• Journal of Veterinary Clinics
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• v.36 no.1
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• pp.46-52
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• 2019

Pimobendan has inotropic and vasodilating effects on cardiovascular system, and pentoxifylline is known to decrease blood viscosity and improve blood flow to the heart. This study investigated the pharmacokinetics and pharmacodynamics following oral administration of pimobendan-pentoxifylline powder mixture in dogs. Eight healthy dogs were included and were divided into control (n = 4) and experimental (n = 4) groups. Vehicle powder and pimobendan-pentoxifylline powder mixture (pimobendane 0.25 mg/kg, pentoxifylline 15 mg/kg) were administrated orally to control and experimental groups, respectively. Plasma samples and measurement of echocardiographic indices were obtained for 24 hours following administration. Pimobendan and pentoxifylline concentrations were investigated using liquid chromatography-mass spectrometer (LC-MS) assay. The elimination half-life ($T_{1/2}$) were $2.65{\pm}1.42hours$ for pimobendan and $0.29{\pm}0.23hours$ for pentoxifylline. The time to reach maximum concentration ($T_{max}$) were $1.08{\pm}0.72hours$ for pimobendan and $0.29{\pm}0.14hours$ for pentoxifylline. The maximum blood concentration ($C_{max}$) were $2.83{\pm}1.50ng/mL$ for pimobendan and $1184.33{\pm}932.37ng/mL$ for pentoxifylline. Among echocardiographic indices, fractional shortening (FS), left ventricular internal diameter at end systole (LVIDs), and pre-ejection period (PEP) showed significant changes at 1-4 hours after the administration of pimobendan-pentoxifylline powder mixture. No adverse effects were observed during the investigation. This study demonstrates that pimobendan-pentoxifylline powder mixture can be used to control cardiovascular diseases in dogs.

• 한국신재생에너지학회:학술대회논문집
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• 2011.05a
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• pp.76.2-76.2
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• 2011

석탄으로부터 합성석유를 생산하는 상용기술을 도입하여 건설하고 이와 더불어 원천기술 개발을 위한 국산화 기술 개발을 병행하여 향후 고유가 시대를 대비한 국가 에너지 안보 확립과 국내 기술 개발의 가속화를 추구해야 할 필요성이 대두되고 있다. 본 타당성 조사는 3종류의 석탄(호주 Wyong탄, 인도네시아 NTC탄, 인도네시아 KBB탄)으로부터 가스화에 의하여 합성석유스를 생산하는 공정에 대한 타당성 조사(Feasibility Study, FS)를 Class 5(하한 -50~-20%, 상한 30~100%)의 정확도로 수행하는 것을 내용으로 하고 있다. 플랜트의 규모는 합성석유 기준으로 20,000배럴/일이다. 플랜트의 건설을 위해서 광양제철소 슬래그처리장 내 12만평 부지에 조성 중인 포스코 SNG 생산공장 부지의 일부를 사용하는 것을 기준으로 하였다. 일반적으로 석탄의 종류에 따라서 가스화기의 종류 및 성능이 결정된다. 본 타당성 조사 연구에서 선정된 3종류의 석탄의 조성, 발열량, 회분 함량 등의 특성을 고려하여 각각의 석탄에 적합한 현존하는 상용급 가스화기를 선정하였다. 해당 석탄이 가스화기 종류에 따라 적절한 전처리 과정(건조, 분쇄, 슬러리화)을 거친 후 가스화기에 공급되는 것을 가정하여 석탄의 원소분석 조성, 발열량, 회분함량, 회분조성, 회 용융점 등의 변수에 따라서 각각 해당 가스화기에서 가스화되었을 때의 생성되는 합성가스의 조건을 시뮬레이션을 통하여 얻었다. 가스화기 시뮬레이션 결과를 토대로 합성석유 및 합성천연가스 생산을 위한 공정의 물질수지식 및 에너지수지식이 계산되었으며 이로부터 각 공정에서 발생되는 부생성물과 폐기물에 대한 양이 결정되고 이를 처리하는 방안 등도 제시되었다. 실증시설은 20,000배럴/일 규모의 CTL 및 전기 병산 시설이 적합하다. 더 큰 규모 공장은 투자비가 너무 커서 유가 또는 석탄가 변동에 따라 사업의 수익성이 크게 변하여 위험도가 큰 단점이 있기 때문이다. CTL 공장에 전기 병산이 추천되는 이유는 산소생산공장(APU), 압축 등 석탄전환공장에는 자체적인 전기수요가 막대하여 따로 스팀터빈용 발전소를 운영하므로 이를 효율적으로 대체하고자 하기 때문이다. 즉, 석탄가스화에 의해 기름을 최대한 만들고 미반응가스는 가스터빈 및 스팀터빈의 복합발전에 의해 고효율로 전기를 생산하면 최소의 비용으로 최대한 전기를 생산하여 자체소비 전력을 충당하고 남는 전기는 판매하여 수익률을 높일 수 있다.

