• Title/Summary/Keyword: $LD_{50}$

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Sensory Characteristics of Doenjang with Added Licorice Powder as Assessed by Response Surface Methodology (반응표면분석법을 이용한 감초분말 첨가 된장의 관능적 특성)

  • Kim, Mi-Lim;Park, Eun-Jung;Jeong, Ji-Suk
    • Korean journal of food and cookery science
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    • v.26 no.1
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    • pp.62-71
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    • 2010
  • The followings describes the result of making doenjang with added licorice (Glycyrrhiza uralensis) powder. and investigating its sensory characteristics and physicochemical quality. General preference was high at 20% salinity and 2% licorice (LD204), and 16% salinity and 2% licorice (LD162). The moisture content was unchanged in the control group, while it was reduced in LD204 and LD162 in the first week of fermentation, but showed little change after then. pHs were all in the range 5.90~5.97 on day 0, but decreased from 5.90 to 5.72 in the control group in the fifth week. LD204 changed from 5.95 on day 0to 5.42 in the first week, and then it gradually increased again and became 5.93 in the fifth week, which was similar to that of day 0. LD162 was 5.97 on day 0 and showed cyclic slight increases and decreases in the first week. It increased to 6.32 in the fifth week, which was higher than that of day 0 that is, its pH was higher than that of LD204. The acidity showed a difference right after it was made. In the control group, lactic acid content gradually increased from 0.16% on day 0 to the highest, 0.59%, in the fourth week. It slightly decreased in the fifth week. LD204 slowly increased from 0.25% on day 0 to a maximum, 0.50%, in the fourth week. It also slightly decreased in the fifth week, quite similarly to that of the control group. LD162, gradually increased from 0.22% on day 0 to the highest, 0.49, in the third week, and decreased after the fourth week. Salinity was 29.5%, 22.0%, and 18% in each of the control group, LD204, and LD162 on day 0 but increased to 34.0%, 29.0%, and 26.0% in the fifth week. Soluble solid was $32^{\circ}Brix$, $28^{\circ}Brix$, and $26^{\circ}Brix$ in each of the control group, LD204, and LD162 on day 0, but slightly increased to $40^{\circ}Brix$, $32^{\circ}Brix$, and $30^{\circ}Brix$ on the fifth day. It is thought that because of the sweetness of licorice, the higher-salinity doenjang earned a higher sensory test score than that of traditional doenjang. If its salinity is lowered a little, it could be used as a sauce, even possibly having medical effects as well.

The Study of Luppe Smelting with Converting Dust and Slag (제강전로 더스트와 슬래그를 이용한 루페제련에 관한 연구)

  • 황용길;이상화;김재일;김연수
    • Resources Recycling
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    • v.7 no.2
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    • pp.39-45
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    • 1998
  • We smelted thc pellets made by mixing the distilled carbon from wlISte Lires, LD converter dust and slag with reduction process in the revcrberatory furnace. Thc obtained results are as follows 1) The removal mte of zinc appears above 97% after T reducing the pellets at $1300^{\circ}C$ for Ihr and the zinc content in the residue are 0.1~D.2%. 2) Under the mixing condition of 500 g LD dust. 150-200 g LD slag and 30-50 g distilled carbon of waste lires the removal raho of zinc shows above 95%, while t the 50-60% Fe remains in the residue. 3) After smelting at $1350^{\circ}C$ for 3hrs, the recovery ratio of pig iron reduced from lhe p pellets containing 15-20% LD slag and 4.1-7.2% distilled carbon of waste tires appears in the range of 89.3-92%. 4) Tbe c chemical composition of the recovered pig iron is 1.7%C, O.05%P, 0.05%S and balance Fe. 5) Tbe recovered dust from the d dust collcctor alter finishing the reduction rcaction appears as a crude zinc oxide conLaining 60% zinc.

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Studies on the Radiosensitivity and Mutation Induction of Tree Species in Korea (주요수종(主要樹種)의 방사선감수성(放射線感受性) 및 변이(變異)에 관(關)한 연구(硏究))

  • Kim, Chi Moon
    • Journal of Korean Society of Forest Science
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    • v.25 no.1
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    • pp.73-79
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    • 1975
  • The Koran native economic and ornamental trees consisting 12 species of 4 gymnosperm families and 3 strains, 6 varieties and 18 species of 12 angiosperm families were irradiated by X-and ${\gamma}$-ray at three different dose rates; 1) acute, 2) semi-acute, and 3) chronic irradiation in order to know their radiosensitivities and the radition effects on mutation induction. Different materials such as seeds, cuttings, scions and plants of the above trees were used in this study, depended upon tree. Most of the materials irradiated showed a high radiosensitivity. The LD-50 of conifer trees ranged from 1.2kR to 13.2kR, averaging 5.4kR which was remarkably higher than field crops. On the other hand the LD-50 dose of hard wood trees ranged from 7.0kR to 18.5kR, averaging 12.7kR. All the tested trees were classified into several categories based upon the relative radiosensitivity of each species which was measured at the dose of LD-50. Variegation was most common among the induced mutants. The other mutations were albino, chlorophyll deficiency, deformed leaf and fruits. It was noticeable that giant-leaf bud-sport mutants were induced in Chinese chestnut (Castanea bungeana) and yellow leaf bud-sport ones appeared in oriental arborvitae (Thuja orientalis).

