• 동의신경정신과학회지
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• 제21권4호
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• pp.1-11
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• 2010

Objectives : The purpose of this study was investigated that correlation between Temperament and Character Inventory(TCI) and Beck Depression Inventory (EDI). State-Trait Anxiety Inventory(STAI) in traffic accident patients. Methods: We investigated 30 cases of traffic accident patients. The patients answered that questionnaire about temperament. character and depression. anxiety. TCI and BDI. STAI were used to get to know that answers. Results: Depression is positive correlated with novelty seeking and harm avoidance in temperament. In character. depression is negative correlated with self directedness, and positive correlated with self-transcendence. Anxiety is positive correlated with harm avoidance in temperament. and negative correlated with self directedness. Conclusions : The results of correlation between TCI and BD I. STAI in traffic accident patients were consistent with previous studies in general person.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제6권1호
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• pp.18-33
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• 1995

본 논문에서는 청소년 경계선 장애의 개념의 발달, 역학, 공존 질환 및 감별 진단, 유형 분류, 정신 역동학적 이론, 생물학적 이론, 실험적인 연구등을 통한 병인론, 추적 연구에 대한 문헌 고찰을 하였고 청소년기에 재현되는 재접근기(rapproachment)의 혼란에 의해 현상학적으로 경계선 성격 장애와 같은 모습을 보이는 상태를 통틀어 청소년의 경계선 상태(adolescent borderline state)라고 정의하였으며 이를 성인의 경계선 성격 장애와는 다른 청소년의 한 ‘과정’으로서 개념화하였다. 또한 저자들은 청소년기의 경계선 상태를 다음의 네가지 유형으로 나누고 각각의 증례를 제시하였다 (1) 청소년 과정으로서의 경계선 상태 (2) 정신병적 상태와 연관되어 나타나는 경계선 상태 (3) 전형적 경계선 성격 장애의 시작으로서의 경계선 상태 (4) 기질적 질환과 연결되어 나타나는 경계선 상태. 결론적으로 청소년기의 경계선 장애는 단순히 아동기의 분리-개별화 단계의 실패가 지속되어 생기는 것이 아니라 이와 유사한 과제가 발달의 주제로 재현되는 청소년기의 이차 분리 개별화 과정의 갈등에 의한 것이고 만약 이 시기에 갈등의 해소가 안되면 성인기에서는 경계선 성격 장애로 나타날 수 있을 것이라고 생각되었다.

• 대한의생명과학회지
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• 제2권1호
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• pp.21-30
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• 1996

Mitogen-activated protein (MAP) kinase는 여러 세포증식 촉진인자들에 의하여 자신이 인산화됨으로써 활성화되어 다른 protein kinase를 인산화시키는 역할을 하는 세포내 신호전달의 중요한 효소이다. 본 연구에서는 P388 murine leukemia 세포 파쇄액에서 SP sephadex C-50, phenyl superose, Mono Q column을 통하여 MAP kinase를 분리한 결과, 44 kD와 66kD의 isoform을 확인할 수 있었다. 면역 T 세포의 $p56^{kk}$의 N-terminal로부터 유전자 재조합 방법을 통하여 glutathion-s-transferase(GST) fusion protein을 얻은 후 분리한 MAP kinase의 기질로 사용하여 본 결과, wild type과 mutant간에 인산화 정도의 차이를 확인할 수 있어 MAP kinase의 또 다른 기질로 이용할 수 있는 가능성을 제시하였다.

• 생물정신의학
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• 제17권4호
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• pp.203-209
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• 2010

Objectives : Increasing evidence suggests the presence of neurobiological bases for temperamental characteristics in humans. Brain correlates of harm avoidance(HA) have been most extensively studied using functional and structural brain imaging methods due to its potential link with anxiety and depressive disorders. To date, however, we are not aware of any reports that have examined the potential relationship between HA levels and regional cortical thickness. The aim of the current study is to examine the cortical thickness which is associated with HA temperament in healthy young subjects. Methods : Twenty-eight young, healthy individuals(13 men and 15 women, mean age, $29.4{\pm}6.3$ years) were screened for eligibility and administered the Korean version of the Cloninger's Temperament and Character Inventory and underwent high-resolution structural magnetic resonance imaging scanning. Results : HA was associated with cortical thickness in the right superior frontal cortex and in the left parietal cortex, adjusted for age and sex and corrected for multiple comparisons using the permutation testing method. Conclusion : Individual temperamental differences in HA are associated with structural variations in specific areas of the brain. The fact that these brain regions are involved in top-down modulations of subcortical fear reactions adds functional significance to current findings.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제17권2호
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• pp.124-130
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• 2006

