• Title/Summary/Keyword: $K^{+}$ channels

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Pressure and Flow Distribution in the Inlet Plenum of a Pebble Bed Modular Reactor (PBMR)

  • Ahmad, Imteyaz;Kim, Kwang-Yong
    • 유체기계공업학회:학술대회논문집
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    • 2005.12a
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    • pp.244-249
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    • 2005
  • Flow distribution and pressure drop analysis for an inlet plenum of a Pebble Bed Modular Reactor (PBMR) have been performed using Computational Fluid Dynamics. Three-dimensional Navier-Stokes equations have been solved in conjunction with $k-{\epsilon}$ model as a turbulence closure. Non-uniformity in flow distribution is assessed for the reference case and parametric studies have been performed for rising channels diameter, Reynolds number and angle between the inlet ports. Also, two different shapes of the inlet plenum namely, rectangular shape and oval shape, have been analysed. The relative flow mal-distribution parameter shows that the flow distribution in the rising channels for the reference case is strongly non-uniform. As the rising channels diameter decreases, the uniformity in the flow distribution as well as the pressure drop inside the inlet plenum increases. Reynolds number is found to have no effect on the flow distribution in the rising channels for both the shapes of the inlet plenum. The increase in angle between the inlet ports makes the flow distribution in the rising channels more uniform.

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Sympathetic and parasympathetic regulation of sodium transporters and water channels in rat submandibular gland

  • Jung, Hyun;Ryu, Sun-Youl
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.32 no.1
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    • pp.1-7
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    • 2006
  • The present study was aimed to explore the role of sympathetic and parasympathetic nerves in the regulation of sodium transporters and water channels in the salivary gland. Rats were denervated of their sympathetic and parasympathetic nerves to the submandibular gland, and the glandular expression of sodium transporters and water channels was determined by Western blot analysis. The expression of either ${\alpha}1$ or ${\beta}1$ subunit of Na, K-ATPase was not significantly affected either by the sympathetic or by the parasympathetic denervation. The expression of subunits of epithelial sodium channels was significantly increased both in the denervated and contralateral glands either by the sympathetic or by the parasympathetic denervation. Neither the sympathetic nor the parasympathetic denervation significantly altered the expression of aquaporin-1 (AQP1). Nor was the expression of AQP4 affected significantly by the parasympathetic or the sympathetic denervation. On the contrary, the expression of AQP5 was significantly increased not only by the parasympathetic but also by the sympathetic denervation. These results suggest that sympathetic and parasympathetic nerves have tonic regulatory effects on the regulation of certain sodium transporters and AQP water channels in the salivary gland.

Large Eddy Simulation of Heat Transfer Performance Enhancement due to Unsteady Flow in Compound Channels (복합 부수로의 비정상 유동이 유발하는 난류열전달 증진에 대한 LES 해석)

  • Hong, Seong-Ho;Shin, Jong-Keun;Choi, Young-Don
    • Korean Journal of Air-Conditioning and Refrigeration Engineering
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    • v.23 no.2
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    • pp.132-138
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    • 2011
  • In the present article, we investigate numerically turbulent flow of air through compound rectangular channels. Large eddy simulation(LES) is employed for unsteady turbulence modeling. LES gives better predictions for the axial mean velocity distribution than those of other turbulent models. Strong large-scale quasi-periodic flow oscillations are observed in most of the geometries investigated. Such large-scale flow oscillations in compound rectangular channels are similar to the quasi-periodic flow pulsation through the gaps between fuel rod bundle in nuclear reactor. It exists in any longitudinal connecting gap between two flow channels. The frequency of this flow oscillation is determined by the geometry of the gap. The large scale cross motions through the rectangular compound channels induce significant heat transfer enhancement of the compound channel flow.

