• Title/Summary/Keyword: 광음향 현미경

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A low noise, wideband signal receiver for photoacoustic microscopy (광음향 현미경 영상을 위한 저잡음 광대역 수신 시스템)

  • Han, Wonkook;Moon, Ju-Young;Park, Sunghun;Chang, Jin Ho
    • The Journal of the Acoustical Society of Korea
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    • v.41 no.5
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    • pp.507-517
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    • 2022
  • The PhotoAcoustic Microscopy (PAM) has been proved to be a useful tool for biological and medical applications due to its high spatial and contrast resolution. PAM is based on transmission of laser pulses and reception of PA signals. Since the strength of PA signals is generally low, not only are high-performance optical and acoustic modules required, but high-performance electronics for imaging are also particularly needed for high-quality PAM imaging. Most PAM systems are implemented with a combination of several pieces of equipment commercially available to receive, amplify, enhance, and digitize PA signals. To this end, PAM systems are inevitably bulky and not optimal because general purpose equipment is used. This paper reports a PA signal receiving system recently developed to attain the capability of improved Signal to Noise Ratio (SNR) and Contrast to Noise Ratio (CNR) of PAM images; the main module of this system is a low noise, wideband signal receiver that consists of two low-noise amplifiers, two variable gain amplifiers, analog filters, an Analog to Digital Converter (ADC), and control logic. From phantom imaging experiments, it was found that the developed system can improve SNR by 6.7 dB and CNR by 3 dB, compared to a combination of several pieces of commercially available equipment.

3-D Analysis of Semiconductor Surface by Using Photoacoustic Microscopy (광음향 현미경법을 이용한 반도체 표면의 3차원적 구조 분석)

  • Lee, Eung-Joo;Choi, Ok-Lim;Lim, Jong-Tae;Kim, Ji-Woong;Choi, Joong-Gill
    • Journal of the Korean Chemical Society
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    • v.48 no.6
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    • pp.553-560
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    • 2004
  • In this experiment, a three dimensional structure analysis was carried out to examine the surface defects of semiconductor made artificially on known scale. It was investigated the three dimensional imaging according to the sample depth and the thermal diffusivity as well as the carrier transport properties. The thermal diffusivity measurement of the intrinsic GaAs semiconductor was also analyzed by the difference of frequency-dependence photoacoustic signals from the sample surface of different conditions. Thermal properties such as thermal diffusion length or thermal diffusivity of the Si wafer with and without defects on the surface were obtained by interpreting the frequency dependence of the PA signals. As a result, the photoacoustic signal is found to have the dependency on the shape and depth of the defects so that their structure of the defects can be analyzed. This method demonstrates the possibility of the application to the detection of the defects, cracks, and shortage of circuits on surface or sub-surface of the semiconductors and ceramic materials as a nondestructive testing(NDT) and a nondestructive evaluation(NDE) technique.

Development and Application of Photoacoustic Microscope using Accelerometer (가속도센서를 이용한 광음향현미경의 제작과 응용)

  • Kim, D.H.;Kwon, Oh-Yang
    • Journal of the Korean Society for Nondestructive Testing
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    • v.14 no.4
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    • pp.219-227
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    • 1995
  • A two-dimensional photoacoustic microscope utilizing photoacoustic signals generated by periodic heating of specimen surface with Argon ion laser and measured by accelerometer has been developed. Several aluminum specimens with various defects have been examined, characteristics of the microscope have been evaluated and optimal experimental conditions have been determined by examining the dependence on several experimental conditions including the modulation frequency and the beam width of laser.

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Signal-Characteristic Analysis with Respect to Backing Material of PVDF-Based High-Frequency Ultrasound for Photoacoustic Microscopy (광음향 현미경을 위한 PVDF 기반 고주파수 초음파 변환기의 흡음층 소재에 따른 신호 특성 분석)

  • Lee, Junsu;Chang, Jin Ho
    • Journal of the Korean Society for Nondestructive Testing
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    • v.35 no.2
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    • pp.112-119
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    • 2015
  • Photoacoustic microscopy is capable of providing high-resolution molecular images, and its spatial resolution is typically determined by ultrasonic transducers used to receive the photoacoustic signals. Therefore, ultrasonic transducers for photoacoustic microscopy (PAM) should have a high operating frequency, broad bandwidth, and high signal-reception efficiency. Polyvinylidene fluoride (PVDF) is a suitable material. To take full advantage of this material, the selection of the backing material is crucial, as it influences the center frequency and bandwidth of the transducer. Therefore, we experimentally determined the most suitable backing material among EPO-TEK 301, E-Solder 3022, and RTV. For this, three PVDF high-frequency single-element transducers were fabricated with each backing material. The center frequency and -6 dB bandwidth of each transducer were ascertained by a pulse-echo test. The spatial resolution of each transducer was examined using wire-target images. The experimental results indicated that EPO-TEK 301 is the most suitable backing material for a PAM transducer. This material provides the highest signal magnitude and a reasonable bandwidth because a large portion of the energy propagates toward the front medium, and the PVDF resonates in the half-wave mode.

Simultaneous Imaging Using Combined Optical Coherence Tomography (OCT) and Photoacoustic Microscopy (PAM) (광간섭 단층 촬영 장치와 광음향 현미경의 결합을 통한 동시 이미지 획득 연구)

  • Kim, Sehui;Lee, Changho;Han, Seonghoon;Kang, Hyun Wook;Oh, Junghwan;Kim, Jeehyun;Kim, Chulhong
    • Journal of Biomedical Engineering Research
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    • v.34 no.2
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    • pp.91-96
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    • 2013
  • In this study, we developed an integrated optical coherence tomography - photoacoustic microscopy (OCT-PAM) system to simultaneously provide optical absorption and scattering information. Two different laser sources, such as a pulsed laser for PAM and a superluminescent diode for OCT, were employed to implement the integrated OCT-PAM system. The performance of the OCT-PAM system was measured by imaging carbon fibers. We then imaged black and white hairs to demonstrate the simultaneous OCT-PAM imaging capabilities. As a result, OCT can produce 3-D images of both black and white hairs, whereas PAM is only able to image the black hair due to strong optical absorption of black hair.