Objectives : The objective of this study was to evaluate the differences in patterns of temperament and character, as assessed by the Junior Temperament and Character Inventory (JTCI), between the children with attention-deficit/hyperactivity disorder (ADHD) and the control group in a community sample. In addition, we examined the potential differences on JTCI profiles according to the ADHD subtypes. Methods : Parents of 185 ADHD subjects (mean age $9.0{\pm}1.7$ years), as diagnosed by the DISC-IV, and 185 age- and gender-matched comparison children have completed the parent's version of the JTCI. Results : The ADHD group scored significantly higher in Novelty Seeking and lower in Persistence than the comparison group on JTCI. However, there were no significant differences in the temperament or character profiles by the ADHD subtypes. Conclusion : The results of this study suggest that the temperamental factors of higher Novelty Seeking and lower Persistence are related to ADHD. The temperament or character profiles in this study do not provide support for the distinctiveness of the ADHD subtypes.

• 생물정신의학
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• 제17권3호
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• pp.136-144
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• 2010

Objectives : The $2^{nd}$ to $4^{th}$ digit length(2D : 4D) ratio reflects the amount of exposure and sensitivity to the prenatal sex hormone and it is considered to be the most convenient and useful way to understand the influence of sex hormone in the determination of human behavioral traits. This study was carried out to find the correlation between the 2D : 4D ratio and characteristics of temperament and character in Korean university students. We assumed that 2D : 4D ratio would show a strong correlation with temperament which is defined to be an inclination of an automatical emotional response to a stimulus. Methods : Participants were 104 university students who completed 2 self-report measures : Temperament and Character Inventory(TCI), Temperament Test. We examined the 2D : 4D ratio of each subject by measuring the lengths of the $2^{nd}$ and $4^{th}$ fingers using a photocopy measurement. We performed statistical analyses using correlation test and t-test to examine the relationship between 2D : 4D ratio and psychological characteristics. Results : We found out the typical sex difference in 2D : 4D ratio. Women had significantly higher 2D : 4D ratio than men. TCI-Character factor(TCI-C) didn't show any significant correlation with the 2D : 4D ratio. TCI-Tempterament factor(TCI-T) and the item of Temperament Test showed a significant correlation with the 2D : 4D ratio. In correlation analysis of the total group including all women and men, the 2D : 4D ratio showed a significant positive correlation in a subscale(shyness with stranger) of harm avoidance scales in TCI-T. In correlation analysis of women's group, the 2D : 4D ratio showed a significant positive correlation in two subscales( fear of uncertainty) and[shyness to stranger] of harm avoidance scales in TCI-T. In correlation analysis of men's group, the 2D : 4D ratio showed a significant negative correlation with a sanguine temperament item of the Temperament Test. Conclusion : The results suggest that the amount of exposure to sex hormone in the prenatal period seems to have an impact on the determination of temperament and characteristics.

• 동의신경정신과학회지
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• 제23권4호
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• pp.95-106
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• 2012

Objectives : The purpose of this study is to study the personality traits of Sasang constitutions by comparing the profiles of Temperament and Character Inventory (TCI) and Eysenck Personality Questionnaire (EPQ). Methods : A total of 110 healthy people (20 to 40 years old), except for 2 Taeyangin (TY type), were analyzed; 45 Taeeumin (TE type), 32 Soyangin (SY type), and 31 Soeumin (SE type). A Sasang constitutional medicine specialist diagnosed the Sasang constitution after analyzing the result of a Two Step Questionnaire for Sasang Constitution Diagnosis (TS-QSCD), the external appearance, temperament and symptoms. The dimensions of TCI and EPQ were compared among the different Sasang constitutions, using an analysis of variance, and correlations between TCI and EPQ were analyzed by a Pearson correlation method. Results : Among the four temperament dimensions of TCI, SY type showed a significantly higher score than the SE type in Novelty Seeking. SE type showed significantly higher score than TE and SY type in Harm Avoidance. SY type showed significantly higher score than SE type in Reward Dependence. TE and SY type showed significantly higher score than SE type in Persistence. There were no significant differences in the character dimensions of Self-directness, Cooperativeness and Self-Transcendence. Among the seven dimensions of EPQ, TE and SY type showed significantly higher score than SE type in Extraversion. SE type showed significantly higher score than SY type in Lie. SY type showed significantly higher score than TE and SE type in Impulsiveness. Conclusions : The results demonstrated that there are some significant differences of personality traits among Sasang constitutions. This could help diagnose and understand each Sasang constitution.