Properties and Performance of Space-Time Bit-Interleaved Coded Modulation Systems in Fast Rayleigh Fading Channels

  • Park, Dae-Young;Byun, Myung-Kwang;Lee, Byeong-Gi
    • Journal of Communications and Networks
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    • v.6 no.1
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    • pp.1-8
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    • 2004
  • In this paper, we investigate the properties and performance of space-time bit-interleaved coded modulation (STBICM) systems in fast Rayleigh fading channels. We first show that ST-BICM with QPSK signaling in fast fading channels possesses the uniform distance property, which makes performance analysis tractable. We also derive the probability distribution of the squared Euclidean distance between space-time symbols assuming uniform bit-interleaving. Based on the distribution, we show that the diversity order for each codeword pair becomes maximized as the frame length becomes sufficiently long. This maximum diversity order property implies that the bit-interleaver transforms an ST-BICM system over transmit diversity channels into an equivalent coded BPSK system over independent fading channels. We analyze the performance of ST-BICM in fast fading channels by deriving an FER upper bound. The derived bound turns out very accurate, requiring only the distance spectrum of the binary channel codes of ST-BICM. Numerical results demonstrate that the bound is tight enough to render an accurate estimate of performance of ST-BICM systems.

Heuristic Algorithms for Constructing Interference-Free and Delay-Constrained Multicast Trees for Wireless Mesh Networks

  • Yang, Wen-Lin;Kao, Chi-Chou;Tung, Cheng-Huang
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.5 no.2
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    • pp.269-286
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    • 2011
  • In this paper, we study a problem that is concerning how to construct a delay-constrained multicast tree on a wireless mesh network (WMN) such that the number of serviced clients is maximized. In order to support high-quality and concurrent interference-free transmission streams, multiple radios are implemented in each mesh node in the WMNs. Instead of only orthogonal channels used for the multicast in the previous works, both orthogonal and partially overlapping channels are considered in this study. As a result, the number of links successfully allocated channels can be expected to be much larger than that of the approaches in which only orthogonal channels are considered. The number of serviced subscribers is then increased dramatically. Hence, the goal of this study is to find interference-free and delay-constrained multicast trees that can lead to the maximal number of serviced subscribers. This problem is referred as the MRDCM problem. Two heuristics, load-based greedy algorithm and load-based MCM algorithm, are developed for constructing multicast trees. Furthermore, two load-based channel assignment procedures are provided to allocate interference-free channels to the multicast trees. A set of experiments is designed to do performance, delay and efficiency comparisons for the multicast trees generated by all the approximation algorithms proposed in this study.

Strategic Analysis of the Multilateral Bargaining for the Distribution Channels with Different Transaction Costs (거래비용이 상이한 복수의 유통채널에 대한 다자간 협상전략에 관한 연구)

  • Cho, Hyung-Rae;Rhee, Minho
    • Journal of Korean Society of Industrial and Systems Engineering
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    • v.38 no.4
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    • pp.80-87
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    • 2015
  • The proliferation of the Internet and communication technologies and applications, besides the conventional retailers, has led to a new form of distribution channel, namely home sopping through the telephone, TV, catalog or the Internet. The conventional and new distribution channels have different transaction costs perceived by the consumers in the following perspectives: the accessibility to the product information, the traffic cost and the opportunity cost for the time to visit the store, the possibility of 'touch and feel' to test the quality of the product, the delivery time and the concern for the security for the personal information. Difference in the transaction costs between the distribution channels results in the different selling prices even for the same product. Moreover, distribution channels with different selling prices necessarily result in different business surpluses. In this paper, we study the multilateral bargaining strategy of a manufacturer who sells a product through multiple distribution channels with different transaction costs. We first derive the Nash equilibrium solutions for both simultaneous and sequential bargaining games. The numerical analyses for the Nash equilibrium solutions show that the optimal bargaining strategy of the manufacturer heavily depends not only on the degree of competition between the distribution channels but on the difference of the business surpluses of the distribution channels. First, it is shown that there can be four types of locally optimal bargaining strategies if we assume the market powers of the manufacturer over the distribution channels can be different. It is also shown that, among the four local optimal bargaining strategies, simultaneous bargaining with the distribution channels is the most preferred bargaining strategy for the manufacturer.

