• Journal of Nutrition and Health
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• 제36권10호
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• pp.1013-1021
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• 2003

Anemia, the condition of the diminished concentration of hemoglobin per erythrocyte is common in patients with cancer and is a frequent complication of myelosuppressive chemotherapy. Cham-Dang-Gui (Angelicae Gigantis Radix) has been used in traditional Korean medicine to treat hematologic deficiencies. In this study, Cyclophosphamide (CYP), an alkylating agent that has a broad spectrum of anti-cancer activities, was intraperitoneally injected into the experimental animals to suppress the bone marrow thereafter, causing anemia. The hemopoietic effects of Cham-Dang-Gui were examined using anemic rat model. Rats were divided into five groups: CON (control group), ANS (CYP-injected + normal diet), AND (CYP-injected + normal diet + Cham-Dang-Gui), ALS (CYP-injected + low iron diet), and ALD (CYP-injected + low iron diet + Cham- Dang-Gui) groups. CYP (30 mg/kg) was intraperitoneally injected to rats for 3 days to induce anemic condition. Saline or Cham-Dang-Gui was administrated orally during the entire experimental period. CYP injection decreased body weight gain and food consumption in comparison with CON group. Oral administration of Cham-Dang-Gui extract with normal iron diet significantly prevented the lower body weight gain. The blood level of hemoglobin, iron status (serum iron, transferrin, ferritin and TIBC) and blood level of vitamin B-12 in Cham-Dang-Gui treated groups were significantly higher than those of Cham-Dang-Gui untreated groups regardless of amount of iron in the diet. Taken together, it could be concluded that the Cham-Dang-Gui extract could improve anemic condition induced by CYP injection by improving hematological value, iron status and vitamin B12 status in rats.

• 한국식품영양학회지
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• 제32권5호
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• pp.408-416
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• 2019

This study investigated the anti-inflammatory effects of processed (Beopje) curly dock (Rumex crispus L.) in LPS (lipopolysaccharide)-stimulated murine RAW 264.7 cells. The experimental group was classified into five groups : LPS no treatment, CD (curly dock), CD-B (CD processed through Beopje), LPS, LPS+CD-B (LPS+CD processed through Beopje) and LPS+CD (LPS+CD). Treatment of the Raw 264.7 cell lines using LPS led to a significant increase in NO production, pro-inflammatory cytokines ($TNF-{\alpha}$, IL-6 and $IL-1{\beta}$), and inflammation related genes (COX-2 and iNOS). Investigation of the inhibitory effects of CD and processed CD on NO production and expression of iNOS and COX-2 was done in LPS-induced RAW 264.7 cells. There was significant inhibition of NO production by LPS+CD and LPS+CD-B in a dose-dependent manner (p<0.05). Particularly, LPS+CD-B exhibited reduced mRNA expression of iNOS and COX-2 and NO production as compared to LPS+CD in Raw 264.7 cell lines (p<0.05). These results may explain some known biological activities of curly dock including the anti-inflammatory effects. CD-B in particular exhibited the highest anti-inflammatory effects of inhibiting production of NO, through the regulation of inflammatory related genes and pro-inflammatory cytokines. These results of Beopje processing might help decrease the anti-biological effects and increase several active substances of curly dock.

• 한국식품영양학회지
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• 제34권5호
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• pp.526-536
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• 2021