• 정신신체의학
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• 제15권1호
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• pp.35-43
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• 2007

연구목적: 고등학생을 대상으로 계절성 평가 도구인 계절성 양상 평가 설문지(Seasonal Pattern Assessment Questionnaire, SPAQ)와 인격 성향을 평가하는 기질과 성격 검사(Temperament and Character Inventory, TCI)와의 상관관계에 대해 조사하여 계절성과 인격 구조와의 유전적 요인과의 관계에 대해 알아보고자 하였다. 방법: 서울에 거주하는 600명의 고등학생을 대상으로 Rosenthal의 SPAQ와 Cloninger의 TCI 한국어판을 사용하였다. 결과 : 여학생은 harm avoidance, reward dependence, cooperativeness에서 높은 점수가 나온 반면 남학생에서는 persistence, self-transcendence에서 높은 점수가 나왔다. 총계절성 점수(Global seasonality score)와 TCI의 하부척도를 비교한 결과 harm avoidance, self-transcendence와는 정적 상관관계가 나타났으며, self-directedness, cooperativeness와는 부적 상관관계가 나타났다. 로지스틱 회귀분석 결과, SAD의 경우 회귀계수는 self-directedness와 유의한 부적 상관관계가 나타났으며 self-transcendence와는 정적 상관관계가 나타났다. S-SAD의 경우에는 cooperativeness와 부적 상관관계를 보였으며 self-transcendence와는 정적 상관관계를 보였다. GSS가 11점 이상일 경우에는 그렇지 않은 경우에 비해 self-transcendence 점수가 높게 나타났으며, 겨울에 가장 기분이 저하되는 경우에는 그렇지 않은 경우에 비해 더 낮은 cooperativeness 점수를 보였다. 계절성 변동이 중등도 이상의 문제를 일으키는 경우에는 높은 harm avoidance, self-transcendence 점수를 보였다. 결론: 계절성과 성격 및 기질적인 부분이 서로 연관성을 보였다. 이 연구가 우리나라에서 고등학생을 대상으로 한 최초의 연구로서 여기에서 보인 결과들은 임상적 적용에 도움을 줄 수 있을 것으로 보인다.

• 한국학교보건학회지
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• 제23권2호
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• pp.181-191
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• 2010

Purpose: The purpose of this study is to analyze the drinking status and to identify the impacts of depression, temperament, characteristic on drinking status in the vocational high school students. Methods: By using stratified sampling, 416 vocational high school students in Gangwon Do were selected and surveyed through self -administered questionnaires. Data were analyzed by SPSS 12.0 using $x^2$-test, t-test, ANOVA, Pearson correlation coefficient and multiple regression. Results: 88% of students had experienced of drinking. Depression was observed 59.1% of students from light to severe depression score. There was a positive correlation among drinking, the school records, novelty seeking, reward dependence and persistence. Also, there was a negative correlation among drinking, economic status, harm avoidance. The significant predictors of drinking were school records, depression, novelty seeking and persistence. Conclusion: These results suggest that vocational high school students who have the factors identified in this study are regarded as having the potential to drink. The results of this study can provide the information for the development of the health promotion program.

• 한국농촌간호학회지
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• 제2권1호
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• pp.14-23
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• 2007

Purpose: The purpose of this study was to analyze the smoking behaviors and to identify the impact of depression, temperament, and characteristics of smoking experience on rural adolescents. Method: A survey using a self-administered questionnaire was done of 310 rural high school students. Using SPSS 12.0, Pearson correlation coefficients and multiple regression were used to analyze the data. Results: The smoking rate of rural high school students was higher than that of the national rate for this age group. Serious depression was observed in the rural high school students. There was a positive correlation among smoking experience, school records, novelty seeking and a negative correlation between smoking and cooperativeness. The significant predictors of smoking experience were type of school, satisfaction with school, school records, novelty seeking, reward dependence and cooperativeness. These factors accounted for 38.9% of variances in the smoking experience of rural adolescents. Conclusion: These results suggest that adolescents who exhibit factors identified in this study are regarded as having the potential to smoke, and this result proposes the basis for program development for the prevention of smoking and smoking cessation.