• KSBB Journal
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• v.23 no.5
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• pp.425-430
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• 2008

Hydrogen sulfide ($H_2S$) is a by-product of metabolism of amino acids including sulfur and alcoholic fermentation, it is generally thought of in terms of a poisonous gas. Though $H_2S$ can have a negative impact on the perceived quality of fermented drinks due to an undesirable aroma, it plays prominent roles as a neuromodulator in the mammalian brain as well as a smooth muscle relaxant. Nowadays studies on the proteins which produce $H_2S$ are carried out in various fields such as structure, function, and metabolism. Here we propose to develop a simple and rapid $H_2S$ forming assay method, which will lead to speed up preparing the $H_2S$ forming proteins for identification by MALDI-TOF MS analysis. We detected three kinds of proteins which produce $H_2S$ in the crude extract of Saccharomyces cerevisiae. Those proteins were cystathionie $\beta$-synthase, O-acetylserine sulfhydrylase, and cystathionine $\gamma$-lyase.

• Journal of Veterinary Clinics
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• v.32 no.5
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• pp.399-403
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• 2015

Peritoneal dialysis (PD) is a treatment for renal failure and acute poisoning, and uses the patient's peritoneum in the abdomen as a membrane across which fluids and dissolved substances are exchanged from the blood. In this study, we evaluated the therapeutic efficacy and complications of automated peritoneal dialyzer (APD) in dogs with renal failure. PD was performed in 10 dogs using a swan neck catheter (Neonatal, Coviden) and automatic APD. The efficacy for each dog was assessed by calculating urea reduction ratio (URR) and creatinine reduction ratio (CRR). Mean concentrations of pre-dialysis creatinine and blood urea (BUN) were $7.09{\pm}3.84$ and $145.8{\pm}48.5$, respectively. The mean number of peritoneal dialysis cycles applied was $6{\pm}1$ cycles. Peritoneal dialysis resulted in a significant decrease in BUN concentration in 7/10 dogs, while a significant decrease in creatinine concentration in 9/10 dogs. The mean of URR was higher than that of CRR ($0.39{\pm}0.16$ vs $0.38{\pm}0.13$). The mean CRR and URR per dialysis cycles were $0.064{\pm}0.023$ and $0.065{\pm}0.023$, respectively. Complications found in this study were catheter occlusion, subcutaneous dialysate leakage, septic peritonitis, hypoalbuminemia and overhydration. This study found PD using a swan neck catheter and APD machine showed acceptable efficacy for successful peritoneal dialysis in dogs. However, close monitoring is required to minimize the risk of complication.

• Proceedings of the Korean Institute Of Construction Engineering and Management
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• autumn
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• pp.113-119
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• 2003

Since Lean Construction has been introduced as a new management approach to improve productivity in the construction industry, much research is in progress to develop lean concepts and principles for better implementation and to get results of the successful adaptation of lean ideas from manufacturing for application in the construction industry. Currently, several construction companies in the USA have applied the Last Planner System (LPS), a decentralized system developed by the Lean Construction Institute. Thus, there are demands to share information how other companies implement lean construction, to identify the benefits and barriers of lean implementation in the construction fields, and finally to improve their lean implementation. This study carried out case studies to assess current lean construction projects with the objective to find out how effectively and to what extent lean construction is being adapted by the construction industry. This study will only introduce the Last Planner which has four levels in the LPDS, findings based on interviews with project participants, and observations from the projects. This study will also provide empirically identified success factors associated with lean implementation on the construction site. Finally, the recommendations are offered to support the effort of adaptation of lean construction in the domestic construction industry. Even though lean construction still stood on the bridge crossing from current practice to lean practice, it is the researcher's conviction that lean construction would be successfully adapted to the construction industry in the near future and would be recognized as an effective management innovation.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2004.05a
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• pp.624-627
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• 2004