This study was conducted to investigate the anti-obesity effect of Discorea Japonica Thunb. fermented with Monascus After inducing obesity by feeding hight fat diet (diet induced obesity model: DIO) for four weeks, each 8 rats were assigned to normal (Nor), high fat diet (HF), high fat diet containing orlistat (PC), high fat diet containing different concentration of Discorea Japonica Thunb. fermented with Monascus (UPDM_L, UPDM_H) and Discorea Japonica Thunb. (UPD) extract. Although the UPD, UPDM_L (ultrafine pulverized Discorea Japonica Thunb. fermented with Monascus: 400 mg/kg) and UPDM_H (DIO oral administration ultrafine pulverized Discorea Japonica Thunb. fermented with Monascus: 800 mg/kg) showed weight gain inhibition effects, the results of poor obesity inhibition rather than PC were confirmed. However, it showed a more effective weight loss effect in UPDM_H than UPD, and significantly reduced the weight of epididymal fat and subcutaneous fat. Furthermore, the possibility of anti-obesity effects of Discorea Japonica Thunb. fermented with Monascus can be confirmed by observing the effects of reducing serum total cholesterol, triglyceride and LDL concentrations, reducing ALT and AST levels, and inhibiting fat build-up in liver tissue. It is believed that Discorea Japonica Thunb. fermented with Monascus can be expected to utilize as a functional material that is important to improve anti-obesity and metabolic syndrome.

• 한국식품영양학회지
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• 제34권2호
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• pp.146-155
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• 2021

This study observed the anti-inflammatory effect of the polysaccharide derived from the mycelium of Tremella fuciformis in mice with colitis induced with dextran sulfate sodium (DSS). The experimental groups were normal, DSS, DSS-TFL50, DSS-TFH100, and suflasalazine. Body weights, colon lengths, and organ weights were measured, and the plasma level of pro-inflammatory cytokine and mRNA and protein expression in colon tissue were analyzed. Body weight loss, a symptom of DSS-induced colitis, was suppressed by DSS-TF and the speed of weight recovery proceeded rapidly. In addition, DSS-TF showed a significant inhibitory effect on the decrease of colon length typically caused by colon damage. TNF-α, IL-6 and IL-1β cytokine levels in plasma were reduced in DSS-TF and positive control groups. TNF-α, COX-2 and IL-1β mRNA expression in colon tissue were inhibited in DSS-TF and positive control, and it was significantly different from that of the DSS group. The protein expression of inflammation-related genes (IL-6, TNF-α and COX-2) in the colon tissue was significantly increased by DSS compared to that of the normal group, but by DSS-TFL50, DSS-TFH100 and sulfasalarin decreased. In conclusion, the polysaccharide derived from the mycelium of Tremella fuciformis showed the anti-inflammatory effect on DSS-induced colitis in mice.

• 대한건축학회논문집:계획계
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• 제35권2호
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• pp.105-114
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• 2019

Yeongbojeong was a famous pavilion of Joseon, which was located in Chungcheong-Suyeong, Ocheon-myeon, Boryeong-si. It was an open place for poets and calligraphers to freely visit during 400 years. Until today, it is widely said that Yeongbojeong was newly built by LeeRyang in 1504, who was Sugunjeoldosa(naval forces officer). The researcher investigated Gyujanggak to search Lee Maenghyu's "Asulrok-Book", and it was determined that Yeongbojeong was created by Gang Soon, 36 years earlier than LeeRyang. Accordingly, this research aimed at determining the appropriateness of the creation of Yeongbojeong. "Asulrok-Book", which said, "Yeongbojeong was Wonjeong(園亭) of Gang Soon during Yejong's reign", however this research could settle imperfection of Geungeo Gimun which was not clearly explained. Yeongbojeong was created due to Gang Soon's Wonjeong in 1468, however he was also a traitor and was executed, so that nobody wanted to mention about it. Therefore, it was determined that no phrase related to the record of creation of Yeongbojeong by Gang Soon out of lots of Yongbojeong Jeyoungsi and Gimun. Lee Maenghyu was a brave scholar who recorded 'Yeongbojeong was Gang Soon's Wonjeong' confidently, breaking such taboo. This research intended to clearly investigate the year of foundation of Yeongbojeong and establish the history of Chungcheong-Suyeong by thoroughly analyzing newly discovered "Asulrok-Book", existing "Ocheong GoonJi", and "Chungcheongsaryejib" and considering the fact relevance. As the result of this research, it was determined that Yeongbojeong was Gang Soon's Wonjeong through "Asulrok-Book". The point that Yeongbojeong was forfeited reverted to neighboring Chungcheong-Suyeong after Gang Soon was executed due to his participation in a conspiracy also was a newly discovered fact. LeeRyang, Sugunjeoldosa, can be said a brave commander, since he put up the original Yeongbojeong instead of abandoning the name Yeongbojeong of Gang soon. So far, Yeongbojeong is widely accepted as 'new construction of Yeongbojeong by LeeRyang in 1504'. However, since the record of Gang Soon's Wonjeong was discovered, and as the result of diversified analysis and examination, it is proper to correct the foundation year of Yeongbojeong as 1468.

