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http://dx.doi.org/10.3345/kjp.2008.51.8.842

A comparison between impulse oscillometry system and spirometry for spirometry for detecting airway obstruction in children  

Hur, Hae Young (Department of Pediatrics, College of Medicine, Pochon CHA University)
Kwak, Ji Hee (Department of Pediatrics, College of Medicine, Pochon CHA University)
Kim, Hyoung Yun (Department of Pediatrics, College of Medicine, Pochon CHA University)
Jung, Da Wun (Department of Pediatrics, College of Medicine, Pochon CHA University)
Shin, Yoon Ho (Department of Pediatrics, College of Medicine, Pochon CHA University)
Han, Man Yong (Department of Pediatrics, College of Medicine, Pochon CHA University)
Publication Information
Clinical and Experimental Pediatrics / v.51, no.8, 2008 , pp. 842-847 More about this Journal
Abstract
Purpose : Measurement of forced expiratory volume in 1 second ($FEV_1$) is usually difficult to obtain in children under six years of age because it requires active cooperation. This study evaluates the sensitivity of impulse oscillometry system (IOS) parameters for detecting airway obstruction in comparison with $FEV_1$. Methods : We studied 174 children who performed the lung function and methacholine challenge tests to diagnose asthma by IOS and spirometry. Children were divided into two subgroups according to their $PC_{20}$, which is a parameter for bronchial sensitivity. We compared IOS parameters with $FEV_1$ at the baseline, post-methacholine challenge, and evaluated their correlation. Results : At the baseline, reactance at 5 Hz (X5) and resistance at 5 Hz (R5) significantly differed between the $PC_{20}$ positive ($PC_{20}{\leq}16mg/mL$) group and $PC_{20}$ negative ($PC_{20}$ >16 mg/mL) group; however, $FEV_1$, $FEV_1$ % predicted, $FEV_1_-Zs$ (Z score) did not differ. $FEV_1$ is correlated with X5 (r=0.45, P<0.01) and R5 (r=-0.69, P<0.01). $FEV_1_-Zs$ is also correlated with X5_Zs (r=-0.26, P<0.01) and R5_Zs (r=-0.31, P<0.01). After the methacholine challenge test, dose-response slopes in $FEV_1$ and X5 significantly differed between the two subgroups (P<0.05). Conclusion : IOS parameters were more discriminative than $FEV_1$ for detecting decreased baseline lung function between two subgroups and have a good correlation with $FEV_1$.
Keywords
Impulse oscillometry; Forced expiratory volume in 1 second; Spirometry; Children;
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Times Cited By KSCI : 1  (Citation Analysis)
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