• 한국식품저장유통학회지
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• 제19권2호
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• pp.201-208
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• 2012

본 연구는 엄나무와 참죽 햇순의 blanching 조건을 제시하기 위해 blanching 온도와 식염의 농도에 따른 품질 변화와 관능적 특성을 평가하였다. 또한 해동방법에 따른 이화학적 및 관능적 특성을 평가하여 엄나무와 참죽 햇순의 품질을 향상시킬 수 있는 해동방법을 제시하고자 하였다. 엄나무와 참죽 햇순은 식염 첨가량(무첨가, 1%, 2%)과 blanching 시간(3분, 6분)을 달리하여 blanching하였으며, 해동은 저온($4^{\circ}C$), 상온($25^{\circ}C$), microwave를 이용하였다. Blanching 조건에 따른 색도, chlorophyll 함량, texture 측정 및 관능검사를 실시한 결과, 엄나무와 참죽 햇순은 $95^{\circ}C$, 식염 첨가 없이 3분간 blanching한 경우 품질 변화와 기호도가 가장 높게 나타났다. 해동방법에 따른 품질 특성을 평가한 결과 엄나무 햇순의 경우 상온 및 microwave 해동 시, 참죽 햇순의 경우 색도는 저온에서, texture는 상온해동에서 품질이 높게 평가되었으며, 해동방법에 따른 엄나무와 참죽 햇순의 기호도는 모두 microwave로 해동 시 가장 높게 평가되었다.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 1998년도 천연항암자원개발에 관한 국제학술회의 논문집 및 1998년도 한국자원식물학회 정기학술발표회 논문요약
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• pp.89-109
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• 1998

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.255.3-256
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• 2002

In the previous studies. we confirmed the anti-inflammatory components of Kalopanax pictus bark using activity-guided fractionation in vivo. For the elucidation of anti-inflammatory mechanism, we evaluated the effects of these components on the inhibition of NF-$\sub$K/B activity and human leukocyte elastase. A cell-based assay system developed in our laboratory was used in transfectant RAW 264.7 cells. (omitted)

• Archives of Pharmacal Research
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• 제21권1호
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• pp.24-29
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• 1998

To search for the anti-diabetic principle from the stem bark of Kalopanax pictus, seven kinds of chemical constituents including hederagenin glycosides and phenolic glycosides wre isolated. The anti-diabetic evaluation of these isoltes in the streptozotocin-induced diabetic rats exhibited that kalopanaxsaponin A has a potent anti-diabetic activity in contrast to a mild activity of hederagenin. In addition, significant hypocholesterolemic and hypolipidemic activities of kalopanaxsaponin A and hederagenin were observed. The structure-activity relationship of kalopanaxsaponin A was also investigated in the present work.

• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2008년도 추계학술발표회
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• pp.404-405
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• 2008

• Bulletin of the Korean Chemical Society
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• 제32권11호
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• pp.4049-4054
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• 2011

A new compound, kalopanaxin F (3), and 11 known compounds (1, 2, 4-12), were isolated from the stem bark of Kalopanax pictus. Their structures were elucidated on the basis of chemical and spectroscopic methods. Five of the compounds (2, 3, 5, 6, and 12) significantly inhibited $TNF{\alpha}$-induced NF-${\kappa}B$ transcriptional activity in HepG2 cells in a dose-dependent manner, with $IC_{50}$ values ranging from 6.2 to 9.1 ${\mu}M$. Furthermore, the transcriptional inhibitory function of these compounds was confirmed based on decreases in COX-2 and iNOS gene expression in HepG2 cells. Compounds 3-7, 9, and 12 significantly activated the transcriptional activity of PPARs dose-dependently, with $EC_{50}$ values ranging from 4.1-$12.7{\mu}M$. Compounds 4 and 5 exhibited $PPAR{\alpha}$, $PPAR{\gamma}$, and $PPAR{\beta}({\delta})$ transactivational activities in a dose-dependent manner, with $EC_{50}$ values of 16.0 and 17.0, 8.7 and 16.5, 26.2 and 26.3 ${\mu}M$, respectively.

