• 대한공업교육학회지
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• 제34권2호
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• pp.248-266
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• 2009

이 연구의 목적은 일반계 고등학교 기술교육에서 강의식 수업만을 받은 학생과 강의식 수업을 받은 후 학습 내용과 관련 있는 프로젝트를 수행하게 한 학생과, 그리고 강의식 수업을 받지 않고 프로젝트만을 수행하며 스스로 학습한 학생들 간의 학업성취도에는 어떤 차이가 있는가를 규명하는 것이었다. 고등학교 1학년 3개 학급 학생을 대상으로 '원자력 발전'에 대한 내용으로 실험을 실시한 후, '지식, 이해, 적용' 영역에 대한 학업성취도 효과를 분석하기 위하여 '사후 검사 통제 집단 설계'를 통한 실험 연구를 수행 하였다. 연구 결과는 다음과 같다. 첫째, 일반계 고등학교 기술교과에서 강의식 수업만 실시한 집단, 강의식 수업과 프로젝트 수업을 모두 실시한 집단, 프로젝트만을 수행하는 집단과의 '지식' 영역의 학업성취도에는 차이는 없었다. 하지만 평균값을 보면 강의식 수업과 프로젝트를 모두 수행한 학생들이 학업성취도에서 긍정적인 면을 보이고 있었다. 둘째, 강의식 수업만 실시한 집단, 강의식 수업과 프로젝트 수업을 모두 실시한 집단, 프로젝트만을 수행하는 집단과의 '이해' 영역의 학업성취도에는 차이는 없었다. 셋째, 강의식 수업만 실시한 집단, 강의식 수업과 프로젝트 수업을 모두 실시한 집단, 프로젝트만을 수행하는 집단과의 '적용' 영역의 학업성취도에는 차이가 없었다.

• 대한한의정보학회지
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• 제21권1호
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• pp.23-34
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• 2015

This study is aimed to verify what effects horseback riding has in treating hospitalized patients with low back pain in the Korean medicine hospital. The method of this study is choosing 31 people among hospitalized male and female patients whose chief complaints were low back pain in 2 Korean medicine hospital in Gyeonggi Province. 14 people who agreed to take horseback riding treatment were classified into experimental group and 17, the rest of the people, were classified into control group. Both experimental group and control group were treated with Korean medicine. In addition, only experimental group performed horseback riding program. Changes of temperature difference by digital infrared thermal imaging(DITI), sit and reach test and visual analogue scale(VAS) survey were used as measuring tools. IBM SPSS Statistics 21 was used in processing statistics. Mean ${\pm}$standard deviation was indicated down to two places of decimals and the level of significance was judged as p<0.05. The summary of this study's result is as in the following. First of all, the meaningful difference was shown in the experimental group but not in the control group in the difference of temperature between Yintang and Kwanwon(the difference between up and down). Secondly, there were significant difference in the experimental group which performed horseback riding treatments but not in the control group resulting from examining the change of temperature difference between left and right Yongchon. Thirdly, there were significant difference between experimental and control group in the change of sit and reach. Especially, the change was much more in experimental group. As known from the results above, patients who only were treated with Korean medicine relieved low back pain, reordered pelvis and improved the motor ability. However, the group which carried out horseback riding at the same time reordered pelvis and improved the motor ability more obviously.

• 인간행동과 음악연구
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• 제7권1호
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• pp.37-59
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• 2010

