• Korean journal of applied entomology
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• v.25 no.3 s.68
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• pp.191-192
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• 1986

• Biomolecules & Therapeutics
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• v.12 no.2
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• pp.101-107
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• 2004

Repeated administration of psychostimulants such as amphetamines increases locomotor activity in rodents. These drugs, including methamphetamine, enhance dopaminergic neurotransmission and result in hyper-locomotion and behavioral sensitization. It is well known that the existence of a complex balance between the cholinergic and dopaminergic systems in the central nervous system. Thus, behavioral sensitization by methamphetamine may be related to the expression of the M1 muscarinic acetylcholine receptors gene. The present study investigated the changes of M1R mRNA in hyperlocomotor activity and behavioral sensitization by methamphetamine (2 mg/kg) in mice. Our results showed that M1R mRNA expression was increased in the frontal cortex and the hippocampus region (the CA2 region) in the acute methamphetamine administered group compared to the saline administered group. In the chronic group, M1R mRNA expression was increased in the frontal cortex ill1d the hippocampus regions (CA2 and DG regions) in melt1amphetamine administered group compared to saline control group. These results indicate that acute or chronic treatment of mathamphetamine leads to the region-specific changes in mRNA expression levels of M1R. Therefore, Therefore, the present result suggests that M1R may play a role in modulating of methamphetamine-induced behavioral sensitization in mice.

• Journal of the Korean Society of Radiology
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• v.14 no.7
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• pp.907-913
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• 2020

There have been continuous controversies on medical X-ray protection and numerous researchers have been trying to prevent unnecessary exposure to radiation. As X-ray passes through the patient and obtains an image, it creates scattered ray due to interactions such as photoelectric effect and Compton scattering with the subject. As a result, both medical radiation staff and patient are exposed to unnecessary radiation on areas other than the target area. In response, this study will be assuming a body of a female, radiating X-ray on the phantom under the conditions of lumbar spine AP test, and measuring scattered ray around breasts and thyroid glands. Then, The experiment results were as follows. After application of non-shielding material, the average of scattered ray was 0.88 mR in thyroid measurement, 3.34 mR, Lt Axillary 3.54 mR, and Rt Axillary 3.03 mR in mamonary measurement but, After application of shielding material, the average of scattered ray was 0.16 mR in thyroid measurement, 0.60 mR, Lt Axillary 0.64 mR, and Rt Axillary 0.54 mR in mamonary measurement showing average scattered ray protection effect of about 82%. This study suggested the manufacturing method of a Jelly-type shielding material, identified the possibilities of researches on mixing various substances with radiology field, and verified the usability of the Jelly-type shielding material as a substitute for existing protection tools.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.30 no.2
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• pp.235-240
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• 2004

In order to develop new anti-photoaging agents from marine natural products, Zostera marina L. was selected for its antioxidative activity and inhibition of matrix metalloproteinase-1 (MMP-1) expression. Three compounds (compounds 1, 2, and 3) were isolated from the extract, and they were identified as apigenin-7-O-${\beta}$-D-glucoside (1), chrysoeriol (2), and luteolin (3). These compounds have SC$\_$50/ values of 0.18 mM, 0.68 mM, and 0.01 mM against l,l-dipheny1-2-picrylhydrazyl radical and 0.04mM, 0.03mM, and 0.01mM against the superoxide radical in the xanthine/xanthine oxidase system, respectively. Compound 3 suppressed the expression of MMP-1 by up to 44% at 35.0${\mu}$M and inhibited the production of interleukin 6, which is known as a cytokine that induces MMP-1 expression. In addition, the wrinkle improvement effect of the formulation with Z. marina extract was measured. As a result, remarkable reduction was found in the fine wrinkle and skin roughness after application of the cream with 3.0% this extract for 8 weeks. In conclusion, the isolated compounds from Z. marina extract were good antioxidant and suppressor of MMP-1 expression and the formulation with the extract diminished the skin wrinkle. Therefore, the extract can be used as a new anti-aging agent for application in cosmetic.

