• Title/Summary/Keyword: 고지혈증

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Lipid-lowering Effect of Chunggantang in Poloxamer-407 induced Hyperlipidemia Model in Rat (Poloxamer-407로 유발시킨 고지혈증에 대한 청간탕의 효과)

  • Park, Hong-Hak;Cho, Jung-Hyo;Shin, Jang-Woo;Lee, Yeon-Weol;Yoo, Hwa-Seung;Lee, Nam-Heon;Yun, Dam-Hee;Cho, Chong-Kwan;Son, Chang-Gue
    • The Journal of Internal Korean Medicine
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    • v.26 no.4
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    • pp.820-827
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    • 2005
  • 연구목적: 본 연구는 Poloxamer-407로 유발시킨 고지혈증에 대한 청간탕의 효과를 알아보기 위해 수행되어졌다. 실험방법: Poloxamer-407로 쥐에 고지혈증을 유발시킨후 청간탕과 Lipidil을 경구 투여하여 혈청 cholesterol, 고밀도 지단백, 중성지질을 측정하였으며, 지질대사와 관련된 ACAT, DGAT, $CYP7{\alpha}H$, LDL receptor의 gene expression을 RT-PCR를 통해 비교 분석하였다. 실험결과: 청간탕 투여군은 혈청 콜레스테롤을 각각 32% 와 65% (p<0.05)로, 혈청 중성지방을 각각 21% 와 51% (p<0.05)로 감소시켰다. 또한, 청간탕은 LDL 수용체와 $CYP7{\alpha}H$ 유전자 발현을 증가시켰다. 결론: 이상의 연구로부터 우리는 청간탕이 지질의 흡수, 저장을 억제하고 콜레스테롤의 분비를 촉진함으로써 고지혈증에 일정한 효과가 있음을 알 수 있었다.

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Effect of Seatangle Oligosaccharide Drink on Oxidation of Serum Lipid and Bleeding and Plasma Clotting Time in Rats Fed a Hyperlipidemic Diet (해조 올리고당 음료가 고지혈증 유도 쥐에 있어서 혈액 지질 산화 및 혈액ㆍ혈장 응고에 미치는 영향)

  • 주동식;이진경;김옥선;조순영;이득식;제외권;최종원
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.32 no.8
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    • pp.1370-1376
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    • 2003
  • We investigated the effect of seatangle drink and seatangle extract on lipid oxidation, blood coagulation and intestinal movement in rats fed a hyperlipidemic diet. In the dietary hyperlipidemic induced group, the serum superoxide dismutase activity decreased and formation of hydroxy radical increased when compared to normal group, but these were controlled by seatangle drink treatment. The decreased of bleeding time and increased of tissue factor in the dietary hyperlipidemic rats were regulated by seatangle drink and seatangle extract, and especially the activity of tissue factor was remarkably decreased. Seatangle drink and seatangle extract were increased contraction on intestinal movement. Therefore, it can be concluded that seatangle drink or seatangle extract treatment depresses changing in absorption of gastrointestinal track in rats fed a hyperlipidemic diet.

The effect of onion on hyperlipidemia: Meta-analysis (양파의 고지혈증 효과에 대한 메타분석)

  • Choi, Kiheon
    • Journal of the Korean Data and Information Science Society
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    • v.23 no.6
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    • pp.1103-1115
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    • 2012
  • In this study, we studied the effect of onion on hyperlipidemia in terms of factors, such as body weight, liver weight, kidney weight, heart weight, blood glucose, total cholesterol, triglycerides, HDL-cholesterol, and LDL-cholesterol. The hyperlipidemia supplement was significantly effective on the liver weight, kidney weight, blood glucose, total cholesterol, triglycerides, and LDL-cholesterol with the fixed effect model. However, the liver weight, blood glucose, total cholesterol, and triglycerides were significantly decreased with the random effect model on the heterogeneous factors selected by Galbraith plot. The existence of publication bias was checked by using a funnel plot.

A Case Report for a Obese Patient Accompanied with Hypertension, Dyslipidemia and Osteoarthritis (고혈압, 고지혈증, 퇴행성 관절염을 동반한 비만 환자의 증례보고)

  • Kim, Dong-Yeol;Kim, Gil-Su
    • Journal of Korean Medicine for Obesity Research
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    • v.1 no.1
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    • pp.13-20
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    • 2001
  • Obesity is an excess of body fat frequently resulting from an imbalance between energy intake and expenditure, raises the risk of morbidity from chronic diseases such as hypertension, dyslipidemia, type 2 diabetes, coronary heart disease, stroke, fatty liver and osteoarthritis. Recently we experienced a 51 years old obese woman who was accompanied with hypertension, dyslipidemia and osteoarthritis. Through weight reduction program(very low calorie diet, Chegameuiintang, exercise) during 3 months, total weight loss was 17.0kg, her condition was improved.

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Effects of Apo E Polymorphisms and Dietary Counseling on the Levels of Plasma Lipids in Hyperlipidemic Patients (고지혈증 환자에서 Apo E 유전자 다형성과 영양상담에 의한 식사조절이 혈청지질 농도에 미치는 영향)

  • 김수정;조여원;임정은;김영설
    • Journal of Nutrition and Health
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    • v.31 no.9
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    • pp.1411-1421
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    • 1998
  • The purpose of this study was to investigate the effects of apo E polymorphisms and dietary counseling on the levels of plasma lipids in hyperlipidemic patients. The changes of serum lipids were assessed f3r 34 hyperlipidemic out-patients who changed their basal diet containing 20.1% fat(236.0mg cholesterol/day), 15.7% protein, and 64.2% carbohydrate to a diet containing 18.3% fat(109.8mg cholesterol/day), 15.7% protein, and 66.0% carbohydrate for 12 weeks. At the beginning of this study, the levels of plasma LDL-cholesterol were high according to apo E genotypes in the following order : E2/3

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Analysis of the Correlation Between Ultrasonography Diagnosis Fatty Liver Grade and Hyperlipidemia and Obesity Indicators by Age Groups (연령대별 초음파 진단 지방간 등급과 고지혈증 및 비만 지표 간의 상관관계 분석)

  • Hyeon, Sang-Yeon;Seoung, Youl-Hun
    • Journal of the Korean Society of Radiology
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    • v.14 no.7
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    • pp.863-870
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    • 2020
  • The purpose of this study was to analyze the correlation between the grade of fatty liver diagnosed by ultrasonography and hyperlipidemia and obesity indicators by age groups. A total of 1,470 patients of various sex and age groups were examined by abdominal ultrasonography at the H Center in Chungbuk. The patients were classified as normal and fatty liver by age groups (below twenty, the thirties, forty, fifties, and over sixties). The grade of fatty liver was classified in detail as Grade 1 (mild fatty liver), Grade 2 (moderate fatty liver), Grade 3 (severe fatty liver). We selected indicators of hyperlipidemia as total cholesterol, triglyceride, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol. The obesity indicators were height, weight, body mass index, and waist circumference. The demographical descriptive statistic analysis and frequency analysis by age groups were performed. The difference of average and correlation between hyperlipidemia and obesity indicators were analyzed. As a result, patients over 60 have fatty liver regardless of sex. there was a difference between triglyceride, high-density lipoprotein cholesterol, weight, body mass index, and waistline for all age groups. The degree of fatty liver was highly correlated with waist size and body mass index for all age groups.