• The Journal of Engineering Geology
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• v.28 no.3
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• pp.475-488
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• 2018

This study evaluates geothermal system efficiency in terms of input power and heat exchange volume on the heat-source and load sides, by applying a combined open-closed type loop system comprising a geothermal system and a groundwater well to a cultivation site. In addition, this study analyzes the effects of heating and cooling for a complex geothermal system, by evaluating the temperatures of an external site and a cultivation site during operation. During cooling operations the heat exchange volume on the heat source side, average 90.0kW/h for an open type system with an input of 235L/minute groundwater, and 40.1kW/h for a closed type system with an input of 85L/minute circulating water, for a total average heat exchange volume of 130.1kW/h. The actual heat exchange volume delivered on the load side averages 110.4kW/h. The average EER by analysis of the geothermal system's cooling efficiency is 5.63. During heating operation analysis, the heat exchange volume on the heat source side, average 60.4kW/h in an open type system with an input of 266L/minute groundwater, and 22.4kW/h in closed type system with an input of 86L/minute circulating water, for a total average heat exchange volume of 82.9kW/h. The actual heat exchange volume delivered on the load side averages 112.0kW/h in our analysis. The average COP determined by analysis of the geothermal system's heating efficiency is 3.92. Aa a result of the tradeoff between the outside temperature and the inside temperature of the production facility and comparing the facility design with a combined well and open-closed loops geothermal(CWG) system, we determine that the 30RT-volume CWG system temperature are lower by $3.4^{\circ}C$, $6.8^{\circ}C$, $10.1^{\circ}C$ and $13.4^{\circ}C$ for ouside temperature is of $20^{\circ}C$, $25^{\circ}C$, $30^{\circ}C$ and $35^{\circ}C$, respectively. Based on these results, a summer cooling effect of about $10^{\circ}C$ is expected relative to a facility without a CWG system as the outside temperature is generally ${\geq}30^{\circ}C$. Our results suggest that a complex geothermal system provides improvement under a variety of conditions even when heating conditions in winter are considered. Thus It is expected that the heating-cooling tradeoffs of complex geothermal system are improved by using water screen.

• Journal of agricultural medicine and community health
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• v.3 no.1
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• pp.5-9
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• 1978