본 연구는 동일한 병렬기계에서의 총 납기지연의 합을 최소화하는 일정계획 문제에 대해 다룬다. 이 문제는 Lenstra et al. (1977)에 의해 NP-hard로 알려져 있으며, 작업의 수와 기계의 수가 큰 현실적 문제에 대해 적절한 시간 내에 최적해를 찾는다는 것은 사실상 불가능하다. 따라서 본 연구에서는 이 문제를 해결하기 위하여 혼합형 유전 알고리즘(hybrid genetic algorithm)을 제안한다. 혼합형 유전 알고리즘에서는 임의로 발생시킨 모집단에 대해 먼저 유전 알고리즘(genetic algorithm)이 세대를 진행하며 해를 개선한다. 유전 알고리즘이 일정기간동안 더 이상 해를 개선하지 못하면, 부분탐색 알고리즘(local-search algorithm))이 유전 알고리즘의 모집단의 개체들에 대해 해의 개선을 시도한다. 즉, 부분 탐색 알고리즘은 모집단 속의 각각의 개체를 초기해로 하여 모집단 내의 개체 수만큼의 부분 최적해(local optimum)들을 구한다. 이렇게 구한 부분 최적해들로 새로운 모집단을 구성하면 다시 유전 알고리즘이 진행된다. 이 과정을 종료조건에 이를 때까지 번갈아가며 반복 수행한다. 본 연구에서 제안한 유전 알고리즘에서는 Bean(1994)이 제안한 Random key 방법으로 개체를 표현하였으며 Park(2000)이 제안한 3가지 교차 연산자들을 채용하였다. 부분탐색 알고리즘을 위해서는 쌍대교환(pair-wise interchange) 방법을 통해 이웃해를 생성하였다. 선행실험을 통하여 제안한 혼합형 유전알고리즘에서 사용하는 다양한 모수(parameter)값들을 최적화하였으며 알고리즘의 성능을 비교하기 위하여 기존의 알고리즘과도 비교실험을 수행하였다.복적인 지표가 채택되는 경우를 포함하고 있다. 셋째는 추상적이며 측정이 어려운 지표를 채택하고 있는 경우이다. 여기에는 지표에 대한 정확한 정의가 이루어져 있지 않아 피 평가자가 불필요하거나 과다한 평가 자료를 준비해야 하거나 평가자로 하여금 평가 시 혼돈을 유발할 가능성이 있거나, 또는 상위개념의 평가항목과 하위개념의 평가항목이 혼재되어 구분이 모호한 경우를 포함하고 있다. 바탕으로 '생태적 합리성'이라는 체계적인 지식교육을 거쳐서, '환경정의' 의식의 제고로 이어가고, 굵직한 '환경갈등'의 상황에서 뚜렷한 정치적 태도와 실천을 할 수 있는 '생태적 인간상'의 육성으로 나아갈 수 있어야 한다는 것이 필자의 생각이다. 이를 위해서는 어찌되었건 체험학습 영역에서는 환경현안에 대한 사회적 실천을 '교육 소재'로 삼을 수 있어야 하며, 교과학습 영역에서는 한국사회의 환경현안에 대한 정치경제적 접근을 외면하지 말고 교과서 저작의 소재로 삼을 수 있어야 하며, 이는 '환경관리주의'와 '녹색소비'에 머물러 있는 '환경 지식교육'과 실천을 한단계 진전시키는 작업으로 이어질 것이다. 이후 10년의 환경교육은 바로 '생태적 합리성'과 '환경정의'라는 두 '화두'에 터하여 세워져야 한다.배액에서 약해를 보였으나, 25% 야자지방산의 경우 50 ${\sim}$ 100배액 어디에서도 액해를 보이지 않았다. 별도로 적용한 시험에서, 토마토의 경우에도 25% 야자지방산 비누 50 ${\sim}$ 100배액 모두 약해를 발생하지 않았으나, 오이에서는 25% 야자지방산 비누 100배액에도 약해를 나타내었다. 12. 이상의 결과, 천연지방산을 이용하여 유기농업에 허용되는 각종의 살충비누를 제조할 수 있었으

• Journal of Intelligence and Information Systems
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• v.13 no.3
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• pp.119-140
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• 2007

