• 제어로봇시스템학회:학술대회논문집
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• 2005.06a
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• pp.1183-1188
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• 2005

In this paper, we propose a 3D automated measuring system which measures the mandibular movements and the reference plane of the jaw movements. In diagnosis and treatment of the malocclusions, it is necessary to estimate the mandibular movements and the reference plane of the jaw movements. The proposed system is configured with double stereo-cameras, PC, two moving pattern plates(MPPs), two fixed pattern plates(FPPs) and one orbital marker. The virtual pattern plate is applied to calculate the homogeneous transformation matrices which describe the coordinates systems of the FPP and MPP with respect to the world coordinates system. To estimate the parameters of the hinge axis, the Euler's theorem is applied. The hinge axis points are intersections between the FPPs and the hinge axis. The coordinates of a hinge axis point with respect to the MPP coordinates system are set up to fixed value. And then, the paths of the jaw movement can be calculated by applying the homogeneous transformation matrix to fixed hinge axis point. To examine the accuracy of the measurements, experiments of measuring the hinge axis points and floating paths of them are performed using the jaw motion simulator. As results, the measurement errors of the hinge axis points are within reasonable boundary, and the floating paths are very similar to the simulator's moving path.

• Journal of the Korean Institute of Telematics and Electronics D
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• v.36D no.10
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• pp.37-44
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• 1999

This paper report the implementation results of Monte Carlo numerical calculation for ion distributions in plasma dry etching chamber and of the surface evolution simulator using cell removal method for topographical evolution of the surface exposed to etching ion. The energy and angular distributions of ion across the plasma sheath were calculated by MC(Monte Carlo) algorithm. High performance MPP(Massively Parallel Processing) algorithm developed in this paper enables efficient parallel and distributed simulation with an efficiency of more than 95% and speedup of 16 with 16 processors. Parallelization of surface evolution simulator based on cell removal method reduces simulation time dramatically to 15 minutes and increases capability of simulation required enormous memory size of 600Mb.

• Biomolecules & Therapeutics
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• v.22 no.4
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• pp.275-281
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• 2014

Autophagy is a series of catabolic process mediating the bulk degradation of intracellular proteins and organelles through formation of a double-membrane vesicle, known as an autophagosome, and fusing with lysosome. Autophagy plays an important role of death-survival decisions in neuronal cells, which may influence to several neurodegenerative disorders including Parkinson's disease. Chebulagic acid, the major constituent of Terminalia chebula and Phyllanthus emblica, is a benzopyran tannin compound with various kinds of beneficial effects. This study was performed to investigate the autophagy enhancing effect of chebulagic acid on human neuroblastoma SH-SY5Y cell lines. We determined the effect of chebulagic acid on expression levels of autophagosome marker proteins such as, DOR/TP53INP2, Golgi-associated ATPase Enhancer of 16 kDa (GATE 16) and Light chain 3 II (LC3 II), as well as those of its upstream pathway proteins, AMP-activated protein kinase (AMPK), mammalian target of rapamycin (mTOR) and Beclin-1. All of those proteins were modulated by chebulagic acid treatment in a way of enhancing the autophagy. Additionally in our study, chebulagic acid also showed a protective effect against 1-methyl-4-phenylpyridinium ($MPP^+$) - induced cytotoxicity which mimics the pathological symptom of Parkinson's disease. This effect seems partially mediated by enhanced autophagy which increased the degradation of aggregated or misfolded proteins from cells. This study suggests that chebulagic acid is an attractive candidate as an autophagy-enhancing agent and therefore, it may provide a promising strategy to prevent or cure the diseases caused by accumulation of abnormal proteins including Parkinson's disease.