이제까지 알려진 바에 의(依)하면 우리 나라에서 간(肝) 및 폐(肺)디스토마 분포양상(分布樣相)은 강원도지역(江原道地域)이 가장 저율(低率)로 나타난 것을 볼 수 있다. 그 이유(理由)로서는 이들 양흡충은 반드시 제(第)1 및 제(第)2중간숙주(中間宿主)를 통한 生活環(생활환)이 완성(完成)되어야만 하는데, 이들 중간숙주분포(中間宿主分布)가 강원도지역(江原道地域)이 낮은 까닭인듯 하다. 우연(偶然)한 기회(機會)에 저자(著者)는 강원도(江原道)의 일부지역(一部地域)은 폐(肺)디스토마의 감염(感染)이 적지 않다는 정보(情報)를 입수(入手)하고 이에 흥미(興味)를 갖게 되었으며, 특(特)히 농후감염지역(濃厚感染地域)으로 예상(豫想)되는 횡성군(橫城郡)의 일부지역(一部地域), 폐(肺), 청일면(廳日面) 신대리(里) 일대(一帶)와 서원면(面) 유현리(里)에서의 간(肝) 및 폐(肺)디스토마의 감염상(感染相)을 파악(把握)할 목적(目的)으로 본(本) 조사(調査)를 전도(全圖)하였다. 검사방법(檢査方法)으로는 일단(一旦) 간(肝) 및 폐(肺)디스토마의 VBS 항원(抗原)으로 피내반응검사(皮內反應檢査)를 실시(實施)하여 간(肝)디스토마 피내반응검사(皮內反應檢査)에 대(對)해서는 객담검사(喀痰檢査)와 면역혈청반응으로 보체결합반응(補體結合反應), 간접형광항체반응(間接螢光抗體反應) 및 Ouchterlony 반응(反應)을 하여 좀더 정확(正確)한 감염상황(感染狀況)을 파악(把握)하고저 하였다. 그 결과(結果)의 개요(槪要)는 아래와 같다. 1. 횡성군(橫城群) 신대리(里)와 우현리(里)의 주민(住民) 680명(名)에 대(對)한 폐(肺)디스토마의 VBS항원(抗原)에 의(依)한 피내반응양성율(皮內反應陽性率)은 12.4%이었고 간(肝)디스토마의 피내반응양성율(皮內反應陽性率)은 12.5%이었다. 2. 성별(性別)에 따른 피내반응양성율(皮內反應陽性率)의 차이(差異)는 간(肝)디스토마의 경우, 여자(女子) 7.4%에 비(比)하여 남자(男子)가 17.1%이었고, 폐(肺)디스토마의 경우는 여자(女子)가 20.7%인데 반(反)하여 남자(男子)가 42.9%로서 2배(倍) 이상(以上)의 고율(高率)이었다. 3. 연령별(年令別)로 보면, 간(肝)디스토마 피내반응양성율(皮內反應陽性率)은 31~40재(才)가 22.1%로 가장 고율(高率)이었고, 폐(肺)디스토마 양성율(陽性率)은 21~30재(才) 사이가 58.5%로서 가장 높았다. 4. 폐(肺)디스토마 피내반응양성자(皮內反應陽性者)에 대(對)하여 객담검사(喀痰檢査)를 실시(實施)한 바 105명(名) 중 11명(名)(10.5%)의 충란검출자(蟲卵檢出者)를 볼 수 있었다. 또 이들에 대(對)한 면역혈청반응(免疫血淸反應)으로 보체결합반응(補體結合反應), 간접형광항체반응(間接螢光抗體反應) 및 Ouchterlony 반응(反應)을 실시(實施)한 바, 각각 42.5%, 50.3% 및 45.8%로서 거의 일치(一致)된 성적(成績)을 나타내어 피내반응양성자(皮內反應陽性者)의 약반수(約半數)에서 이들 혈청반응(血淸反應)이 양성(陽性)으로 나타났다.

• Nuclear Medicine and Molecular Imaging
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• v.40 no.4
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• pp.211-217
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• 2006

Purpose: Recombinant ScFv lym-1 was produced, using pET vector system for large scale production. Methods: ScFv lym-1 gene inserted pET-22b (+) vector, was expressed in E.coli BL-21 strain. ScFv lym-1 antibody extracted from periplasm, was purified with His-Taq column. To evaluated immunoreactivity with Raji cell, ScFv lym-1 was labeled with I-125 and I-125 ScFv lym-1 was purified with desalting column. Raji cell was injected into the C57BR/cdJ SCID mice. Gamma camera imaging were taken time point at 1, 8, 24, and 48 hr with 8 mm pinhole collimator. Results: An active scFv lym-1 could be produced in E. coli with soluble iron using PET vector system. Immuuoreaetivity and affinity constant of IgG lym-1 were 54% and $1.83{\times}10^9M^{-1}$, respectively, and those of scFv lym-1 were 53.7% and $1.46{\times}10^9M^{-1}$, respectively. Biodistribution of I-125 scFv lym-1 antibody showed faster clearance in blood, spleen, kidney and than I-125 IgG lym-1 antibody. Gamma camera image of I-125 scFv lym-1 antibody showed faster clearance and tumor targeting liver than I-125 IgG lym-1 antibody. Conclusions: In vitro properties of scFv lym-1 were similar to those of IgG lym-1. ScFv lym-1 showed faster blood clearance than IgG lym-1 There results suggest that scFv lym-1 antibody can be useful for tumor imaging agent.

