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New Cosmetic Agents for Anti-aging from Zostera marina L.  

Jin-Hui, Kim (R&D Center, Hanbul Cosmetic Co.,)
Kyung-Eun, Lee (R&D Center, Hanbul Cosmetic Co.,)
Jin-Hwa, Kim (R&D Center, Hanbul Cosmetic Co.,)
Young-Ho, Cho (R&D Center, Hanbul Cosmetic Co.,)
Sung-Min, Park (R&D Center, Hanbul Cosmetic Co.,)
Jeong-Jae, Lee (R&D Center, Hanbul Cosmetic Co.,)
Bum-Chun, Lee (R&D Center, Hanbul Cosmetic Co.,)
Hyeong-Bae, Pyo (R&D Center, Hanbul Cosmetic Co.,)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.30, no.2, 2004 , pp. 235-240 More about this Journal
Abstract
In order to develop new anti-photoaging agents from marine natural products, Zostera marina L. was selected for its antioxidative activity and inhibition of matrix metalloproteinase-1 (MMP-1) expression. Three compounds (compounds 1, 2, and 3) were isolated from the extract, and they were identified as apigenin-7-O-${\beta}$-D-glucoside (1), chrysoeriol (2), and luteolin (3). These compounds have SC$\_$50/ values of 0.18 mM, 0.68 mM, and 0.01 mM against l,l-dipheny1-2-picrylhydrazyl radical and 0.04mM, 0.03mM, and 0.01mM against the superoxide radical in the xanthine/xanthine oxidase system, respectively. Compound 3 suppressed the expression of MMP-1 by up to 44% at 35.0${\mu}$M and inhibited the production of interleukin 6, which is known as a cytokine that induces MMP-1 expression. In addition, the wrinkle improvement effect of the formulation with Z. marina extract was measured. As a result, remarkable reduction was found in the fine wrinkle and skin roughness after application of the cream with 3.0% this extract for 8 weeks. In conclusion, the isolated compounds from Z. marina extract were good antioxidant and suppressor of MMP-1 expression and the formulation with the extract diminished the skin wrinkle. Therefore, the extract can be used as a new anti-aging agent for application in cosmetic.
Keywords
ani-aging; antioxidant; matrix metalloproteinase-1; Zostera marina L.; luteolin;
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