• Korean Journal of Environment and Ecology
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• v.25 no.6
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• pp.903-910
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• 2011

The research was carried out in order to find climate factors which determine the distribution of Machilus thunbergii, and the potential habitats under the current climate and three climate change scenario by using classification tree (CT) model. Four climate factors; the minimum temperature of the coldest month (TMC), the warmth index (WI), summer precipitation (PRS), and winter precipition (PRW) : were used as independent variables for the model. The model of distribution for Machilus thunbergii (Mth-model) constructed by CT analysis showed that minimum temperature of the coldest month (TMC) is a major climate factor in determining the distribution of M. thunbergii. The area above the $-3.3^{\circ}C$ of TMC revealed high occurrence probability of the M. thunbergii. Potential habitats was predicted $9,326km^2$ under the current climate and $61,074{\sim}67,402km^2$(South Korea: $58,419{\sim}61,137km^2$, North Korea: $2,655{\sim}6,542km^2$) under the three climate change scenarios (CCCMA-A2, CSIRO-A2, HADCM3-A2). The Potential habitats was to predicted increase by 51~56%(South Korea: 49~51%, North Korea: 2~5%) under the three climate change scenarios. The potential expand of M. thunbergii habitats has been expected that it is competitive with warm-temperate deciduous broadleaf forest. M. thunbergii is evaluated as the indicator of climate change in Korea and it is necessary for M. thunbergii to monitor of potential habitats.

• Asian-Australasian Journal of Animal Sciences
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• v.24 no.11
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• pp.1483-1503
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• 2011

To advance the effectiveness of the current Hanwoo improvement system, we developed a general simulation that compared a series of breeding schemes under realistic user circumstances. We call this system the Integrated General Model (IGM) and it allows users to control the breeding schemes and selection methods by manipulating the input parameters. The Current Hanwoo Performance and Progeny Test (CHPPT) scheme was simulated with a Modified Hanwoo Performance and Progeny Test (MHPPT) scheme using a Hanwoo Breeding Farm cow population of the Livestock Improvement Main Center (LOMC) of the National Agricultural Cooperatives Federation (NACF). To compare the two schemes, a new method, the Simple Hanwoo Performance Test (SHPT), which uses ultrasound technology for measuring the carcass traits of live animals, was developed. These three models, including the CHPPT, incorporated three types of selection criteria: phenotype (PH), true breeding value (TBV), and estimated breeding value (EBV). The simulation was scheduled to mimic an actual Hanwoo breeding program; thus, the simulation was run to include the years 1983-2020 for each breeding method and was replicated 10 times. The parameters for simulation were derived from the literature. Approximately 642,000 animals were simulated per replication for the CHPPT scheme; 129,000 animals were simulated for the MHPPT scheme and 112,000 animals for the SHPT scheme. Throughout the 38-year simulation, all estimated parameters of each simulated population, regardless of population size, showed results similar to the input parameters. The deviations between input and output values for the parameters in the large populations were statistically acceptable. In this study, we integrated three simulated models, including the CHPPT, in an attempt to achieve the greatest genetic gains within major economic traits including body weight at 12 months of age (BW12), body weight at 24 months of age (BW24), average daily gain from 6 to 12 months (ADG), carcass weight (CWT), carcass longissimus muscle area (CLMA), carcass marbling score (CMS), ultrasound scanned longissimus muscle area (ULMA), and ultrasound scanned marbling score (UMS).

• Journal of Life Science
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• v.30 no.9
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• pp.826-833
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• 2020

Phospholipase C gamma (PLCγ) has critical roles in receptor tyrosine kinase- and non-receptor tyrosine kinase-mediated cellular signaling relating to the hydrolysis of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P₂] to produce inositol 1,4,5 trisphosphate (IP₃) and diacylglycerol (DAG), which promote protein kinase C (PKC) and Ca²⁺ signaling to their downstream cellular targets. PLCγ has two isozymes called PLCγ1 and PLCγ2, which control cell growth and differentiation. In addition to catalytically active X- and Y-domains, both isotypes contain two Src homology 2 (SH2) domains and an SH3 domain for protein-protein interaction when the cells are activated by ligand stimulation. PLCγ also contains two pleckstrin homology (PH) domains for membrane-associated phosphoinositide binding and protein-protein interactions. While PLCγ1 is widely expressed and appears to regulate intracellular signaling in many tissues, PLCγ2 expression is restricted to cells of hematopoietic systems and seems to play a role in the regulation of immune response. A distinct mechanism for PLCγ activation is linked to an increase in phosphorylation of specific tyrosine residue, Y783. Recent studies have demonstrated that PLCγ mutations are closely related to cancer, immune disease, and brain disorders. Our review focused on the physiological roles of PLCγ by means of its structure and enzyme activity and the pathological functions of PLCγ via mutational analysis obtained from various human diseases and PLCγ knockout mice.