• Journal of the Korean Society of Hazard Mitigation
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• v.7 no.3
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• pp.19-31
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• 2007

Humidity and strain were estimated for understanding the relation between humidity change by self-desiccation and shrinkage in high-performance concrete with low water binder ratio and containing fly ash and blast furnace slag. Internal humidity change and shrinkage strain were about 10%, 10%, 7%, 11%, 11% and $320{\times}10^{-6}$, $270{\times}10^{-6}$, $231{\times}10^{-6}$, $371{\times}10^{-6}$, $350{\times}10^{-6}$ respectively on OPC30, O30F10, O30F20, O30G40, O30G50 and from the results, fly ash made humidity change and strain decrease but slag increase comparing with ordinary portland cement. Considering only relation internal humidity and shrinkage by self-desiccation, humidity change and shrinkage represented the strong linear relation regardless of mineral admixture. For specifying the relation on internal humidity change and autogenous shrinkage strain, shrinkage model was established which is driven by capillary pressure in pore water and surface energy in hydrates on the assumption of a single network and extended meniscus in pore system of concrete. This model and experimental results had a similar tendency so it would be concluded that the internal humidity change by self-desiccation in HPC originated in small pores less than 20nm, therefore controlling plan on autogenous shrinkage might be focused on surface tension of water and degree of saturation in small pore.

• Membrane Journal
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• v.33 no.4
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• pp.149-157
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• 2023

Covalent organic frameworks (COFs) have shown promise in various applications, including molecular separation, dye separation, gas separation, filtration, and desalination. Integrating COFs into membranes enhances permeability, selectivity, and stability, improving separation processes. Combining COFs with single-walled carbon nanotubes (SWCNT) creates nanocomposite membranes with high permeability and stability, ideal for dye separation. Incorporating COFs into polyamide (PA) membranes improves permeability and selectivity through a synthetic interfacial strategy. Three-dimensional COF fillers in mixed-matrix membranes (MMMs) enhance CO₂/CH₄ separation, making them suitable for biogas upgrading. All-nanoporous composite (ANC) membranes, which combine COFs and metal-organic framework (MOF) membranes, overcome permeance-selectivity trade-offs, significantly improving gas permeance. Computational simulations using hypothetical COFs (hypoCOFs) demonstrate superior CO₂ selectivity and working capacity relevant for CO₂ separation and H₂ purification. COFs integrated into thin-film composite (TFC) and polysulfonamide (PSA) membranes enhance rejection performance for organic contaminants, salt contaminants, and heavy metal ions, improving separation capabilities. TpPa-SO₃H/PAN covalent organic framework membranes (COFMs) exhibited superior desalination performance compared to traditional polyamide membranes by utilizing charged groups to enable efficient desalination through electrostatic repulsion, suggesting their potential for ionic and molecular separations. These findings highlight COFs' potential in membrane technology for enhanced separation processes by improving permeability, selectivity, and stability. In this review, COF applied for the separation process is discussed.

• The Journal of Korean Academy of Prosthodontics
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• v.50 no.3
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• pp.149-155
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• 2012

Purpose: The purpose of this study was to investigate the influence of mobilization on bone-implant interface prior to osseointegration of fixtures. Materials and methods: The experimental implants (3.75 mm in diameter, 4.0 mm in length) were made of commercially pure (Grade IV) titanium, and were treated with RBM ($MegaGen^{(R)}$: Ca-P). The 80 implants (two in each tibia) were inserted into the monocortical tibias of 20 rabbits which each weighed more than 3.5 kg (Female, New Zealand White). According to the removal torque interval, the groups were divided into 10 groups, Group I (6 wks), Group II (4 days+6 wks), Group III (4 days+1 wk+6 wks), Group IV (1 wk+6 wks), Group V (1 wk+1 wk+6 wks), Group VI (2 wks+6 wks), Group VII (2 wks+ 1 wk+6 wk), Group VIII (3 wks+6 wks), Group IX (3 wks+1 wk+6 wks) and Group X (10 wks). The control groups were Group I and X, the removal torque was measured at 6 wks and 10 wks with a digital torque gauge (Mark-10, USA). In the experimental groups, the removal torque was given once or twice before the final removal torque and the value was measured each time. After which, the implants were put back where they had been except the control groups. All the experimental groups were given a final healing time (6 wks) before the final removal torque test, in which values were compared with the control groups and the 1st and/or 2nd removal torque values in each experimental group. Results: In the final removal torque tests, the removal torque value of Group X (10 wks) was higher than that of Group I (6 wks) in the control groups but not statistically different. There were no significant differences between the experimental groups and control groups (P>.05). In the first removal torque comparison, the experimental groups (4 days or 1 wk) values were significantly lower than the other experimental groups (2 wks or 3 wks). In the comparison of each experimental group according to healing time, the final removal torque value was significantly higher than the 1st torque test value. Conclusion: Once or twice mobilization of fixture prior to osseointegration did not deter the final bone to implant osseointegration, if sufficient healing time was given.