Recommender systems enable a user to decide which information is interesting and valuable in our world of information overload. As the recent studies of distributed computing environment have been progressing actively, recommender systems, most of which were centralized, have changed toward a peer-to-peer approach. Collaborative Filtering (CF), one of the most successful technologies in recommender systems, presents several limitations, namely sparsity, scalability, cold start, and the shilling problem, in spite of its popularity. The move from centralized systems to distributed approaches can partially improve the issues; distrust of recommendation and abuses of personal information. However, distributed systems can be vulnerable to attackers, who may inject biased profiles to force systems to adapt their objectives. In this paper, we consider both effective CF in P2P environment in order to improve overall performance of system and efficient solution of the problems related to abuses of personal data and attacks of malicious users. To deal with these issues, we propose a multi-agent framework for a distributed CF focusing on the trust relationships between individuals, i.e. web of trust. We employ an agent-based approach to improve the efficiency of distributed computing and propagate trust information among users with effect. The experimental evaluation shows that the proposed method brings significant improvement in terms of the distributed computing of similarity model building and the robustness of system against malicious attacks. Finally, we are planning to study trust propagation mechanisms by taking trust decay problem into consideration.

• Economic and Environmental Geology
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• v.47 no.3
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• pp.275-289
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• 2014

Recent scaled-up onshore and offshore field production tests revealed that the expectancy to produce gas from the gas hydrate deposits is gradually increasing, recognizing its potentials as one of the future energy resources. The total produced gas was approximately $480m^3$ by the hot water circulation method for 6 days' operation in Mallik 2002 project in Canada. In Mallik 2006-2008 project, the gas was successfully produced stably by the depressurization method for 6 days, up to $13,000m^3$ cumulatively. The depressurization method applied in the Mallik test was revealed as an effective way to produce gas from gas hydrates. The Alaska North Slope field trial in 2012 to inject mixed gas of $CO_2$ and $N_2$ to exchange $CH_4$ was successfully completed for the first time to produce maximum $1,270m^3$ per day. The remarkable achievement is that Japan has completed first offshore production test in the Eastern Nankai Trough, and produced approximately $120,000m^3$ of methane by the depressurization method for 6 days in March 2013. The technical challenges and uncertainties obtained from Nankai Trough production test give Korea more considerations in the aspects of well completion, reservoir formation and seafloor stability, sand control, flow assurance, and etc., due to the different geological environments and geomechnical properties in Ulleung Basin in Korea.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.16 no.3
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• pp.347-357
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• 2018

The applicability of room temperature ionic liquids (RTILs), 1-alkyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([$C_nmim$] [$Tf_2N$]), was investigated for the extraction of Am(III) and Eu(III) from nitric acid using n-octyl(phenyl)-N,N-diisobutyl carbamoylmethyl phosphine oxide (CMPO) and tri-n-butylphosphate (TBP) as extractants. The distribution ratios of Am(III) and Eu(III) in CMPO-TBP/[$C_nmim$][$Tf_2N$] were measured as a function of various parameters such as the concentrations of nitric acid, CMPO, and TBP. The results were compared with those obtained in CMPO-TBP/n-dodecane (n-DD). With comparable concentrations of the extractants, the distribution ratios obtained with RTILs were much higher than those obtained with n-DD. It was observed that the extraction efficiency was less for Eu(III) than for Am(III). The extraction of Am(III) and Eu(III) decreased with increases in the feed acidity for all three RTILs. The results suggest that the extraction of Am(III) and Eu(III) by CMPO in RTILs from nitric acid proceeds through the cation-exchange mechanism. The distribution ratios of Am(III) and Eu(III) increased with increases in the concentration of CMPO for all three RTILs. A linear regression analysis of the extraction data resulted in a straight line with a slope of about 3, suggesting the involvement of 3 molecules of CMPO during the extraction process.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.33 no.3
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• pp.189-196
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• 2007