• Applied Biological Chemistry
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• v.36 no.3
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• pp.163-171
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• 1993

The collagens from filefish (Novoden modestus) and cod (Gadus macrocephalus Tilesius) skin were isolated and their physicochemical properties were investigated. Glutamic acid, hydroxyproline, valine and phenylalanine in the filefish skin collagen (FSC) were presented at higher levels than those of cod skin collagen (CSC), but the contents of glycine, proline and serine were contrary. The content of essential amino acids of FSC (265 residues/1000 residues) was higher than CSC (229 residues). The solubilities of both collagens were the lowest at pH 7.0, but precipitously increased at acid zone(below pH 5.0). FSC has lower viscosity than CSC. Furthermore, while the viscosities of both collagens were the lowest at pH 7.0, the viscosities of FSC and CSC were the highest at pH 4.0 and pH 2.0, respectively. The denaturation temperature of $FS(25^{\circ}C)$ was higher than $CSD\;(17^{\circ}C)$. The free hydrophobic residue contents of FSC and CSC tended to increase till $60^{\circ}C,\;and\;50^{\circ}C$ respectively, and to decrease thereafter. Hydration capacities of both collagens were the lowest at pH 7.0, and CSC had the superior hydration capacity to FSC. In addition, emulsifying and emulsifying stability of CSC was also superior to FSC.

• Journal of radiological science and technology
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• v.18 no.1
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• pp.63-70
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• 1995

In this pauper, the back, forward, side and $45^{\circ}$ oblique scatter dose were measured the X-ray exposure conditions 60, 80, 100, 120kV, FFD 100cm, FS $20\times20cm$, toward the $25\times25cm\times10\sim20cm$ of solid water, paraffin and MiX-DP phantom, and Pb, Cu, Al, and styrofoam meterials, by the electrometer and 5.3 cc ionization chamber. The obtained results are summarized as following. 1. The percentage depth dose(PDD) at the range of the diagnostic x-ray energy were appeared 50 % depth dose at the 2 cm depth with 60 kV, and 5 cm depth with 120 kV X-ray, 10 % depth dose at the 10 cm depth with 60 kV and 14 cm depth with 120 kV X-ray, 5 % below depth dose at the 20 cm depth. 2. The back scatter dose which were generated the surface of Pb, Cu and Al metal plates were 10 % below, and than the back scatter dose at the Pb plate were a most amount of these which were about 10 %, and were appeared the order of Cu and Al. 3. The percentage forward scatter were appeared from 50 % to 65 %, and the more phantom thicknees become, the more forward scatter were increased with the ratio of 5 % per 5 cm thickness. 4. The percentage back scatter which were generated the tissue equivalence meterials solid water, paraffin and MiX-DP were from 20 % to 40 %, and than the back scatter dose at the solid water were a mest amount of those, and paraffin and MiX-DP were appeared with the next values. 5. The percentage $90^{\circ}$ lateral and $45^{\circ}$ oblique side scatter dose were measured from 4 % to 12 %. a most amount of scatter dose which were generated from the patient in radiography were the forward scatter, the next values were the back scatter, the third values were the $90^{\circ}$ lateral scatter.

• Journal of the Korean Geosynthetics Society
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• v.9 no.3
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• pp.77-85
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• 2010

The change of water level in reservoirs is an important factor causing failure of bank slopes, i.e. landslide. The water level of Three Gorges reservoir in China fluctuate between 145 m and 175 m, as a matter of flood control. During its normal operational state, the rate of water level fluctuation is supposed to range from 0.67 m/d to 3.0 m/d. Majiagou slope is located on the left bank of Zhaxi River, 2.1 km up from the outlet. Zhaxi River is a tributary of the Yangtze River within the Three Gorges area, of which the water level changes with the reservoir. At the back of Majiagou slope, a 20 m long and 3~10 cm wide fissure developed just after the reservoir water level rose from 95 m to 135 m in 2003. This big fissure was a full suggestion of potential failure of this slope. In this study, unsaturated-saturated seepage analyses were carried out to simulate the change of pore-water pressures in the bank slope subjected to the reservoir water level change. The obtained pore-water pressures were then used to evaluate the change in factor of safety (FS) with reservoir water level. It was found that the phreatic line showed a delayed response with respect to the change of the reservoir water level, because the seepage through soil layer was generally slower than water flows itself. During the rising and drawdown process, the phreatic lines take the shapes of concave and convex, respectively. And the fluctuation of reservoir water level just affected the front part of the bank slope, but had little influence on the back of the slope.

