• Biomolecules & Therapeutics
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• v.15 no.2
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• pp.108-117
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• 2007

The aim of the present study was to investigate the effect of glibenclamide, a hypoglycemic sulfonylurea, which selectively blocks ATP-sensitive K$^+$ channels, on secretion of catecholamines (CA) evoked by cholinergic stimulation and membrane depolarization from the isolated perfused rat adrenal glands. The perfusion of glibenclamide (1.0 mM) into an adrenal vein for 90 min produced time-dependently enhanced the CA secretory responses evoked by ACh (5.32 mM), high K$^+$ (a direct membrane depolarizer, 56 mM), DMPP (a selective neuronal nicotinic receptor agonist, 100 ${\mu}$M for 2 min), McN-A-343 (a selective muscarinic M1 receptor agonist, 100 ${\mu}$M for 2 min), Bay-K-8644 (an activator of L-type dihydropyridine Ca$^{2+}$ channels, 10 ${\mu}$M for 4 min) and cyclopiazonic acid (an activator of cytoplasmic Ca$^{2+}$-ATPase, 10 ${\mu}$M for 4 min). In adrenal glands simultaneously preloaded with glibenclamide (1.0 mM) and nicorandil (a selective opener of ATP-sensitive K$^+$ channels, 1.0 mM), the CA secretory responses evoked by ACh, high potassium, DMPP, McN-A-343, Bay-K-8644 and cyclopiazonic acid were recovered to the considerable extent of the control release in comparison with that of glibenclamide-treatment only. Taken together, the present study demonstrates that glibenclamide enhances the adrenal CA secretion in response to stimulation of cholinergic (both nicotinic and muscarinic) receptors as well as by membrane depolarization from the isolated perfused rat adrenal glands. It seems that this facilitatory effect of glibenclamide may be mediated by enhancement of both Ca$^{2+}$ influx and the Ca$^{2+}$ release from intracellular store through the blockade of K$_{ATP}$ channels in the rat adrenomedullary chromaffin cells. These results suggest that glibenclamide-sensitive K$_{ATP}$ channels may play a regulatory role in the rat adrenomedullary CA secretion.

• Journal of Institute of Control, Robotics and Systems
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• v.19 no.6
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• pp.527-533
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• 2013

BCI (Brain-Computer Interface) is a system that transforms a subject's brain signal related to their intention into a control signal by classifying EEG (electroencephalograph) signals obtained during the imagination of movement of a subject's limbs. The BCI system allows us to control machines such as robot arms or wheelchairs only by imaging limbs. With the exact same experiment environment, activated brain regions of each subjects are totally different. In that case, a simple approach is to use as many channels as possible when measuring brain signals. However the problem is that using many channels also causes other problems. When applying a CSP (Common Spatial Pattern), which is an EEG extraction method, many channels cause an overfitting problem, and in addition there is difficulty using this technique for medical analysis. To overcome these problems, we suggest an optimal channel selection method using a BPSO (Binary Particle Swarm Optimization), BPSO with channel impact factor, and GA. This paper examined optimal selected channels among all channels using three optimization methods and compared the classification accuracy and the number of selected channels between BPSO, BPSO with channel impact factor, and GA by SVM (Support Vector Machine). The result showed that BPSO with channel impact factor selected 2 fewer channels and even improved accuracy by 10.17~11.34% compared with BPSO and GA.

• JSTS:Journal of Semiconductor Technology and Science
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• v.1 no.1
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• pp.50-69
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• 2001

Three kinds of high-speed signaling methods for synchronous DRAM (SDRAM) bus interface channels (PC-133, Direct-Rambus, and SSTL-2) were analyzed in terms of the timing budget and the physical transmission characteristics. To analyze the SDRAM bus interface channels, loss mechanisms and the effective characteristic impedance method were reviewed and the ABCD matrix method was proposed as an analytic and yet accurate method. SPICE simulations were done to get the AC responses and the eye patterns of the three SDRAM bus interface channels for performance comparisons. Recent progress and future trend for SDRAM bus interface standards were reviewed.

• Journal of Fisheries and Marine Sciences Education
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• v.26 no.5
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• pp.1090-1095
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• 2014

The experimental and numerical studies of the single-phase flow pressure drop in parallel micro-channels were performed. The parallel micro-channels consisted of 15 channels with depth 0.2mm, width 0.45mm and length 60mm. The FC-72 was used as the working fluid and the mass fluxes ranged from 62.8 to $1371.6kg/m^2s$. The numerical analysis was performed iterative calculations to solve governing equations and finds the appropriate value. The experimental data was compared with the numerical data, the results showed good agreement with the numerical data.

• Proceedings of the KACD Conference
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• 2001.11a
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• pp.581.1-581
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• 2001

Trigeminal nerve functions movement and sensation on orofacial region. Therefore, it is very important in dental clinic. Neurons with their cell bodies in trigeminal ganglion of trigeminal nerve root are primary sensory neurons and playa role of tactile sense, pressure, vibration and pain of orofacial area. Transmission of these senses depends on ion channels, we know that trigeminal ganglion neuron exists many kind of ion channels. Methods of definition on ion channel are several, but in this study we use immunostaining for detection of ion channels.(omitted)

• BMB Reports
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• v.46 no.6
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• pp.295-304
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• 2013

Extracellular acidification occurs not only in pathological conditions such as inflammation and brain ischemia, but also in normal physiological conditions such as synaptic transmission. Acid-sensing ion channels (ASICs) can detect a broad range of physiological pH changes during pathological and synaptic cellular activities. ASICs are voltage-independent, proton-gated cation channels widely expressed throughout the central and peripheral nervous system. Activation of ASICs is involved in pain perception, synaptic plasticity, learning and memory, fear, ischemic neuronal injury, seizure termination, neuronal degeneration, and mechanosensation. Therefore, ASICs emerge as potential therapeutic targets for manipulating pain and neurological diseases. The activity of these channels can be regulated by many factors such as lactate, $Zn^{2+}$, and Phe-Met-Arg-Phe amide (FMRFamide)-like neuropeptides by interacting with the channel's large extracellular loop. ASICs are also modulated by G protein-coupled receptors such as CB1 cannabinoid receptors and 5-$HT_2$. This review focuses on the physiological roles of ASICs and the molecular mechanisms by which these channels are regulated.

