• Asian Pacific Journal of Cancer Prevention
• /
• v.17 no.4
• /
• pp.1903-1907
• /
• 2016

Background: Studies of effects of IL-1 polymorphisms, CYP2C19 genotype together with antibiotic resistance for H. pylori eradication are rare worldwide. The present study was designed to evaluate efficacy of 10-day sequential therapy (SQT) and 14-day standard triple therapy (STT) with four- times-daily dosing of amoxicillin for H. pylori eradication related to these important host and bacterial factors in Thailand. Materials and Methods: This prospective randomized study was performed during March 2015 to January 2016. H. pylori infected gastritis patients were randomized to receive 10-day sequential therapy and 14-day standard triple therapy. CYP2C19 genotyping, IL1 polymorphism (IL-1B and IL-1RN genotypes) and antibiotic susceptibility tests were performed in all patients. 13C-UBT was conducted to confirm H. pylori eradication at least 4 weeks after treatment. Results: A total of 100 patients (33 males and 67 females, mean age=51.1 years) were enrolled. Eradication rate by PP analysis was 97.9% (47/48) with the 10-day SQT regimen and 87.8% (43/49) with 14-day STT regimen (97.9% vs 87.8%; p-value=0.053). Antibiotic susceptibility testing demonstrated 45% resistance to metronidazole, 14.8% to clarithromycin, and 24.1% to levofloxacin. CYP2C19 genotyping revealed 44.9% RM, 49% IM and 6.1% PM. IL-1B and IL-1RN genotypes were demonstrated as 21.4% for CC, 48.1% for TC, 36.8% for TT, 72.7% for 1/1, and 21.2% for 1/2 genotypes, respectively. The 10-day SQT regimen provided 100% eradication in patients with clarithromycin or dual clarithromycin and levofloxacin H. pylori resistant strains. Moreover, the 10-day SQT regimen resulted in a 100% eradication rate in all patients with CYP2C19 genotype RM and almost type of IL-1B (TC and TT) and IL1-RN genotypes ( 1/2 and other). Conclusions: Treatment with 10-day sequential therapy is highly effective for H. pylori eradication regardless of the effects of clarithromycin resistance, dual clarithromycin and levofloxacin resistance, CYP2C19 genotype, IL-1B and IL1-RN genetic polymorphisms and can be used as effective first line therapy in Thailand.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.21 no.10
• /
• pp.55-63
• /
• 2020

Road traffic noise is a major complaint. Porous pavement (PP) has been proposed as an effective method for reducing road traffic noise, but it has not been applied much due to the lack of quantitative evaluation. In this study, the noise reduction of single-layer porous pavement (SLPP) and double-layer porous pavement (DLPP) was evaluated. The noise was measured using the CPX method, and the driving speed was measured every 10km/h from 50km/h to 80km/h. The differences in noise level between the two PPs were statistically significant. The driving speed had no significant effect on the difference in noise between the two PPs. The DLPP showed a 6.6dB(A) reduction in average and a 6.3dB(A) reduction at the 95% confidence level compared to the SLPP. Reducing noise by 5dB(A) is equivalent to reducing traffic to 1/3 or lowering the vehicle's speed to 1/2. Sensitively, it is possible to recognize a 3dB(A) and 5dB(A) difference. The DLPP and SLPP were very effective in reducing traffic noise.

• The korean journal of orthodontics
• /
• v.39 no.5
• /
• pp.330-336
• /
• 2009

Objective: To examine the differences in lateral cephalometric characteristics between patients with dental protrusion and crowding in order to determine what factors affect dental protrusion or crowding while both malocclusion types are caused by large tooth size. Methods: Twenty nine individuals with dental protrusion and 22 individuals with dental crowding were enrolled in this study. All subjects had larger teeth than average and Class I molar relationships. Craniofacial characteristics and hyoid bone positions were determined from lateral cephalograms and compared between the two groups. Results: In the comparisons of craniofacial characteristics, the measurements indicating maxillary length and facial convexity showed greater values in the protrusion group than in the crowding group. Comparisons of hyoid bone positions showed that the hyoid bone was positioned more anteriorly and superiorly in the protrusion group than in the crowding group. Conclusions: The results of the present study indicate that some craniofacial characteristics and tongue position may affect the development of dental protrusion or crowding; when an individual has large teeth, dental protrusion or crowding might be determined according to maxillary growth and tongue position.

