• Journal of Korean Clinical Nursing Research
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• v.24 no.1
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• pp.1-9
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• 2018

Purpose: The study was to examine the effects of the individual education about chemotherapy for cancer patients as well as their family who are receiving the first chemotherapy on self-care knowledge, self-care performance, family support, and anxiety level. Methods: A non-equivalent control group was used in this interventional study. A total of 50 patients with cancer aged above 19 in the K university hospital, Seoul, Korea, participated in the study (Experimental group: n=25, Control group: n=25). The education about chemotherapy was offered one week after hospital discharge, which was followed by telephone counseling Data were analyzed by the SPSS/WIN 20.0 program using percentage, frequency, mean, standard deviation, $x^2$ test, and independent t-test. Results: The experimental group showed a significantly better self-care knowledge (t=4.094, p<.001), self-care performance (t=3.532, p=001), family support (t=2.170, p=.035), and anxiety control (t=4.780, p<.001) than the control group. Conclusion: The findings suggest that the individual education should be considered for cancer patients and their family in the clinical fields.

• Natural Product Sciences
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• v.17 no.3
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• pp.212-215
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• 2011

In the course of screening anti-adipogenic activity of natural products employing the preadipocyte cell line, 3T3-L1 as an in vitro assay system, the EtOAc fraction of the stem barks of Acer tegmentosum Maxim (Aceraceae) showed significant inhibitory activity on adipocyte differentiation as assessed by measuring fat accumulation using Oil Red O staining. Activity-guided fractionation led to the isolation of active constituent, (+)-catechin. (+)-Catechin showed inhibitory activity on adipocyte differentiation in dose-dependent manner. Further studies with interval treatment demonstrated that (+)-catechin exerted inhibitory activity on adipocyte differentiation via acting on early stage of adipogenesis. Our present study also showed that (+)-catechin significantly inhibited the preadipocyte proliferation. Taken together, these results suggest that (+)-catechin, a constituent of A. tegmentosum might contribute the anti-adipogenic activity of A. tegmentosum.

• Journal of Korean Society for Quality Management
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• v.44 no.3
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• pp.689-706
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• 2016

Purpose: This study identifies causality in IoT-based healthcare user's experience(playful experience, economical experience), trust, usage, degree of dependence and continuous use intention, especially focused on chinese case. Methods: Face to face interviews was conducted for people who has experience in the use of the Xiaomi Mi band. This study used Partial Least Square(PLS) method with the questionnaires from the interview. Results: IoT-based healthcare users taking playful experience have a strong trust in a positive economic experiences. Also, the user recognizing the experience as an economic one shows stronger intention to use continuously. Conclusion: By getting healthcare users have more economic experience, they have continuous use intention of healthcare product. The empirical findings can be applied to the related companies strategy building.

• International Journal of Advanced Culture Technology
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• v.7 no.3
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• pp.25-34
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• 2019

Purpose: The purpose of this study was to examine the effects of health promotion program, which was based on the Health Belief Model, on the health belief, health promoting behavior and quality of life for middle-aged women. Methods: The study focused nonequivalent control group pretest-posttest design. Data were collected among 40 middle-aged women (20 were experimental group and 20 were control group) on 1st November 2014 and 25th April 2015. The experimental group received 12 sessions of health promotion program for aging preparation once a week for 12 weeks. Data were analyzed by ${\chi}^2$ and t-test and paired t-test using the PASW 21.0 program. Results: The study results shown that, health belief (t=-2.94, p=.006), health promoting behavior (t=-4.76, p<.001) and higher quality of life (t=-7.65, p<.001) scores of experimental group were higher than the control group. Conclusion: The health promotion program based on the Health Belief Model was effective and increased the health belief and health promoting behavior and quality of life among middle-aged women. It seems health promotion program is necessary to improve middle age women's health and quality of later life.

• Journal of Life Science
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• v.24 no.3
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• pp.323-328
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• 2014

MicroRNAs comprise a family of small noncoding RNAs that modulate physiological processes, including adipogenesis. MicroRNA-17 (miR-17) promotes adipocyte differentiation and enhances lipid accumulation. The transcriptional regulation of miR-17 during adipogenesis remains unknown. In this study, we investigated whether miR-17 is a target of peroxisome proliferator-activated receptor ${\gamma}$ ($PPAR{\gamma}$), which is a key regulator of adipogenesis. The levels of miR-17 and the expression of $PPAR{\gamma}$ increased after the induction of adipocyte differentiation. Three putative peroxisome proliferator response elements (PPREs) were identified in the miR-17 promoter region. Using chromatin immunoprecipitation and luciferase reporter assays, we observed the interaction of $PPAR{\gamma}$ with the miR-17 promoter. Mutagenesis experiments showed that the -677/-655 region of the miR-17 promoter could function as a PPRE site. These results suggest that $PPAR{\gamma}$ is essential for transcriptional activation of the miR-17 gene, thereby contributing to understanding the molecular mechanism of adipogenesis in adipocytes.

