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The Relationship between Harm Avoidance Temperament and Right Frontal and Left Parietal Lobes in Young Adults : A Cortical Thickness Analysis  

Kim, Da-Jung J. (Interdisciplinary Program in Neuroscience, Seoul National University College of Natural Sciences)
Lyoo, Young-Wook (Seoul Science High School)
Park, Young-Jun (Seoul Science High School)
Ahn, Tae Joo (Seoul Science High School)
Choi, Byeong Joo (Seoul Science High School)
Shin, E-Kyung (Department of Chemistry, New York University)
Kim, Tae-Suk (Department of Psychiatry, Catholic University of Korea College of Medicine)
Publication Information
Korean Journal of Biological Psychiatry / v.17, no.4, 2010 , pp. 203-209 More about this Journal
Abstract
Objectives : Increasing evidence suggests the presence of neurobiological bases for temperamental characteristics in humans. Brain correlates of harm avoidance(HA) have been most extensively studied using functional and structural brain imaging methods due to its potential link with anxiety and depressive disorders. To date, however, we are not aware of any reports that have examined the potential relationship between HA levels and regional cortical thickness. The aim of the current study is to examine the cortical thickness which is associated with HA temperament in healthy young subjects. Methods : Twenty-eight young, healthy individuals(13 men and 15 women, mean age, $29.4{\pm}6.3$ years) were screened for eligibility and administered the Korean version of the Cloninger's Temperament and Character Inventory and underwent high-resolution structural magnetic resonance imaging scanning. Results : HA was associated with cortical thickness in the right superior frontal cortex and in the left parietal cortex, adjusted for age and sex and corrected for multiple comparisons using the permutation testing method. Conclusion : Individual temperamental differences in HA are associated with structural variations in specific areas of the brain. The fact that these brain regions are involved in top-down modulations of subcortical fear reactions adds functional significance to current findings.
Keywords
Harm avoidance; Cortical thickness; Personality; Temperament and Character Inventory; Magnetic resonance imaging;
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1 Hyler SE, Skodol AE, Oldham JM, Kellman HD, Doidge N. Validity of the Personality Diagnostic Questionnaire- Revised: a replication in an outpatient sample. Compr Psychiatry 1992;33:73-77.   DOI   ScienceOn
2 Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960;23:56-62.   DOI
3 Sung SM, Kim JH, Yang E, Abrams KY, Lyoo IK. Reliability and validity of the Korean version of the Temperament and Character Inventory. Compr Psychiatry 2002;43:235-243.   DOI   ScienceOn
4 Athinoula A. Martinos Center for Biomedical Imaging. FreeSurfer. Available from http://surfer.nmr.mgh.harvard. edu/.
5 Fischl B, Sereno MI, Dale AM. Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. Neuroimage 1999;9:195-207.   DOI   ScienceOn
6 Dotson VM, Davatzikos C, Kraut MA, Resnick SM. Depressive symptoms and brain volumes in older adults: a longitudinal magnetic resonance imaging study. J Psychiatry Neurosci 2009;34:367-375.
7 Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996;274:1527-1531.   DOI
8 Hariri AR. The neurobiology of individual differences in complex behavioral traits. Annu Rev Neurosci 2009;32:225-247.   DOI   ScienceOn
9 Yang TT, Simmons AN, Matthews SC, Tapert SF, Frank GK, Bischoff-Grethe A, et al. Adolescent subgenual anterior cingulate activity is related to harm avoidance. Neuroreport 2009;20:19-23.   DOI   ScienceOn
10 Pessoa L. On the relationship between emotion and cognition. Nat Rev Neurosci 2008;9:148-158.   DOI   ScienceOn
11 Huettel SA, Song AW, McCarthy G. Decisions under uncertainty: probabilistic context influences activation of prefrontal and parietal cortices. J Neurosci 2005;25:3304-3311.   DOI   ScienceOn
12 Hariri AR, Bookheimer SY, Mazziotta JC. Modulating emotional responses: effects of a neocortical network on the limbic system. Neuroreport 2000;11:43-48.   DOI   ScienceOn
13 Kimbrell TA, George MS, Parekh PI, Ketter TA, Podell DM, Danielson AL, et al. Regional brain activity during transient self-induced anxiety and anger in healthy adults. Biol Psychiatry 1999;46:454-465.   DOI   ScienceOn
14 Davidson RJ. Anxiety and affective style: role of prefrontal cortex and amygdala. Biol Psychiatry 2002;51:68-80.   DOI   ScienceOn
15 Beauregard M, Levesque J, Bourgouin P. Neural correlates of conscious self-regulation of emotion. J Neurosci 2001;21:RC165.
