• Korean Journal of Clinical Laboratory Science
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• v.51 no.2
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• pp.245-251
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• 2019

This study examined the effects of 2-methoxy-1,4-naphthoquinone (MQ) on the monocyte chemoattractant protein-1 (MCP-1)-induced migration of monocytes, which is an important phenomenon for the body defense and immune response. MQ is a major component extracted from Impatiens balsamina leaves, which have been used for many years in Asian medicine for the treatment of a range of diseases and pain. The cytotoxicity of MQ began to appear at a concentration of $10{\mu}M$, and approximately 50% cytotoxicity was confirmed at $100{\mu}M$. The MCP-1 induced migration of the THP-1 monocyte cell line increased after MQ treatment in a dose dependent manner and the largest increase was observed at $0.1{\mu}M$. The level of cAMP expression decreased after a treatment with $0.1{\mu}M$ MQ. The phosphorylation of extracellular signal-regulated kinases 1/2 (Erk1/2), a key signaling protein involved in the signaling pathway of C-C motif chemokine receptor 2 (CCR2), a receptor for MCP-1, was increased by the simultaneous treatment of $0.1{\mu}M$ MQ. These results show that MQ increases the MCP-1-induced migration of THP-1, decreases the level of cAMP expression, and increases the level of Erk1/2 phosphorylation.

• (The)Study of the Eastern Classic
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• no.55
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• pp.265-291
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• 2014

Cheongeumrok is the journal of Gwonwoo(卷宇) Hong Chan-yu(1915-2005) during the period of January 9, 1969~January 14, 1982. He was personally involved in the foundation of a corporation called Yudohoi and also all of its operation, which makes him the most knowledgeable person about its history. His Cheongeumrok thus seems worthy enough as a proper material to arrange its history. Cheongeumrok consists of total 19 books, amounting to approximately 3,300 pieces of squared manuscript paper containing 200 letters per piece. He wrote it in Chinese and sometimes followed the Hangul-style word order while writing in Chinese. Many parts of the manuscript were written in a cursive hand with many Chinese poems embedded throughout it. The manuscript offers major information related to the corporation Yudohoi extracted from his journal. 1. There was a meeting of promoters to commemorate the foundation of the corporation in November, 1968, and it was in January, 1969 that it was established after getting a permit from the Ministry of Culture and Communication in January, 1969(Permit No. of Ministry of Culture and Communication: Da(다)-2-3(Jongmu(宗務)1732.5)). 2. Its office was moved from the original location of the 3rd floor of Wonnam Building, 133-1 Wonnam-dong, Jongro-gu, Seoul(currently Daekhak Pharmacy in front of Seoul National University Hospital) to Room 388 of Gwangjang Company, 4 Yeji-dong, Jongro-gu(office of Heungsan Social Gathering) and to second floor of KyungBo building, 21 Kyansu-dong, and to 3rd floor of Geongguk Building in Gyeongwoon-dong. 3. Its operational costs were covered by the supports of Seong Sang-yeong, the eldest son of Seong Jong-ho, the chairman of the board, later Kim Won-tae and Gwon Tae-hun, next chairmen of the board, and Hong Chan-yun, a director, since 1979. 4. His Confucian activities include participating in Seonggyungwan Seokjeonje (成均館 釋奠), joining in the erection of the Parijangseo(巴里長書) Monument and the publication of its commemorative poetry book, compiling the biographies(not completed) of Confucian patriotic martyrs for independence, and participating in the establishment of family rituals and regulations as a practice member. 5. His Yudohoi had a dispute with Seonggyungwan and lost a suit at the High Court in July, 1975 and Supreme Court in February, 1976. 6. There were discussions about its unification with Seonggyungwan Yudohoi, but there was hardly any progress. 7. Yudohoi started to provide full-scale courses on Confucian and Chinese classics under the leadership of Director Hong Chan-yu in 1979, and they have continued on today. Its courses for scholarship students including those for common citizens boast a history of 29 years and 220 graduates.