• 한국식품저장유통학회지
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• 제11권3호
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• pp.299-303
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• 2004

음나무 껍질을 추출한 추출물에 대하여 농축 및 당첨가에대한 변화를 살펴보았다. Glucose 첨가 추출물은 첨가하지 않은 추출물보다 pH가 낮게 나타났으나 저장기간이 경과함에 따라증가하였다. 색도의 경우 당도 및 glucose 첨가량이 높아질수록 명도 및 황색도는 낮아지는 경향을 나타내었으며 전반적으로 저장기간이 길어지면서 다소 감소하는 경향을 보였다. 총산에 있어서는 다소 낮은 유기산 함량을 나타내었으며 저장기간에 따른 큰 변화는 보이지 않았다. 미생물은 2 $^{\circ}$Brix에서 생육이 저해되었으며 Glucose를 첨가한 경우도 1$\%$ 이상에서는 미생물이 검출되지 않았다. 음나무 껍질 1 $^{\circ}$Brix 이상의 농축물은 냉장보관으로 저장성이 있는 것으로 나타났다.

• 동의생리병리학회지
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• 제18권4호
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• pp.1129-1133
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• 2004

For the purpose of developing new anti-HIV agents from natural sources, the extracts of Kalopanax pictus were tested for their inhibitory effects on HIV-1 replication and its essential enzymes as the reverse transcriptase (RT). protease and α-glucosidase. In the assay of HIV-1-infected human T-cell line, water extracts of stem and leafstalk inhibited the HIV-1-induced cytopathic effects with Ie (inhibitory concentration) of 25 and 50㎍/㎖, respectively. Moreover water extracts (100㎍/㎖) of stem and leafstalk showed strong activity of 80% and 90% on anti-HIV-1 RT using Enzyme Linked Oligonucleotide Sorbent Assay (ELOSA) method. In the HIV-1 protease inhibition assay, aqueous stem extract inhibited the activity of the enzyme to cleave an oligopeptide, resembling one of the cleavage sites in the viral polyprotein which can only be processed by HIV-1 protease with 58%, but no glucosidase inhibitory activities. We found out this result, for these samples it is possible that the inhibition of the viral replication in vitro is due to the inhibition at least one of RT and protease. It would be of great interest to identify the compounds which are responsible for this inhibition, since all therapeutically useful agent up to date are RT, PR and α-glucosidase inhibitors.

• 한국식품영양과학회지
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• 제41권12호
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• pp.1686-1692
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• 2012

개두릅 추출물의 항산화 활성을 증가시킬 수 있는 적정추출방법을 개발하기 위하여 상온교반, 초음파, 감압, 환류냉각, 환류냉각과 초음파 병행 추출법을 이용하여 추출한개두룹 추출물의 항산화 활성을 비교하였다. 추출수율은 환류냉각과 초음파 병행 추출물에서 높게 나타났다. 총 폴리페놀 및 총 플라보노이드의 함량 또한 환류냉각과 초음파 병행추출물이 각각 153.43 mg GAE/g, 62.53 mg RE/g으로 높았으며, 모든 추출물은 항산화 실험에서 농도 증가에 비례하여 활성이 증가하였다. 환류냉각과 초음파 병행 추출물은 추출농도 1,000 ${\mu}g/mL$에서 DPPH와 ABTS 라디칼 소거능(90.85%, 99.83%), 환원력(OD 0.95, 700 nm), 아질산염 소거능(55.46%), ferrous ion chelating 효과(45.12%)가 우수하거나 유사하였다.

• Journal of the Korean Wood Science and Technology
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• 제20권4호
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• pp.73-84
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• 1992

It was observed that the hot-water extract of the bark of Kalopanax pictus N. had the highest anti-complementary activity among the 11 kinds of forest materials. Methanol-and ethanol-soluble portions had low anti-complementary activities, but crude polysaccharide. HKP-0 had a high activity of 80%. HKP-0 contained 54.8% of total sugar and 27.9% of protein. The neutral sugars of HKP-0 consisted of mainly arabinose, galactose and glucose. HKP-4 fraction obtained by cetavlon treatment of HKP-0 showed the highest anti-complementary activity of 90%. The activity was not changed by pronase digestion bu decreased greatly by periodate oxidation. HKP-4 consisted of mainly arabinose and glucose with molar ratio of 1.0 : 22.4, HKP-4-I, an unabsorbed fraction from HKP-4 on DEAE Sepharose CL-6B column showed higher yield and activity than those of absorbed fractions. HKP-4-I was homogeneous, and its molecular weight was about 25,000. HKP-4-I contained 84.0% of neutral sugar and consisted of arabinose and glucose with molar ratio of 1.0 : 11.2. The anti-complementary activity of HKP-4-I was not decreased by the treatment of polymyxin B, and the polysaccharide activated both classical and alternative pathway in complement system. Void volume fraction obtained from HKP-4-I hydrolyzed with ${\alpha}$-amylase on Sephadex G-25 column only had a high anti-complementary activity.