• Geophysics and Geophysical Exploration
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• v.3 no.2
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• pp.70-75
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• 2000

In the seismic migration, Kirchhoff and reverse time migration are used in general. In the reverse time migration using wave equation, two-way and one-way wave equation are applied. The approach of one-way wave equation uses approximately computed downward continuation extrapolator, it need tess amounts of calculations and core memory in compared to that of two-way wave equation. In this paper, we applied one-way wave equation to pre-stack reverse time migration. In the frequency-space domain, forward propagation of source wavefield and back propagration of measured wavefield were executed by using monochromatic one-way wave equation, and zero-lag cross correlation of two wavefield resulted in the image of subsurface. We had implemented prestack migration on a massively parallel processors (MPP) CRAYT3E, and knew the algorithm studied here is efficiently applied to the prestck migration due to its suitability for parallelization.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2013.10a
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• pp.346-349
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• 2013

This paper describes a triple-input energy harvesting circuit using solar, vibration and thermoelectric energy with MPPT(Maximum Power Point Tracking) control. The designed circuit employs MPPT control to harvest maximum power available from a solar cell, PZT vibration element and thermoelectric generator. The harvested energies are simultaneously combined and stored in a storage capacitor, and then managed and transferred into a sensor node by PMU(Power Management Unit). MPPT controls are implemented using the linear relation between the open-circuit voltage of an energy transducer and its MPP(Maximum Power Point) voltage. The proposed circuit is designed in a CMOS 0.18um technology and its functionality has been verified through extensive simulations. The designed chip occupies $945{\mu}m{\times}995{\mu}m$.

• Journal of Power Electronics
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• v.11 no.6
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• pp.870-879
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• 2011

Regulated peak power tracking (RPPT) systems such as the series structure and the series-parallel structures are commonly used in satellite space power systems. However, these structures process the solar array power or the battery power to the load through two cascaded regulators during one orbit cycle, which reduces the energy transfer efficiency. Also the battery charging time is increased due to placement of converter between the battery and the solar array. In this paper a parallel structure has been proposed which can improve the energy transfer efficiency and the battery charging time for satellite space power RPPT systems. An analogue controller is used to control all of the required functions, such as load voltage regulation and solar array stabilization with maximum power point tracking (MPPT). In order to compare the system efficiency and the battery charging efficiency of the proposed structure with those of a series (conventional) structure and a simplified series-parallel structure, simulations are performed and the results are analyzed using a loss analysis model. The proposed structure charges the battery more quickly when compared to the other two structures. Also the efficiency of the proposed structure has been improved under different modes of solar array operation when compared with the other two structures. To verify the system, experiments are carried out under different modes of solar array operation, including PPT charge, battery discharge, and eclipse and trickle charge.

• Korean Journal of Soil Science and Fertilizer
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• v.49 no.5
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• pp.429-433
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• 2016

Adsorption and precipitation of cadmium (Cd) could be dependent on rate of P addition and Cd level in soil. Therefore, the objective of this study was to examine how addition rate of P affect mechanisms of Cd immobilization such as adsorption and precipitation in different levels of Cd in soil. Arable soils were spiked with inorganic Cd ($CdCl_2$) to give a total Cd concentration of 10, 100, and $1,000mg\;Cd\;kg^{-1}$. Monopotassium phosphate ($KH_2PO_4$, MPP) was selected as phosphate material and mixed with the pretreated arable soil at the rates of 0, 800, 1,600 and $3,200mg\;P\;kg^{-1}$. The mixture soils were incubated at $25^{\circ}C$ for 8 weeks in dark condition. Soil pH decreased with increasing MPP addition rate in all levels of Cd but negative charge of soil increased, thereby reducing 1 M $NH_4OAc$ extractable Cd. Soil solutions were undersaturated with respect to $CdCO_3$ and $Cd_3(PO_4)_2$ with all P addition rate in soil with low Cd level (${\leq}100mg\;Cd\;kg^{-1}$) but supersaturated in soil with high Cd level ($1,000mg\;Cd\;kg^{-1}$). From the above results, Cd solubility was controlled by precipitation of Cd minerals such as $CdCO_3$ and $Cd_3(PO_4)_2$ in soil with high Cd level but by Cd adsorption induced by increase in negative charge of soil with low level of Cd.