• Korean Journal of Environmental Biology
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• v.38 no.4
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• pp.658-666
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• 2020

The purpose of this study was to select a suitable planting substrate for multilayered plantings in an apartment landscape space. The experiment was conducted between May to October 2019, at the National Institute of Horticultural and Herbal Science. Planting substrate was prepared in six repetitions of eight treatment zones using mulching material, horticultural soil, bottom ash, and subgrade soil. Rosa hybrid 'Barkarole' and Hydrangea macrophylla 'Nikko Blue' were selected as the experimental plants. We investigated the monthly variation and effect of the substrate type on the growth (plant height, number of branches, leaf length, leaf width, and plant area of the substrates) of the plants. In R. hybrid 'Barkarole' grown in 20 cm of horticultural soil and 10 cm of bottom ash, the plants were taller(102.2±5.8 cm), had more branches (5.5±0.6 each), longer leaves (10.9±1.0 cm), and greater leaf width (6.2±0.5 cm) and plant area (4077.1±416.6 cm²)(p<0.05). H. macrophylla 'Nikko Blue' showed the best growth from 3cm of mulching, 20cm of horticultural topsoil, and 10cm of bottom ash, which resulted in taller plants (43.6±2.1 cm), more branches (4.9±0.8 each), longer leaves (7.2±0.5 cm), and greater leaf width(4.3±0.3 cm) and plant area (344.5±43.2 cm²). Through this study, it was possible to propose an optimal planting substrate for shrubs for multi-layered landscaping.

• Korean Journal of Environmental Biology
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• v.38 no.4
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• pp.733-743
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• 2020

We estimated the carbon storage of coal mines reclaimed using Betula platyphylla (BP), Pinus koraiensis (PK), and Pinus spp. (PS, Pinus densiflora, Pinus rigida, and Pinus thunbergii). The carbon storage of tree biomass (TB), forest floor(FF), mineral soil (MS), and the total forest were quantified. Reclaimed sites were located in Gangwon-do, Gyeongsangbuk-do, and Jeollanam-do; reclamation was conducted at various times in each region. The carbon storage (ton C ha^-1) in FF (BP: 3.31±0.59, PK: 3.60±0.93, PS: 4.65±0.92), MS (BP: 28.62±2.86, PK: 22.26±5.72, PS: 19.95±3.90), and the total forest(BP: 54.81±7.22, PK: 47.29±8.97, PS: 45.50±6.31) were lower than that of natural forests (NF). The carbon storage in TB was lower in BP (22.57±6.18) compared to NF, while those in PK(21.17±8.76) and PS (20.80±6.40) were higher than in NF. While there were no significant differences in the carbon storage of TB, FF, and the total forest among tree species, results from MS showed a significant difference among species. TB and the total forest carbon storages in all sites increased after reclamation. Soil pH and cation exchange capacity values in BP and PS were lower than in NF. Amounts of labile carbon, available phosphate, and microbial biomass carbon in reclaimed sites were less than half of NF. There are a number of methods that could increase the reclamation efficiency. Applications of lime or organic fertilizers, as well as tillage operations, may improve soil properties in reclaimed coal mines. Additionally, pruning and thinning would increase tree growth thereby increasing carbon storage.

• Korean Journal of Heritage: History & Science
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• v.54 no.1
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• pp.120-137
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• 2021

There were five palaces built during the Joseon Period. Gyeongbokgung Palace was the first one, founded in the 4th year of King Taejo (1395), and depending on the historical interpretation, Changdeokgung Palace, Changgyeonggung Palace, Gyeongungung Palace (Deoksugung), and Gyeongdeokgung Palace (Gyeonghuigung) were also built. The palaces represent the best architecture of the time. In addition, the palaces of the Joseon period have been rebuilt several times, so they contain the architectural history of the Joseon period over the last 500 years. In this paper, all the excavations of five palaces in the Joseon Period were surveyed, and the foundations of the buildings were analyzed. In particular, the aim of this paper is to investigate Jeoksim (foundations of buildings under cornerstone) to understand the characteristics of each palace by period. Accordingly, the changes of the construction techniques of the foundations of the palaces were studied. There are a total of 23 types of Jeoksim. All five palaces have a certain type (I~V) of construction technique, thus it was confirmed that there was a certain pattern in the method of constructing the foundations of palace buildings in the Joseon Dynasty. In addition, Jeoksim was mainly built by certain materials and construction methods (I-1) during the 14th to the 17th century, but new types of Jeoksim were built in the palaces starting from the 18th century, during the reign of King Jeongjo. In the 19th century, when King Gojong sat on the throne, the Jeoksim was built in various shapes, materials, and in 22 types of construction methods. Up to now, research on the remains of palaces were mainly conducted on the Gyeongbokgung Palace, so it was not possible to confirm the foundations of 17th-18th century buildings, where reconstruction had stopped after the Imjin War in 1592. However, through this study, it was possible to classify the transition periodsstheir features periods of palace building foundation construction from the 14th to the 20th century by comparing the remains of five palace building sites.

