• Molecules and Cells
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• 제38권5호
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• pp.432-440
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• 2015

Human osteosarcoma usually presented a high tendency to metastatic spread and caused poor outcomes, however, the underlying mechanism was still largely unknown. In the present study, using a series of in vitro experiments and an animal model, we investigated the roles of HOX antisense intergenic RNA (HOTAIR) during the proliferation and invasion of osteosarcoma. According with our results, HOTAIR was commonly overexpressed in osteosarcoma, which significantly correlated with advanced tumor stage, highly histological grade and poor prognosis. In vitro and in vivo experiments demonstrated that knockdown of HOTAIR could notably suppress cellular proliferation, inhibit invasion and decrease the secretion of MMP2 and MMP9 in osteosarcoma. Collectively, our results suggested that HOTAIR might be a potent therapeutic target for osteosarcoma.

• 한국화재소방학회논문지
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• 제21권1호
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• pp.19-28
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• 2007

구급대원의 직무만족도를 조사한 결과 119구급대원의 업무스트레스 정도는 업무스트레스 척도를 구성하고 있는 영역 전체 평균 4점 만점의 2.54(SD.44)점이었다. 119구급대원이 느끼는 영역별 피로 정도는 영역 전체 평균 4점 만점의 2.09(SD.49)점로 나타났다. 119구급대원의 직무만족도 정도는 전체 평균 5점 만점의 2.71점으로 조사됐다. 본 연구는 구급대원의 직무만족도 향상을 위해 구급대원의 신규채용확대, 임용전 교육실시, 해외연수 등을 통한 구급대원의 지속적인 교육훈련, 구급장비의 지원확대와 현대화, OAT제도 도입운영 등의 방안을 제시하였다.

• 대한소아치과학회지
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• 제3권1호
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• pp.19-31
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• 1976

To study the eruption pattern of the mandibular first permanent molar, the author took 263 cases of Oblique Cephalogram from age 3 to 6 years old children and observed the vertical and mesiodistal directional change and tooth axis change. The following results were obtained.; 1. The eruption pattern of the mandibular first permanenl molar was changed at about 60~66 months or calcification stage IX. 2. At the early stage, the path of eruption of the mandibular first permanent molar directed upward and forward and after calcification stage IX it changed to the direction of upward. 3. The height of the alveolar bone of the upper part of the mandibular first permanent molar was almost equal to that of the interseptal bone of the first and second deciduous molar, but the height showed gradual descent afterwards. 4. At the early stage, the distance from the distal end of the mandibular second deciduous molar to the anterior portion of the ascending ramus was 1.2~1.4 times larger than the mesio-distal diameter of the mandibular first permanent molar, but at the later stage it was enlarged 1.7~1.9 times larger than the mesiodistal diameter of the mandibular first permanent molar.

• 치과방사선
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• 제25권2호
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• pp.281-286
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• 1995

Tooth length determination is a crucial step in endodontic treatment. Traditionally, radiographs are used to confirm working length of the root length. This study was performed to evaluate the radiographic distortion(magnification) and calculate correction coefficients for the object-film distance. Ninty-six radiographs were made of eight extracted teeth(two upper first premolars, two lower first premolars, two upper first molars, and two lower first molars) by using the 16 inch long cone paralelling techniques with 1mm interval from 5 to 16mm tooth-film distance. The results were as follows. 1. The least mean radiographic distortion from 5 to 16mm tooth-film distance was 2.42±0.68％(the length of mesiobuccal cusp-mesial root of lower first molars), the greatest distortion was 4.74±1.36％(the length of mesiobuccal cusp-mesiobuccal root of upper first molars). 2. The greatest correction coefficient was 0.986(the mesiobuccal cusp-mesial root of lower first molars, the lowest one was 0.937(the mesiobuccal cusp-mesiobuccal root of upper first molars).

• Restorative Dentistry and Endodontics
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• 제6권1호
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• pp.63-70
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• 1980

This study was to determine the incidence of pulp stone in each tooth by means of analyzing 375 orthopantomograph taken from 375 patients (252 male), 125 female). The pictures were grouped by age, 20s, 30s, 40s, 50s, and sex. The results were as follows 1. In the group of 20s, male showed the highest incidence in the first molar (40~50%) and the second highest was in the 2nd molar about 35%~50%. In the female group, the first molar and the second molar showed 25%~40%. 2. In the group of 30s, the highest value was found on the first molar and the next was the 2nd molar which appeared 30%~40% in male. In the female, the first molar was 55%~70% and the 2nd molar 30%~50% 3. In the group of 40s, the first molar represented highest value about 45%~60% and the 2nd molar was 40~60% in the male. Female group also showed in the first molar 30%~50% and the second molar 25~30%. 4. In the group of 50s, the highest incidence was 40%~60% on the first molar and next was 35%~50% on the second molar in male, in femalegroup showed 30%~50% on the first molar and 25%~50% on the second molar. 5. The incidence in upper was higher than that of lower. 6. Comparison between right and left showed right was slightly higher than left side.

• Asian Pacific Journal of Cancer Prevention
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• 제15권9호
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• pp.4071-4077
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• 2014

Background: The effects of CYP1A1 gene polymorphisms on the risk of bladder cancer (BC) remain controversial. We carried out a meta-analysis to clarify the role of CYP1A1 gene polymorphisms in BC. Material and Methods: A comprehensive literature search was conducted up to November 20, 2013. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to estimate the strength of the association. Meta-regression, subgroup analysis, sensitivity analysis and publication bias were also performed. Results: Eight studies involving 1,059 BC cases and 1,061 controls were included. The meta-analysis showed that there was no significant association between the two common mutations of CYP1A1 and BC risk. For the I1e462Val A/G polymorphism with GG vs. AA the OR was 1.47 (95 % CI= 0.70-3.07, P =0.308). For the MspI T/C polymorphism, though a slight trend was found this was not statistically nonsignificant (CC vs.TT, OR = 1.24, 95 % CI= 0.98-1.58, P =0.078). Subgroup analyses by ethnicity also found no obvious association between CYP1A1 and BC risk. Conclusion: The present meta-analysis suggests that CYP1A1 polymorphism is not associated with bladder cancer risk.

