DOI QR코드

DOI QR Code

Simultaneous Imaging Using Combined Optical Coherence Tomography (OCT) and Photoacoustic Microscopy (PAM)

광간섭 단층 촬영 장치와 광음향 현미경의 결합을 통한 동시 이미지 획득 연구

  • Kim, Sehui (School of Electrical Engineering and Computer Science, Kyungpook National University) ;
  • Lee, Changho (School of Electrical Engineering and Computer Science, Kyungpook National University) ;
  • Han, Seonghoon (School of Electrical Engineering and Computer Science, Kyungpook National University) ;
  • Kang, Hyun Wook (Department of Biomedical Engineering, Pukyong Nationala University) ;
  • Oh, Junghwan (Department of Biomedical Engineering, Pukyong Nationala University) ;
  • Kim, Jeehyun (School of Electrical Engineering and Computer Science, Kyungpook National University) ;
  • Kim, Chulhong (Creative IT Excellence Engineering, POSTECH)
  • Received : 2013.03.19
  • Accepted : 2013.05.01
  • Published : 2013.04.30

Abstract

In this study, we developed an integrated optical coherence tomography - photoacoustic microscopy (OCT-PAM) system to simultaneously provide optical absorption and scattering information. Two different laser sources, such as a pulsed laser for PAM and a superluminescent diode for OCT, were employed to implement the integrated OCT-PAM system. The performance of the OCT-PAM system was measured by imaging carbon fibers. We then imaged black and white hairs to demonstrate the simultaneous OCT-PAM imaging capabilities. As a result, OCT can produce 3-D images of both black and white hairs, whereas PAM is only able to image the black hair due to strong optical absorption of black hair.

