• Title/Summary/Keyword: 기초의학

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The Effect Analysis of COVID-19 vaccination on social distancing (코로나19 백신접종이 사회적 거리두기 효과에 미치는 영향분석)

  • Moon, Su Chan
    • Journal of the Korea Convergence Society
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    • v.13 no.2
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    • pp.67-75
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    • 2022
  • The purpose of this study is to present an appropriate management plan as a supplement to the scientific evidence of the currently operated distancing system for preventing COVID-19. The currently being used mathematical models are expressed as simultaneous ordinary differential equations, there is a problem in that it is difficult to use them for the management of entry and exit of small business owners. In order to supplement this point, in this paper, a method for quantitatively expressing the risk of infection by people who gather is presented in consideration of the allowable risk given to the gathering space, the basic infection reproduction index, and the risk reduction rate due to vaccination. A simple quantitative model was developed that manages the probability of infection in a probabilistic level according to a set of visitors by considering both the degree of infection risk according to the vaccination status (non-vaccinated, primary inoculation, and complete vaccination) and the epidemic status of the virus. In a given example using the model, the risk was reduced to 55% when 20% of non-vaccinated people were converted to full vaccination. It was suggested that management in terms of quarantine can obtain a greater effect than medical treatment. Based on this, a generalized model that can be applied to various situations in consideration of the type of vaccination and the degree of occurrence of confirmed cases was also presented. This model can be used to manage the total risk of people gathered at a certain space in a real time, by calculating individual risk according to the type of vaccine, the degree of inoculation, and the lapse of time after inoculation.

Study of Spectral Doppler Waveform Interpretation and Nomenclature in Peripheral Artery (말초 동맥 분광 도플러 파형 해석 및 명명법에 대한 고찰)

  • Ji, Myeong-Hoon;Seoung, Youl-Hun
    • Journal of the Korean Society of Radiology
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    • v.16 no.5
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    • pp.649-660
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    • 2022
  • In 1959, Satomura used spectral Doppler ultrasound to express the velocity of red blood cells according to time change, and Kato defined a zero-base line that could tell the direction of blood flow, making it possible to know the direction of blood flow. This became the basis for the widely used classifications of Triphasic, Biphasic, and Monophasic. However, the above classification has limitations that confuse users with the meaning and timing of use in a clinical environment. As a result, the American Society for Vascular Medicine (SVM) and the Society for Vascular Ultrasound (SVU) A consensus document on Doppler waveform analysis was declared by the joint committee. This study tried to review this consensus and to suggest nomenclature and modifiers that can be used in the domestic vascular ultrasound clinical field. The joint committee formed by SVM and SVU recommended that the use of the triphasic waveform and the biphasic waveform be used as a multiphasic waveform rather than being used due to the ambiguity of interpretation. In addition, it was agreed to name the hybrid-type waveform, which is a monophasic and high-resistance waveform, which has always been a problem of interpretation in a clinical environment, as an intermediate resistive waveform. In addition, in order to increase the communication efficiency between the interpreter and the sonographer, waveform analysis was classified into a main descriptor and a modifier, and it was recommended to use a single nomenclature by unifying various synonyms. It is expected that this literature review will provide accurate arterial spectral Doppler waveform interpretation and an agreed-upon nomenclature to radiologists performing vascular ultrasound examination in clinical practice, and will be utilized as basic data that can contribute to the improvement of public health.

Bibliographic Analysis of Aging Anxiety and Lifestyle (노화불안과 라이프스타일에 대한 계량서지학적 분석)

  • Park, Sun Ha;Park, Hae Yean;Lim, Young Myoung
    • Therapeutic Science for Rehabilitation
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    • v.11 no.2
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    • pp.25-37
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    • 2022
  • Objective : Through the bibliographic analysis method, the flow of research is grasped from a macroscopic point of view and the connection system of key words is conducted. The purpose of this is to provide basic data for conducting research on aging anxiety and lifestyle. Methods : Among the bibliographic analysis methods, a citation analysis method that identifies the association based on the number of citations and a simultaneous appearance word analysis method that identifies the association based on the number of keywords appeared was used. VOSviewer was used to cluster and chart the analyzed information. Results : The frequency of occurrence of papers by year showed a gradual increase until 2017 and a rapid increase from 2018. In the field of research paper study, research was most actively conducted in the field of psychiatry. In the citation analysis, the United States, Australia, and the United Kingdom showed high correlation with each other, and as a result of conducting simultaneous word analysis on major keywords, words with high association with aging anxiety were found to be depression. Conclusion : This study is meaningful in that it grasped the flow of aging anxiety and lifestyle research from a macroscopic point of view using a bibliographic analysis method. Based on this, it is expected to understand the importance of lifestyle from the preventive point of view of aging and to be used as basic data for intervention and related education.