본 연구에서는 지역아동센터 아동의 또래 관계 기술 증진을 목표로 하는 창작 음악극 프로그램의 효과성을 검증하고자 또래 관계 기술의 하위요인과 관련한 단계별 목표로 구성된 음악극 만들기 프로그램을 K 지역아동센터 소속 아동 6명에게 10주간 주 2회 총 20회기 제공하였다. 대상자의 또래 관계 기술에 대한 변화를 알아보고자 프로그램 실시 전후에 대상아동과 기관 담당교사에게 각각 또래 관계 기술 척도와 수정된 사회적 기술 척도(교사용)를 실시하였다. 또한 세션 회기별 아동의 음악적 언어적 반응에 대한 기록 자료를 바탕으로 또래 관계 기술의 하위요인에 따라 범주화하여 제시하였다. 대상 아동들이 기록한 또래 관계 기술 척도 및 하위요인인 주도성과 공감/협동 요인의 평균 점수에서 상승을 나타냈으며 통계적으로 유의미하였다(p < .05). 기관 아동복지교사에 의해 작성된 사회적 기술 척도의 사전 사후 검사 점수와 하위 요인인 협력, 자아통제와 자아주장 요인의 평균 점수 모두 상승되었다. 세션 관찰 분석 결과에서는, 초반에 나타나던 비주도성, 자기주장성 결여, 비공감, 비협동 등의 부정적 요인이 세션의 진행에 따라 점차 긍정적인 요인으로 변화된 것으로 나타났다. 따라서 창작 음악극 프로그램은 지역아동센터 아동의 또래 관계기술을 증진시키는 데 효과적인 중재도구임을 시사한다고 볼 수 있다.

• 자원환경지질
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• 제29권2호
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• pp.215-225
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• 1996

All the radionuclides in high-level nuclear waste will decay to harmless levels eventually but for some radionuclides decay is so slow that their radiation remains dangerous for times on the order of tens or hundreds of thousands of years. At the present time, the most favorite disposal plan for high-level radioactive waste is a mined geological disposal in which canister enclosing stable solid form of radioactive waste is placed in mined cavities locating hundred meters below the surface. The chief hazard in such disposal is dissolution of radionuclides from the waste in the groundwater that will eventually carry the dissolved radionuclides to surface environments. The hazard from possible escape of the radionuclides through groundwater can be delayed by engineered and geologic barriers. The engineered barriers can become useless by unexpected geologic catastrophe such as volcanism, earthquake, and tectonic movement and by fraudulent work such as careless construction, improperly welded canisters within the first few decades or centuries. As a result, dangerously radioactive waste which is still intensively radioactive is directly exposed to attack by moving groundwater. All the more, it is almost impossible to control repositories for times more than 10,000 years. Therefore, naturally controlled geologic, barriers whose properties will not be changed within 10,000 years are important to guarantee the safety of repositories of high-level radioactive waste. In Sweden and France, the suitability of granite for the mined geological disposal of high-level waste has been studied intensively. According to the research in Sweden and France, granites has the following physio-chemical characteristics which can delay the transportation of radionuclide by groundwater. First, the permeabilities of granites decreases as the depth increases and is $10^{-8}{\sim}10^{-12}m/s$ at depth below 300 m. Second, groundwater at depth below 300 m has pH=7-9 and reducing condition (Eh=-0.1~0.4). This geochemical condition is desirable to prevent both canister and solid waste from corrosion. Third most radionuclides are not transported by low solubilities and some radionuclide with high solubility such as Cs and Sr are retarded by absorption of geologic media through which ground water flows. Therefore, if high-level waste is disposed at depth below 300 m in the granite body which has a low permeability and is geologically stable more than 10,000 years, the safety of repositories from the hazard due to radionuclide escape can guaranteed for more than 10,000 years.

• Asian-Australasian Journal of Animal Sciences
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• 제28권8호
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• pp.1075-1083
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• 2015