Transient receptor potential melastatin type 7 channels are involved in zinc-induced apoptosis in gastric cancer

  • Kim, Byung-Joo
    • Animal cells and systems
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    • v.15 no.2
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    • pp.123-130
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    • 2011
  • Transient receptor potential melastatin 7 (TRPM7) channels are novel $Ca^{2+}$-permeable non-selective cation channels that are ubiquitously expressed. Activation of TRPM7 channels has been shown to be involved in the survival of gastric cancer cells. Here we show evidence suggesting that TRPM7 channels play an important role in $Zn^{2+}$- mediated cellular injury. Using a combination of electrophysiology, pharmacological analysis, small interfering RNA (siRNA) methods and cell death assays, we showed that activation of TRPM7 channels augmented $Zn^{2+}$-induced apoptosis of AGS cells, the most common human gastric adenocarcinoma cell line. The $Zn^{2+}$-mediated cytotoxicity was inhibited by the non-specific TRPM7 blockers $Gd^{3+}$ or 2 aminoethoxydiphenyl borate (2-APB) and TRPM7 specific siRNA. In addition, we showed that overexpression of TRPM7 channels in HEK293 cells increased $Zn^{2+}$- induced cell injury. Thus, TRPM7 channels may represent a novel target for physiological disorders where $Zn^{2+}$ toxicity plays an important role.

Study of Relationship on TaiYin-disease between the Chapter of Channels in Miraculous Pivot of Emperor's Classic of Internal Medicine and in ShangHanRun (『영추ㆍ경맥편』과 『상한론』의 태음병의 상관성 연구)

  • Lee Seung Yeul;Kim Yon Tae;Shin Heung Mook
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.18 no.2
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    • pp.396-400
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    • 2004
  • The oriental medical doctors who had studied Shang Han Run thought highly of meridians and until now it was generally known that the chapter of heat in the Plain Questions of Emperor's Classic Internal Medicine(ECIM: 皇帝內經, 素門, 熱論) was the basis of Shang Han Run. The chapter of heat in the Plain Questions of ECIM was the first text in which the basic theory on six-channels according to the types of illness was introduced. In my point of view, the theory of treating six-channels had close relation to the Chapter of Channels in Miraculous Pivot of ECIM(皇帝內經, 靈樞ㆍ經脈篇) as well as the chapter of heat in the Plain Questions of ECIM. Therefore I took a look at the origin of treating six-channels in Shang Han Lun and illuminated again the meaning to compare the parts of in Shang Han Lun with the Chapter of Channels in Miraculous Pivot of ECIM. Conclusion : The symptoms of TaiYin-channel(太陰經) in the Chapter of Channels in Miraculous Pivot of ECIM were, for the most part, accord with those of TaiYin-disease in Shang Han Lun. Furthermore, the symptoms in Shang Han Lun were explained definitely and in detail. Therefore the theory of Shang Han Lun has been developed on the basis of ECIM with the changes of the times. TaiYin-disease implied symptoms of pi-spleen meridian(脾經) and fei-lung meridian(肺經). Therefore Shang Han Lun was the foundation of treatment based on overall analysis of signs and symptoms(辨證論治) in respect of meridian as well as the text in which the steps of infectious diseases(外感病) of human bodies were explained.

