normally specified as the number of flashovers per 100[km] per year. The phenomenon of an insulator flashover by a lightning stroke is a very complex electromagnetic event. And to calculate the lightning outage rates of transmission lines, so many calculation should be repeated because there are many overhead lines and power lines. Therefore it is necessary to develope a program for it. In this paper, we briefly introduce the basic concept for lightning outage calculation algorithm and the program.

• Neonatal Medicine
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• v.16 no.2
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• pp.221-233
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• 2009

Purpose: Erythropoietin (EPO) has neuroprotective effects in many animal models of brain injury, including hypoxic-ischemic (HI) encephalopathy, trauma, and excitotoxicity. Current studies have demonstrated the neuroprotective effects of EPO, but limited data are available for the neonatal periods. Here in we investigated whether recombinant human EPO (rHuEPO) can protect the developing rat brain from HI injury via modulation of NMDA receptors. Methods: In an in vitro model, embryonic cortical neuronal cell cultures from Sprague-Dawley (SD) rats at 19-days gestation were established. The cultured cells were divided into five groups: normoxia (N), hypoxia (H), and 1, 10, and 100 IU/mL rHuEPO-treated (H+E1, H+ E10, and H+E100) groups. To estimate cell viability and growth, a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay was done. In an in vivo model, left carotid artery ligation was performed on 7-day-old SD rat pups. The animals were divided into six groups; normoxia control (NC), normoxia Sham-operated (NS), hypoxia-ischemia only (H), hypoxia-ischemia+vehicle (HV), hypoxia-ischemia+rHuEPO before a HI injury (HE-B), and hypoxia-ischemia+rHuEPO after a HI injury (HE-A). The morphologic changes following brain injuries were noted using hematoxylin and eosin (H/E) staining. Real-time PCR using primers of subunits of NMDA receptors (NR1, NR2A, NR2B, NR2C and NR2D) mRNA were performed. Results: Cell viability in the H group was decreased to less than 60% of that in the N group. In the H+E1 and H+E10 groups, cell viability was increased to >80% of the N group, but cell viability in the H+E100 group did not recover. The percentage of the left hemisphere area compared the to the right hemisphere area were 98.9% in the NC group, 99.1% in the NS group, 57.1% in the H group, 57.0% in the HV group, 87.6% in the HE-B group, and 91.6% in the HE-A group. Real-time PCR analysis of the expressions of subunits of NMDA receptors mRNAs in the in vitro and in vivo neonatal HI brain injuries generally revealed that the expression in the H group was decreased compared to the N group and the expressions in the rHuEPO-treated groups was increased compared to the H group. Conclusion: rHuEPO has neuroprotective property in perinatal HI brain injury via modulation of N-methyl-D-aspartate receptors.