• Asian Pacific Journal of Cancer Prevention
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• 제13권2호
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• pp.737-742
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• 2012

To evaluate efficacy of microwave ablation in a primary clinical study, sixty patients (44 men, 16 women; mean age 53 years) with 96, 1-8 cm (mean $3.20{\pm}0.17$ cm) liver cancers were treated with 2,450-MHz internally cooled-shaft antenna. Complete ablation (CA) and local tumor progression (LTP) rates as well as complications were determined. CA rates in small (< 3.0 cm), intermediate (3.1-5.0 cm) and large (5.1-8.0 cm) liver cancers were 96.4% (54/56), 92.3% (24/26) and 78.6% (11/14), respectively. During a mean follow-up period of $17.17{\pm}6.52$ months, LTP occurred in five (5.21%) treated cases. There was no significant difference in the CA and LTP rates between the HCC and liver metastasis patient subgroups (P<0.05). Microwave ablation provides a reliable, efficient, and safe technique to perform hepatic tumor ablation.

• 한국융합학회논문지
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• 제6권3호
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• pp.1-12
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• 2015

본 연구의 목적은 응급처치교육을 받은 대상자들이 인식하는 응급처치에 대한 인식 유형별 차이를 이해하여, 이에 따른 응급처치와 관련된 교육내용 및 교육방법과 응급처치 관련 실무 중재 방안 개발의 기초를 제공하는 데 있다. 본 연구방법은 J지역에 있는 일반인과 의료인 중 응급처치 교육을 받은 48명을 P-표본으로 추출하여 30개의 진술문을 사용해 자료분석은 PC QUANL program으로 처리하였다. 자료수집은 2010년 3월부터 2010년 7월까지하였다. 응급처치에 대한 일반인의 인식유형은 3개의 유형이 나타났다. 제1유형은 '시간 중시형', 제2유형은 '최초 반응자 중시형', 제3유형은 '융합교육 중시형', 제4유형은 '일반인 가능성형'으로 나타났다. 본 연구결과 응급처치 유형에 따른 개별화되고 단계적인 교육방법과 중재방안의 개발이 필요함을 알 수 있다.

• 융합보안논문지
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• 제14권6_2호
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• pp.83-88
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• 2014

초동수사란 사건발생의 초기에 행하는 긴급한 수사 활동이다. 초동수사가 잘못되면 사건이 영원히 미궁에 빠지거나 많은 증거가 사라져버리게 된다. 따라서 초동수사가 잘못되면 많은 인력과 예산을 낭비하거나 또 다른 피해자가 발생하게 되는 것이다. 초동수사는 범죄현장을 중심으로 한 수사와 피해자중심수사 그리고 피해품 중심 수사 등이 있다. 현장중심 수사는 범죄현장주변에서 유류품의 발견, 범행일시의 확정, 참고인의 발견, 지리감 등을 파악하는 수사 활동이다. 피해자 중심수사는 피해자의 인적사항, 피해자 및 가족의 생활상태, 재산상태, 교우관계, 가정 내부사정 등을 파악하여 범인을 검거하는 수사방법이다. 피해품 중심수사는 범죄피해품의 소재 이동경로를 추적하여 범인을 검거하는 방법이다. 경찰의 초동수사역량을 강화하기 위해서는 초동수사에 대한 교육을 강화하고, FTX(현장훈련)를 지속적으로 실시하여야 할 것이다. 그리고 초동수사매뉴얼을 제작하여 활용하여야 하며, 사건분석시스템을 구축할 필요가 있다. 또한 과학수사기법의 개발과 국민의 협조가 필요하다. 앞으로는 사건에 대한 초동수사부터 철저히 하여 국민에게 믿음을 줄 수 있는 경찰이 되어야 할 것이다.

• 한국의상디자인학회지
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• 제16권3호
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• pp.33-48
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• 2014

Based on the advent and dissemination of new developments concerning information & telecommunications technology, web services have brought new paradigms into society, thus facilitating the birth and evolution of various service industries to society as a whole. This study is aimed at investigating the expansion of the first Birthday party culture and design examples of the first Birthday partywear appearing in social media, through an inquiry into the communication functions inherent in social media. Also, the development of the first Birthday partywear designs for women aged 20 to 30 years was accomplished by categorically analyzing design characteristics in preferred fashion styles uploaded and shared within online childcare communities. First, it can be concluded that due to the bidirectional flow of information between corporations and consumers occurring from the expansion of social media, the entire structure of the market is undergoing great changes. Next, the need for the supply of professionalized the first Birthday partywear can be proved by the influx of party planners and caterers into this new industry. Third, Through a categorical analysis of these 523 photos, elegance style was the most preferred while classic and romantic styles followed. Last of all, 5 pieces of partywear reflecting contemporary consumer lifestyles which focus on 'enjoying one's own life' were created under the concept of 'Romantic chic'. The created designs aim to present a style which follows the predominant trend of elegance, classic and romantic, whilst keeping sensitivity in moderation. In this context, this study has aimed to present fundamental research data in the field of online the first Birthday partywear, through the development of the first Birthday partywear design based on the first Birthday party consumer characteristics gleaned from various forms of social media.