The Literatural Study on Acupuncture and Moxibustion Therapy of Arthalgia Syndrome (비증(痺症)의 침구치료(鍼灸治療)에 관한 문헌적(文獻的) 고찰(考察))

  • Je, Byung Sun;Lim, Lark cheol;Oh, Min Suck
    • Journal of Haehwa Medicine
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    • v.13 no.1
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    • pp.61-69
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    • 2004
  • I have come to next conclusions in consequence of documentary study about medical books of many generations regarding acupuncture and moxibustion therapy of arthalgia syndrome. 1. Jing point of regular channels is most used. Next there are extraordinary point, ashi point in the acupuncture and moxibustion therapy of arthalgia syndrome. 2. The gall baldder channel of foot-shaoyang is most used. Next there are the urinary bladder channel of foot-taiyang, the large intestine channel of hand-yangming, the stomach channel of foot-yangming, the small intestine channel of hand-taiyang, the spleen channel of foot-taiyin, the liver channel of foot-jueyin, the triple-warmer channel of hand-shaoyang, the du channel, the lung channel of hand-taiyin, the kidney channel of foot-shaoyin, the pericardium channel of hand-jueyin, the heart channel of hand-shaoyin, the ren channel in the order of frequency in used channel among the twelve channels. 3. Three yang channels of foot is most used. Next there are three yang channels of hand, three yin channels of hand, three yin channels of foot in the order of frequency in use among the twelve channels. 4. The gall baldder channel of foot-shaoyang is most used. Next there are the urinary bladder channel of foot-taiyang, the large intestine channel of hand-yangming, the triple-warmer channel of hand-shaoyang, the stomach channel of foot-yangming, the small intestine channel of hand-taiyang, the liver channel of foot-jueyin, the lung channel of hand-taiyin, the spleen channel of foot-taiyin, the kidney channel of foot-shaoyin, the du channel, the pericardium channel of hand-jueyin, the ren channel the heart channel of hand-shaoyin in the order of frequency in used point among the twelve channels. 5. Huantiao is most used. Next there are Weizhong, Quchi, Yangfu, Chize Feiyang Xiyangguan Xiguan Tianjing, Sanli Xiaoluo in the order of frequency in use. 6. Jing point in the order of frequency of use, expel wind-evil and remove wetness-evil on the Acupuncture and Moxibustion Therapy of Arthalgia Syndrome.

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FRACTAL ANALYSIS OF TIDAL CHANNEL USING HIGH RESOLUTION SATELLITE IMAGES

  • Eom, Jin-Ah;Lee, Yoon-Kyung;Ryu, Joo-Hyung;Won, Joong-Sun
    • Proceedings of the KSRS Conference
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    • 2007.10a
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    • pp.29-32
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    • 2007
  • Tidal channel development is influenced by sediment type, grain size, composition and tidal current. Tidal channels are usually characterized by channel development, density and shape. Quantitative analysis of tidal channels using remotely sensed data have rarely been studied. The objective of this study is to quantify tidal channels in terms of fractal dimension and compare different inter-tidal channel patterns. For the fractal analysis, we used Box counting method which had been successfully applied to streams, coastlines and others linear features. For a study, the southern part of Ganghwado tidal flats was selected where is famous for high dynamics of tidal currents and vast tidal flats. This area has different widths and lengths of tidal channels. IKONOS and Komsat-2 MSC images were used for extracting tidal channels, and the Box counting method was applied to obtain fractal dimensions (D) for each tidal channel. Yeochari area possesses channels with linear pattern and less dense development and accordingly show low D values ranging from 1.037 to 1.038. On other hands, area (near Donggumdo and Yeongjongdo ) of dendrites channel pattern and dense development resulted in high D values from 1.2057 to 1.2667. Also, area possesses channels with linear pattern had low density about $18{\sim}24%$. Area of dendritic channel pattern had high density about $34{\sim}69%$. The difference of fractal dimensions about 0.2 according to channel development in tidal flats is relatively large enough to use as an index for tidal channel classification. Also, area where channels showed linear pattern had low density about $18{\sim}24%$. Area of dendritic channel pattern had high density about $34{\sim}69%$. Using fractal dimension and density, it would be possible to quantify the tidal channel development in association with surface characteristics.

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