• Title/Summary/Keyword: 교정인자

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Quality Correction for Ir-192 Gamma Rays in Air Kerma Strength Dosimetry Using Cylindrical Ionization Chambers (원통형 전리함을 이용한 Ir-192 선원에 대한 공기커마세기 측정 시 선질보정에 관한 연구)

  • Jeong, Dong-Hyeok;Kim, Jhin-Kee;Kim, Ki-Hwan;Oh, Young-Kee;Kim, Soo-Kon;Lee, Kang-Kyoo;Moon, Sun-Rock
    • Progress in Medical Physics
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    • v.20 no.1
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    • pp.30-36
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    • 2009
  • The quality correction in the air kerma dosimetry for Ir-192 using farmer type ionization chambers calibrated by Co-60 quality is required. In this study we determined quality factor ($k_u$) of two ionization chambers of PTW-N30001 and N23333 for Ir-192 source using dosimetric method. The quality factors for energy spectrum of microSelectron were determined as $k_u$=1.016 and 1.017 for PTW-N30001 and N23333 ionization chambers respectively. We applied quality factors in air kerma dosimetry for microSelectron source and compared with reference values. As a results we found that the differences between reference air kerma rate and measured it with and without quality correction were about -0.5% and -2.0% respectively.

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Transplantation of Brain-Derived Neurotrophic Factor-Expressing Mesenchymal Stem Cells Improves Lower Urinary Tract Symptoms in a Rat Model (뇌유래신경영양인자 발현 중간엽 줄기세포의 하부요로증상 개선 효과)

  • Jeon, Seung Hwan;Park, Mi-Young
    • Korean Journal of Clinical Laboratory Science
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    • v.52 no.4
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    • pp.417-424
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    • 2020
  • This study aimed to explore the effects of brain-derived neurotrophic factor (BDNF), produced by engineered immortalized mesenchymal stem cells (imMSC), on lower urinary tract symptoms (LUTS) in a rat model with neurogenic bladder (NB). Forty-eight Sprague-Dawley (SD) rats were randomly divided into the following groups: Sham control, LUTS, LUTS+imMSC (treated with immortalized MSC), and LUTS+BDNF-eMSC (treated with BDNF-expressing MSC) groups. LUTS was induced by a crush injury to the major pelvic ganglion (MPG). Bladder function was tested under anesthesia, and bladder tissue strips were collected thereafter for contractility test and western blot analysis. Western blot results showed that the expression of both Angiopoietin 1 (Ang 1) and platelet-derived growth factor (PDGF) increased with MSC injection. The effect of treatment with BDNF-eMSC on LUTS was also evaluated, and the results were found to be better than those with imMSC (P<0.05). BDNF-eMSC prevented fibrosis in the bladder tissue and significantly reduced caspase-3 levels. In conclusion, high expression of BDNF in vivo resulted in recovery of bladder function and contractility, along with the inhibition of apoptosis in a rat model.

Expression of Epidermal Growth Factor Receptor in the Inflamed Gingival Epithelium and the Dental Follicle (염증성 치은 상피와 치낭의 표피성장인자 수용체의 발현 및 실험적 치아이동에 미치는 영향에 관한 연구)