The Comparison of Health Status, Functional Status, and Home Environment Hazards in Terms of the Fear of Falling in Community-dwelling Older Adult (재가 노인의 낙상공포 여부에 따른 건강상태, 신체기능상태 및 가정환경 위험 비교)

  • Lim, Kyung-Choon;June, Kyung Ja;Yoon, Jong-Lull
    • 한국노년학
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    • v.29 no.4
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    • pp.1577-1589
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    • 2009
  • The purpose of this study was to compare the health status, functional status, and home environment hazards by the fear of falling and explore the factors that contribute to the fear of falling. This was a descriptive study. Data were collected for two years with 973 older adults who enrolled in a health center at A city. Trained nurses visited subjects' home and collected data using Resident Assessment Instrument MDS-HC. The average age of the subjects was 76.8 (±7.6) and female was 74.8%. 20.7% of subjects reported fear of falling. In terms of the fear of falling, two groups were compared. There were significant differences in vision, urinary incontinence, pain that interrupts daily activity, unstable gait, comorbidities, frequency of depressive or anxious sign. The greater the age, IADL and ADL dependency, comorbidities, unstabled gait, the more fear of falling. In conclusion, this study reassured the importance of assessing the major factors related to fear of falling such as age, IADL and ADL, comorbities, gait among older adults. This study will contribute to establish strategies for preventing fall. Reducing the fear of falling through the comprehensive nursing intervention will ultimately improve the quality of life in the elderly.

Effect of Adefovir Dipivoxil on the Inhibition of Osteogenic Differentiation of Mesenchymal Stem Cells and Osteoblasts (아데포비어가 중간엽 줄기세포와 조골세포의 골형성 분화 억제에 미치는 영향)

  • Ho PARK
    • Korean Journal of Clinical Laboratory Science
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    • v.55 no.4
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    • pp.284-290
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    • 2023
  • Adefovir dipivoxil (ADV) is used for the treatment of hepatitis and acquired immunodeficiency syndrome, but long-term use can cause osteoporosis. In this study, the effect of ADV on the osteocyte maturation process was evaluated at the level of undifferentiated cells using mesenchymal stem cells (MSCs) and osteoblasts (MG63). First, MSCs and MG63 cells were treated with ADV at different concentrations, and then a Cell Counting Kit-8 analysis was performed to determine the effect on the proliferation of each cell. Additionally, crystal violet and Hoechst staining were performed for the morphological analysis of each cell and nucleus. To determine the cause of cell hypertrophy, the transforming growth factor-beta (TGF-β) expression was investigated, and alkaline phosphatase (ALP) staining and activity were measured to determine the degree of differentiation of the MSCs and MG63 cells into mature osteocytes. The results confirmed that the ADV increases the expression of TGF-β in MSCs and MG63 cells, causing cellular and nuclear hypertrophy, and can cause osteoporosis by inhibiting cell proliferation and affecting the differentiation of mature osteocytes. Therefore, it is believed that these results can be used as a basis for understanding the adverse effects of ADV at a cytological level in basic medicine and clinical research.

A STUDY FOR THE DEVELOPMENT OF KOREAN CHILD REARING INVENTORY FOR SOCIAL PHOBIA (사회공포증과 관련된 양육태도검사의 개발 연구)

  • Oh, Kang-Seob;Lee, Si-Hyung;Huh, Myo-Yeon
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • v.9 no.2
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    • pp.198-208
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    • 1998
  • The purpose of this study was to develop a 'Korean Child Rearing Attitudes Inventory', in order to understand the effects of parents rearing attitudes on social phobia. The total subjects were 392 high school students in Seoul. The scales wwereadministered to the subjects and we examined the reliability and validity. The results were as follows. According to the factor analysis, six factors abstracted from the father's rearing attitudes:rejection, high expectation, anxious, control, emotional care and overconcern of other's opinion. By the method of reliability analysis and factor analysis, finally selected items were 60. The reliability of the factors ranged from .76 to .90 by Cronbach ${\alpha}$. Five factors abstracted from the mother's rearing attitudes:anxious, high expectation, rejection, emotional care and overconcern of other's opinion. And total selected items of mother's rearing attitudes were 61. The reliability of the factors ranged from .72 to .91 by Cronbach ${\alpha}$. The construct validity and reliability of this inventory were supported.

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Application of Chaotic Analysis to Electroencephalography : Preliminary Study (혼돈 이론을 이용한 뇌파 분석에 대한 기초 연구)

  • Park, Hae Jeong;Park, Kwang Suk;Kwon, Jun Soo
    • Korean Journal of Biological Psychiatry
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    • v.2 no.2
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    • pp.257-265
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    • 1995
  • The object of this study is to apply a chaotic signal analysis method to the EEG research, especially in the aspect of neuropsychiatry, and to get some inspection of the chaotic phenomena according to the brain sites and subjects. We have acquired 21 channel EEG data and one EOG according to the international 10-20 system and calculated the correlation dimension. The subject groups are schizophrenics, bipolar disorder, major depression and normal control. They were all awoke and eye-closed. We have found no distinctive features from our experiments except temporal regions have slightly higher correlation dimension. There is also no specific distinctions between groups. We conjecture that these results are mainly because the subjects were not well controlled. EEG dimension may change in accordance with to the age, sex, medication and the time data were selected to calculate. We have also considered some conditions for a better and more objective research of chaotic analysis to EEG research. Better conditioning and standardizing the calculation of correlation dimension is necessary for the application of the chaotic analysis to neuropsychiatry.

