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Age or Basal Serum FSH Levels; Which One is Better for Prediction of IVF Outcomes in Patients with Decreased Ovarian Reserve? (난소의 기능이 저하된 불임 환자에서 연령 및 기저 혈중 FSH 수치가 체외수정시술의 예후에 미치는 영향에 관한 연구)

  • Yu, Young;Kim, Min-Ji;Cho, Yeon-Jean;Yeon, Myeong-Jin;Ahn, Young-Sun;Cha, Sun-Hwa;Kim, Hye-Ok;Park, Chan-Woo;Kim, Jin-Young;Song, In-Ok;Koong, Mi-Kyoung;Kang, Inn-Soo;Jun, Jong-Young;Yang, Kwang-Moon
    • Clinical and Experimental Reproductive Medicine
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    • v.34 no.3
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    • pp.189-196
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    • 2007
  • Objectives: The purpose of this study is to investigate the clinical significance of age and basal serum FSH in predicting the outcomes of in vitro fertilization (IVF) in patients with poor-ovarian response. Methods: From January 2000 to December 2004, 85 second IVF cycles of 85 poor-ovarian response patients under the age of 42 with a back-ground of the first IVF cycles at our infertility center and 5 or less oocytes were retrieved and their basal serum FSH levels of 15$\sim$25 mIU/ml were enrolled in this study. Exclusion criteria were patients with a male factor for the etiology of infertility and undergoing genetic diagnosis of embryo such as PGD. Flare-up protocol was used for ovarian stimulation in all cases. Results: When we stratified the study groups by patient's age, the younger age group (age<35, n=35) showed significantly higher implantation rate (19.0% versus 4.0%, p<0.05) and higher ongoing pregnancy rate (100% versus 14.3%, p<0.05) than the older age group (age$\geq$35, n=50). And then, when we stratified the study populations by basal serum FSH level, the lower FSH group (basal serum FSH<20 mIU/ml, n=58) showed significantly higher number of retrieved oocytes (4.6$\pm$0.7 versus 2.2$\pm$0.5, p<0.05) and lower cancellation rate (19.0% versus 55.6%, p<0.05) than higher FSH group (basal serum FSH$\geq$20 mIU/ml, n=27). Conclusions: In conclusion, it was suggested that the patient's age could predict the IVF outcomes in respect to its potency of pregnancy and ongoing pregnancy. Serum basal FSH levels could predict more accurately the ovarian response of cycle, but not clinical outcomes.

Recovery of Precious Metals from Waste PCB and Auto Catalyst Using Arc Furnace (귀금속 함유 폐기물로부터 아크로를 이용한 유가금속 회수)

  • Ban Bong-Chan;Kim Chang-Min;Kim Young-Im;Kim Dong-Sn
    • Resources Recycling
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    • v.11 no.6
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    • pp.3-11
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    • 2002
  • Recently, waste printed circuit board (PCB) has significantly increased in its amount due to the rapid development of electronic industries. Since several kinds of noxious materials and also valuable metals are contained in it, the waste PCB is in an urgent need of recycling for the dual purposes for the prevention of environmental pollution and recovery of valuable resources. Also, the catalyst which equipped in the exhaust pipes of automobiles to reduce emission of air pollutants contains precious met-als so that their recovery from the waste auto-catalysts is required. In this study, the recovery of valuable metals from waste PCB and auto-catalyst by arc furnace melting process has been investigated, which is known to be very stable and suitable f3r less production of pollutants due to its high operating temperature. The effect of the kind of flux on the recovery of precious metals was examined by using quicklime, converter slag, and copper slag as the flux. In addition, the influence of direct and alternating current and the applying direction of direct current has been investigated. It was observed that using converter or copper slag as a flux was more desirable for a higher efficiency in the precious metal recovery compared with quicklime. For the effect of current, application of direct current taking the bottom as a negative pole generally showed a better efficiency for the extraction of valuable metals from waste PCB, which was also observed for the case of waste auto-catalyst. The average recovery of precious metals from both wastes by arc furnace melting process was very high, which was up to in the range of 95~97%.

