• 대한한방부인과학회지
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• 제24권1호
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• pp.87-98
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• 2011

Objectives: To evaluate the clinical use of Kupperman's Index, Menopausespecific quality of life questionnaire(MENQOL), Menopause Rating Scale(MRS) by comparison with the Subjective measures of hot flush. Methods: The participants were 107 women (45-60 yr) who were not currently on hormone therapy, and had reached hot flash scores of 10 or higher. The evaluating indexes of this trial are hot flush score, hot flush VAS, Hot flush consistence time, sweating VAS, Kupperman`s Index, Menopause-specific quality of life questionnaire (MENQOL), Menopause Rating Scale(MRS). Results: 1. The hot flush score, hot flush VAS, sweating VAS were significantly correlated with each other, but the Hot flush consistence time with no special relationship was found on Subjective measures of hot flush 2. The Kupperman's Index, Menopause-specific quality of life questionnaire (MENQOL) and Menopause Rating Scale(MRS) were significantly correlated with each other. 3. There was significant correlation between Subjective measures of hot flush and Menopause-specific quality of life questionnaire(MENQOL), Thus Menopausespecific quality of life questionnaire(MENQOL) is considered the most suitable on hot flush related research. Conclusions: There was significant correlation between Subjective measures of hot flush and Menopausal scale, thus the use of various indicators are needed for the assessment of climacteric symptoms.

• 대한한방부인과학회지
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• 제24권1호
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• pp.42-62
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• 2011

Objective: This study was performed to investigate the effect of acupuncture at HT8 on brain activity in perimenopausal women using fMRI. Methods: 15 healthy perimenopausal women volunteered in the study. No stimulation, sham stimulation, duration of acupuncture treatment on HT8, and rotation of acupuncture treatment on HT8 were randomly given for 6 minutes, with 20 seconds' intervals. Results: 1. In comparison with sham stimulation(Sham-B) and duration of acupucture (S1-B, S1-Sham, S2-S1), the areas of fMRI signal activation areas were just like cases including no stimulation. But the areas of vision were activated in S1-Sham. 2. In comparison with duration of acupuncture(S1-B, S1-Sham, S2-S1) and rotation of acupuncture(S2-B, S2-Sham, S2-S1), the areas of vision were activated in duration of acupuncture, and Supplementary motor area(SMA) were especially activated in rotation of acupuncture. Conclusions: After using fMRI and analysing effect of acupuncture treatment at HT8, we could confirm that fMRI signal activation areas by acupuncture treatment at HT8 were different from areas by sham stimulation. And according to acupuncture stimulation methods with duration and rotation, etc, we could confirm the specific reactions of series, and could get useful basic data for research of acupuncture from now on.

• 대한한방부인과학회지
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• 제24권4호
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• pp.95-104
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• 2011

Objectives: The purpose of this study is to investigate the relationship between the degree of menopausal symptom and granulocyte/lymphocyte ratio, and heart rate varibility(HRV). Methods: From 11th April 2011 to 20th May 2011, a total 30 female subjects (age 41-60) was recruited. We evaluated the degree of menopausal symptoms by Kupperman' s index and measured subject's WBC differential count and HRV. The data were analyzed by Kruskal-Wallis test and Spearman correlation test using SPSS/PC ver 13.0 program. Results: 1. There was no statistically significant difference in granulocyte/lymphocyte ratio and HRV among 4 classified groups according to Kupperman's index.- Mild, Moderate, Severe and Urgent. 2. Granulocyte ratio and general symptom score(within Kupperman's index) significantly showed negative correlation coefficient(r=-0.499, p=0.005), and Lymphocyte ratio and general symptom score significantly showed positive correlation coefficient (r=0.374, p=0.042). 3. Granulocyte/lymphocyte ratio and HRV showed no significant correlation. Conclusions: There was no significant relation among the degree of menopausal symptoms and granulocyte/lymphocyte ratio, and HRV. But furthermore large scale study is required.

