• Proceedings of the Korea Water Resources Association Conference
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• 2023.05a
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• pp.92-92
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• 2023

본 연구에서는 대한민국 도시 유역에 대하여 딥러닝 네트워크 기반의 분산형 수문 모형을 개발하였다. 개발된 모형은 완전연결계층(Fully Connected Layer)으로 연결된 여러 개의 장단기 메모리(LSTM-Long Short-Term Memory) 은닉 유닛(Hidden Unit)으로 구성되었다. 개발된 모형을 사용하여 연구 지역인 중랑천 유역을 분석하기 위해 1km² 해상도의 239개 모델 격자 셀에서 10분 단위 레이더-지상 합성 강수량과 10분 단위 기온의 시계열을 입력으로 사용하여 10분 단위 하도 유량을 모의하였다. 모형은 보정과(2013~2016년)과 검증 기간(2017~2019년)에 대한 NSE 계수는각각 0.99와 0.67로 높은 정확도를 보였다. 본 연구는 모형을 추가적으로 심층 분석하여 다음과 같은 결론을 도출하였다: (1) 모형을 기반으로 생성된 유출-강수 비율 지도는 토지 피복 데이터에서 얻은 연구 지역의 불투수율 지도와 유사하며, 이는 모형이 수문학에 대한 선험적 정보에 의존하지 않고 입력 및 출력 데이터만으로 강우-유출 분할과정을 성공적으로 학습하였음을 의미한다. (2) 모형은 연속 수문 모형의 필수 전제 조건인 토양 수분 의존 유출 프로세스를 성공적으로 재현하였다; (3) 각 LSTM 은닉 유닛은 강수 자극에 대한 시간적 민감도가 다르며, 응답이 빠른 LSTM 은닉 유닛은 유역 출구 근처에서 더 큰 출력 가중치 계수를 가졌는데, 이는 모형이 강수 입력에 대한 직접 유출과 지하수가 주도하는 기저 흐름과 같이 응답 시간의 차이가 뚜렷한 수문순환의 구성 요소를 별도로 고려하는 메커니즘을 가지고 있음을 의미한다.

• Sleep Medicine and Psychophysiology
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• v.26 no.1
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• pp.5-15
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• 2019

Chronotype (CT) is defined as an inter-individual difference in sleep-wake cycles and daily activities. Previous studies have suggested that this individual difference can influence our biological and psychological functioning. Literature regarding the psychometric properties and validity of CT measures are reviewed. We provide an overview of biological indicators (sleep-wake cycle, body temperature, cortisol, and melatonin) that are used for distinguishing two chronotypes: morningness (MT) and eveningness (ET). We also review the differences between CT in relation to personality traits and the occurrence of psychopathology. In addition, the methodological limitations of studies on CT are discussed. Finally, future research directions in terms of CT are proposed.

• Childhood Kidney Diseases
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• v.6 no.1
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• pp.48-55
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• 2002

Purpose: Thin glomerular basement membrane nephropathy (TGBMN) is recognized as the leading cause of microscopic hematuria in both children and adults. However thinning of glomerular basement membrane (TCBM) has been found in healthy adult and also is known to be associated with various renal diseases such as Alport syndronh, IgA nephropathy and mesangial proliferative glomerulonephritis. The association of TGBM with minimal change nephrotic syndrome (MCNS) has been very rare so that the present study was undertaken to determine the relationship between TGBM and MCNS. Methods: The study population consisted of 49 children with biopsy- proven MCNS who have been admitted to the pediatric department of Kyungpook University Hospital during the past 5 years from 1997 to 2001. Group I consisted of 8 children associated with TGBM and Group II 41 children without TCBM. Various parameters such as age of illness, duration from discovery of illness to the time of biopsy, family history of hematuria and other laboratory tests were compared between these two groups and the following results were obtained. Results: Age distribution showed slightly older age in Group I ($7.1{\pm}3.5$ years) compared to Group II ($4.8{\pm}2.9$ years). However this was not statistically different (P=0.056). Family history of hematuria was noted in 2 cases in Group II. Though statistically not significant, hematuria was seen in 2 out of 8 cases ($25\%$) in MCNS children with TGBM, compared to 7 out of 41 cases ($17\%$) with MCNS children without TGBM. Other parameters such as BUN, creatinine, 24 hours urine protein excretion, serum protein, albumin, cholesterol, and T4/T8 ratio, showed no difference. Also renal biopsy finding showed no significant difference and the thickness of glomerular basement membrane in Croup I was $188{\pm}30nm$. Conclusion: TGBM was found in 8 out of 49 children with MCNS ($16.3\%$). And this high frequency of occurrence indicates that these association is not an incidental findings. Typical clinical findings of TCBMN was not noted in all of the 8 children with MCNS associated with TGBM, suggesting that thinning of glomerular basement membrane (TCBN) is secondary to rather than the cause of MCNS. (J Korean Soc Pediatr Nephrol 2002;6: 48-55)