Adipose tissue deposited within muscle fibers, known as intramuscular fat (IMF or marbling), is a major determinant of meat quality and thereby affects its economic value. The biological mechanisms that determine IMF content are therefore of interest. In this study, 48 genes involved in the bovine peroxisome proliferator-activated receptor signaling pathway, which is involved in lipid metabolism, were investigated to identify candidate genes associated with IMF in the longissimus dorsi of Hanwoo (Korean cattle). Ten genes, retinoid X receptor alpha, peroxisome proliferator-activated receptor gamma (PPARG), phospholipid transfer protein, stearoyl-CoA desaturase, nuclear receptor subfamily 1 group H member 3, fatty acid binding protein 3 (FABP3), carnitine palmitoyltransferase II, acyl-Coenzyme A dehydrogenase long chain (ACADL), acyl-Coenzyme A oxidase 2 branched chain, and fatty acid binding protein 4, showed significant effects with regard to IMF and were differentially expressed between the low- and high-marbled groups (p<0.05). Analysis of the gene co-expression network based on Pearson's correlation coefficients identified 10 up-regulated genes in the high-marbled group that formed a major cluster. Among these genes, the PPARG-FABP4 gene pair exhibited the strongest correlation in the network. Glycerol kinase was found to play a role in mediating activation of the differentially expressed genes. We categorized the 10 significantly differentially expressed genes into the corresponding downstream pathways and investigated the direct interactive relationships among these genes. We suggest that fatty acid oxidation is the major downstream pathway affecting IMF content. The PPARG/RXRA complex triggers activation of target genes involved in fatty acid oxidation resulting in increased triglyceride formation by ATP production. Our findings highlight candidate genes associated with the IMF content of the loin muscle of Korean cattle and provide insight into the biological mechanisms that determine adipose deposition within muscle.

• Asian-Australasian Journal of Animal Sciences
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• 제31권2호
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• pp.189-197
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• 2018

Objective: Hemicastration is a unilateral orchiectomy to remove an injured testis, which can induce hormonal changes and compensatory hypertrophy of the remaining testis, and may influence spermatogenesis. However, the underlying molecular mechanisms are poorly understood. Here, we investigated the impact of hemicastration on remaining testicular function. Methods: Prepubertal mice (age 24 days) were hemicastrated, and their growth was monitored until they reached physical maturity (age 72 days). Subsequently, we determined testis DNA methylation patterns using reduced representation bisulfite sequencing of normal and hemicastrated mice. Moreover, we profiled the testicular gene expression patterns by RNA sequencing (RNA-seq) to examine whether methylation changes affected gene expression in hemicastrated mice. Results: Hemicastration did not significantly affect growth or testosterone (p>0.05) compared with control. The genome-wide DNA methylation pattern of remaining testis suggested that substantial genes harbored differentially methylated regions (1,139) in gene bodies, which were enriched in process of protein binding and cell adhesion. Moreover, RNA-seq results indicated that 46 differentially expressed genes (DEGs) involved in meiotic cell cycle, synaptonemal complex assembly and spermatogenesis were upregulated in the hemicastration group, while 197 DEGs were downregulated, which were related to arachidonic acid metabolism. Integrative analysis revealed that proteasome 26S subunit ATPase 3 interacting protein gene, which encodes a protein crucial for homologous recombination in spermatocytes, exhibited promoter hypomethylation and higher expression level in hemicastrated mice. Conclusion: Global profiling of DNA methylation and gene expression demonstrated that hemicastration-induced compensatory response maintained normal growth and testicular morphological structure in mice.

• 약학회지
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• 제57권3호
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• pp.205-212
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• 2013

Dissolution test has been performed to control drug quality and to predict in vivo drug release profile of solid dosage forms, so there's a drift towards setting dissolution test instead of disintegration test. However, some solid dosage forms in Korea Pharmaceutical Codex (KPC) are not established the dissolution test yet, so these monographs are necessary to set the specification of dissolution test. In this study, we developed the specification and test method of dissolution test for itopride hydrochloride tablets and tiropramide hydrochloride tablets which are not established the dissolution test yet. According to the "Manual for Guideline Application for Validation of Analytical Procedures" and "Guidelines on Specification of Dissolution test for Oral dosage form" of Korean Pharmacopoeia (KP), we validated and established each development method. Based on the preliminary dissolution profile, we set the dissolution condition(paddle apparatus, pH 1.2 media, 50 rpm). For this condition, we performed the main dissolution test to determine the specification (45 min, 85%). Finally, we validated each analytical method by specificity, linearity, accuracy and precision. These developed methods will be included the next supplement of KPC and also contributed to the quality control of medicines.