• Korean Journal of Agricultural and Forest Meteorology
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• v.17 no.3
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• pp.227-235
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• 2015

Using eddy covariance method, net ecosystem exchange (NEE) of $CO_2$ ($F_{CO_2}$), $H_2O$ (LE), and sensible heat (H) can be approximated as the sum of eddy flux ($F_c$) and storage flux term ($F_s$). Depending on strength and distribution of sink/source of scalars and magnitude of vertical turbulence mixing, the rates of changes in scalars are different with height. In order to calculate $F_s$ accurately, the differences should be considered using scalar profile measurement. However, most of flux sites for agricultural lands in Asia do not operate profile system and estimate $F_s$ using single-level scalars from eddy covariance system under the assumption that the rates of changes in scalars are constant regardless of the height. In this study, we measured $F_c$ and $F_s$ of $CO_2$, $H_2O$, and air temperature ($T_a$) using eddy covariance and profile system (i.e., the multi-level measurement system in scalars from eddy covariance measurement height to the land surface) at the Chengmicheon farmland site in Korea (CFK) in order to quantify the differences between $F_s$ calculated by single-level measurements ($F_s_{-single}$ i.e., $F_s$ from scalars measured by profile system only at eddy covariance system measurement height) and $F_s$ calculated by profile measurements and verify the errors of NEE caused by $F_s_{-single}$. The rate of change in $CO_2$, $H_2O$, and Ta were varied with height depending on the magnitudes and distribution of sink and source and the stability in the atmospheric boundary layer. Thus, $F_s_{-single}$ underestimated or overestimated $F_s$ (especially 21% underestimation in $F_s$ of $CO_2$ around sunrise and sunset (0430-0800 h and 1630-2000 h)). For $F_{CO_2}$, the errors in $F_s_{-single}$ generated 3% and 2% underestimation of $F_{CO_2}$ during nighttime (2030-0400 h) and around sunrise and sunset, respectively. In the process of nighttime correction and partitioning of $F_{CO_2}$, these differences would cause an underestimation in carbon balance at the rice paddy. In contrast, there were little differences at the errors in LE and H caused by the error in $F_s_{-single}$, irrespective of time.

• Journal of Nutrition and Health
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• v.39 no.4
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• pp.417-425
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• 2006

The purpose of this study were to a) investigate operation of human resource in contract foodservice management company (CFMC), b) identify the staffing indices for the establishment an labor productivity for CFMC, and c) develop standardized model of staffing demand as foodservice's scale in CFMC. The data was collected using FS intra-net system from 138 contract-managed foodservice operations in A CFMC and statistical analysis was completed using the SAS/win package (ver. 8.0) for description analysis, ANOVA, Duncan multiple comparison, pearson correlation analysis, and regression analysis. The types of operation were included factory (45%), small scale operation (26%), office (11%), department store (10%), training institute (4%), and hospital (3%). The distribution of foodservice scale was classified by meal served was as follows; 'less than 500 meals (47%)', 'from 500 to 1500 meals (25%)', 'from 1500 to 2500 meals (17%)', and 'more than 2500 meals (12%)'. There was two types of contract method, fee-contract (53%) and profit-and-loss contract (46%) Some variables were significantly high operation indices such as selling price, food cost, monthly sales, net profit and others were significantly low operation indices such as labor, meal time a day in the small foodservice on meal scale (p<.001). The more foodservice was large, the more human resource was disposed on dietitian, cook, cooking employee altogether (p<.001). Foodservice in A CFMC was divided into 2 groups by 500 meals a day, according to comparative analysis of labor productivity as meal scale per working hour, meal scale a day and operation indices as meal per foodservice employee, meal per cooking employee (p<.001). The regression equation model was developed as 'the number of employees=1.82+0.014 ${\times}$ meal served' in the operation of less than 500 meals, 'the number of employees=9.42+0.013 ${\times}$ meal scale a day -0.94 ${\times}$ meal scale per working hour' in the operation over 500 meal scale using labor productivity indices and operation indices. Therefore, CFMC could be enhanced efficiency of human resource arrangement using the standardized model of staffing demand and would be increased effectiveness of profit.