• Progress in Medical Physics
• /
• v.13 no.2
• /
• pp.55-61
• /
• 2002

In this work, EPM (effective point of measurement) of parallel plate ionization chamber with three different spacing were investigated. If the plate separation is less than 2 mm one generally assumes that the effective point of measurement is just behind the front window of the parallel plate ionization chamber. For chamber with relatively large separation, such as the ones used for very accurate exposure measurements, this assumption breaks down and the EPM depends on plate separation and thickness of the front window. For parallel plate chambers, conventional theoretical analyses suggest that the EPM is the inner front wall and that it shifts towards the geometric centre of the chamber as the plate separation increases. The PP-IC (parallel plate ionization chamber) is fabricated using acrylic plate for the chamber medium and printed circuit board for electrical configuration. The various sizes of the sensitive volumes designed so far are 0.9, 1.9, and 3.1 cc. The gap between two electrodes ranges from 3, 6, and 10mm. Also the charge-to-voltage converter is designed to collect the electrons produced in the ionization chamber cavity. As the result of our experiment, the EPM shift was within 0.6 mm in photon beams and 0.4 mm to 2.5 mm in electron beams for the plate separation of 6 mm and 10 mm. EPM shifts towards the geometric center of the chamber as the plate separation increases.

• Polymer(Korea)
• /
• v.26 no.2
• /
• pp.260-269
• /
• 2002

The fire resistance of particulate polypropylene composite systems were investigated by using various reinforced particles such as zeolite, talc, $CaCO_3$ particles. In this study, The effect of particle size on the thermal properties of composite and the effect of reinforced particles on the fire resistance were studied. The inorganic reinforced particles used in this study were recycled zeolite(average particle diameter=85.34 $mu extrm{m}$), $CaCO_3$ (33.93 $mu extrm{m}$), and talc (18.51 $mu extrm{m}$). The fire resistance of composite systems was thoroughly examined by measuring limited oxygen index (LOI, ASTM D2863) and cone calorimetry (ASTM E1354, ISO 5660). Thermal stability of composite systems was thoroughly examined by measuring TGA. The flame retardants (DBDPO) and reinforced particles reduce the maximum heat release rate (M-HRR) in the order of Talc > $CaCO_3$ > recycled Zeolite. Comparing the cone calorimetry experimental results of the particle reinforced polymer composite system exhibited twice higher efficiency than DBDPO in polypropylene systems, and the LOI also showed similar trends to the cone calorimetry experiments. The optical and scanning electron microscopy techniques were used to investigate the composites ash layer and the core fracture surfaces in the burning process. The reinforcing inorganic particles seemed to accumulate at the surface of ash layer, and subsequently intercept the oxygen transport and heat transfer into the core area.

• Polymer(Korea)
• /
• v.30 no.1
• /
• pp.85-89
• /
• 2006

The effect of vapor grown carbon fiber (VGCF) contents on electrical and rheological properties of VGCF filled polyphenylene sulfide (PPS) composites prepared through melt mixing using a twin screw exruder was studied. This method was proved to be quite effective to produce good dispersion of VGCF in the matrix even for highly filled PPS. From the dependence of the electrical conductivity on VGCF content, the percolation phenomena began to occur above $10\;wt\%$. While there is only a marginal increase of viscosity for 1 and $5\;wt\%$ VGCF filled PPS, the composites containing $10\;wt\%$. While VGCF showed abrupt increase in viscosity as well as flattening of frequency vs modulus curve, indicating a transition from a liquid-like to a solid-like behavior due to the creation of VGCF network. This result agrees well to the fact that the network formation in the composite can be composite by rheological property dependence on filler content as well as by electrical conductivity measurement.

• Resources Recycling
• /
• v.25 no.2
• /
• pp.17-24
• /
• 2016

This study aims at evaluating environmental impacts on recycling process of used small household appliances. The recycling process mainly consists of manual dismantling, crushing and various sorting processes to effectively recover valuable resources and to minimize environmental impact. In this study, life-cycle assessment (LCA) methodology is applied to analyze major environmental parameters such as GWP, ADP, POCP, EP, etc. One of the major impact categories on the weight basis in the recycling process is global warming (GWP) 57.1%, next to ADP 35.4% and POCP 4.8%, respectively. As a result of environmental impact on recovery of valuable resources/ton, the GWP of plastics for ABS is highest (33.7%) compared to ferrous metals (9.4%). The effects of environmental and economical benefit are also analyzed to compare with the amount of virgin materials to be recycled by recycled materials. In addition, recycled materials are also more economical in comparison to virgin materials due to the environmental avoiding effect by recycling. In conclusion, the key environmental issues related to the recycling of e-wastes are analyzed and therefore, the effective recycling process will contribute to mitigate global warming potential in the near future.

• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
• /
• 2000.11a
• /
• pp.207-208
• /
• 2000

Since trichloroethylene (TCE), dichloroethylene (DCE), and vinyl chloride (VC) arise from anaerobic degradation of tetrachloroethylene (PCE) and TCE, there is interest in creating aerobic remediation systems that avoid the highly toxic VC and cis-DCE which predonominate in anaerobic degradation. However, it seemed TCE could not be degraded aerobically without an inducing compound (which also competitively inhibits TCE degradation). It has been shown that TCE induces expression of both the toluene dioxygenase of p. putida F1 as well as toluene-p-monooxygenase of P.mendocina KRI. We investigated here the ability of PCE, TCE, and chlorinated phenols to induce toluene-o-xylene monooxygenase (ToMO) from P.stutzeri OX1. ToMO has a relaxed regio-specificity since it hydroxylates toluene in the ortho, meta, and para positions; it also has a broad substrate range as it oxidizes o-xylene, m-xylene, p-xylene, toluene, benzene, ethylbenzene, styrene, and naphthalene; chlorinated compounds including TCE, 1, 1-DCE, cis-DCE, trans-DCE, VC, and chloroform : as well as mixtures of chlorinated aliphatics (Pseudomonas 1999 Maui Meeting). ToMO is a multicomponent enzyme with greatest similarity to the aromatic monooxygenases of Burkholderia pickettii PKO1 and P.mendocina KR1. Using P.sturzeri OX1, it was found that PCE induces P.mendocina KR1 Using P.situtzeri OX1, it was found that PCE induces ToMO activity measured as naphthalene oxygenase activity 2.5-fold, TCE induces 2.3-fold, and toluene induces 3.0 fold. With the mutant P.stutzeri M1 which does not express ToMO, it was also found there was no naphthalene oxygenate activity induced by PCE and TCE; hence, PCE and TCE induce the tow path. Using P.putida PaW340(pPP4062, pFP3028) which has the tow promoter fused to the reporter catechol-2, 3-dioxygenase and the regulator gene touR, it was determined that the tow promoter was induced 5.7-, 7.1-, and 5.2-fold for 2-, 3-, 4-chlorophenol, respectively (cf. 8.9-fold induction with o-cresol) : however, TCE and PCE did not directly induce the tou path. Gas chromatography and chloride ion analysis also showed that TCE induced ToMO expression in P.stutzeri OX1 and was degraded and mineralized. This is the first report of significant PCE induction of any enzyme as well as the first report of chlorinated compound induction of the tou operon. The results indicate TCE and chlorinated phenols can be degraded by P.stutzeri OX1 without a separate inducer of the tou pathway and without competitive inhibition.

• Journal of Mushroom
• /
• v.8 no.1
• /
• pp.37-40
• /
• 2010

This study was carried out to develop the best medium of new oyster mushroom for bottle culture. The new oyster mushroom cv. Miso is a Pleurotus ostreatus developed at the Chungnam Agricultural Research & Extension Services. For the bottle culture media, poplar sawdust+beet pulp+cottonseed meal (5:3:2), poplar sawdust+wheat husk meal (8:2), poplar sawdust+beet pulp+cottonseed meal (6:2:2), poplar sawdust+beet pulp+cottonseed meal (4:4:2), and poplar sawdust+beet pulp+wheat husk meal (7:1:2) were used in 850cc PP bottle. The pH was 5~6 and the C/N ratio 19.7~28.3 in bottle culture media. The time of pinhead formation was 5 to 6 days. For the fruiting body formation after inoculation took 29~31 days. The yield of fruiting body of poplar sawdust+beet pulp+wheat husk meal (7:1:2) medium was the highest at 110.4g/bottle compared to other media. Therefore, such cultivation medium would be appropriate for the commercial production of bottle culture in the new oyster mushroom 'Miso'.

• Korean Journal of Food Science and Technology
• /
• v.45 no.3
• /
• pp.339-344
• /
• 2013

Application of intense pulsed light (IPL) treatment is an emerging technology with interesting prospects in food preservation. However, information concerning the factors affecting the inactivation of microorganisms and their impact on the quality of fresh-cut food is scarce. In this study, the effects of IPL treatment on the microbial inactivation and physicochemical change in paprika were determined. The viability of bacteria in paprika treated with IPL decreased slightly with the treatment time. In addition, water content was slightly decreased after IPL treatment regardless of the color of paprika. However, except in red paprika, sugar content increased after IPL treatment. The pH of paprika increased in all samples, and the polyphenol content decreased with treatment time, but these differences were very small. After IPL treatment of paprika, vitamin C content increased in yellow and red samples. Hunter color values-lightness (L), redness (a), and yellowness (b)-increased in red paprika, but all values decreased in orange paprika.