• The korean journal of orthodontics
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• v.22 no.3 s.38
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• pp.735-753
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• 1992

The purpose of this study was to analyze the positions of upper and lower incisors according to facioskeletal patterns. The lateral cephalometric radiographs of sixty persons with normal occlusion, forty persons with Class II Division 1 malocclusion, and forty persons with Class III malocclusion all above the age of 18, were analyzed. The following results were obtained. 1. C I angle, the measurement related to masticatory system, were $89.20{\pm}4.34^{\circ}$ in normal occlusion group, $81.68{\pm}士5.95^{\circ}$ in Class II Division 1 malocclusion group and $101.96{\pm}6.31^{\circ}$ in Class III malocclusion group. 2. In comparison with the positions of upper and lower incisors according to facioskeletal patterns, Class II Division 1 malocclusion group showed that upper incisors were different significantly in all measurements and inclined labially (P < 0.05). Lower incisors were different significantly in all measurements except LI-APog, LI-APog (mm), LI-AB, LI-AB (mm) and inclined labially (P < 0.05), Class III malocclusion group showed that upper incisors were different significantly in all measurements except UI-SN, UI-OP, and inclined labially (P < 0.05). Lower incisors were different significantly in all measurements and inclined lingually (P < 0.05). 3. In all facioakeletal patterns, LI-SN and LI-PH ware correlated moderately to facioskeletal measurements, and FMA was correlated moderately to measurements of lower incisor position. 4. Regardless of the facioskeletal patterns, the reference planes equally applicable were AB line in the measurements of upper incisor and APog line in the measurements of lower incisor.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.19
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• pp.8377-8382
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• 2014

Background: Oral squamous cell carcinoma (OSCC) is the sixth most common malignancy worldwide. Cancer development and progression require inactivation of tumor suppressor genes and activation of proto-oncogenes. The well recognized mechanism of action demonstrated for chemotherapeutic agents is induction of apoptosis via reactivation of p53. In this context, we evaluate the efficacy of IV and oral routes of our novel PH and temperature sensitive doxorubicin-methotrexate-loaded nanoparticles (DOX-MTX NP) in affecting p53 profile in an OSCC rat model. Methods: In this study, 120 male rats were divided into 8 groups of 15 animals each. The new formulated DOX-MTX NP and free doxorubicin were IV and orally given to rats with 4-nitroquinoline-1-oxide induced OSCC. Results: Results showed that both DOX and DOX-MTX-NP caused significant increase in mRNA levels of P53 compared to the untreated group (p<0.000). With both DOX and DOX-MTX NP, the IV mode was more effective than the oral (gavage) route (p<0.000). Surprisingly, in oral mode, p53 mRNA was not affected in DOX treated groups (p>0.05), Nonetheless, both IV and oral administration of MTX-DOX NP showed superior activity (~3 fold) over free DOX in reactivation of p53 in OSCC (p<0.000). The effectiveness of oral route in group treated with nanodrug accounts for the enhanced bioavailability of nanoparticulated DOX-MTX compared to free DOX. Moreover, in treated groups, tumor stage was markedly related to the amount of p53 mRNA (p<0.05). Conclusion: Both oral and IV application of our novel nanodrug possesses superior activity over free DOX-in up-regulation of p53 in a OSCC model and this increase in p53 level associated with less aggressive tumors in our study. Although, impressive results obtained with IV form of nanodrug (-21 fold increase in p53 mRNA level) but both forms of nanodrug are effective in OSCC, with less toxicity normal cells.

• Korean Journal of Occupational Health Nursing
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• v.14 no.2
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• pp.93-107
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• 2005

Purpose: The purpose of this study is to identify the trends of studies on work-related musculoskeletal disorder and to suggest the direction of future research. Method: 144 research thesis for a degree on work-related musculoskeletal disorder were systematic reviewed and published from Jan. 1990 to Mar. 2005. The analyzed using descriptive statistics, an actual number, percentage. Result: As its result the work-related musculoskeletal disorder research which is announced from domestic the doctorate dissertation at the 2004 year 42 the most many 144 dissertation middle most to be 129 in master degree dissertation was 15 in Ph D degree. Dissertation contents character the contents against the result relation that it analyzes especially and a condition and an obstacle was many most at 84. Research plan in most description investigation research 121 the dissertation field to be the especially public health (hygiene, industry and environment) at this 57 most many research object person distribution manufacturing industry in the research object one dissertation was many most at the 40. The tools which are used in each measurement in the question tool which it uses most the question price of land which uses the condition investigation ticket which it made from the NIOSH and the ANSI most many 33, the hazard which analyzes a work attitude in the tool which it uses the RULA was many most at 14. In the stress test tool social psychological healthy measurement PWI (Psychological Wellbeing Index) the dissertation which uses the Job Strain of the Karasek Model to be many most at 19 PWI (Psychological Wellbeing Index) 7 easy use. Work-related musculoskeletal disorder measurement hazard in physiological index and the machinery and tools which it uses there were 9 researches to use an electromyogram most plentifully. With the effect goes to a work-related musculoskeletal disorder they are 33 where the age is many most from general quality. From healthy act with the relation of smoking the year to be many from 16 dissertations. Work of the corpse an attitude (the attitude which is inappropriate) with 5 and the work market the work burglar is many most at 9, the society-support of 36 where the stress is many psychologically most, the stress and service also the most many duty discretion (authority and autonomy) is 6 at the duty demand boat song 9. The service career to be many is 22 of extraordinarily with relation of service. Conclusion: It is recommended the research which it sees being limited in only domestic thesis for a degree the international comparative study to become accomplished. It comes to think with the fact that it will be necessary to make the protocol which it conforms in the civil official guide the test researches for the protocol or arbitration program which is standardized are necessary. Prevention and the civil official of work relation bones and sinews standing total disease hazard scientific base one program is necessary with base.