  • Kim, Young Ho;Bae, Chang
    • The korean journal of orthodontics
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    • v.27 no.2
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    • pp.349-357
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    • 1997
  • Epidermal growth factor(EGF), a single chain polypeptide of 53 amino acids with a molecular weight of 6,045 Da, was first isolated from the male mouse submandibular glands. EGF stimulates cellular proliferation and differentiation in several tissues and accelerates the rate of wound healing. EGF is bound to the specific receptor(EGFR) on the cell membrane of its target cell. EGFR is a transmembrane glycoprotein with a molecular weight of 170,000 Da and is detectable on a large variety of cell types and tissues. The authors investigated the expression of EGFR in the normal and inflamed human gingival epithelium to study the role of EGFR in the inflammation of the gingival epithelium, and the expression of EGFR in the dental follicle by using in situ mRNA hybridization and immunohistochenistry. The results weree as follows : 1. The expression of EGFR mRNA in the normal gingival epithelium on in situ mRNA hybridization was mainly localized on the basal cell layer, and the spinous layer was weakly positive The granular and cornified layers were negative 2. The expression of EGFR protein in the normal gingival epithelium on inmunohistochemistry was localized on the cornified and granular layers, and the spinous layer was weakly positive. The basal cell layer was completely negative 3. The expression of EGFR mRNA in the inflamed gingival epithelium on in situ mRNA hybridization was evenly and homogeneously distributed in the whole layers of the gingival epithelium except the cornified layer. The staining intensity appeared to increase progressively from the basal cell layer to the cornified layer. 4. The expression of EGFR protein in the inflamed gingival epithelium on immunohistochemistry was evenly and homogeneously distributed in the whole layers of the gingival epithelium. The staining intensity appeared to increase progressively from the cornified layer to the basal cell layer. 5. Strong positive reaction was seen in the epithelial cell rests of Malassez, whereas only background staining was seen in other cells of the dental follicle. In conclusion, the up-regulation of EGFR in the inflamed gingival epithelium and the high amounts of EGFR in the epthelial cell rests of Malassez in the dental follicle can be regarded as responses to the possible damages to the oral environment to maintain the homeostatic conditions.

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The Significance of Maturation Score of Brain Magnetic Resonance Imaging in Extremely Low Birth Weight Infant (초극소 저체중 출생아의 뇌 MRI 상 Maturation Score의 의의)

  • Song, In-Gu;Kim, Su-Yeong;Kim, Cur-Rie;Kim, Yoon-Joo;Shin, Seung-Han;Lee, Seung-Hyun;Lee, Jae-Myoung;Lee, Ju-Young;Kim, Ji-Young;Sohn, Jin-A;Lee, Jin-A;Choi, Chang-Won;Kim, Ee-Kyung;Cheon, Jung-Eun;Kim, Woo-Sun;Kim, Han-Suk;Kim, Byeong-II;Kim, In-One;Choi, Jung-Hwan
    • Neonatal Medicine
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    • v.18 no.2
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    • pp.310-319
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    • 2011
  • Purpose: The aim of this study was to investigate the effect of perinatal risk factors on brain maturation and the relationship of brain maturation and neurodevelopmental outcomes with brain maturation scoring system in brain MRI. Methods: ELBWI infants born at the Seoul National University Children's Hospital from January 2006 to December 2010 were included. A retrospective analysis was performed with their medical record and brain MR images acquired at near full term. We read brain MRI and measured maturity with total maturation score (TMS). TMS is a previously developed anatomic scoring system to assess brain maturity. The total maturation score was used to evaluate the four parameters of maturity: (1) myelination, (2) cortical infolding, (3) involution of glial cell migration bands, and (4) presence of germinal matrix tissue. Results: Images from 124 infants were evaluated. Their mean gestational age at birth was 27.1${\pm}$2.1 weeks, and mean birth weight was 781.5${\pm}$143.9 g. The mean TMS was 10.8${\pm}$2.0. TMS was significantly related to the postmenstrual age (PMA) of the infant, increasing with advancing postmenstrual age (P<0.001). TMS showed no significance with neurodevelopmental delay, and with brain injury, respectively. Conclusion: TMS was developed for evaluating brain maturation in conventional brain MRI. The results of this study suggest that TMS was not useful for predicting neurodevelopmental delay, but further studies are needed to make standard score for each PMA and to re-evaluate the relationship between brain maturation and neurodevelopmental delay.