• The Korean Journal of Mycology
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• v.21 no.3
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• pp.172-187
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• 1993

Forty eight fungal isolates were isolated from the maeius collected through the whole nation. Out of them, nine isolate were observed to be zygomyceteous fungi(4 genera and 9 species): Mucor hiemalis, M. circinelloides f. griseo-cyanus, M. circinelloides, M. jansseni, M. racemosus f. racemosus, Mortierella isabellina, Rhizopus stolonifer, R. oryzae, and Absidia corymbifera. Four species(M. circinelloides f. griseo-cyanus, M. hiemalis, M. jansseni, and R. oryzae) identified here were known as species involved in maeiu but not described in detail. The others were first reported as a species inhabiting in the maeiu. Two species of M. hiemalis f. hiemalis. and M. circinelloides f. griseo-cyanus were determined to play a role in biochemical changes of soybean in the fermentation of maeiu. However, the others seldom inhabited but considered to be comtaminated fungi in maeiu.

• Animal cells and systems
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• v.5 no.3
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• pp.217-224
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• 2001

The present study examines the expression and regulation of gonadotropin-releasing hormone (GnRH) and its receptor (GnRH-R) mRNA levels during mouse ovarian development. A fully processed, mature GnRH mRNA together with intron-containing primary transcripts was expressed in the immature mouse ovary as determined by Northern blot analysis and reverse transcription-polymerase chain reaction (RT-PCR). The size of ovarian GnRH mRNA was similar to that of hypothalamus, but its amount was much lower than that in the hypothalamus. Quantitative RT-PCR procedure also revealed the expression of GnRH-R mRNA in the ovary, but the estimated amount was a thousand-fold lower than that in the pituitary gland. We also examined the regulation of ovarian GnRH and GnRH-R mRNA levels during the follicular development induced by pregnant mare's serum gonadotropin (PMSG) and/or human chorionic gonadotropin (hCG). Ovarian luteinizing hormone receptor (LH-R) mRNA was abruptly increased st 48 h after the PMSG administration and rapidly decreased to the basal level thereafter. Ovarian GnRH mRNA level was slightly decreased at 48 h after the PMSG administration, and then returned to the basal value. GnRH-R mRNA level began to increase at 24 h after the PMSG treatment, decreased below the uninduced basal level at 48 h, and gradually increased thereafter. HCG administration did not alter ovarian GnRH mRNA level, while it blocked the PMSG-induced increase in GnRH mRNA level. Taken together, the present study demonstrates that the expression of GnRH and GnRH-R mRNA are regulated by gonadotropin during follicular development, suggesting possible intragonadal paracrine roles of GnRH and GnRH-R in the mouse ovarian development.

• Journal of The Korean Astronomical Society
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• v.28 no.2
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• pp.153-167
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• 1995

More than 22,300 stars in NGC 6752 were measured over the region of 5' < r < 23' in B and V AAT plates. The most of these are main sequence(MS) stars and about 130 blue horizontal branch(BHB) stars were detected. The C-M diagram of all measured stars shows gaps appearing at $V{\approx}15.^{m}2$ and $16.^{m}2$ along the red giant branch(RGB) and their appearance shown by Lee & Cannon(1980) is found to be independent of measured region. The bimodal distribution of BHB stars is confirmed again and a wide gap shown by Lee & Cannon(1980) at $V{\approx}16^m$ is clearly seen for stars in the outer part (8' < r < 13') in the cluster. It is noted, however, that this gap is occupied by about a dozen of BHB staIs located in the inner region (5' < r < 8'). The number ratio of bright BHB star (V < $15^m$) to faint BHB stars (V > $15^m$) decreases with increasing radial distance from the cluster center. Three faintest BHB stars were found, and two stars ($V{\approx}18.^{m}5$) of there are located in the inner region of $r{\approx}6'$ and the other faintest one ($V{\approx}19.^{m}3$) located in the outer part of $r{\approx}13'$. Also a bluest star of (B - V) $\approx$ -0.5 at $V{\approx}17.^{m}2$ is found but it is located at the outer part of $r{\approx}13'$ in NE region. Therefore, the membership of the faintest BHB star and bluest star is suspected. The luminosity function(LF) and mass function(MF) for NGC 6752 were derived for MS stars. The LF for stars of $M_v\;<\;6^m$ in the outer part of r > 8' shows a consistency with that derived by Penny & Dickens(1986).