• Journal of Fashion Business
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• v.5 no.4
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• pp.37-55
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• 2001

This study put its major concern in consumer behavior during a purchase of fashion products through the Internet marketing channels. Therefore, it investigated the Internet shopping and tried to find the reasons why clothes shopping through the Internet marketing channels is not popular enough. Then, alternative marketing strategies would be suggested which is accessible from the relationship marketing approach. The study adopted a qualitative research method to implement those purposes. In-depth interviews were conducted with the interviewees who had an experience of buying a fashion merchandise through the Internet or who had such an intention. And the information on stages of decision-making process and actual purchase was obtained by participating in and observing the process. The results revealed stages of decision-making in purchasing a fashion product through the Internet channels, the process of relationship development, and the elements of relationship marketing which affect purchase intention. The elements of relationship marketing to promote a purchase of a clothing product via the Internet marketing channels included convenience; communication and socal experience; sensual information; risk acknowledgement and pursuit for safety; and usage of complexed marketing channels. Based on these, a few strategic points such as remote reality, database of communication basis, strengthening individualized services, and development of complex marketing channels were suggested.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.29 no.4
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• pp.100-106
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• 2006

We analyze a voice/data integrated traffic model of the cellular mobile communication system with hybrid guard channels for voice and handoff calls. In a multi-service integrated wireless environment, quality of service guarantee is crucial for smooth transportation of real time information. Real time voice traffic requires a guaranteed upper bounded on both delay and packet error rate, whereas data traffic does not. Voice traffic has high transmission priority over data packets. Thus one of the important problems is the design of admission control schemes which can efficiently accommodate the differential quality of service requirements. In this paper, a hybrid guard channel scheme is considered in which arriving calls are assigned channels as long as the number of busy channels in the cell is below a predetermined first threshold. When the number of busy channels reaches the first threshold, new originating data calls are queued in the infinite data buffer. Then reaches second threshold, only handoff calls are assigned the remaining channels and new originating voice calls are blocked. We evaluate the system by a two-dimensional Markov chain approach and generating function method and obtain performance measures included blocking probability and forced termination probability.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.13 no.11
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• pp.5410-5426
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• 2019

With the advent of the fifth-generation (5G) era, Massive multiple-input multiple-output (MIMO) relay systems have experienced the rapid development. Recently, the performance analysis models of Massive MIMO relay systems have been proposed, which are mostly based on Rayleigh fading channels. In order to create a more suitable model for 5G Internet of Things scenarios, our study is based on the Rician fading channels, where line-of-sight (LOS) path exists in the channels. In this paper, we assume the channel state information (CSI) is perfect. In this case, we use statistical information to derive the analytical exact closed-form expression for the achievable sum rate of the uplink for the Massive MIMO two-hop relay system over Rician fading channels. Moreover, considering the different communication scenarios, we derive the analytical exact closed-form expression for the achievable sum rates of the uplink for other three scenarios. Finally, based on these expressions, we make simulations and analyze the performance under different transmit powers and Rician-factors, which provides a theoretical basis and reference for further research.

• Proceedings of the Ginseng society Conference
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• 1998.06a
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• pp.182-189
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• 1998

Administration of ginsenosides, a mixture of saponin extracted from Panax ginseng, decreased blood pressure in rat. Previous studies have shown that ginsenosides caused endothelium-dependent relaxation, which was associated with the formation of cyclic GMP, suggested that ginsenosides caused release of nitric oxide (NO) from the vascular endothelium. The aim of the present study was to characterize the endothelium-independent relaxation to ginsenosides in the isolated rat aorta. Ginsenosides caused a concentration-dependent relaxation of rat aortic rings without endothelium constricted with 25 mM KCI but affected only minimally those constricted with 60 mM KCI. Ginsenoside Rg3 (Rg3) was a more potent vasorelaxing agonist than total ginsenoside mixture and also the ginsenoside PPT and PPD groups. Relaxation to ginsenosides were markedly reduced by TEA, but not by glibenclamide. Rg3 significantly inhibited Cal'-induced concentration-contraction curves and the "50a2'influx in aortic rings incubated in 25 mM KCI whereas those responses were not affected in 60 mM KCI. Rg3 caused efflux of $"Rb in aortic rings that was inhibited by tetraethy- lammonium (TEA), an inhibitor of Ca"-dependent K'channels, but not by glibenclamide, an inhibitor of AfP-dependent K'channels. These findings indicate that ginsenosides may induce vasorelaxation via activation of Ca2'-dependent K'channels resulting in hyperpolarization of the vas- cular smooth muscle with subsequent inhibition of the opening of voltage-dependent Caf'channels. These effects could contribute to explain the red ginseng-associated vasodilation and the beneficial effect on the cardiovascular system.