16 Benuzzi F, Lui F, Duzzi D, Nichelli PF, Porro CA. Does it look painful or disgusting? Ask your parietal and cingulate cortex. J Neurosci 2008;28:923-931.   DOI   ScienceOn
17 Vickery TJ, Jiang YV. Inferior parietal lobule supports decision making under uncertainty in humans. Cereb Cortex 2009;19:916-925.   DOI
18 Turner RM, Hudson IL, Butler PH, Joyce PR. Brain function and personality in normal males: a SPECT study using statistical parametric mapping. Neuroimage 2003;19:1145-1162.   DOI   ScienceOn
19 Youn T, Lyoo IK, Kim JK, Park HJ, Ha KS, Lee DS, et al. Relationship between personality trait and regional cerebral glucose metabolism assessed with positron emission tomography. Biol Psychol 2002;60:109-120.   DOI   ScienceOn
20 Bourgeois JP, Goldman-Rakic PS, Rakic P. Synaptogenesis in the prefrontal cortex of rhesus monkeys. Cereb Cortex 1994;4:78-96.   DOI   ScienceOn
21 Pakkenberg B, Gundersen HJ. Neocortical neuron number in humans: effect of sex and age. J Comp Neurol 1997;384:312-320.   DOI   ScienceOn
22 Most SB, Chun MM, Johnson MR, Kiehl KA. Attentional modulation of the amygdala varies with personality. Neuroimage 2006;31:934-944.   DOI   ScienceOn
23 Cloninger CR, Svrakic DM, Przybeck TR. A psychobiological model of temperament and character. Arch Gen Psychiatry 1993;50:975-990.   DOI   ScienceOn
24 Svrakic DM, Draganic S, Hill K, Bayon C, Przybeck TR, Cloninger CR. Temperament, character, and personality disorders: etiologic, diagnostic, treatment issues. Acta Psychiatr Scand 2002;106:189-195.   DOI   ScienceOn
25 Elovainio M, Kivimaki M, Puttonen S, Heponiemi T, Pulkki L, Keltikangas-Jarvinen L. Temperament and depressive symptoms: a population-based longitudinal study on Cloninger's psychobiological temperament model. J Affect Disord 2004;83:227-232.   DOI
26 Starcevic V, Uhlenhuth EH, Fallon S, Pathak D. Personality dimensions in panic disorder and generalized anxiety disorder. J Affect Disord 1996;37:75-79.   DOI   ScienceOn
27 Cloninger CR. A unified biosocial theory of personality and its role in the development of anxiety states. Psychiatr Dev 1986;4:167-226.
28 Pujol J, Lopez A, Deus J, Cardoner N, Vallejo J, Capdevila A, et al. Anatomical variability of the anterior cingulate gyrus and basic dimensions of human personality. Neuroimage 2002;15:847-855.   DOI   ScienceOn
29 Iidaka T, Matsumoto A, Ozaki N, Suzuki T, Iwata N, Yamamoto Y, et al. Volume of left amygdala subregion predicted temperamental trait of harm avoidance in female young subjects. A voxel-based morphometry study. Brain Res 2006;1125:85-93.   DOI   ScienceOn
30 Gardini S, Cloninger CR, Venneri A. Individual differences in personality traits reflect structural variance in specific brain regions. Brain Res Bull 2009;79:265-270.   DOI   ScienceOn
31 Yamasue H, Abe O, Suga M, Yamada H, Inoue H, Tochigi M, et al. Gender-common and -specific neuroanatomical basis of human anxiety-related personality traits. Cereb Cortex 2008;18:46-52.   DOI
32 Fischl B, Dale AM. Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proc Natl Acad Sci U S A 2000;97:11050-11055.   DOI
33 Wood JN, Grafman J. Human prefrontal cortex: processing and representational perspectives. Nat Rev Neurosci 2003;4:139-147.   DOI   ScienceOn
34 First MB, Gibbon M, Spitzer RL, Williams JBW. User's Guide for the Structured Clinical Interview for DSM-IV Axis I Disorders, Research Version 2.0. New York, NY: Biometrics Research Department, New York State Psychiatric Institute;1996.