• Journal of the Chungcheong Mathematical Society
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• v.18 no.1
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• pp.87-93
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• 2005

For a left R-module M, we identify certain submodules of M that play a role analogous to that of ideals in the ring R. We investigate some properties of M-ideals in the submodules of M and also study Jacobson radicals of a submodule of M.

• Korean Journal of Clinical Pharmacy
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• v.22 no.2
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• pp.176-180
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• 2012

The stability of triamcinolone in three kinds of oral liquid syrups at 4 and $25^{\circ}C$ was studied for 21 days. Twenty tablets of 4 mg triamcinolone were mixed with 100 mL of each oral liquid syrup, which is Levotuss$^{(R)}$Syrup (levodropropizine 6 mg/mL), Ucerax$^{(R)}$Syrup (hydroxyzine 2 mg/mL), and Xyzal$^{(R)}$Liquid (levocetirizine 0.5 mg/mL). The chromatographic analysis after deliberate degradation showed no evidence of any breakdown product likely to interfere with the chromatographic peak of the parent substance. The relationship between triamcinolone concentrations and peak areas was linear from 50 to 1000 ${\mu}g/mL$ ($r^2$ = 0.9998). The analysis method was precise, with coefficients of variation no greater than 5.4%. Triamcinolone was stable for up to 14 and 21 days in Levotuss$^{(R)}$Syrup at 25 and $4^{\circ}C$, respectively; in Ucerax$^{(R)}$Syrup and Xyzal$^{(R)}$Syrup, it was stable for at least 21 days at both temperatures. The percentages of initial triamcinolone concentration remaining after 21 days were $72.3{\pm}3.2$ and $94.9{\pm}6.0%$ and $93.2{\pm}4.9$ and $92.4{\pm}5.7%$, and $92.6{\pm}1.2$ and $92.7{\pm}2.2%$ in Levotuss$^{(R)}$Syrup, Ucerax$^{(R)}$Syrup, and Xyzal$^{(R)}$Syrup at 25 and $4^{\circ}C$, respectively. The pH variations of all test solutions were within 0.8. Based on the results, it was concluded that triamcinolone in three oral liquid syrups which are Levotuss$^{(R)}$syrup, Ucerax$^{(R)}$syrup and Xyzal$^{(R)}$syrup was chemically and physically stable in both states of refrigeration and room temperature for at least 14 days.

• Bulletin of the Korean Mathematical Society
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• v.56 no.5
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• pp.1187-1198
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• 2019

Let R be a domain with its field Q of quotients. An R-module M is said to be weak w-projective if $Ext^1_R(M,N)=0$ for all $N{\in}{\mathcal{P}}^{\dagger}_w$, where ${\mathcal{P}}^{\dagger}_w$ denotes the class of GV-torsionfree R-modules N with the property that $Ext^k_R(M,N)=0$ for all w-projective R-modules M and for all integers $k{\geq}1$. In this paper, we define a domain R to be w-Matlis if the weak w-projective dimension of the R-module Q is ${\leq}1$. To characterize w-Matlis domains, we introduce the concept of w-Matlis cotorsion modules and study some basic properties of w-Matlis modules. Using these concepts, we show that R is a w-Matlis domain if and only if $Ext^k_R(Q,D)=0$ for any ${\mathcal{P}}^{\dagger}_w$-divisible R-module D and any integer $k{\geq}1$, if and only if every ${\mathcal{P}}^{\dagger}_w$-divisible module is w-Matlis cotorsion, if and only if w.w-pdRQ/$R{\leq}1$.