Packet Performance Simulation of ACL/SCO Link in Bluetooth Piconet (블루투스 Piconet에서 ACL/SCO 링크의 패킷 성능 시뮬레이션)

  • Kim, Do-Gyun;Roh, Jae-Sung;Cho, Sung-Eon;Cho, Sung-Joon;Kim, Jung-Sun
    • Journal of Advanced Navigation Technology
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    • v.6 no.1
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    • pp.77-83
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    • 2002
  • The emergence of Bluetooth as a radio interface scheme has allowed electronic devices to be instantly interconnected as ad-hoc networks. These short range ad-hoc wireless networks are called piconets, operated in the unlicensed 2.45 GHz ISM(Industrial, Scientific, Medical) band where up to eight devices may be used to configure single or overlapping piconets. In this paper, we have simulated the PER(Packet Error Rate), the ratio of received packet and payload BER(Bit Error Rate) of piconet with packet types of Bluetooth ACL/SCO(Asynchronous Connection Less/Synchronous Connection Oriented) link over wireless ad-hoc environment. The Rayleigh fading effects are considered as channel model, and the simulation results are based on the baseband model of Bluetooth specification. From the simulation results, the PER and the throughput of Bluetooth piconet are sensibly affected by the packet type of ACL/SCO link.

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The Petrov-Galerkin Natural Element Method : II. Linear Elastostatic Analysis (페트로프-갤러킨 자연요소법 : II. 선형 정탄성 해석)

  • Cho, Jin-Rae;Lee, Hong-Woo
    • Journal of the Computational Structural Engineering Institute of Korea
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    • v.18 no.2
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    • pp.113-121
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    • 2005
  • In order to resolve a common numerical integration inaccuracy of meshfree methods, we introduce an improved natural clement method called Petrov-Galerkin natural element method(PG-NEM). While Laplace basis function is being taken for the trial shape function, the test shape function in the present method is differently defined such that its support becomes a union of Delaunay triangles. This approach eliminates the inconsistency of tile support of integrand function with the regular integration domain, and which preserves both simplicity and accuracy in the numerical integration. In this paper, the validity of the PG-NEM is verified through the representative benchmark problems in 2-d linear elasticity. For the comparison, we also analyze the problems using the conventional Bubnov-Galerkin natural element method(BG-NEM) and constant strain finite clement method(CS-FEM). From the patch test and assessment on convergence rate, we can confirm the superiority of the proposed meshfree method.

저온 대기압 플라즈마의 생의학 응용

  • Lee, Hyeon-U;Lee, Jae-Gu
    • Proceedings of the Korean Vacuum Society Conference
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    • 2011.02a
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    • pp.265-267
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    • 2011
  • 저온 대기압 플라즈마는 21세기에 들어 생의학 분야에 이용될 수 있는 새로운 도구로서 많은 관심을 받고 있다. 대기압 플라즈마는 고가의 진공 장비를 필요로 하지 않고 저전력 구동이 가능하기 때문에 저비용 구동이 가능하고 방전 장치와 전력공급 장치의 소형화에 매우 유리하다. 특히 저온 대기압 플라즈마는 고온의 전자와 저온의 이온 입자가 공존하는 열적 불평형(thermal non-equilibrium) 상태에 있기 때문에 플라즈마의 저온 특성은 유지하면서도 (${\sim}30^{\circ}C$) 물리/화학적 반응성은 매우 높아 그 응용 분야가 매우 넓다. 플라즈마의 다양한 생의학 분야 응용 가운데 세포의 사멸 유발 또는 생장 촉진, 살균/멸균, 지혈, 상처 치유 등에 저온 대기압 플라즈마가 매우 뛰어난 효능을 보인다는 것이 국내외의 다양한 연구를 통해 밝혀지고 있다 [1]. 20 kHz 정현파로 구동되는 플라즈마 장치를 이용한 암 세포 제거 실험에서 플라즈마 처리 효과를 증대시키기 위해 항체-금나노입자 중합체를 암 세포에 주입시켰다 (그림 1(a)). 그 결과 세포의 사멸율은 74%로서 플라즈마 또는 플라즈마-금나노입자만을 처리한 경우에 비하여 사멸율이 매우 높게 나타났다 (그림 1(b)). 이를 통해 암세포 선택성을 가진 항체-금나노입자 중합체와 플라즈마 처리 기술을 융합한 암 세포의 선택적 사멸 유발 기술의 개발 가능성이 열렸다. 또한 플라즈마 처리를 통해 일어나는 세포의 자멸사 기작이 Cytochrome C의 방출 이후 이어지는 Caspase-3의 활성화 경로와 관계가 있음이 밝혀졌다 (그림 1(c)). 치아 미백은 최근 부상하고 있는 저온 대기압 플라즈마의 새로운 응용 분야이다 [5-6]. 대기압에서 동작하는 헬륨 플라즈마 제트를 미백제(과산화수소)와 함께 발치된 치아에 적용하였을 때 (그림 2(a)) 미백제만을 사용하였을 경우에 비해 치아의 색상 변화가 2배 이상 크게 나타나는 것을 확인하였다 (그림 2(b)). 이처럼 최근 그 범위가 크게 넓어지고 있는 저온 대기압 플라즈마의 생의학 응용 기술의 최적화를 위해서는, 다양한 생의학 응용 분야에 따라 요구되는 플라즈마의 특성 및 응용별 기저 기 작에 대한 이해와 연구가 필요하다.