A Review of Statistical Methods in the Korean Journal of Orthodontics and the American Journal of Orthodontics and Dentofacial Orthopedics (대한치과교정학회지(KJO)와 미국교정학회지(AJODO)에서 사용된 통계기법의 비교분석 및 고찰(1999-2003))

  • Lim, Hoi-Jeong
    • The korean journal of orthodontics
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    • v.34 no.5 s.106
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    • pp.371-379
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    • 2004
  • The purpose of this study was to investigate the changes and types of statistical methods used in the Korean Journal of Orthodontics (KJO) and the American Journal of Orthodontics and Dentofacial Orthopedics (AJODO) from )999 to 2003. The frequency of use, transitions, assumption check of statistical methods and types of advanced statistical methods were examined from each journal. The study consisted of 247 articles published in the KJO and randomly chosen 50 articles per year which were original articles and used statistical methods T-test, analysis of variance(ANOVA), correlation analysis, nonparametric analysis. regression analysis chi-square test. factor analysis, were the order of statistical methods most frequently used in the KJO, while t-test. ANOVA, nonparametric analysis, correlation analysis, regression analysis, chi-square test. factor analysis. were the order of statistical methods used in the AJODO The changes of statistical methods observed in the KJO were not significant $(X^2=17.4\;p=0.5881)$ but the changes observed in the AJODO was seen to be significant $(x^2=42.4,\;p=0.0397)$ Some of the studies examined had overlooked the assumptions of the statistical methods employed. Data investigation such as outlier should be performed before analysis and alternative statistical approaches are applied for a small sample size. Types of advanced statistical methods were factor analysis and discriminant analysis in the KJO and Intention-To-Treat (ITT) analysis in clinical trials through multi-center, survival analysis and Generalized Estimating Equations (GEE) in the AJODO. Appropriate analysis approaches and interpretations should be applied for the correlated and repeated measurements of the orthodontic data set.

Comparison and Analysis of Photon Beam Data for Hospitals in Korea and Data for Quality Assurance of Treatment Planning System (국내 의료기관들의 광자 빔 데이터의 비교 분석 및 치료계획 시스템 정도관리자료)

  • Lee, Re-Na;Cho, Byung-Chul;Kang, Sei-Kwon
    • Progress in Medical Physics
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    • v.17 no.3
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    • pp.179-186
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    • 2006
  • Purpose: Photon beam data of linear accelerators in Korea are collected, analyzed, and a simple method for checking and verifying the dose calculations in a TPS are suggested. Materials and Methods: Photon beam data such as output calibration condition, output factor, wedge factor, percent depth dose, beam profile, and beam quality were collected from 26 institutions in Korea. In order to verify the accuracy of dose calculation, ten sample planning tests were peformed. These Include square, elongated, and blocked fields, wedge fields, off-axis dose calculation, SSD variation. The planned data were compared to that of manual calculations. Results: The average and standard deviation of photon beam quality for 6, 10, and 15 MV were $0.576{\pm}0.005,\;0.632{\pm}0.004,\;and\;0.647{\pm}0.006$, respectively. The output factors of 6 MV photon beam measured at depth of dose maximum for $5{\times}5cm,\;15{\times}15cm,\;20{\times}20cm\;were\;0.944{\pm}0.006,\;1.031{\pm}0.006,\;and\;1.055{\pm}0.007$. For 10 MV photon beam, the values were $0.935{\pm}0.006,\;1.031{\pm}0.007,\;1.054{\pm}0.0005$. The collected data were not enough to calculate average, the output factors for 15MV photon beam with field size of $5{\times}5cm,\;15{\times}15cm,\;20{\times}20cm\;were\;0.941{\pm}0.008,\;1.032{\pm}0.004,\;1.049{\pm}0.014$. There was seven institutions $e{\times}ceeding$ tolerance when monitor unit values calculated from treatment planning system and manually were compared. The measured average MU values for the machines calibrated at SAD setup were 3 MU and 5 MU higher than the machines calibrated at SSD for 6 MV and 10 MV, respectively except the wedge case. When the wedges were inserted, the MU values to deliver 100 cGy to 5 cm depends on manufactures. When the same wedge angle was used, Siemens machine requires more MUs then Varian machine. Conclusion: In this study, photon beam data are collected and analyzed to provide a baseline value for chocking beam data and the accuracy of dose calculation for a treatment planning system.

