Archives of Pharmacal Research
- Volume 21 Issue 1
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- Pages.24-29
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- 1998
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
A Potent Anti-diabetic Agent from Kalopanax pictus
-
Park, Hee-Juhn
(Department of Botanical Resources, Sangji University)
;
-
Kim, Dong-Hyun
(College of Pharmacy, Kyung-Hee University)
;
-
Choi, Jong-Won
(College of Pharmacy, Kyungsung University)
;
-
Park, Jong-Hee
(College of Pharmacy, Pusan National University)
;
- Han, Yong-Nam (Natural Products Research Institute, Seoul National University)
- Published : 1998.02.01
Abstract
To search for the anti-diabetic principle from the stem bark of Kalopanax pictus, seven kinds of chemical constituents including hederagenin glycosides and phenolic glycosides wre isolated. The anti-diabetic evaluation of these isoltes in the streptozotocin-induced diabetic rats exhibited that kalopanaxsaponin A has a potent anti-diabetic activity in contrast to a mild activity of hederagenin. In addition, significant hypocholesterolemic and hypolipidemic activities of kalopanaxsaponin A and hederagenin were observed. The structure-activity relationship of kalopanaxsaponin A was also investigated in the present work.