• Journal of Korea Water Resources Association
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• v.47 no.6
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• pp.501-511
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• 2014

The effects of initial conditions and input values of the rainfall-runoff model were studied in the applications of a lumped concept model for flood event data extension. For the initial conditions of the rainfall-runoff model, baseflow effects and spatial distributions of saturation points ($R_{sa}$) for the storage function methods (SFM) were analyzed. In addition, researches on the effects of rainfall data conditions as input values for the rainfall-runoff model were performed. The Chungju Dam watershed was selected and divided into 3 catchments including smaller size of 22 sub-catchments. The observed discharge and inflow amounts at Yeongwol 1, Chungju Dam, and Yeongwol 2 water level stations were individually operated as criteria for flood data extension in 30 flood events from 1993 to 2009. Direct and base flow were distinguished from a stream flow. In order to test capability of flood data extension, obtained base flow was applied to the rainfall-runoff model for three water level stations. When base flow was adopted in the model, the Nash-Sutcliffe Efficiency(NSE) was increased. The numbers of over satisfaction for model performance (>0.5) were increased over 10%. Saturation points ($R_{sa}$) which strongly influence the runoff amount when rainfall starts were optimized based on the runoff amount at three water level stations. The sizes of saturation points for three locations were similar which means saturation point size is not depending on the runoff amount. The effects of rainfall information for flood runoff were tested at 2002ev1 and 2008ev1. When increased the amount of rainfall information, the runoff simulations were closer to the simulations with full of rainfall information. However, the size of improvement was not substantial on rainfall-runoff simulations in terms of the size of total amount of rainfall.

• Tuberculosis and Respiratory Diseases
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• v.42 no.2
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• pp.184-205
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• 1995

Background: Pulmonary toxicity by bleomycin has multiple mechanisms including direct tissue toxicity due to oxygen-derived free radicals and indirect toxicity through amplification of pulmonary inflammation. To evaluate the effect of chelators or free radical scavenger to lung damage induced by bleomycin, penicillamine as a copper chelator, deferoxamine as an iron chelator and vitamin E as a free radical scavenger were administered. Methods: Two hundred Wistar rats were divided into five groups: Control, bleomycin treated, bleomycin-penicillamine treated, bleomycin-deferoxamine treated, and bleomycin-vitamin E treated groups. Rats sacrificed on day 1, day 3, day 4, day 7, day 14, and day 28 after treatment. Bronchoalveolar lavage, light microscopic and immunohistologic studies for type I, III, IV collagens, fibronectin, laminin and NBD phallicidin were evaluated. Results: There was a significant increase in the total cell counts of bronchoalveolar lavage on day 1 from all treated animals and vitamin treated group showed an abrupt decrease in total cell counts with decrease of neutrophils on day 3. Bleomycin-vitamin E treated group had the least histologic changes such as pulmonary fibrosis. The alveolar basement membranes were positive for type IV collegen and laminin. Basement membranes of bleomycin, bleomycin-penicillamine, or bleomycin-deferoxamine treated groups were disrupted and fragmented on day 4 or 7. The bleomycin-vitamin E treated group had intact basement membranes until day 28. Conclusion: Bleomycin-induced pulmonary fibrosis was related to the severity of acute injury to oxygen radicals or activation of neutrophils and disruption of basement membrane. Vitamin E seemed to be the most effective antioxidant in the inhibition of bleomycin-induced pulmonary injury and fibrosis.