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Significance of Early Visual Responses to Anti-Vascular Endothelial Growth Factor in Age-related Macular Degeneration (신생혈관 연령관련황반변성에서 항혈관내피세포성장인자 주입술 시행 후 시력 반응의 의의)

  • Song, Hee Jun;Yang, Ji Ho;Kim, Do Gyun
    • Journal of The Korean Ophthalmological Society
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    • v.59 no.11
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    • pp.1030-1038
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    • 2018
  • Purpose: To evaluate whether early visual acuity response at 4 weeks after the first intravitreal anti-vascular endothelial growth factor (VEGF) injection or 4 weeks after the third injection in neovascular age-related macular degeneration (nAMD) is associated with 12-month follow-up outcome. Methods: Thirty treatment-naive patients (30 eyes) with nAMD, treated with intravitreal anti-VEGF, were retrospectively included. Initially, all patients were injected at least three times for three consecutive months and followed up with a pro re nata regimen for at least 12 months. The relationship between 4 weeks after the first and third anti-VEGF injections in visual acuity response was explored, including the mean change from baseline in best-corrected visual acuity (BCVA). The mean change in BCVA was classified into three groups according to visual improvement: <1, 1-<3, or ${\geq}3$ logMAR line(s) in BCVA. The associations among baseline characteristics (gender, age, duration of symptoms, initial BCVA, central macular thickness, and intraocular pressure) and visual acuity responses 4 weeks after the first and third anti-VEGF injections were also assessed. Results: The proportions of eyes with <1, 1-<3, and ${\geq}3-line(s)$ improvement at 4 weeks after the first injection were 6 eyes (20%), 7 eyes (23.3%), and 17 eyes (56.6%), respectively. The proportions of eyes with <1, 1-<3, and ${\geq}3-line(s)$ improvement at 4 weeks after the third injection were 9 eyes (30%), 9 eyes (30%), and 12 eyes (40%), respectively. A BCVA response ${\geq}3-lines$ improvement at 4 weeks after the third injection showed significant associations with ${\geq}3-line(s)$ improvement and BCVA response at 12 months in multiple logistic and linear regression analyses (p = 0.04). Conclusions: In this study, BCVA response ${\geq}3-lines$ improvement at 4 weeks after the third injection showed a significant association with ${\geq}3-line(s)$ improvement and BCVA response at 12 months.

LiF(Mg, Cu, Na, Si) Thermoluminescent Dosimeters for In-phantom Dosimetry of $^{60}Co\;{\gamma}$-rays (LiF(Mg, Cu, Na, Si) 열형광선량계를 사용한 $^{60}Co\;{\gamma}^-$선의 수중 흡수선량 측정)

  • Kim, Hyun-Ja;Chung, Woon-Hyuk;Lee, Woo-Gyo;Doh, Sih-Hong
    • Journal of Radiation Protection and Research
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    • v.15 no.2
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    • pp.57-65
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    • 1990
  • Newly developed LiF(Mg, Cu, Na, Si) thermoluminescence phosphors sealed in a plastic capsules (32mm dia., 0.9mm wall thickness) were used for in-phantom dosimetry of $^{60}Co$ $\gamma$-irradiation. The absorbed doses in water were determined by applying the general cavity theory to the absorbed dose in TLD cavity, which was computed from exposure. The absorbed doses at various sites in the water-phantom were measured by LiF(Mg, Cu, Na, Si) TLD and compared with doses obtained by the ionization method. Both results were consistent within the experimental fluctuation$({\pm}3%)$ Central axis percentage depth doses and phantom-air ratios measured by LiF(Mg. Cu, Na, Si) TLD showed good agreement with the published values[Br. J. Radiology, Suppl. 17(1983)].