• 사상체질의학회지
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• 제23권3호
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• pp.351-360
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• 2011

1. Objective: This study was designed to analyze the characteristics of each Sasang constitutional type using the Temperament and Character Inventory (TCI). 2. Methods: A total of 135 healthy subjects (age 19-30) participated in this study, consisting of 35 Soyang-type, 66 Taeeum-type, 30 Soeum-type, and 4 Taeyang-type subjects. A Sasang Constitutional Medicine specialist determined each subject's Sasang constitutional type based on the Two Step Questionnaire for Sasang Constitution Diagnosis (TS-QSCD) and comprehensive constitutional assessment. The subjects were also asked to complete the TCI. 3. Results: Among the four temperament dimensions, the Soyang- and Taeeum-type subjects showed significantly higher scores than the Soeum-type subjects in Novelty Seeking (NS). The Soeum-type subjects showed significantly higher scores than the Taeum- and Soyang-type subjects in Harm Avoidance (HA) (Soeum type > Taeeum type > Soyang type). The Soyang-type subjects showed significantly higher scores than the Soeum-type subjects in Reward Dependence (RD). The Soyang- and Taeeum-type subjects showed significantly higher scores than the Soeum-type subjects in Persistence (P). Among the three character dimensions, the Soyang-type subjects showed significantly higher score than the Taeeumand Soeum-type subjects in Self-Directedness (SD) (Soyang type > Taeeum type > Soeum type). The Soyang-type showed significantly higher scores than the Taeeum-type in Cooperativeness (C). 4. Conclusions: Differences in temperament and character were discovered across the Sasang constitutional types. The Sasang constitutional characteristics should be investigated in larger studies in the future. Similar studies could add to the growing knowledge of Sasang constitutional typology and contribute to a more accurate Sasang constitutional diagnosis.

• 한국식품저장유통학회지
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• 제14권1호
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• pp.24-29
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• 2007

월동배추의 저장방법에 따른 특성과 김치를 위해 절였을 경우 특성을 조사하여 배추의 효과적인 저장방법을 구명하고자 하였다. 저장방법(PE 필름백, 플라스틱 컨테이너, 망저장, 움저장)에 따른 배추의 특성을 3개월 동안 조사한 결과, PE 필름백에 저장한 배추가 겉잎이 부패하는 단점이 있으나 다른 처리에 비해 감모율, 정선 손실율, 외관 등에서 비교적 좋은 결과를 보여주었다. 그러나 저장방법을 달리하여 배추를 절였을 경우에 처리별로 절임특성이 큰 영향을 보이지 않았다. 본 실험 결과로 월동배추의 저장 방법이 절임 특성에는 큰 영향이 없지만 저장방법에 따라서 중량 감모 및 정선손실 정도에 영향을 미치므로 배추는 저장중의 이러한 손실을 줄이고 신선도를 유지할 수 있는 방법에 대한 연구가 보다 필요할 것으로 생각된다.

• 한국사회복지학
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• 제69권1호
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• pp.59-77
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• 2017

본 연구는 종단적 시각에서 손자녀 돌봄 유형과 중 고령층 여성의 건강과의 관계를 살펴봄으로써, 한국 여성노인의 노후생활에 대한 이해를 제고하는데 그 의미가 있다. 이를 위해 국민노후보장패널 2차년도 자료부터 5차년도 자료를 사용하여 손자녀 돌봄 유형을 돌봄지속, 돌봄전이, 돌봄중단, 미돌봄으로 구분하고 이 유형들이 50대 이상 중 고령층 여성의 신체건강 및 정신건강에 미치는 영향을 알아보고자 하였다. 연구결과, 인구사회학적 요인을 통제한 상태에서 손자녀를 돌보지 않는 여성에 비해 손자녀를 돌보다가 중단한 여성일수록 좋은 신체건강 수준을 보였다. 하지만 손자녀 돌봄 경험은 여성의 정신건강에 유의미한 영향을 보이지 않았다. 이를 통해, 손자녀 돌봄 유형이 중 고령층에 있는 여성의 신체건강과 정신건강에 미치는 영향은 다를 수 있음을 확인하였다. 본 연구의 결과를 바탕으로, 손자녀 돌봄을 제공하는 여성노인의 건강한 노후생활을 위한 후속 연구의 필요성 및 제고방안을 논의하였다.