Keywords

References

  1. D. Huang et al., "Optical coherence tomography," Science, vol. 254, no. 5035, pp. 1178-1181, 1991. https://doi.org/10.1126/science.1957169
  2. Lihong V. Wang and Hsin-i Wu, BIOMEDICAL OPTICS: Principles and Imaging, John Wiley & Wiley & Sons Inc., the United States of America, pp. 181, 2007.
  3. Alexander Sergeev, V. Gelikonov, G. Gelikonov, Felix Feldchtein, R. Kuranov, N. Gladkova, N. Shakhova, L. Snopova, A. Shakhov, I. Kuznetzova, A. Denisenko, V. Pochinko, Yu Chumakov, and O. Streltzova, "In vivo endoscopic OCT imaging of precancer and cancer states of human mucosa", Optics Express, vol. 1, no. 13, pp. 432-440, 1997. https://doi.org/10.1364/OE.1.000432
  4. Nam Hyun Cho, Unsang Jung, Suhwan Kim and Jeehyun Kim, "Non-Destructive Inspection Methods for LEDs Using Real-Time Displaying Optical Coherence Tomography", Sensors, vol. 12, no. 8, pp. 10395-10406, 2012. https://doi.org/10.3390/s120810395
  5. C. Kim, C. Favazza, and L. V. Wang, "In vivo photoacoustic tomography of chemicals: high-resolution functional and molecular optical imaging at new depths", Chemical Reviews, vol. 110, no. 5, pp. 2756-2782, 2010. https://doi.org/10.1021/cr900266s
  6. W. J. Akers, C. Kim, M. Berezin, K. Guo, R. Furhop, G. M. Lanza, G. M. Fischer, E. Daltrozzo, L. V. Wang, S. Achilefu, "Noninvasive Fluorescence and Photoacoustic Sentinel Lymph Node Identification using Dye-loaded Perfluorocarbon Nanoparticles", ACSNano, vol. 5, no. 1, pp. 173-182, 2011. https://doi.org/10.1021/nn102274q
  7. C. Kim, E. Todd, K. Maslov, L. Jankovic, W. J. Arkers, S. Achilefu, J. Margenthaler, M. Pashley, and L. V. Wang, "Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes", Journal of Biomedical Optics, vol. 15, no. 4, pp. 046010, 2010. https://doi.org/10.1117/1.3469829
  8. C. Kim, M. Jeon, and L. V. Wang, "Nonionizing Photoacoustic Cystography in vivo", Opt. Lett., vol. 36, no. 18, pp. 3599-3601, 2011. https://doi.org/10.1364/OL.36.003599
  9. Yu Zhangl, Xin Cai, Sung-Wook Choi, Chulhong Kim, Lihong V. Wang, Younan Xia, "Chronic label-free volumetric photoacoustic microscopy of melanoma cells in three dimensional porous Scaffolds", Biomaterials, vol. 31, no. 33, pp. 8651-8658, 2010. https://doi.org/10.1016/j.biomaterials.2010.07.089
  10. C. Kim, E. C. Cho, J. Chen, K. H. Song, L. Au, C. Favazza, Q. Zhang, C. M. Cobley, F. Gao, Y. Xia, and L. V. Wang, "In vivo molecular photoacoustic tomography of melanomas targeted by bio-conjugated gold nanocages", ACSNano, vol. 4, no. 8, pp. 4559-4564, 2010. https://doi.org/10.1021/nn100736c
  11. Jacob Staley, Patrick Grogan, Abbas K. Samadi, Huizhong Cui, Mark S. Cohen, Xinmai Yang, "Growth of melanoma brain tumors monitored by photoacoustic microscopy", J. Biomed. Opt., vol. 15, no. 4, pp. 040510, 2010. https://doi.org/10.1117/1.3478309
  12. Li Li, Konstantin Maslov, Geng Ku, and Lihong V. Wang, "Three-dimensional combined photoacoustic and optical coherence microscopy for in vivo microcirculation studies", Optics Express, vol. 17, no. 19, pp. 16450-16455, 2009. https://doi.org/10.1364/OE.17.016450
  13. Xiangyang Zhang, Hao F. Zhang, Shuliang Jiao, "Optical coherence photoacoustic microscopy: accomplishing optical coherence tomography and photoacoustic microscopy with a single light source", Journal of Biomedical Optics, vol. 17, no. 3, pp. 030502-030502-3, 2012. https://doi.org/10.1117/1.JBO.17.3.030502
  14. X. Zhang et al., "Dual-band spectral-domain optical coherence tomography for in vivo imaging the spectral contrasts of the retinal nerve fiber layer", Opt. Express, vol. 19, no. 20, pp. 19653-19659, 2011. https://doi.org/10.1364/OE.19.019653
  15. H. Wang et al., "Label-free bond-selective imaging by listening to vibrationally excited molecules", Phys. Rev. Lett., vol. 106, no. 23, pp. 238106, 2011. https://doi.org/10.1103/PhysRevLett.106.238106
  16. S. Jiao et al., "Simultaneous multimodal imaging with integrated photoacoustic microscopy and optical coherence tomography," Opt. Lett., vol. 34, no. 19, pp. 2961-2963, 2009. https://doi.org/10.1364/OL.34.002961
  17. E. Z. Zhang, B. Povazay, J. Laufer, A. Alex, B. Hofer, B. Pedley, C. Glittenberg, B. Treeby, B. Cox, P. Beard, and W. Drexler, "Multimodal photoacoustic and optical coherence tomography scanner using an all optical detection scheme for 3D morphological skin imaging," Biomedical optics express, vol. 2, no. 8, pp. 2202-2215, 2011. https://doi.org/10.1364/BOE.2.002202
  18. W. Song, Q. Wei, T. Liu, D. Kuai, J. M. Burke, S. Jiao, and H. F. Zhang, "Integrating photoacoustic ophthalmoscopy with scanning laser ophthalmoscopy, optical coherence tomography, and fluorescein angiography for a multimodal retinal imaging platform," Journal of biomedical optics, vol. 17, no. 6, pp. 061206, 2012. https://doi.org/10.1117/1.JBO.17.6.061206
  19. Li L, Maslov K, Ku G, Wang LV., "Three-dimensional combined photoacoustic and optical coherence microscopy for in vivo microcirculation studies.", OPTICS EXPRESS, vol. 17, no. 19, pp. 16450-16455, 2009. https://doi.org/10.1364/OE.17.016450
  20. Maria Valeria Robles Velasco, Tania Cristina de Sa Dias, Anderson Zanardi de Freitas, Nilson Dias Vieira Júnior, Claudinéia Aparecida Sales de Oliveira Pinto, Telma Mary Kaneko, André Rolim Baby, "Hair fiber characteristics and methods to evaluate hair physical and mechanical properties ", Brazilian Journal of Pharmaceutical Sciences, vol. 45, no. 1, pp. 153-162, 2009. https://doi.org/10.1590/S1984-82502009000100019
  21. N.CHEN, B.BHUSHAN, "Morphological, nano-mechanical and cellular structural characterization of human hair and conditioner distribution using torsional resonance mode with an atomic force microscope", Journal of Microscopy, vol. 220, no. 2, pp. 96-112, 2005. https://doi.org/10.1111/j.1365-2818.2005.01517.x
  22. Zoccola M, Mossotti R, Innocenti R, Loria DI, Rosso S, Zanetti R, "Near infrared spectroscopy as a tool for the determination of eumelanin in human hair", Pigment Cell Res., vol. 17, no. 4, pp. 379-385, 2004. https://doi.org/10.1111/j.1600-0749.2004.00157.x
  23. Tan Liu,Qing Wei,Jing Wang,Shuliang Jiao, Hao F. Zhang, "Combined photoacoustic microscopy and optical coherence tomography can measure metabolic rate of oxygen", Biomed Opt Express, vol. 2, no. 5, pp. 1359-1365, 2011. https://doi.org/10.1364/BOE.2.001359
  24. Alexandre R. Tumlinson, Jennifer K. Barton, Boris Povazay, Harald Sattman, Angelika Unterhuber, Rainer A. Leitgeb, Wolfgang Drexler, "Endoscope-tip interferometer for ultrahigh resolution frequency domaing optical coherence tomography in mouse colon", OPTICS EXPRESS, vol. 14, no. 5, pp. 1878-1887, 2006. https://doi.org/10.1364/OE.14.001878