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CHILDHOOD ONSET SCHIZOPHRENIA IN DEVELOPMENTAL ASPECT (소아 정신분열병의 발달학적 측면)

  • Lee, Young-Sik
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • v.16 no.2
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    • pp.173-182
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    • 2005
  • This review is a clinical and research update of recent literature related to childhood onset schizophrenia (with an onset of psychosis by age 12). Childhood onset schizophrenia(COS) is a rare disorder, but that may represent a more homogeneous patient population in which to search for risk or etiologic factors of schizophrenia. These overview data show that COS shares the same clinical and neurobiological features as later onset forms of the disorder. Compared with later onset schizophrenia, however, this subgroup of patients appear to have more severe premorbid neurodevelopmental abnormalities, more cytogenic abnormalies, poor outcome, and potentially greater family histories of schizophrenia and associated spectrum disorders. Future studies of this subgroup may provide important clues as to the genetic basis for schizophrenia and how gene products influence certain feature of the disease, such as age of onset and mode of inheritance.

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NEUROCHEMICAL BASIS OF CEREBRAL DEVELOPMENT (뇌신경발달의 신경생화학적 기초)

  • Kim Boong-Nyun;Cho Soo-Churl
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • v.16 no.1
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    • pp.15-25
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    • 2005
  • During the recent decade, the new data about normal neurochemical system development have been accumulated very much. Based on these new data, the up-to-date theory and hypothesis have been developed. These development of this field results from the technological/methodological development which increase the sensitivity, specificity and validity of neurochemical research. Especially, molecular technological development support the recent neurochemical development. In this review article, the authors described the recent research findings in the field of normal neurochemical development of neurotransmitter system in animal and human. Most of child psychiatric disorder, especially neuropsychiatric developmental disorders (ADHD, Autism, Tourette's disorder, MR etc) seem to have underlying neurochemical developmental problems in the pathophysiological basis. So, the data on the normal ontogeny of neurotransmitter system can be the most valuable resources for the research on the etiology of the diverse child psychiatric disorders.

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The Difference of Weight Distribution Index in Elderly People According to Gender (노인의 성별에 따른 체중분포 차이)

  • Yoon, Se-Won;Kwon, Hye-Min;Kang, Yang-Hoon
    • Journal of the Korean Society of Physical Medicine
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    • v.7 no.1
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    • pp.103-110
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    • 2012
  • 연구목적 : 본 연구는 노인의 성별이 낙상에 영향을 줄 수 있는 체중분포지수에 미치는 차이를 알아보고자 한다. 연구방법:광주광역시 소재 빛고을 노인건강타운 물리치료실을 이용하는 65세 이상 66명(남성 33명, 여성 33명) 노인을 대상으로 남성노인 평균연령은 70.97세, 여성노인 평균연령은 71.39세로 모든 대상자는 TETRAX의 체중분포지수(weight distribution index; WDI)를 이용하여 성별에 따라 그 차이를 비교 분석하였다. 측정 방법 은 안정된 발판에서 눈을 뜨고 정면을 향한 자세, 안정된 발판에서 눈을 감고 정면을 향한 자세, 불안정한 발판에서 눈을 뜨고 정면을 향한 자세, 불안정한 발판에서 눈을 감고 정면을 향한 자세, 안정된 발판에서 눈을 감고 고개를 오른쪽으로 돌린 자세, 안정된 발판에서 눈을 감고 고개를 왼쪽으로 돌린 자세, 안정된 발판에서 눈을 감고 고개를 뒤로 젖힌 자세, 안정된 발판에서 눈을 감고 고개를 숙인 자세로 측정하였고, 분석방법은 SPSS version 12.0을 이용하여 통계처리 하였고, 남녀 간의 안정성지수와 체중분포지수의 평균차이 검정은 독립표본 t-검정을 실시하였다. 통계학적 유의성을 검증하기 위해 ${\alpha}$는 유의수준 0.05로 하였다. 연구결과 : 성별에 따른 WDI비교에서 불안정한 발판과 안정된 발판에서 눈을 뜬 상태와 감은 상태에 정면을 향한 자세, 안정된 발판에서 눈을 감고 고개를 왼쪽과 오른쪽으로 돌린 자세에서 유의한 차이가 있었으나 안정된 발판에서 고개를 뒤로 젖힌 자세와 고개를 숙인자세에서는 유의한 차이는 없었다. 결론 : 본 연구의 결과를 바탕으로 성별에 따른 노인의 WDI에 영향을 미칠 수 있는 요인을 파악하여 낙상예방프로그램 기초자료로 활용 될 것으로 생각된다.