• 대한한방부인과학회지
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• 제24권4호
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• pp.71-84
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• 2011

Purpose: To evaluate the correlation of MRS, MENQOL, HRV, Yin-Deficiency Questionnaire and the clinical use of Yin-Deficiency Questionnaire by comparison with MRS, MENQOL, and HRV. Methods: The participants were 21 women(44-58yr) with hot flush who were not currently on hormone therapy. The evaluating index of this trial are MRS, MENQOL, HRV, Yin-Deficiency Questionnaire. Results: The MRS and the MENQOL were significantly correlated with each other. The MRS and the HRV(LF/HF ratio) were significantly correlated with each other. The MENQOL and the HRV(LF/HF ratio) were significantly correlated with each other. The MRS somatic subscale and the Yin-Deficiency Questionnaire were significantly correlated with each other. The MENQOL and the Yin-Deficiency Questionnaire were significantly correlated with each other. The Yin-Deficiency Questionnaire and the HRV(LF/HF ratio) were significantly correlated with each other. Conclusions: The Yin-Deficiency Questionnaire is a valuable tool of oriental medicine for assessment of symptoms. The Yin-Deficiency Questionnaire were significantly correlated with the MRS somatic subscale, the MENQOL and the HRV(LF/HF ratio). Yin-Deficiency Questionnaire could serve as an adequate diagnostic instrument of oriental medicine for menopausal syndrome. Further large-scale study is needed for evaluation of the correlation of these measurements related with Menopausal syndrome and the clinical use of Yin-Deficiency Questionnaire.

• Journal of Nutrition and Health
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• 제39권2호
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• pp.121-132
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• 2006

Minerals are extremely important in human metabolism, growth, and tissue repair. The risks of disturbances in mineral nutrition and metabolism are high following menopause. The aim of the study was to investigate the mineal nutrition status in middle-aged women (Pre & Postmenopausal) and the relation to climacteric symptoms. In the present study, we conducted the anthropometric measurement, climacteric symptoms survey and the dietary intakes including macronutrients, vitamins and minerals to assess the nutrient intakes. Also plasma mineral levels (Ca, P, Mg, Na, K, Fe, Cu, Zn) was measured. The participants were 105 middle-aged women (pre=51, Postmenopausal=54). The anthropometric measurement showed that 74% of subjects was overweight and obesity. The energy intakes were 83% of Korean EER. The macromineral intake (Ca, P, Mg, Na, K), Ca, P and Mg were 65%, > 116% and > 107% of Korean RI. Na and K intakes were > 243% and 53% of Korean AI. For the trace mineral intake (Fe, Cu, Zn), Fe, Cu and Zn intakes were 82%, > 146%, and 94% of Korean RI. The serum mineral concentration measurement, in case of Ca, Fe and Zn, > 10% of subjects showed lower level than normal clinical range. The most frequently appeared climacteric symptoms were dry eye, forgetfulness, difficult concentration, shoulder pain, fatique, depression & lonesomeness, backache, snore, dry skin, ankle & knee pain. In relation to mineral nutrition with climacteric symptoms, significant correlations have been founded between Ca intake and difficult concentration, Mg intake and snore, Fe & Zn intake and forgetfulness & dry skin, serum Ca concentration and forgetfulness, serum Na concentration and dry eyes & snore, serum K concentration and shoulder pain. From these results, it has been indicated that some mineral nutrition status may effect the prevention and reduction of climacteric symptoms in pre and postmenopause women.

• 대한한방부인과학회지
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• 제28권1호
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• pp.85-91
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• 2015

Objectives: Postmenopausal symptoms are subject to many factors. Recently, obesity has been suggested as a factor of hot flush. So this study aims to report the relationship between body composition and Menopause Rating Scale (MRS), The Menopause-specific Quality of Life Questionnaire (MENQOL) of postmenopausal women. Methods: We studied 42 climacteric women who had visited Kyung Hee University Hospital at Gangdong from April 2011 to July 2014. 42 women had filled out MRS, MENQOL, and they had taken body composition tests. Pearson correlation tests were conducted. (Correlation was statistically significant at the 0.05 level) Results: Correlation between psychological subscale of MENQOL and Waist-Hip Ratio (WHR) was statistically significant (pearson correlation coefficient=0.385; p-value=0.012). But other subscales of MRS and MENQOL were not statistically related with body composition. Conclusions: WHR could be an important factor of psychological health of menopausal women. So, abdominal fat reduction must be considered when curing menopausal symptoms. In connection with climacteric depression, well-designed studies would be necessary.