• The Transactions of the Korean Institute of Power Electronics
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• v.16 no.5
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• pp.521-531
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• 2011

This paper presents the variable perturbation and observation(VPO) maximum power point tracking(MPPT) control of the photovoltaic(PV) system considering the shadow influence. The output characteristics of the solar cell is a nonlinear and affected by a temperature, the solar radiation and influence of a shadow. MPPT control is a very important technique in order to increase an output and efficiency of the solar power generation. Conventional perturbation and observation(PO) and incremental conductance(IC) are the method finding MPP by the continued self-excitation vibration. The MPPT control is unable to be performed by rapid output change affected by the shadow. To solve this problem, this paper proposes the VPO MPPT algorithm which changes step size according to output variation. The response characteristics of VPO MPPT algorithm proposed in this paper compares with response characteristics of conventional MPPT algorithm about the radiation, temperature and shadow influence. The validity of the algorithm proposed in this paper prove through the results of the comparisons.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2016.10a
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• pp.533-536
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• 2016

This paper describes a vibrational energy harvesting circuit with MPPT control. A high-performance AC-DC converter of which the efficiency is improved by using body-bias technique and bulk-driven technique is proposed and applied for the vibrational energy harvesting circuit design. MPPT (Maximum Power Point Tracking) control function is implemented using the linear relationship between the open-circuit voltage of a vibrational device and its MPP voltage. The designed MPPT control circuit traces the maximum power point by periodically sampling the open circuit voltage of a vibrational device, makes the reference voltages using sampled voltage and delivers the maximum available power to load. The proposed circuit is designed with a $0.35{\mu}m$ CMOS process, and the chip area is $1.21mm{\times}0.98mm$.

• Biomolecules & Therapeutics
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• v.29 no.6
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• pp.615-629
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• 2021

An active compound, triterpene saponin, astersaponin I (AKNS-2) was isolated from Aster koraiensis Nakai (AKNS) and the autophagy activation and neuroprotective effect was investigated on in vitro and in vivo Parkinson's disease (PD) models. The autophagy-regulating effect of AKNS-2 was monitored by analyzing the expression of autophagy-related protein markers in SH-SY5Y cells using Western blot and fluorescent protein quenching assays. The neuroprotection of AKNS-2 was tested by using a 1-methyl-4-phenyl-2,3-dihydropyridium ion (MPP⁺)-induced in vitro PD model in SH-SY5Y cells and an MPTP-induced in vivo PD model in mice. The compound-treated SH-SY5Y cells not only showed enhanced microtubule-associated protein 1A/1B-light chain 3-II (LC3-II) and decreased sequestosome 1 (p62) expression but also showed increased phosphorylated extracellular signal-regulated kinases (p-Erk), phosphorylated AMP-activated protein kinase (p-AMPK) and phosphorylated unc-51-like kinase (p-ULK) and decreased phosphorylated mammalian target of rapamycin (p-mTOR) expression. AKNS-2-activated autophagy could be inhibited by the Erk inhibitor U0126 and by AMPK siRNA. In the MPP⁺-induced in vitro PD model, AKNS-2 reversed the reduced cell viability and tyrosine hydroxylase (TH) levels and reduced the induced α-synuclein level. In an MPTP-induced in vivo PD model, AKNS-2 improved mice behavioral performance, and it restored dopamine synthesis and TH and α-synuclein expression in mouse brain tissues. Consistently, AKNS-2 also modulated the expressions of autophagy related markers in mouse brain tissue. Thus, AKNS-2 upregulates autophagy by activating the Erk/mTOR and AMPK/mTOR pathways. AKNS-2 exerts its neuroprotective effect through autophagy activation and may serve as a potential candidate for PD therapy.