Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
권호 표지

Sci-B-Vac의 급성독성에 관한 연구

  • 이영순 (서울대학교 수의과대학 공중보건학 교실) ;
  • 강경선 (서울대학교 수의과대학 공중보건학 교실) ;
  • 서광원 (서울대학교 수의과대학 공중보건학 교실) ;
  • 남기환 (서울대학교 수의과대학 공중보건학 교실) ;
  • 조재진 (서울대학교 수의과대학 공중보건학 교실)
  • Published : 1993.12.01
Download PDF
⟨ Previous Next ⟩

Abstract

SCi-B-Vac, the 3rd hepatitis B vaccine , was selected for clinical evaluation on the basis of toxicologic profiles in preclinical studies. These studies were performed to obtain information on its toxic signs, organs which are mainly affected, and to estimate its lethality in mice and rats given Sci-B-Vac through two routes of administratin. In male and female rats given a single intragastrical dose of Sci-B-Vac, we estimated that $LD_{50}$ values were over 2.00 ml/100g B.W. (10ng/ml), respectively.

Keywords

References

  1. 한국독성학회지 v.8 랫드와 마우스에서 cis-Malonato[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane]platinum(Ⅱ) (SKI 2053R)의 급성독성에 관한 연구 강경선;신동진;조재진;김형욱;김배환;이영순
  2. 랫드와 마우스에서 유전자재조합 돼지성장홀몬의 급성독성에 관한 연구 v.8 강경선;신동진;김형욱;조재진;서광원;이영순
  3. 국립보건안전 연구원 예규 제10호 "의약품 등의 독성시험 기준" 국립보건안전연구원
  4. J. Virol. v.558 Hepatitis delta virus:protein composition of delta antigen and its hepatitis B virus-derived envelope Bonino,F.;Heermann,K.H.;Rizzetto,M.;Gerlich,W.H.
  5. Microb Pathog v.12 Recent developments in the molecular cloning and characterization of hepatitis C and E virus Bradley,D.W.;Beach,M.J.;Purdy,M.A.
  6. Science v.256 Researchers fret over neglect of 600million patients Gibbons,A.
  7. J. Infect. Dis. v.164 An epidemic of hepatitis A attributable to the ingestion of raw clams in Shanhai,China Halliday,M.L.;Kang,L.Y.;Zhou,T.K.(et al.)
  8. JID v.168 Prevention of acute and chronic liver disease through immunization:Hepatitis B and beyond Harold,S.M.
  9. Protecting the world's children:vaccines and immunization, a symposium Providing immunization:the state-of-art Henderson,R.H.
  10. Hepatitis frontiers A water-borne ruban epidemic of hepatitis Melnick,F.L.;Hartmen,F.W.(ed.);LoGrippo,G.A.(ed.);Matffer,J.G.(ed.);Barron,J.(ed.)
  11. JAVMA v.266 The measles epidemic. The problems. barriers and recommendations National Vaccine Advisory Committee
  12. Viral hepatitis and liver disease Hepatitis A virus and the molecular biology of picornaviruses:a case for a new genus of the family Picornaviridae Wimmer,E.;Muridn,A.D.;Hollinger,F.B.(ed.);Lemon,S.M.(ed.);Margolis,H.S.(ed.)