• The Journal of Korean Academy of Prosthodontics
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• v.46 no.2
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• pp.185-192
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• 2008

Purpose: This study was designed to investigate the fitness of adjustable dental impression trays on the Caucasian and African American. Material and methods: The size and shape of these trays were designed from the results of the dental arch size of Korean adults. Tray samples were made by CAD-CAM working. Sixty Caucasian (male:30, female:30) and sixty African American (male:30, female:30) were selected for taking irreversible hydrocolloid impression using these trays. The author measured the width and length of impression material on the several measuring points. Results: 1. Uniform impression material width was achieved by controling the width of the tray using stops and beveled guides. 2. In the maxillary tray on the Caucasian, the impression material thickness was measured to be rather great showing thickness of the midpalatal part 13.0 mm. 3. In the maxillary tray on the African American, the impression material thickness was measured to be rather great showing thickness of the midpalatal part 12.0 mm, posterior palatal part 11.0 mm and the labial frenum width was 11.0 mm. 4. In the maxillary tray on the African American, the impression material width of posterior border (0.8 mm) was measured to be small. 5. In the mandibular tray on the Caucasian, the impression material width was measured (2.7-6.7 mm) and posterior border width (2.1 mm) was measured small. The impression material length was measured (2.8-6.7 mm). 6. In the mandibular tray on the African American, the impression material width was measured to be rather great showing width of the labial frenum 9.2 mm and the width of posterior border was measured too small (0.3 mm). Conclusion: This adjustable dental tray shows good accuracy to Korean because it was designed by the analysis of the dental arch size of Korean adult model. With this result, it can be applied to Caucasian and African American, we can take more easy and accurate dental impressions.

• Proceedings of the Korea Water Resources Association Conference
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• 2012.05a
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• pp.904-904
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• 2012

강우-유출모형중 단기 홍수 사상 모형은 주로 집중형으로 하천유량 모의에 중점을 두어 왔고, 장기유출모형은 분포형으로 기저유출 모의에 중점을 두어 왔다. 단기 홍수사상 모형은 유역 전반에 걸친 수자원의 분포특성을 파악하기 힘들다는 단점이 있고, 장기유출모형은 단기 홍수사상을 분석하기 힘들다는 단점이 있다. 이와 같은 단점은 두 모형을 함께 이용하여 보완할 수 있다. 따라서 본 연구에는 단기 홍수사상모형인 HEC-HMS모형과 장기유출모형인 SWAT모형을 연동하기 위하여 두 모형에 공통으로 적용되는 매개변수 CN값을 적절히 구해 이용하여야 한다. 두 모형에서 CN값을 얻는 방법은 첫 번째, HEC-HMS모형의 홍수기 호우사상별 최적평균 CN값을 구하는 것이고, 두 번째, SWAT모형 내에서 적용되는 일별 CN값을 구하는 것이다. 그리고 두 모형의 매개변수를 이용하여 보정 3년(2002년~2004년), 검증 2년(2005년~2006년), 적용 3년(2007년~2009년)을 모델링하여 SWAT-HMS모형의 유출분석 신뢰성을 판단하였다. 보정 3년 결과로 선행 5일강우량 기준으로 150mm 이하이면 모의가능하고, 150mm 이상이면 과소 모의되는 SWAT모형의 단점을 알 수 있었다. 검증을 실시한 2년은 SWAT-HMS모형의 중요 매개변수인 CN값을 HEC-HMS모형의 CN값과 SWAT모형의 CN값을 적용한 결과를 비교하여 상관계수 0.90과 0.95를 얻었으며, SWAT-HMS모형에 적용되는 매개변수 CN값은 SWAT모형의 CN값을 사용할 경우 더욱 신뢰할 수 있음을 알았다. 적용 3년(2007년~2009년)은 SWAT모형의 CN값을 SWAT-HMS모형에 적용하여 유출분석을 하였으며, 관측치와 모의치의 상관계수 0.95라는 신뢰할 수 있는 결과를 얻었다. 그리고 관측치와 모의치의 첨두유량은 평균적으로 5% 이내의 차이로 정확한 모의결과를 얻을 수 있었다. 따라서 본 연구는 격자분포형 유출모형인 SWAT모형과 집중형 유출모형인 HEC-HMS모형을 두 모형에 공통으로 적용되는 매개변수 CN값을 이용하여 두 모형이 가지는 단점을 해소하여 보다 정확한 유출분석 결과를 얻을 수 있는 방법을 제시 하였다.