• 한국식품영양학회지
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• 제35권2호
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• pp.116-126
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• 2022

The purpose of this study was to analyze the anti-inflammatory effect of Chung-Dae Indigo Pulverata Levis, indigo naturalis) produced during indigo dyeing. As a result of in vitro cytotoxicity experiments using RAW 264.7 cell, Chung-Dae extract did not inhibit cell proliferation in Raw 264.7 cells in the range of 1~32 ㎍/mL. NO production was significantly reduced when Chung-Dae extracts were treated at concentrations of 2, 8, and 32 ㎍/mL (p<0.05). The pro-inflammatory cytokines TNF-α, IL-6, IL-1β and IFN-γ significantly decreased when the Chung-Dae extract was treated at concentrations of 2, 8, and 32 ㎍/mL compared to the LPS group, and similarly, the TNFα and IL-6 mRNA levels also decreased. Additionally, the mRNA level of COX-2 was also suppressed. At the protein expression level, the expression of TNF-α, IL-6, iNOS and COX-2 were observed with LPS and Chung-Dae extract significantly decreased compared to the group treated with only LPS (p<0.05). From the above results, it shows that Chung-Dae extract, a plant-derived compound, inhibits the inflammatory response induced by LPS in RAW 264.7 cells. and in particular, regulates the inflammatory response by inhibiting the expression of pro-inflammatory cytokines and inflammation-related enzymes.

• 한국식생활문화학회지
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• 제22권3호
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• pp.373-381
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• 2007

The elderly population in Korea is growing rapidly and their nutritional status is not acceptable. Data were collected from the self-administered questionnaire of 495 free living elderly, over 65years old, in Korea to asses the intake and consumption pattern of milk and dairy products. The questionnaire contains demographics, health related characteristics, and perception on milk, and consumption behaviors of milk and dairy products. Most of the elderly subjects understood that milk is good foods in terms of nutritive value and health. And 67% of the subjects satisfied with the sanitation status of milk on the markets. The kind of milk that majority of the subjects consumed was whole milk, and only 5.1% of them consumed low fat milk. Less than 20% of the subjects consumed milk everyday, living alone group consumed milk less frequently than living with others. It was found that the majority of the elderly subjects did not meet current recommendation for milk. Liquid and curd type yogurt were the major dairy products used among elderly, and the reasons were good taste and digestion. They believed that these kinds of dairy products help constipation and digestion problems. The price of milk was ranked for the first factor needed to be considered for milk and dairy products consumption in elderly korean.

• 한국식품영양학회지
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• 제37권3호
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• pp.139-151
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• 2024