• Clinics in Shoulder and Elbow
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• v.4 no.2
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• pp.173-180
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• 2001

Aim: To evaluate validity and responsiveness of four shoulder scoring systems. Material and Method: Twenty-five cases of shoulder instability(22 traumatic, 3 non-traumatic) and twenty-three cases of rotator cuff tear(12 small or medium, 10 large or massive) treated surgically were evaluated with the Shoulder Function Score of the University of Pennsylvania(Penn FS), Constant Score, UCLA Shoulder Rating Scale and Simple Shouler Test(SST), preoperatively and at final follow-up. The average follow-up was 16.0 months in instability group and 17.5 months in rotator cuff tear group. Using the SPSS program, Pearson linear correlation coefficiency(PLCC) between the scores were calculated. And to assess the construct validity, PLCC between patients' satisfaction and the scores were also calculated. Responsiveness was measured by the standardized response mean(SRM). Result: In instability group, correlation between the scoring systems was low preoperatively except between Constant and SST, but high after operation. Patients' satisfaction with the scores showed low PLCC preoperativley, but high PLCC postoperatively. SRM was high in PENN and UCLA, but when the satisfaction segment of the score was eliminated from UCLA, the SRM was the lowest. In rotator cuff tear group, there was high correlation between the scores not only preoperatively but postoperatively. And the patients' satisfaction matched well with the scores. SRM was particularly high in UCLA and SST. Even when satisfaction segment was eliminated from UCLA, the SRM was still the highest. Conclusion : Evaluation by the 4 scoring systems investigated in the study showed less consistency in instability than rotator cuff tear in terms of correlation and validity. Responsiveness was generally higher in rotator cuff tear group than in instability group except for Pennsylvania Shoulder Function Score. Therefore it is construed that use of any among the four scoring systems doesn't make difference in evaluation of rotator cuff lesions. However in instability group, care is needed because different result may be obtained according to the selection of a scoring system.

• Korean Journal of Remote Sensing
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• v.16 no.3
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• pp.243-260
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• 2000

Ocean remote sensing reflectance of just above water level was modeled using inherent optical properties of seawater contents, total absorption (a) and backscattering(bb) coefficients ($R_{rs}$=0.046 $b_b$/(a+$b_b$). This modeling was based on the specific absorption and backscattering coefficients of 5 optically active seawater components； phytoplankton pigments, non-chlorophyllous suspended particles, dissolved organic matters, heterotrophic microorganisms, and the other unknown particle components. Simulated remote sensing reflectance($R_{rs}$) and water leaving radiance(Lw) spectra were well agreed with in-situ measurements obtained using a bi-directional fields remote spectrometer in coastal waters and open ocean. $R_{rs}$ values in SeaWiFS bands from the model were analyzed to develop 2-band ratio ocean color chlorophyll with those observed insitu. Also, chlorophyll algorithm based on remote reflectance developed in this study fell in those obtained by a SeaBAM working group. The model algorithms were examined and compared with those observed insitu. Also, chlorophyll algorithm based on remote reflectance developed in this study fell in those obtained by a SeaBAM working group. The remote reflectance model will be very helpful to understand the variation of water leaving radiances caused by the various components in the seawater, and to develop new ocean color algorithm for CASE-II water using neural network method or other analytical method, and in the model of fine atmospheric signal correction.

• Journal of the Korean Geotechnical Society
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• v.25 no.1
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• pp.65-76
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• 2009

The unsaturated characteristics of Korean weathered granite soils have been studied to investigate the influence of saturated permeability, rainfall intensity and soil-water characteristic curve (SWCC) on the slope stability. The upper, average and lower SWCCs were estimated from the publication and experimental results using the statistical concept. The roughly estimated SWCC can be used for the soils without experimental results by relating SWCC with the particle size distribution curve. An appropriate ratio between the saturated permeability and the rainfall intensity ($k_s$/i) was also suggested for practical use in designing the slopes by investigating the time-dependent variation of slope instability during the rainfall. The slope stability was deteriorated from the initiation of rainfall and recovered again after the factor of safety reached the critical value. The FS of the slope decreased at first and then increased after reaching the critical value during the rainfall. As a result, the slope instability was not related with an absolute rainfall intensity but with the ratio between the saturated permeability and the rainfall intensity. In case of the upper SWCC, the critical condition occurred when the ratio between the saturated permeability and the rainfall intensity was in the range of $1.0{\sim}2.0$.