• Journal of Korea Water Resources Association
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• v.42 no.6
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• pp.445-455
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• 2009

In this paper proportional hazards models for the first through seventh break of 150 mm cast iron pipes in a case study area are established. During the modeling process the assumption of the proportional hazards for covariates on the hazards is examined to include the time-dependent covariate terms in the models. As a result, the pipe material/joint type and the number of customers are modeled as time-dependent for the first failure, and for the second failure only the number of customers is modeled as time-dependent. From the analysis on the baseline hazard functions the failure hazards are found to be generally increasing for the first and second failure, while the hazards of the third break and beyond showed a form of a bath-tub. Furthermore, the changes in the baseline hazard rates according to the time and number of break reflect that the general condition of the pipes is deteriorating. The factors causing pipe break and their effects are analyzed based on the estimated regression coefficients and their hazard ratios, and the constructed models are verified using the deviance residuals of the models.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.33 no.2
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• pp.148-152
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• 2000

To provide basic information on the integumentary system of the blenny, Pholis nebulosa, ultrastructures of epidermal and dermal layer were examined by means of the light and transmission electron microscope. The skin of the blenny consisted of epidermal and dermal layer. Epidermal layer consisted of supporting cell and unicellular gland. The supporting cells were classified into superficial cell, intermediated cell and basal cell, and the gland cells were classified into mucous secretory cell and club cell. The cytoplasm of supporting cells was divided into cortex and medullar part. In the cortex and medullar part, microfilaments and cell organelles were well developed, respectively. Superficial cell of epidermal layer was cuboidal and contained nucleus of horseshoe shape. Intermediated cell had a nucleus of irregular form and the electron density was higher than the other supporting cells, Basal cell was columnar, but nucleus was situated in the upper cytoplasm. Cell organelles of the basal cell were poor than the other supporting cells, but membrane interdigitations were well developed. The cytoplasm of mucous secretory cell had a well-developed ovoid secretory granules, which reacted to red with AB-PAS reaction. The club cell had a we31-developed round secretory granules and endoplasmic reticulum. figment cells were classified into two type. The one contained pigment granules of electron dense, and the other contained reflecting platelets. The cytoplasm of fibrocyte had n well developed rough endoplasmic reticulum.

• Applied Microscopy
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• v.32 no.1
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• pp.57-66
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• 2002

The structures of sucker of two Cobiidae; Common freshwater goby and Triden goby were observed by light and electron microscopy. Scanning electron microscopy revealed the characteristic narrow ridges and grooves on the apical portion of sucker of Common freshwater goby, and hexagonal structures similar to a honeycomb representing the intercellular junctional area on the middle and basal portions. Some ridges were present on the epithelial surface on the middle and basal portions. The openings of several mucus-secreting cells were present between main epithelial cells. Light and transmission electron microscopy revealed the core of the fin; soft rays with a surrounding dense collagen fiber layer. Some loosely arranged fibers (collagen fiber) radiated toward the surface epithelium. The surface epithelium was cuboidal or columnar in shape. Scanning electron microscopy revealed the coiled irregular ridges and grooves, which was less developed and had sparser distribution than in Common freshwater goby, on the apical portion of sucker of Triden goby. The middle and basal portions had honeycomb structures as in Common freshwater goby. Fewer mucoussecreting cells were present. Light and transmission electron microscopy showed the core of soft rays, dense collagen fiber layer, however, the radiating fibers observed in the Common freshwater goby was rarely present. The sucker was thinner because the epithelium is squamous or polygonal in shape and rare presence of the radiating fibers.