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Analysis of E-polarized Plane Wave Scattering by a Tapered Resistive Strip Grating in a Grounded Double Dielectric Layer (접지된 2중 유전체 사이의 저항 띠 격자 구조에 의한 E-분극 전자파 산란 해석)

  • Tchoi, Young-Sun;Yang, Seung-In
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.18 no.6 s.121
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    • pp.656-663
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    • 2007
  • In this paper, when a E-polarized plane wave is incident on the grating consisting of tapered resistive strips, electromagnetic scattering is analyzed using the method of moments(MoM). The induced current density of each resistive strip in a grounded double dielectric layer is expected to blow up at both edges. To satisfy this, the induced surface current density is expanded in a series of Chebyshev polynomials of the second kind. The scattered electromagnetic fields are expanded in a series of Floquet mode functions. The boundary conditions are applied to obtain the unknown current coefficients. According to the variation of the involving parameters such as strip width and spacing and angle of the incident field, numerical simulations are performed by applying the Fourier-Galerkin moment method. The numerical results of the normalized reflected power for resistive strips case for several resistivities are obtained.

Ensemble Design of Machine Learning Technigues: Experimental Verification by Prediction of Drifter Trajectory (앙상블을 이용한 기계학습 기법의 설계: 뜰개 이동경로 예측을 통한 실험적 검증)

  • Lee, Chan-Jae;Kim, Yong-Hyuk
    • Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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    • v.8 no.3
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    • pp.57-67
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    • 2018
  • The ensemble is a unified approach used for getting better performance by using multiple algorithms in machine learning. In this paper, we introduce boosting and bagging, which have been widely used in ensemble techniques, and design a method using support vector regression, radial basis function network, Gaussian process, and multilayer perceptron. In addition, our experiment was performed by adding a recurrent neural network and MOHID numerical model. The drifter data used for our experimental verification consist of 683 observations in seven regions. The performance of our ensemble technique is verified by comparison with four algorithms each. As verification, mean absolute error was adapted. The presented methods are based on ensemble models using bagging, boosting, and machine learning. The error rate was calculated by assigning the equal weight value and different weight value to each unit model in ensemble. The ensemble model using machine learning showed 61.7% improvement compared to the average of four machine learning technique.

A comparison between impulse oscillometry system and spirometry for spirometry for detecting airway obstruction in children (소아의 기도 폐쇄 평가에서 impulse oscillometry system과 폐활량 측정법의 비교)