• 대한한방부인과학회지
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• 제21권4호
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• pp.159-168
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• 2008

Purpose: The purpose of this study is to investigate the characters of Yangdorak in climacteric women. Methods: We analyzed the measurement value of Yangdorak on 37 climacteric women, aged 45-60 years. The patient's symptoms were assessed by modified Kupperman's index. Statistical analysis was performed using SPSS 13.0 for windows program. one-sample t-test. pearson correlation coefficient. Results: The results were as follows. 1. The average value of Yangdorak in 37 patients with climacteric women was 29.02$\pm$16.85. 2. According to the comparison of mean value with the each meridian value of Yangdorak. H1, H5 is high, F2, F3, F5 is low significantly. 3. The number of Pyesaek is more than Gyeokcha. 4. The Yangdorak value(F2) had significant correlation with modified Kupperman's index. Conclusion: The result suggests that Yangdorak values in H1, H5, F2, F3, F5 are related to climacteric. Further study on the yangdorak and climacteric syndrome measured by Kupperman's index is recommended.

• 대한한방부인과학회지
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• 제30권3호
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• pp.54-64
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• 2017

Objectives: The purpose of this study is to demonstrate Heart Rate Variability characteristics of menopausal patients with insomnia. Methods: From March 1, 2014 to June 20, 2017, Heart Rate Variability was measured in 102 menopausal patients who visited Cheonan Korean Medicine Hospital of Daejeon University. We compared accompanying symptoms and Heart Rate Variability values depending on sleep quality in menopausal women. Results: The accompanying symptoms of menopausal patients were as follows: hot flushes (45.1%), tiredness (25.49%), chest discomfort and palpitations (23.53%), headache (17.65%), arthralgia and muscular pain (17.65%), cold sensitivity of hands and feet (15.69%), urinary frequency (14.71%) and anxiety (10.78%). The frequency of chest discomfort and palpitation was significantly higher in the menopausal insomnia group than in normal sleep group. Comparing Heart Rate Variability between two groups, Standard deviation of the NN interval (SDNN), Total Power (TP), and Low Frequency (LF) values were significantly lower in insomnia group. Conclusions: Chest discomfort and palpitations were more frequent in insomnia patients in menopausal women than normal sleep group, and Standard deviation of the NN interval (SDNN), Total Power (TP), Low Frequency (LF) were significantly lower in HRV values.

• 대한한방내과학회지
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• 제43권5호
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• pp.940-950
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• 2022

Objectives: The purpose of this study is to report on the efficacy of Korean medical treatment for treating menopausal vasomotor symptoms (heat flashes and sleep disorders). Methods: We treated a menopausal female patient with heat flashes and sleep disorders using Korean medical treatments (herbal medicines, acupuncture, pharmacopuncture, moxibustion, and chuna). To evaluate the results of this treatment, we used Kupperman's Index and the Numerical Rating Scale to measure heat flashes and total sleeping time, respectively. The patient's general health status was evaluated using the European Quality of Life 5 Dimensions Scale. Results: We observed improvements in Kupperman's Index, the Numerical Rating Scale, the patient's total sleeping time, and the European Quality of Life 5 Dimensions Scale following the treatments. Conclusions: This study suggests that Korean medicine may be an effective treatment for menopausal vasomotor symptoms (heat flashes and sleep disorders).

• 대한한방부인과학회지
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• 제22권3호
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• pp.143-151
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• 2009

Purpose: Among many symptoms that the climacteric patients complain of, the major symptom is heat and cold sensation of body in various pattern. So, we are intended to study patterns of climacteric patients by using D.I.T.I. Methods: We studied 55 patients visiting OO Oriental Hospital from 1st January 2008 to 31th December 2008. The patients were distributed one of patterns by inspecting D.I.T.I. And we investigated the temperature of the region of body in 5 groups. Results: There are five groups in D.I.T.I. Those are heat sensation of face pattern, heat sensation of chest pattern, cold sensation of hand & foot pattern, heat sensation of hand pattern and cold sensation of lower abdomen pattern. 22 subjects are in heat sensation of face group. 12 subjects are in heat sensation of chest group. 12 subjects are in heat sensation of hand group. 6 subjects are in cold sensation of lower abdomen group. 3 subjects are in cold sensation of hand & foot group. Conclusion: 5 patterns of D.I.T.I is showed in climacteric patients. To help oriental medical diagnosis, further studies are needed.