• Proceedings of the Korean Society of Veterinary Clinics Conference
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• 2006.11a
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• pp.106-106
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• 2006

• The Journal of the Korean bone and joint tumor society
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• v.13 no.2
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• pp.135-141
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• 2007

Nodular faciitis is generally considered to be benign proliferation of fibroblasts and myoblasts, and it measures dimension up to 3cm. The characteristics such as rapid growth, abundant cellularity, and mitotic activity occasionally cause these lesions to mimic sarcoma. The authors experienced two cases of nodular fasciitis of the thigh, which were unusually large with dimension of more than 5cm. All of these two cases mimicked sarcoma and one of two cases, which initially mimicked sarcoma clinically and histologically in our hospital, was finally diagnosed as nodular fasciitis after requesting external consultation to several experienced pathologists. All of two cases had no evidence of recurrence at 2 years postoperatively. The lesions of unusually large dimension such as in our cases must be included in the differential diagnosis of soft tissue sarcoma. So we report two cases of nodular fasciitis of the thigh with a review of the current literature.

• Journal of Chest Surgery
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• v.41 no.2
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• pp.292-294
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• 2008

Diffuse pulmonary ossification is a rare entity which was reported just a case in Korea, defined as "wide spread heterotropic bone formation within the lung parenchyme", and it's pathogenesis remains unclear. Generally, diffuse pulmonary ossification is diagnosed by autopsy because most of case is asymptomatic, and classified as either nodular and dendriform diagnosed pathologic examination. We reviewed a case of diffuse dendriform pulmonary ossification with spontaneous pneumothorax.

• Journal of Veterinary Clinics
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• v.31 no.4
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• pp.263-266
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• 2014

We evaluated the change of quadriceps angle (QA) after tibial tuberosity transposition. Twenty-nine animals and 37 limbs of the total 62 case possibilities qualified for this study. The preoperative QA was $24.02{\pm}4.02$ in grade 2, $26.08{\pm}5.66$ in grade 3 and $30.25{\pm}7.41$ in grade 4. The postoperative QA was $21.25{\pm}3.24$ in grade 2, $19.16{\pm}3.92$ in grade 3 and $19.72{\pm}7.30$ in grade 4. The postoperative QA for all grades significantly decreased when compared with the preoperative QA (P < 0.05). However, the postoperative QA values were not within the normal range, although the dogs' prognosis remained good during the 4-month follow-up period. These results suggest that postoperative QA outside of the normal range may be allowed clinically.

• Journal of the Korean Arthroscopy Society
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• v.4 no.1
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• pp.67-70
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• 2000

Osgood-Schlatter's disease is generally treated conservatively. However, surgical treatment is necessary for some patients with recurrent or persistent pain that does not respond to conservative treatment. Most authors recommend the excision of the loose ossicles present around the distal end of the patellar tendon. The authors report the technique of arthroscopic removal of the ossicles for Osgood-Schaltter's disease instead of the conventional technique through the incision at the tibial tuberosity. The advantages of this technique are less damage to the patellar tendon, early postoperative recovery, making no incisional scar in front of the tuberosity which causes the scar discomfort in kneeling, and more cosmetic result.

• Tuberculosis and Respiratory Diseases
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• v.40 no.6
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• pp.714-718
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• 1993

Tracheobronchopathia osteoplastica(TPO) is a rare disorder characterized by submucosal cartilaginous or bony projections into the tracheobronchial lumen with sparing of the posterior membranous portion of tracheobronchial tree. The etiology of TPO is still unknown. A 44-year-old male was admitted to Seoul Paik Hospital Inje University due to left chest pain for 10 days. On the past history he had sufferred from symptoms of bronchitis for several months. He showed radiologically massive pleural effusion in left lung field. Pleural biopsy revealed chronic pleuritis with hemorrhage. Bronchoscopic findings showed multiple intraluminal portruding nodule from just below the vocal cord to carina and both main bronchi. Pathology of bronchoscopic biopsy showed abnormal proliferation of atypical bony and carilagious nodules in the tracheal submucosa. We experianced a case of tracheobronchopathia osteoplastica involving the trachea and main bronchus in 44-year old male, associated with massive pleural effusion. This report is a case of TPO with review of literature.

• Journal of Periodontal and Implant Science
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• v.36 no.3
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• pp.627-637
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• 2006

이 연구는 rh BMP-7-immobilized substrates에 대한 백서 태자 두개관 세포의 반응을 석회화 결절 측정, 알카리 효소 분석, 역전사 중합반응 및 단백질 분석등으로 평가하여 다음과 같은 결과를 얻었다. 1. 배양 14일 째, 석회화 결절 형성율을 측정한 결과, rh BMP-7-immobilized substrates에서 대조군과 비교하여 더 많은 석회화 결절을 형성하였다. 2. 배양 7일에 염기성 인산 분해효소 활성도는 rh BMP-7-immobilized substrates에서 대조군에 비해 효소 활성도가 유의하게 높았다. 3. 역전사 중합반응의 결과에서 BSP 와 OCN 유전자 발현은 대조군보다 더 현저하였다. 4. 단백질 분석에서 rh BMP-7-immobilized substrates와 대조군 모두 Smad 1,5,8 단백질의 인산화를 활성화시키지 못했다. 이상의 결과 rh BMP-7-immobilized substrates는 백서 태자 두개관세포가 조골세포로의 분화와 석회화를 유도하며 따라서 rh BMP-7-immobilized substrates는 임프란트 주변의 골 형성에 유용하리라 사료된다.