• IMMUNE NETWORK
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• v.11 no.5
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• pp.227-244
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• 2011

MicroRNAs (miRNAs) are small noncoding RNA molecules that negatively regulate gene expression via degradation or translational repression of their target messenger RNAs (mRNAs). Recent studies have clearly demonstrated that miRNAs play critical roles in several biologic processes, including cell cycle, differentiation, cell development, cell growth, and apoptosis and that miRNAs are highly expressed in regulatory T (Treg) cells and a wide range of miRNAs are involved in the regulation of immunity and in the prevention of autoimmunity. It has been increasingly reported that miRNAs are associated with various human diseases like autoimmune disease, skin disease, neurological disease and psychiatric disease. Recently, the identification of miRNAs in skin has added a new dimension in the regulatory network and attracted significant interest in this novel layer of gene regulation. Although miRNA research in the field of dermatology is still relatively new, miRNAs have been the subject of much dermatological interest in skin morphogenesis and in regulating angiogenesis. In addition, miRNAs are moving rapidly center stage as key regulators of neuronal development and function in addition to important contributions to neurodegenerative disorder. Moreover, there is now compelling evidence that dysregulation of miRNA networks is implicated in the development and onset of human neruodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Tourette's syndrome, Down syndrome, depression and schizophrenia. In this review, I briefly summarize the current studies about the roles of miRNAs in various autoimmune diseases, skin diseases, psychoneurological disorders and mental stress.

• Journal of Microbiology
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• v.34 no.3
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• pp.215-219
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• 1996

Eight strains of Trichaptun (Polyporaceae), two strains from each species of T. abietinum, T. biforme, T. fusco-violaceum, and T. laricinum were examined to see their phylogenetic relationship by digesting mitochondrial DNAs with EcoRV, Hind III, XbaI, and PstI, and then analyzing fragmentation patterns with the methods of Nei and Li. T. abietinum, T. biforme, and T. laricinum developed an independent phylogenetic lineage, respectively, but T. fusco-violaceum FP-133997-sp showed a close relationship with two strains of T. bioforme, and T. fusco-violaceum HHB-4016-sp barely grouped with those of T. laricinum. Based on the results of the RFLP analysis of mtDNA, it is concluded that T. fusco-violaceum is under way to differentiation into two different subgroups.

• The Journal of the Korea institute of electronic communication sciences
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• v.9 no.5
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• pp.609-616
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• 2014

Recently information industry has developed from IT into ICT. Among ICT area, M2M is evolving into IoT. As progress is being made in the IoT industry, people continue to try converging the IoT and other industries. One good example of such convergence is with sports industry. In this paper, we perform information analysis centered at keyword as a basic research for development of advanced leisure sports industry integrated with the IoT.

• Biomolecules & Therapeutics
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• v.30 no.4
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• pp.299-308
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• 2022

T cells are attractive targets for the development of immunotherapy to treat cancer due to their biological features, capacity of cytotoxicity, and antigen-specific binding of receptors. Novel strategies that can modulate T cell functions or receptor reactivity provide effective therapies, including checkpoint inhibitor, bispecific antibody, and adoptive transfer of T cells transduced with tumor antigen-specific receptors. T cell-based therapies have presented successful pre-clinical/clinical outcomes despite their common immune-related adverse effects. Ongoing studies will allow us to advance current T cell therapies and develop innovative personalized T cell therapies. This review summarizes immunotherapeutic approaches with a focus on T cells. Anti-cancer T cell therapies are also discussed regarding their biological perspectives, efficacy, toxicity, challenges, and opportunities.

• TTA Journal
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• s.110
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• pp.137-139
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• 2007

ITU의 표준화 추진시 관련된 IPR 이슈를 처리하기 위하여, ITU-T IPR 애드혹 회의가 지난 2월 20과 21일 양일간 스위스 제네바에서 개최되었다. 이번 회의에서는 지난 2년여 간 추진되어 오던 ISO, IEC, ITU 등 3개 국제표준화기구의 공통 특허정책을 최종 채택함으로써, 3개 국제표준화기구간에 조화로운 IPR 정책을 추진하는 발판이 마련되었다. 본 원고는 금번 회의결과를 간단히 소개함으로써 ITU 활동에 도움을 주고자 한다.