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Measurement of combustor surface temperature using phosphor thermometry (형광체를 이용한 연소기 표면온도 측정기술)

  • Kim, Yong-Gyoo;Lee, Seok Hwan;Kim, Sunghun;Yang, Inyoung
    • Proceedings of the Korean Society of Propulsion Engineers Conference
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    • 2017.05a
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    • pp.228-231
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    • 2017
  • The surface temperature of a combustor such as an aircraft engine is one of the important measuring factors related to the combustion performance. However, a conventional temperature measurement technique have a large measurement error due to a bad environment such as a combustion flame, vibration, and dust. In order to solve this problem, a technology has been developed which can measure the surface temperature of the combustor in real time using the wavelength change or attenuation time change according to the temperature of the phosphor. In this study, we developed a technique that can measure surface temperature of scram-jet combustor using phosphor thermometry. The calibration curve was obtained according to the temperature from $200^{\circ}C$ to $800^{\circ}C$ in the calibrated temperature chamber. So, we confirmed that phosphor thermometry can be used for measuring surface temperature of scram-jet combustor.

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Developement of Soil Moisture Quality Control System - Evaluation of Spike Detecting Algorithm (토양수분 품질관리 시스템 개발 - 튀는 값 검출 알고리즘 평가)

  • Lee, Yong Jun;Kim, Ki young
    • Proceedings of the Korea Water Resources Association Conference
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    • 2021.06a
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    • pp.407-407
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    • 2021
  • 토양수분량은 그 양은 작지만 다양한 수문현상에 관여하는 주요한 수문인자 중 하나이다. 특히, 강우, 유출, 홍수 및 가뭄 등과 직접적인 연관이 있어 국내에서도 그 중요성이 점차 강조되고 있다. 일찍이 해외에서는 토양수분량 위성자료나 관측기기의 검증 및 교정을 위해 다수의 지상 관측소를 운영해왔으며, ISMN(International Soil Moisture Network)과 같은 기관을 통해 자료의 취합 및 품질관리, 배포 등도 활발하게 이루어지고 있다. 최근 국내에서도 최신 관측기기의 도입이나 수자원위성의 개발 등 토양수분량에 관한 연구가 점차 활발하게 이루어지고 있으며, 위성자료와 관측기기의 검증 및 교정을 위한 지상관측소도 점차 확대되고 있는 추세이다. 하지만, 국내 지상관측소는 현재 다양한 기관과 단체에 의해 운영되고 있으며, 품질관리 기준이 통일되어 있지 않아 자료의 접근 및 활용 측면에서 개선이 필요한 실정이다. 이에 한국수자원조사기술원은 국내 환경에 맞는 품질관리 기준을 제시하고, 자료의 접근성 및 활용성 개선의 토대를 마련하고자 품질관리 시스템을 개발하고 있다. 본 연구는 정량화된 품질관리 기준을 바탕으로 spike를 판별하는 알고리즘에 대한 성능평가를 다루고 있으며, 청미천 토양수분량 관측소 2020년 자료에 임의의 튀는 값(spike)을 추가하고, 해당 이상치의 검출여부를 확인하는 방식으로 진행되었다. 각각의 지점자료에서 강우사상 중 하강부, 무강우기간 중 하강부를 1개씩 선정하고, 해당 구간에 positive spike를 추가한 case와 negative spike를 추가한 case를 생성해 강우조건 및 spike 유형에 따른 검출성능 차이를 평가했다. 평가 결과, 강우기간 검출률 84.3%, 무강우기간 검출률 96.3%로 강우조건에 따른 성능차이가 명확하게 나타났으며, positive spike는 91.7%, negative spike는 88.9%로 spike 유형에 따른 검출성능차이는 미미했다. 강우조건과 spike 유형을 동시에 고려했을 때는 무강우기간의 positive spike가 98.2%로 가장 높은 검출률을 보인 반면에 강우기간의 negative spike는 83.3%로 가장 낮은 검출률을 보였다. 알고리즘이 검사시간대를 중심으로 24시간 동안의 토양수분량 변화를 감지하기 때문에 강우기간에 검출성능이 저하되는 것으로 판단되며, 이를 개선하기 위해선 강우사상에 따른 유동적인 window size 조절 알고리즘의 추가가 필요할 것으로 판단된다.

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