• The Journal of the Korean bone and joint tumor society
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• v.8 no.2
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• pp.39-42
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• 2002

We present a case of the patient with early detection of entrapment of inferior branch of the suprascapular nerve caused by multiple ganglion cysts at the spinoglenoid notch of the scapula, recovering from hypotrophy of the infraspinatus muscle and treating successfully after surgical removal of the cysts, and decompression of the nerve.

• Journal of Periodontal and Implant Science
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• v.35 no.1
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• pp.133-152
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• 2005

1. 목적 Prostaglandin은 치주질환과 관련된 국소적 골 대사에 중요한 역할을 한다. ${\Delta}^{12}PGJ_2$는 생체 내에서 혈장의 존재 하에 형성되는 천연 $PGD_2$ 대사산물이며 peroxisome- proliferator에 의해 활성화되는 감마 수용체 (PPAR ${\Gamma}$)에 대해 높은 친화성을 갖는 리간드로서 핵 수용체군에 속하는 전사조절인자이다. 이 연구의 목적은 골화 과정에서 ${\Delta}^{12}PGJ_2$의 역할을 규명하기 위해, 조골세포주의 증식과 분화에 미치는 영향과 그에 관련된 세포기전을 조사하는 데에 있다. 2. 방법 인간 골육종세포주인 Saos-2 (ATCC.HTB 85)와 쥐의 조골세포주 (MC3T3-E1)를 배양한 후 실험군에 농도가 각각 $10^{-5}$, $10^{-6}$, $10^{-7}$, $10^{-8}$, $10^{-9}$ 몰인 ${\Delta}^{12}PGJ_2$와 ciglitazone (합성 PPAR 감마 길항체)를 첨가하였다. 조골세포에서 PPAR 감마의 발현을 관찰하기 위해 역전사효소-중합효소연쇄반응(RT-PCR)을 특정한 primer를 이용하여 시행하였다. 세포 증식은 1일, 2일, 3 일째에 MIT 분석법으로 측정하였고, 2 일째에 알칼리성 인산효소 (ALPase) 생산을 측정하였다. 위의 결과에서 얻은 적정한 농도에서 다양한 조골세포 분화의 표지자들-제 1 형 교원질, 알칼리성 인산효소, osteopontin 및 bone sialoprotein-에 대한 간이 정량적 역전사효소-중합효소연쇄반응 (semiquantitative RT-PCR)을 실시하였으며 골결절 형성에 대한 효과를 알아보고자 석회화 분석도 시행하였다. 3. 결과 ${\Delta}^{12}PGJ_2$와 ciglitazone 모두 Saos-2 세포주의 증식을 촉진시켰다 .$10^{-8}$ 몰의 ${\Delta}^{12}PGJ_2$와 $10^{-6}$몰의 ciglitazone을 첨가한 실험군을 대조군과 비교했을 때, 시간에 비례하여 세포 증식률이 증가되었다. 알칼리성 인산효소의 활성화 검사에서도 증식률에서와 유사한 결과를 보여주었다. 간이 정량적 RT-PCR에서는 ${\Delta}^{12}PGJ_2$로 처리한 군의 경우 제 1 형 교원질, 알칼리성 인산효소, osteopontin, 그리고 bone sialoprotein의 상대적 mRNA 수준이 유의하게 높았다. 석회화 분석에서는 MC3T3-E1 세포를 $10^{-6}$ 몰의 ${\Delta}^{12}PGJ_2$로 처리한 군과 $10^{-5}$ 몰의 ciglitazone으로 처리한 군에서 현저한 골결절 형성을 보였다. 이러한 결과들은 ${\Delta}^{12}PGJ_2$가 유용한 골 유도물질이 될 수 있으며 또한 그 작용기전이 PPAR 감마-의존형 경로와 연관되어 있음을 보여준다.

• Journal of the Korean Orthopaedic Association
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• v.54 no.1
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• pp.78-83
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• 2019

Tophi is one of the clinical manifestations of gout. On the other hand, it does not draw the patient's attention when it is asymptomatic, which leads to delayed management. The current case is a typical example of delayed diagnosis and management. The authors' preferred management of tophi was medical not surgical, even though the hitherto therapeutic issue has been conservative versus surgical. The authors chose conservative treatment in the osteolytic lesion resulting from huge tophi in the patella, and the report the results of 6 years follow-up.