• Pediatric Infection and Vaccine
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• v.28 no.2
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• pp.92-100
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• 2021

Purpose: Rapid detection of etiologic organisms is crucial for initiating appropriate therapy in patients with central nervous system (CNS) infection. This study aimed to evaluate the diagnostic value of the BioFire^® Meningitis/Encephalitis (ME) panel in detecting etiologic organisms in cerebrospinal fluid (CSF) samples from febrile infants. Methods: CSF samples from infants aged <90 days who were evaluated for fever were collected between January 2016 and July 2019 at the Seoul National University Children's Hospital. We performed BioFire^® ME panel testing of CSF samples that had been used for CSF analysis and conventional tests (bacterial culture, Xpert^® enterovirus assay, and herpes simplex virus-1 and -2 polymerase chain reaction) and stored at -70℃ until further use. Results: In total, 72 (24 pathogen-identified and 48 pathogen-unidentified) CSF samples were included. Using BioFire^® ME panel testing, 41 (85.4%) of the 48 pathogen-unidentified CSF samples yielded negative results and 22 (91.7%) of the 24 pathogen-identified CSF samples yielded the same results (enterovirus in 19, Streptococcus agalactiae in 2, and Streptococcus pneumoniae in 1) as those obtained using the conventional tests, thereby resulting in an overall agreement of 87.5% (63/72). Six of the 7 pathogen-unidentified samples were positive for human parechovirus (HPeV) via BioFire^® ME panel testing. Conclusions: Compared with the currently available etiologic tests for CNS infection, BioFire^® ME panel testing demonstrated a high agreement score for pathogen-identified samples and enabled HPeV detection in young infants. The clinical utility and cost-effectiveness of BioFire^® ME panel testing in children must be evaluated for its wider application.

• Journal of the Korean Orthopaedic Association
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• v.56 no.5
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• pp.398-403
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• 2021

Purpose: A biopsy is needed to diagnose soft tissue tumors. However, it is extremely difficult to pinpoint the site of a tumor due to the heterogeneity of sarcomas. Thus, even when an open biopsy is conducted, it is difficult to diagnose a soft tissue tumor. In such cases, an ultrasound (US)-guided biopsy is used to improve the diagnostic accuracy. This study evaluated the accuracy of US-guided biopsy for a diagnosis of soft tissue tumors found initially in a magnetic resonance (MR) perfusion and assessed the availability of positron emission tomography-computed tomography (PET-CT) for a diagnosis of soft tissue tumors. Materials and Methods: From January 2014 to December 2018, the US-guided biopsy was performed on 152 patients with a suspected soft tissue tumor found in an MR perfusion and 86 cases were definitively diagnosed with a soft tissue tumor. The accuracy of the US-guided biopsy was assessed retrospectively. Among the 86 cases, only MR perfusion was used before the biopsy in 50 cases, while both MR perfusion and PET-CT was conducted on 36 cases. The accuracy was analyzed to determine if the PET-CT could improve the precision of a biopsy. Results: From 86 cases, 34 out of 50 cases, in which only MR perfusion had been conducted, matched the result of the definitive diagnosis and the US-guided biopsy. 32 out of 36 cases, in which both PET-CT and MR perfusion were conducted, matched the definitive diagnosis and the US-guided biopsy. These results show significant differences in the accuracy of US-guided biopsy. In the case of soft tissue sarcomas, 6 out of 12 cases, in which only MR perfusion had been conducted, matched the result of the definitive diagnosis and the US-guided biopsy. 17 out of 18 cases, in which both PET-CT and MR perfusion were conducted, matched the definitive diagnosis. Moreover US-guided biopsy also showed significant differences in the accuracy of US-guided biopsy. Conclusion: In diagnosing soft tissue tumors, a US-guided biopsy is a well-known tool for its high accuracy. However, the heterogeneity of sarcoma makes it difficult to locate the exact site for a biopsy using only MR perfusion. Thus, the use of PET-CT will meaningfully improve the accuracy of a diagnosis by precisely targeting the site for the US-guided biopsy.