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Effects of Sublethal Doses of Imidacloprid on the Brown Planthopper, Nilaparvata lugens $St{\aa}l$ (Homoptera: Delphacidae) (Imidacloprid의 아치사량이 벼멸구(Nilaparvata lugens $St{\aa}l$)의 생물적 특성에 미치는 영향)

  • Choi, Byung-Ryul;Lee, Si-Woo;Song, Yoo-Han;Han, Man-Jong;Yoo, Jai-Ki
    • The Korean Journal of Pesticide Science
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    • v.4 no.2
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    • pp.56-62
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    • 2000
  • Effects of sublethal dose of imidacloprid on biological characteristics, such as longevity, fecundity and excretions from brown planthopper (BPH) and its repellency to imidacloprid were examined. Topical application of imidacloprid to BPH at the dose of $LD_{10}$ and $LD_{30}$ (These values were determined at 48 hours after topical application of imidacloprid) was remarkably increased the mortality from 3 days after application and showed over 90% mortality on 4 days after application. Topical application of imidacloprid at dose of $LD_{10}$ (16 days) showed no difference compared to the control (16.9 days) in the longevity, while application of $LD_{30}$ was reduced the longevity of BPH to 13.5 days. Application of sublethal dose of imidacloprid to BPH adults reduced the number of eggs laid per day and for adult stage, and the hatchability of their eggs. By root zone application at the dose of $LC_{30}$, 50% longevity and 40% fecundity was reduced respectively, but showed no effect on number of eggs laid per day. The day on which BPH laid 50 % of eggs in number were 7.6 days at the $LC_{10}$ and 5.9 days the of $LC_{30}$ respectively. Hatchabilities of the groups treated with imidacloprid were lower than that of the control. Topical application to BPH at the dose of $LD_{10}$ did not reduce the amount of excretes, but application at the dose of $LD_{30}$ was reduced 26.5% of excretion compared to the control. Leaf dipping into the solution of concentration of $LC_{10}$ and $LC_{30}$ was reduced 96.4% and 98.0% of excretion, respectively. And root zone treatment at the concentration of $LC_{10}$ and $LC_{30}$ reduced 79.5% and 96.6% of excretion, respectively. Repellency rates of BPH to imidacloprid were 20% regardless of the dose of application.

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A Study on the Use of LD Clause against the Seller's Breach of Delivery of Goods in the Contract for the International Sale of Goods (국제물품매매계약에서 매도인의 물품인도의무 위반에 대비한 손해배상액의 예정조항 (Liquidated Damage Clause: LD조항)의 활용에 관한 연구 - ICC Model International Sale Contract를 중심으로)

  • Oh, Won-Suk;Youn, Young-MI;Li, Jing Hua
    • THE INTERNATIONAL COMMERCE & LAW REVIEW
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    • v.50
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    • pp.3-25
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    • 2011
  • The purpose of this paper is to examine the use of LD Clause against the seller's breach of contract in connection with delivering the goods in the international sales contract, and international guarantee system using standby L/C or demand guarantee. For this purpose, the author, first, considered the outline of the buyer's remedies in cases that the seller had not performed his obligations in contract and the difficulties in the buyer's remedies. As alternatives for overcoming the difficulties, this author recommended the LD Clauses (Liquidated Damage Clauses) based on ICC Model International Sales Contract, and explained each Model Clause. To enhance the feasibility of LD Clause, this author suggested the guarantee system, like the standby L/C or demand guarantee. But these guarantee systems have several limitations in practical use. Thus, these guarantee systems would greatly contribute to Korean exportation in the future. The reason is that the Korean export structure would be more complex and the period of sales contract would be longer and longer, which result to in long-terms supply contracts. These changes would require the guarantee much urgently.

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The output characteristics of Ti:Sapphire laser pumped by dense plasma light (고밀도 플라즈마 광에 의한 Ti:SAPPHIRE 레이저의 동작)

  • 허서구;양호근;김명환;손연규;윤지홍
    • Korean Journal of Optics and Photonics
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    • v.10 no.2
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    • pp.157-161
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    • 1999
  • A Ti:Sapphire laser pumped by the HCP has been designed and fabricated to study the optimal pumping conditions for lasing. The fluorescence energy converter LD-490 has been used. The result showed that the threshold energy of Ti:Sapphire laser is 1.39 KJ and the best efficiency is $7.13{\times}10^{-3}$% at the concentration $1.0{times}10^{-3}$ Mol/l of LD-490 dye. However, the efficiencies were decreased with the decrease of dye concentrations. The maximum output energy was obtained at 50 Torr Ar pressure, when the input voltage was 15 kV. As a convert dye, BBQ, was added to LD-490 with the rate of 1:1, the output energy was increased, whereas the thereshold energy was decreased as 1.17 kJ.

