The Journal of the Korean Society for Microbiology (대한미생물학회지)

The Korea Society for Microbiology (대한미생물학회)
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In Vitro Antifungal Activity of Amphotericin B, Clotrimazole and 5-Fluorocytosine in Alone and in Combination against Candida Species

Candida균주에 대한 항진균제 Amphotericin B, Clotrimazole 및 5-Fluorocytosine의 단독 및 복합처리에 따른 항균력 검사

  • Koh, Choon-Myung (Department of Microbiology, Wonju Medical College, Yonsei University) ;
  • Joo, Hye-Jung (Department of Microbiology, Wonju Medical College, Yonsei University) ;
  • Park, Hyoung-Sik (Department of Microbiology, Wonju Medical College, Yonsei University)
  • 고춘명 (연세대학교 원주의과대학 미생물학교실) ;
  • 주혜정 (연세대학교 원주의과대학 미생물학교실) ;
  • 박형식 (연세대학교 원주의과대학 미생물학교실)
  • Published : 1984.12.31
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Abstract

The effectiveness of three antifungal antibiotics amphotericin B, clotrimazole and 5-fluorocytosine was tested against 120 clinical isolated Candida species. The minimum inhibitory concentrations of amphotericin B was considerably lower than those of clotrimazole and 5-fluorocytosine. High-level resistance to 5-fluorocytosine was present in 50% of the isolates. The combination of clotrimazole and 5-fluorocytosine produced synergistic inhibition against all 20 strains of Candida albicans tested that were relatively resistant to both antifungal agents.

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