• The Korean Journal of Mycology
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• v.8 no.2
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• pp.85-88
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• 1980

The antifungal activity of salicylaldehyde-o-phenylenediimine, a derivative of Schiff base, was studied in vitro against various species of fungi, especially, dermatophytes. The antifungal tests were performed according to the tube-dilution method, and all subcultures were incubated at room temperature for 14 days. Salicylaldehyde-o-phenylenediimine was effective against fungi such as Trichophyton mentagrophytes, Trichophyton rubrum, Microsporum canis and Fonsecaea compacta. Trichophyton mentagrophytes was inhibited at $20{\mu}g$ per ml, Trichophyton rubrum at $40{\mu}g$ per ml, Microsporum canis at $6{\mu}g$ per ml, and Fonsecaea compacta at $2{\mu}g$ per ml.

• The Journal of the Korean Society for Microbiology
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• v.19 no.1
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• pp.35-40
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• 1984

The effectiveness of three antifungal antibiotics amphotericin B, clotrimazole and 5-fluorocytosine was tested against 120 clinical isolated Candida species. The minimum inhibitory concentrations of amphotericin B was considerably lower than those of clotrimazole and 5-fluorocytosine. High-level resistance to 5-fluorocytosine was present in 50% of the isolates. The combination of clotrimazole and 5-fluorocytosine produced synergistic inhibition against all 20 strains of Candida albicans tested that were relatively resistant to both antifungal agents.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2014.11a
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• pp.65-67
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• 2014

There are many elastomeric joint sealant applications in construction such as structural glazing, weatherproofing and insulating glass fabrication etc. Each sealant joints require unique durability functions to perform well through building life cycle. Elastomeric joints in bathroom and kitchen is one of areas which require durable sealing. In this application, anti fungal durability is proprietary function of sealant during building life cycle. Premature failure of anti fungus resistance of sealant is putting big stresses to general contractor as well as the inhabitants due to costly rework and poor sanitation. Accordingly, when chemists design a product, they must take into account various parameters not only formulation components also test conditions in order to have long term fungal durability. This paper reviews several biocide options with various industry standards for fungus resistance performance to suggest making new test method for construction sealant industry.

• Korean journal of applied entomology
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• v.2
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• pp.12-15
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• 1963

1. The trials were planned to test seven different fungicides for the control of Early blight of potato during the period of 1962 and 1963. 2. All of fungicides tested in the trials were considerably effective to control the disease, as the result of 4 applications which was done in one week intervals from early of June in 1963. All treatments were effective enough to make significant differences from the untreated. Especially, Dithyane M45, Difolatan and Dithane M22 showed satisfactory control even though no significant differences were obtained among them. Besides the three treatments, Bordeaux Mixture were relatively effective.

• YAKHAK HOEJI
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• v.40 no.5
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• pp.507-512
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• 1996

Some allylamine compounds which are benzothiazole substituants in stead of naphthyl ring in naftifine, antifungal agents, were synthesized as potential antimycotics. The interme diate Schiff bases that were obtained by condensation of 2-aminobenzothiazole and trans-cinnamaldehyde, were reduced to imine compounds to give allylamines (5a-5d) after methylation. These compounds which were tested in vitro against five fungal cell lines containing Trichophyton mentagrophytes, showed no activity in 0.1~100${\mu}$g/ml range.

• Journal of Industrial Technology
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• v.1
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• pp.39-45
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• 1981

The typical characteristic shape of the Koryo inlaid celadon Maebyong was reviewed and the symmetry of S curve was analyzed by the method of geometric basis. The contours of Maebyongs sampled were drawn and divided with geometric rectangular proportion. The analytical results showed the static and dynamic symmetric of the vase and the ratios of height and base of the rectangles established for the analysis of their shapes were almost 1:1, 1:${\sqrt{2}}$ and 3:5(known as the Golden Ratio). The excellent beauty of the curve was principally caused by the balanced and harmonius division of the proportional rectangles. The contour line was developed along with the logarithmic spiral modified and introduced lately into the shape of Yi dynasty's liquor bottle.