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A Study on Antibacterial Effects of Ascorbic Acid against Mycobacterium tuberculosis (Ascorbic acid의 항결핵균 작용에 관한 연구)

  • Kim, Jae-Oh;Ho, Soon-Tae;Kim, Chan-Soo
    • The Journal of the Korean Society for Microbiology
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    • v.20 no.1
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    • pp.65-72
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    • 1985
  • Vitamin C is known as an integral element for the formation and maintenance of intercellular supporting structures. Ascorbic acid has been used for the treatment of certain poisonings and hypovitaminosis(scurvy) but also known as a powerful reducing agent, and can kill a variety of bacteria and detoxify bacterial exotoxins including various clostridial exotoxins in vitro. For viruses, vitamin C inactivates herpes virus, vaccinia virus and influenza virus and has been used for the prevention and treatment of the common cold. Thus ascorbic acid plays an important role in antimicrobial action. Scurvy also promotes the development of tubercles in experimentally infected guinea pig and the tuberculosis patients require more vitamin C than normal persons. However there is no reports that ascorbic acid could inhibit the growh of M. tuberculosis. In this paper, antibacterial effects of ascorbic acid against M. tuberculosis were studied. The results are as follows: 1. The single use of the ascorbic acid exhibited antibacterial effect in vitro against $5{\times}10^3/ml$ of M. tuberculosis $H_{37}$ Rv at the concentration of ascorbic acid 0.625mg/ml over 3 hours exposure and 0.05mg/ml over 9 hours exposure. 2. In vivo mice administered with ascorbic acid 50mg/day for 5, 10 and 15 days respectively were protected from M. tuberculosis $2LD_{50}$, $3LD_{50}$, $4LD_{50}$ and $5LD_{50}$ given intravenously.

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Change of Serum Steroid Level in the Whole-body Irradiated Rat (방사선 처리를 받은 흰쥐의 혈청내 스테로이드호르몬의 변화)

  • Shin, Jang-Sik;Lee, Young-Keun;Kim, Moon-Kyoo;Yoon, Yong-Dal
    • Clinical and Experimental Reproductive Medicine
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    • v.21 no.3
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    • pp.297-303
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    • 1994
  • The effect of radiation on the steroidogenesis of rat ovary was investigated. For this purpose, female rats aged 7-8 weeks were exposed to a single dose of ${\gamma}$ radiation(320 rad or 800 rad) by the cobalt-60. At fourth(day of the first estrus) and eighth(day of the second estrus) days after irradiation, the concentrations of serum steroid hormones were determined by radioimmunoassays (RIA). The correlation between survival rate(Y) and radiation dose(X) was Y=-0.06X+100(r=0.89, n=10). Lethal dose$(LD)_{50(30)}$ and $LD_{20(30)}$ were 833.33rad and 333.33rad respectively. The weights of body and ovary was decreased significantly by the $LD_{50(30)}$ irradiation during the 4 days, but both weights were recovered at day 8. The serum levels of 17a-hydroxyprogesterone(170HP) and estradiol($E_2$) in the irradiated rats were not generally different from those of control. However, the levels of testosterone(T) and 19-norterstosterone(19NT) in the irradiated rat at $LD_{50(30)}$ and $LD_{20(30)}$ radiation doses were decreased, while progesterone levels in serum of the irradiated rats were slightly increased. These results suggest that irradiation may inhibit the first step of steroidogenesis, especially the conversion of P to T, in the rat ovary.

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Acute Oral Toxicity of G. bimaculatus in Rats (랫드에 대한 G. bimaculatus의 급성경구독성시험)

  • 김인선;안미영;류강선;이병무
    • Toxicological Research
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    • v.18 no.4
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    • pp.397-400
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    • 2002
  • This study was carried out to investigate the acute toxicity of G. bimaculatus in Sprague-Dawley rats. G. bimaculatus was administered orally at doses of 8, 40, 200, 1000 and 5000 mg/kg. in this study, number of deaths, clinical sign, body weights, and pathological examination were investigated for 14 days after administration of G. bimaculatus. The results indicate that G. bimaculatus did not show any toxic effect in rats and oral $LD_{50}$ value was over 5000 mg/kg in Sprague-Dawley rats.

Sci-B-Vac의 급성독성에 관한 연구

  • 이영순;강경선;서광원;남기환;조재진
    • Toxicological Research
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    • v.9 no.2
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    • pp.225-232
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    • 1993
  • SCi-B-Vac, the 3rd hepatitis B vaccine , was selected for clinical evaluation on the basis of toxicologic profiles in preclinical studies. These studies were performed to obtain information on its toxic signs, organs which are mainly affected, and to estimate its lethality in mice and rats given Sci-B-Vac through two routes of administratin. In male and female rats given a single intragastrical dose of Sci-B-Vac, we estimated that $LD_{50}$ values were over 2.00 ml/100g B.W. (10ng/ml), respectively.

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