• Journal of Life Science
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• v.14 no.5
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• pp.770-777
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• 2004

It has been previously reported that unacetylated a-tropomyosin(TM) produced in E. coli failed to bind to actin while acetylated muscle TM and Ala-Ser dipeptide fusion TM (AS-TM) bound well to actin. In order to determine the structural requirement of the amino terminus for high actin affinity, a recombinant tropomyosin (Ala-TM) that a single Ala residue was added to the amino terminus of Ala-TM was constructed, overexpressed, and purified from E. coli. Actin affinity of Ala-TM was 2.3$\times$$10^{6}$$M^{-1}$, whereas that of unacetylated TM was considerably lower than 0.1$\times$$10^{-6}$$M^{-1}$ indicating that addition of a single Ala residue to the amino terminus drastically increased, at least twenty times, actin affinity of TM. Ala-TM, however, bound to actin about three times weaker than acetylated TM and AS- TM, implying that the addition of an Ala residue was insufficient for complete restoration of high actin affinity. While Ala-TM, AS-TM, and muscle TM showed inhibition and activation of actomyosin Sl ATPase activity depending on myosin Sl concentration, the degree of inhibition and activation was different from each other. AS-TM exhibited the greatest inhibition of the ATPase at low Sl concentration, whereas the greatest activation of the ATPase was observed with muscle TM. These results, together with previous findings, strongly suggested that local structure of the amino terminus is the crucial functional determinant of TM.

• Journal of Periodontal and Implant Science
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• v.32 no.1
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• pp.143-160
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• 2002

타이태늄은 뛰어난 생체적합성과 적절한 물리적 성질을 바탕으로 치과 및 정형외과 영역의 매식재로 널리사용되어져 왔으며, 골과 매식재 사이의 골 융합 정도를 증가시킬 목적으로 물리, 화학적인 방법을 이용한 타이태늄의 표면처리에 관한 많은 연구들이 진행되어 왔다. 최근에는 부착단백질 또는 성장인자를 이용한 생체재료의 표면개질을 통하여 조직적합성 및 치유 능의 개선을 위한 시도들이 있어왔다. Fibronectin(FN)은 주요 세포외기질중의 하나로 생체 내 널리 분포하여 세포의 부착, 이동 및 증식에 관여하는 거대 당단백으로, RGD및 PHSRN 펩타이드 서열이 세포의 인테그린과 결합하여 세포의 활성을 조절하는 것으로 알려져 있다. 이 연구에서는 FN으로 처리된 타이태늄이 조골세포의 부착, 증식 및 분화에 미치는 영향과 이에 따른 석회화 정도에 미치는 영향을 관찰하여 부착분자를 이용한 타이태늄 표면개질의 효과를 규명하고자 하였다. 상업용 순수 타이태늄을 gold thiol법을 이용하여 표면처리 후, 혈장 FN(plasma FN, pFN)과 유전자재조합법을 이용하여 얻은 FN조각(FN type III 7-10, FNIII 7-10)을 피복한 시편을 실험군으로, 아무런 처리를 하지 않은것(smooth surface, SS)과 산 부식(Sandblasted and acid etched, SLA)처리된것을 대조군으로 이용하였다. 배양된 조골세포주(MC3T3-E1)를 사용하여 타이태늄 표면 처리에 따른 세포의 증식, 형태변화, 알칼리성 인산분해효소(ALPase) 생산 및 세포면역형광법을 이용한 분화정도를 시간 경과에 따라 관찰하였다. 조골세포증식의 경우 FNIII 7-10 처리군에서 pFN 처리군 및 대조군에 비해 시간경과에 따라 유의성있는 세포수의 증식이 관찰되었으며(p<0.05), ALPase 생성의 경우에도 FNIII 7-10 처리 군에서 아무 처리도 하지 않은 군에 비해 유의성 있게 높은 효소의 생성이 관찰되었다(p<0.05). 주사전자현미경을 이용한 세포의 형태관찰결과 아무 처리도 하지 않은 군에서는 마름모형태를 나타내었으며, 산 부식 처리된 군에서는 세포가 가시모양의 형태를 보인 반면 FN으로 처리된 두 군에서는 세포의 부착 및 펴짐이 매우 발달되어 있는 모습이 관찰되었다. 세포의 분화정도를 관찰하기 위하여 국소부착키나제(focal adhesion kinase, FAK), 및 actin stress fiber의 분포양상을 세포면역형광법을 이용하여 관찰한 결과 FN으로 표면처리된 두 군에서 아무런 처리도 하지않은 군 및 산 부식처리 한 군에 비해 프라크의 발현이 높게 나타났으며 잘 발달된 actin stress fiber의 소견을 나타내었다. 이 실험의 결과들은 gold thiol 법을 이용한 표면처리 후 FN부착을 통한 타이태늄의 표면개질이 조골세포의 부착, 증식 및 분화에 중요한 역할을 담당하여 석회화 정도를 촉진시키는 것을 보여주었으며, 이런 결과들은 더 짧은 FN조각을 이용한 다른 생체재료의 표면개질에 폭 넓게 응용할 수 있으리라 생각된다.