• Journal of Korea Water Resources Association
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• v.55 no.10
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• pp.737-748
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• 2022

Due to the lack of flood data, the water engineering practice calculates the design flood using rainfall frequency analysis and rainfall-runoff model. However, the rainfall frequency analysis for arbitrary duration does not reflect the regional characteristics of the duration and amount of storm event. This study proposed a practical method to calculate the design flood in a watershed considering the characteristics of storm event, based on the bivariate rainfall frequency analysis. After extracting independent storm events for the Pyeongchang River basin and the upper Namhangang River basin, we performed the bivariate rainfall frequency analysis to determine the design storm events of various return periods, and calculated the design floods using the HEC-1 model. We compared the design floods based on the bivariate rainfall frequency analysis (DF_BRFA) with those estimated by the flood frequency analysis (DF_FFA), and those estimated by the HEC-1 with the univariate rainfall frequency analysis (DF_URFA). In the case of the Pyeongchang River basin, except for the 100-year flood, the average error of the DF_BRFA was 11.6%, which was the closest to the DF_FFA. In the case of the Namhangang River basin, the average error of the DF_BRFA was about 10%, which was the most similar to the DF_FFA. As the return period increased, the DF_URFA was calculated to be much larger than the DF_FFA, whereas the BRFA produced smaller average error in the design flood than the URFA. When the proposed method is used to calculate design flood in an ungauged watershed, it is expected that the estimated design flood might be close to the actual DF_FFA. Thus, the design of the hydrological structures and water resource plans can be carried out economically and reasonably.

• Journal of the Korean Orthopaedic Association
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• v.55 no.2
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• pp.162-168
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• 2020

Purpose: The purpose of this study was to suggest an appropriate treatment method by comparing nonsurgical treatment and surgical treatment for enchondroma in the hands and feet. Materials and Methods: Seventy four cases with enchondroma of the hands and feet from January 1996 to March 2017 were selected to evaluate the functional outcomes. Thirty cases were treated with nonsurgical treatment, and 44 cases were treated with surgical treatment, such as curettage only or curettage with a bone graft. The mean follow-up period was 18.1 months. The functional results were analyzed using the Wilhelm and Feldmeier formula. Results: The mean age was 38 years, and the age range was between eight and 69 years. According to the Wilhelm and Feldmeier formula, the mean score of hand enchondroma was 3.09±0.85 and 3.20±0.91 in the non-operative and operative group, respectively. The mean scores of the foot except for the grip strength were 2.57±0.79 and 2.75±0.50, respectively. No significant difference was observed according to the functional results. Among the 18 cases of enchondroma with pathological fractures, nine cases were treated non-surgically and nine cases were treated by surgically. In all 18 cases, complete bone healing was observed at the final follow-up. Conclusion: Relatively satisfactory results were obtained in both surgical and nonsurgical treatment and there was no significant difference in functional outcomes. In cases of enchondroma in the hands and feet, nonsurgical treatment can also be a good treatment option.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.41 no.5
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• pp.514-520
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• 1996

To clarify the proper nitrogen application level for rasing rice infant seedling under different nursery soil, Dongjinbyeo was raised at seedling box with different basal nitrogen level. The results are as follows. The higher the nitrogen level was, the lower emergence rate and the lower establishment rate. The establishment rate was less than 90%, when the nitrogen was more than 2g/box in hill soil and more than 1g/box in paddy soil. The more the nitrogen level was, the higher the seedling height in hill soil, but was higher in the order of N-2, 3, 1 and 0g /box. Leaf number wasn't significantly different between nusery soils and among nitrogen levels when seedling was raised more than 6 days. The endosperm survival rate was decreased as the increased nitrogen level, but wasn't different between the nursery soils. Amount of root was decreased as the increased nitrogen level in paddy soil, but was heavier in the order of N-1, 0, 2 and 3g /box in hill soil. Mat formation was better as the nitrogen level was decreased in all nursery soils. Considering the emergence rate, seedling charactors and mat formation, the proper nitrogen levels seemed to be 2g /box for hill soil and 1g /box for paddy soil.