In order to investigate the potential of very low molecular weight hyaluronic acid(oligo HA) as a cosmetic ingredient, we first measured its cytotoxicity in fibroblast, keratinocyte, and SIRC cell lines. For efficacy test, its moisturizing effect and penetration rate were evaluated in an artificial skin system and Caco-2 cells. Oligo HA did not show any cytotoxicity at a concentration of 300 ${\mu}g/mL$ in fibroblasts and 1,000 ${\mu}g/mL$ in keratinocytes but it showed weak proliferation. In vitro ocular test, oligo HA showed negligible cytotoxicity at the maximum concentrations used(2,000 ${\mu}g/mL$) in SIRC cells. In the test of the single and repeated cutaneous applications, oligo HA under occlusive patch did not provoke any cumulative irritation and sensitization. Oligo HA at a concentration of 0.01 % exhibited a more potent moisturizing effect than hyaluronic acid at a concentration of 0.01 %. In the permeability test using artificial skin and Caco-2 cell lines, hyaluronic acid(M.W. $1.1{\times}10^6$) was hardly observed in the down medium of the inserts. On the other hand, oligo HA(M.W. 5,000) was detected in the down medium up to 16.0 % at 6 h in Caco-2 cell culture and up to 90 % at 6 h in an artificial skin system. These results suggest that oligo HA could be useful as an active ingredient for cosmetics.

• Membrane Journal
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• v.14 no.2
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• pp.173-184
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• 2004

For the application of direct methanol fuel cell (DMFC), sulfonated polystyrene/teflon (PS/PTFE) composite membranes were developed by changing monomer ratio of styrene and DVB. The composite membranes were prepared as follows: first, the monomer mixtures consisting of styrene, divinyl benzene and AIBN were impregnated in porous PTFE film and then, polymerized under 8$0^{\circ}C$ to give PS/PTFE membranes. Finally, the membranes were reacted with chlorosulfonic acid in 1,2-dichloroethane to give the sulfonated composite membranes. The measurements of ATR-FTIR, SEM, solvent uptake test and ion exchange capacity (IEC) were done for the resulting membranes before or after sulfonation, respectively, which showed the composite membranes with proper crosslinking degree and sulfonic acid content were prepared well as a function of styrene/DVB ratio. ion conductivity and methanol permeability were studied for the sulfonated membranes. It was found that with decreasing the ratio of styrene/DVB, methanol permeability decreased from $6.6{\times}10^{-7}∼1.3{\timas}10^{-7}$ $\textrm{cm}^2$/s, which are much lower values than that of Nafion$^{(R)}$117($1.02{\times}10^{-6}$ $\textrm{cm}^2$/s). Under the same monomer condition, ion conductivity decreased from 0.11 S/cm ($25^{\circ}C$) to 0.08 S/cm ($25^{\circ}C$), which are similar or a little higher values compared with $Nafion^{(R)}117 (1.02{\times}10^{-6}$ $\textrm{cm}^2$/s, 0.0824 S/cm). These two results confirmed the composite membranes prepared could be applied successfully to DMFC.C.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.8 no.2
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• pp.183-198
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• 1997

Objects：This study was carried out to develop the Korean form of Moral Development Inventory for Adolescents designed to assess the principled morality in adolescents. And the auther also intended to find the demographic variables that influence the moral development. Methods：The Korean form inventory was applied to 507 middle and high school adolescents, and retest was done in 42 second year middle school adolescents with 3 weeks interval. Together this inventory, short form of Rest moral development which had been proved its reliability and validity, were administered to the all subjects for concurrent validity. And then the author examined whether this inventory discriminates between conduct disorder patients, psychiatric controls and normal controls in the level of moral development. Results：Test-retest reliability and internal consistency were very satisfactory. Concurrent validity with this inventory was also high level. And conduct disorder patients were scored significant lower than psychiatric and normal controls in the level of principled morality. The mean PM scores did not show significant difference according to the variables such as sex, birth order and religion. But there was significant difference according to the educational level of mother and places. Conclusions：These results indicate that the Korean form of Moral Development Inventory is a reliable and valid rating inventory to assess the moral development level in Korean adolescents.