• The Journal of Korean Academy of Prosthodontics
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• v.50 no.2
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• pp.112-118
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• 2012

Purpose: The purpose of this study was to evaluate the difference in shear bonding strength between resin cements to dental materials when a universal primer (Monobond plus) was applied in place of a conventional primer. Materials and methods: Four groups of testing materials: gold alloy (Argedent Euro, n = 16), non precious metal (T-4, n = 20), zirconia (Cercon, n = 20) and glass ceramic (IPS e.max press, n = 20), were fabricated into discs, which were embedded in an acrylic resin matrix. The gold alloy specimens were airborne-particle abraded, 8 of the specimens were coated with Metal primer II, while the remaining 8 specimens were coated with Monobond plus. The non precious and zirconia specimen were airborne-particle abraded then, the control group received Alloy primer coating, while the other was coated with Monobond plus. Glass ceramic specimens were etched. 10 specimens were coated with Monobond-S and the remaining specimens were coated using Monobond plus. On top of the surface, Multilink N was polymerized in a disc shape. All of the specimens were thermal cycled before the shear bonding strength was measured. Statistical analysis was done with Two sample $t$-test or Mann-Whitney U test (${\alpha}$=.05). Results: There were no significant differences in bonding strength depending on the type of primer used in the gold alloy and glass ceramic groups ($P$>.05), however, the bonding strengths of resin cements to non precious metal and zirconia groups, were significantly higher when the alloy primer was used ($P$<.05). Conclusion: Within the limitations of this study, improvement of universal primers which can be applied to all types of restorations is recommended to precious metals and zirconia ceramics. But, the bond strengths of non precious metals and zirconia ceramics were significantly lower when compared to a 10-MDP primer. More research is needed to apply universal primers to all types of restorations.

• Journal of Korea Water Resources Association
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• v.50 no.5
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• pp.335-346
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• 2017

This study generated the radar-based forecasted rainfall using spatial-scale decomposition method (SCDM) and evaluated the hydrological applicability with forecasted rainfall by KMA (MAPLE, KONOS) in terms of urban flood forecasting. SCDM is to separate the small-scale field (convective cell) and large-scale field (straitform cell) from radar rainfield. And each separated field is forecasted by translation model and storm tracker nowcasting model for improvement of QPF accuracy. As the evaluated results of various QPF for three rainfall events in Seoul and Metropolitan area, proposed method showed better prediction accuracy than MAPLE and KONOS considering the simplicity of the methodology. In addition, this study assessed the urban hydrological applicability for Gangnam basin. As the results, KONOS simulated the peak of water depth more accurately than MAPLE and SCDM, however cannot simulated the timeseries pattern of water depth. In the case of SCDM, the quantitative error was larger than observed water depth, but the simulated pattern was similar to observation. The SCDM will be useful information for flood forecasting if quantitative accuracy is improved through the adjustment technique and blending with NWP.