The objective of this study was to investigate the anticancer effects of EMPS (edible mushroom mycelium polysaccharide: Tremella fuciformis) in animal models with colorectal cancer induced by AOM/DSS. The experimental groups consisted of Nor (normal), NC (AOM/DSS), EMPS (EMPS 50, EMPS 100), and PC (Fluorouracil). The NC group had the highest number of colon tumors, whereas it was observed that tumor occurrence was significantly reduced in the EMPS consumption group. The expression of Bcl-2, an apoptosis inhibitor, was significantly lower in the EMPS 50 & 100 and PC groups. On the other hand, the mRNA gene expression of Bax, a factor that induces apoptosis, was significantly higher in the EMPS 50 & 100 and PC groups compared to the NC group. The mRNA expression levels of TNF-α and COX-2 significantly increased in the NC group, but showed a significant decrease in the EMPS and PC groups, indicating inhibition of the cancer-promoting response of cells. At the phylum level of the mice's intestinal microbial composition, the proportion of Bacteroidetes tended to decrease, while the proportion of Firmicutes tended to increase with EMPS administration. This suggests that changes in the gut microbiota caused by inflammation can be influenced by dietary intake.

• 동아시아식생활학회지
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• 제14권1호
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• pp.64-69
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• 2004

본 연구에서는 이미 항산화 효과로 알려져 있는 대두와 약성이 탁월한 약콩에서 AChE 활성 억제효과와 Free radical scavenger 효과를 노화로 인한 질병 예방효과에 대한 기초자료를 제공하고자 수행하였다. 1. 대두 열탕 추출물의 경우 저농도인 1, 0.1 mg/$m\ell$에서는AChE의 활성 억제 효과가 메탄을 추출물보다 높았다. (P<0.001) 2. 대두, 약콩 메탄올 추출물에서는 고농도인 5 mg/$m\ell$에서 각 시료의 효과가 62.0$\pm$2.43%, 65.0$\pm$3.29%로 비슷했으나 저농도인 0.1 mg/$m\ell$에서는 약콩의 경우 25.5$\pm$0.94%로 약콩이 대두에 비해 유의적인 AChE 억제효과를 나타냈다. (p<0.001) 3. 시간에 따른 Free radical scavenger효과는 비타민 C의 경우 시간에 따라 비슷한 효과를 보였으나 대두와 약콩은 incubating 시간에 따라 free radical 억제효과가 증가해 높은 항산화 효과를 볼 수 있었다. 4. 대두, 약콩 메탄올 추출물에서는 약콩이 고농도인 5mg/$m\ell$에서 약4배 정도의 효과를 보였으며 Free radical scavenger의 50%효과를 나타내는 $IC_{50}$/에서는 약 10배 정도로 높은 Free radical scavenger 효과를 나타내 약콩이 대두에 비해 유의적으로 높은 효과를 나타내었다. 결론적으로, 대두와 약콩의 추출물은 AChE 활성억제효과에 있어서 좋은 효과를 나타내며 또한 노화의 원인과 질병의 원인이 되는 free radical을 억제하는 효과를 가지고 있어 노인성 치매를 비롯하여 파킨슨씨병, 뇌허혈 및 뇌졸중과 같은 각종 노인성 질환예방에 도움이 될 것으로 보인다.

• 한국식품영양과학회지
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• 제38권7호
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• pp.970-975
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• 2009

연중 시중에서 유통되고 있는 배추에서의 잔류농약에 관한 모니터링을 실시하였으며, 동시 다성분 분석이 가능한 160가지의 농약을 대상으로 하였다. 연중 배추 중 농약의 잔류량을 관찰한 결과 12개월 중 8개월은 잔류농약이 검출되지 않았고, 잔류 농약이 검출된 시기는 7월과 8월, 10월과 11월이었다. 월동배추를 제외한 계절에는 배추의 품질이 나빠, 농약 사용량이 많아지기 때문에, 자연히 농약이 잔류할 가능성이 커지기 때문인 것으로 보인다. 각 농약의 잔류량은 7월, 10월, 11월에는 Bifenthrin 0.01, Chlorfenapyr 0.04, Bifenthrin 0.03 ppm이고, 8월에는 Bifenthrin이 각각 $0.01{\sim}0.02\;ppm$으로 이는 모두 각 농약의 MRL 미만의 양이었다. 따라서 연중 시중 유통배추는 농약 잔류에 대해 상당한 안전성을 확보하고 있다고 볼 수 있다.