• YAKHAK HOEJI
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• v.47 no.5
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• pp.293-299
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• 2003

Structure-activity relationship studies of allylamine type of antimycotics were carried out to evaluate the effect of naphthyl and methyl portion of naftifine. Compounds with 4-fluorophenyl(2a-5a), 2-fluorophenyl(2b-5b), 2,4-dichlorophenyl(2c-5c), 2,6-dichlorophenyl(2d-5d), 4-nitrophenyl(2e-5e), and 2,3-dihydro-benzo[1,4]dioxan-6-yl( 2f-5f) instead of naphthyl group with hydrogen(3a-3f), methyl(4a-4f), and ethyl(5a-5f) in the place of methyl in naftifine were synthesized and tested their in vitro anti-fungal activity against five different fungi. Eight compounds(3a, 5a, 3c, 4c, 4d, 5d, 5e, and 4f) showed significant antifungal activity against T. mentagrophytes. (E)-N-Ethyl-(3-phenyl-2-propenyl)-4-nitro-benzenemethaneamine(5e) displayed moderate antifungal activity against all five different fungi.

• Journal of the Korean Applied Science and Technology
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• v.16 no.4
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• pp.299-306
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• 1999

For the synthesis of new antifungal agents, We have synthesized four new ketoconazole derivatives were synthesized by the reaction of cis-[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-1,3-dioxolan-4-yl]methane sulfonate with isolated fig compounds. These compounds were showed strong antifungal activity against C, albicans ATCC 10231. C, utilis. S, cerevisiae ATCC 9763. A and niger ATCC 9029. Among them, sample No.(13) showed potent inhibition activity. Generally, other samples showed biological activity in vitro test. The above results showed the possibility of the development of new antifungal agents.

• Journal of Dental Rehabilitation and Applied Science
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• v.38 no.2
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• pp.120-126
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• 2022

In severe cases of denture stomatitis, antifungal drugs are sometimes ineffective. This case is a 72-year-old patient who was prescribed fluconazole for five months but had no improvement in symptoms. After re-diagnosis, medication was performed, and temporary dentures were fabricated for oral rehabilitation. This report describes that microbiological analysis and adjuvant therapy can be helpful, in case does not improve symptoms even with continuous medication of antifungal agent.

• Journal of Yeungnam Medical Science
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• v.9 no.2
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• pp.396-406
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• 1992

Various susceptibility tests have been used to determine minimal inhibition concentration(MIC) of dermatophytes. They have limitations to apply practically because they need long time to determine MIC. Authors examined MIC of T. rubrum to ketoconazole and itraconazole using 96-well microplate and 24-well macroplate by method of Granade and Artis and tried to check the possibility of this method on clinical application. Nine strains of T. rubrum from patients with dermatophytosis were used. Evaluations of the factors affecting MIC were also tried. The results were as follows. 1. Effect of inoculation density on determination time and MIC : Determination of MIC were possible in 4th days after inoculation at higher inoculation density Caborbance 2.0, 1.0) compared to 6th days at lower inoculation density(absorbance 0.5, 0.25). 2. Effect of incubation temperature on MIC : When incubating at $37^{\circ}C$, MIC were below 0.006-$0.04{\mu}g/ml$ to ketokckonazole and below 0.006-$0.04{\mu}g/ml$ to itraconazole while at $25^{\circ}C$ 0.08-$5.68{\mu}g/ml$ to ketoconazole and 0.006-$0.71{\mu}g/ml$ to itraconazole. Significant reduction of MIC was observed at $37^{\circ}C$ compared to $25^{\circ}C$. 3. Effect of container size on determination time and MIC : When incubating in 96-well microplate and 24-well macroplate, determination of MIC was possible in 4th to 6th days after inoculation in broth-containig 96-well microplate compared to 8th to 12th days in broth-containing 24-well macroplate. But no difference in MIC was observed between different container size. 4. Effect of media on MIC : When using broth as media, MIC were below 0.006-$5.68{\mu}g/ml$ to ketoconazole, below 0.006-$0.36{\mu}g/ml$ to itraconazole in broth-containg 24-well macroplate. When using agar as media, MIC were below 0.006-$5.68{\mu}g/ml$ to ketoconzole, below 0.006-$5.68{\mu}g/ml$ to intraconzole in agar-containing 24-well macroplate. There was slight increase of MIC with agar media compared to broth media. 5. These findings confirm that determination of MIC of dermatophtes by method of Granade and Artis is fast and simple technique for antifungal susceptibility test.