• Korean Journal of Soil Science and Fertilizer
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• v.6 no.4
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• pp.205-211
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• 1973

General physical and chemical characteristics of eleven apple orchard soils derived from granite, granodiorite, diorite, arkose sandstone and shale were investigated in relation to soil profile. The results are summerized as follows: 1. Soils were mostly sandy and showed pH 4.35 to 6.75, 1.14 to 5.58 of organic matter, 0.065 to 0.209% of nitrogen. All properties decreased with depth. 2. Total exchangeable bases of surface soils were comparablly low (4.89 to 17.81me/100g, Ca>Mg>K>Na). Cation exchange capacity ranged from 7.74 to 21.72 mg/100g and base saturation percentage from 22.52 to 94.62%. 3. Phosphorus content of surface soil was very low (less than 35.5 mg/100g). The contents of potassium (7.2-79.2 mg/100g), available copper (1.0-16.9 ppm) and water soluble boron (0.18-0.72 ppm) were high in surface soil but low with depth. The content of manganese showed clear difference with pH, that is, at pH 4 to 6 water soluble manganese ranged from 0.42 to 17.8 ppm and exchangeable manganese from 9.82 to 66.38 ppm but above pH 6 the water soluble was less than 0.70 ppm and the exchangeable less than 22.25 ppm.

• Korean journal of communication and information
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• v.79
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• pp.7-39
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• 2016

Journalism and Mass Communication as an academic field is believed more politicized one than pure literature and natural science. With the growth of the media, there follows additional opportunities for media scholars to take a part in politics as well. Few attention was given to understand the status and mechanism of political intervention either as advisers or decision makers though. This study attempts thus to fill this vacuum. For this, first of all, it examines a various types of laws related to media politics. Total number of 164 scholars who participated in 12 councils and commissions were analyzed on the following step. Research shows that there are patterns which favor Seoul National University, U.S. trained Ph. D and geographic preference to the capital. Neither academic excellence nor commitment to public interest appear to have impact on taking those positions. Taking into account media's expansion into politics, it is inevitable for media scholars to take responsibility not only in policy making but in taking leadership. Accordingly, the question of necessity is not who but how as much as manner. The authors hope this study will be a valuable opportunity to establish a kind of ethical standards in media politics.

• Applied Chemistry for Engineering
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• v.4 no.4
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• pp.731-738
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• 1993

This study showed the adsorption behavior of Cs and Sr into the inorganic ion-exchanger zeolites such as 4A, 13X, AW300, AW500 and natural. It was found that the best type of zeolite is AW500 for Cs and 13X for Sr in terms of ion-exchange capacity. The temperature effect was also examined for the following systems : AW500-Cs, AW300-Cs, natural zeolite-Cs, 4A-Sr and 13X-Sr. Experiments showed that the effect of temperature on the ion-exchange capacity is negligible in all cases except for the systems of 4A-Sr and natural zeolite-Cs. The enhancement in the ion-exchange capacity for 4A-Sr would be caused by the Sr ion movement and the multilayer adsorption due to the heterogeneous characteristics of ion-exchange site. The distribution coefficient was increased with pH of the solution which is in equilibrium with zeolite particles. The values of $K_d$ in the systems of AW500-Cs and 4A-Sr were found to be about $10^3cm^3/g$ and $10^3{\sim}10^4cm^3/g$ respectively.

• The Korean Journal of Ecology
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• v.16 no.4
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• pp.409-416
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• 1993

After spraying simulated sulphuric acid rain (SSAR) to the leaves of Glycine max, Quercus aliena var. pellucida and Pinus rigida, the leachates were consecutively collected and quantitatively determined for the concentration of K and Ca. The amount of the leached ion decreased with subsequent acid treatment for all plants. But as the pH of SSAR decreased, the amount of the leached ion increased. The cumulative quantities of K leached from each species were 1.04 to 1.46 times higher at pH 4.0, 1.09 to 1.58 times higher at pH 3.5 and 1.24 to 2.03 times higher at pH 3.0 compared with pH 5. 6 treatments. The cumulative quantities of Ca leached from each species were 1.23 to 1.47 times higher at pH 4.0, 1.50 to 1.92 times higher at pH 3.5, and 2.45 to 3.30 times higher at pH 3.0 compared with pH 5.6 treatments. The Ca /K ratio in 1000 ml leachate was 1.10 to 2.91 for Q. aliena var. pellucida and 1.68 to 2.98 for P. rigida, but 0.66 to 0.91 for G, max. The Ca /K ratio in 1000 rnl leachate increased for all three species, as the pH of SSAR decreased. Foliage analysis after acid rain treatment showed leaching effect at pH 3.0.