  • Hur, Hae Young;Kwak, Ji Hee;Kim, Hyoung Yun;Jung, Da Wun;Shin, Yoon Ho;Han, Man Yong
    • Clinical and Experimental Pediatrics
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    • v.51 no.8
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    • pp.842-847
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    • 2008
  • Purpose : Measurement of forced expiratory volume in 1 second ($FEV_1$) is usually difficult to obtain in children under six years of age because it requires active cooperation. This study evaluates the sensitivity of impulse oscillometry system (IOS) parameters for detecting airway obstruction in comparison with $FEV_1$. Methods : We studied 174 children who performed the lung function and methacholine challenge tests to diagnose asthma by IOS and spirometry. Children were divided into two subgroups according to their $PC_{20}$, which is a parameter for bronchial sensitivity. We compared IOS parameters with $FEV_1$ at the baseline, post-methacholine challenge, and evaluated their correlation. Results : At the baseline, reactance at 5 Hz (X5) and resistance at 5 Hz (R5) significantly differed between the $PC_{20}$ positive ($PC_{20}{\leq}16mg/mL$) group and $PC_{20}$ negative ($PC_{20}$ >16 mg/mL) group; however, $FEV_1$, $FEV_1$ % predicted, $FEV_1_-Zs$ (Z score) did not differ. $FEV_1$ is correlated with X5 (r=0.45, P<0.01) and R5 (r=-0.69, P<0.01). $FEV_1_-Zs$ is also correlated with X5_Zs (r=-0.26, P<0.01) and R5_Zs (r=-0.31, P<0.01). After the methacholine challenge test, dose-response slopes in $FEV_1$ and X5 significantly differed between the two subgroups (P<0.05). Conclusion : IOS parameters were more discriminative than $FEV_1$ for detecting decreased baseline lung function between two subgroups and have a good correlation with $FEV_1$.

Effects of Changes of Climate, Groundwater Withdrawal, and Landuse on Total Flow During Dry Period (기후, 지하수 취수 및 토지이용 변화의 건기 총유출량에 대한 영향)

  • Lee, Kil-Seong;Chung, Eun-Sung;Shin, Mun-Joo
    • Proceedings of the Korea Water Resources Association Conference
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    • 2006.05a
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    • pp.164-168
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    • 2006
  • 본 연구는 SWAT 모형을 이용하여 기상, 지하수 취수, 토지이용 변화에 대한 건기 총유출량의 민감도를 제시하였으며 더 나아가 보다 일반적인 건기의 총 유출량을 추정하기 위해 건기 총강우량, 전 우기 총강우량, 평균 일 최대온도, 일평균 태양복사량과 같은 기상 변수들과 지하수 취수량 및 도시면적 비율을 이용하여 회귀식을 도출하였다. 도출된 식을 이용하여 기후변화에 대한 변화를 살펴보기 위하여 온도와 강우량의 변화에 대한 건기 총유출량의 변화율을 제시하였는데 기후변화로 인해 온도가 $1^{\circ}C$ 상승할 경우 7.7%, $2^{\circ}C$ 상승시 17.1%, $3^{\circ}C$ 상승할 경우 27.9%의 건기의 총 유출량은 감소하는 것으로 나타났다. 또 건기 총 강우량이 5% 감소할 경우 유출량은 5.63%, 10% 감소할 경우에는 10.41%, 15% 감소할 경우는 14.25% 감소하는 것으로 나타났다. 지하수 취수량은 총 유출량과 관계가 높은데 반해 토지이용 변화는 산간유역인 대상유역의 경우 크게 영향을 미치지 않음을 알 수 있었다. 본 연구에서 제안된 식은 기저유출에 영향을 크게 미치는 강우와 기온 및 태양복사량을 포함하는 기상상태, 지하수 취수량, 도시면적 비율을 변수로 갖는 식이므로 대상유역에 대해 미래 건기의 수자원 확보량을 예측하는데 유용하게 사용될 수 있다.

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A Study on High Resolution Reconstruction Algorithms for improving Resolution (해상도 향상을 위한 고해상도 복원 알고리즘 연구)

  • Baek, Young-Hyun;Moon, Sung-Ryong
    • Journal of the Korean Institute of Intelligent Systems
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    • v.17 no.1
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    • pp.72-79
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    • 2007
  • In this paper, It propose a new restoration algorithm of high resolution, which is reconstructed to high resolution image using low resolution image informations. The proposed algorithm is constructed based on super resolution theory, it is consisted of progressive steps of the integration and construction. It reduced a lot of data-processing capacity and noise with integration through sub-pixel movement and wavelet basis through a higher resolution. As a result, it is shown that the main information is maintained and the error rate is improved. Using expansion fuzzy wavelet B-spline interpolation in stage of construction, it is confirmed that we can achieve smoothing image and good resolution without blur and block.