• Journal of Ginseng Research
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• v.45 no.6
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• pp.744-753
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• 2021

Background: Gintonin-enriched fraction (GEF) is a new non-saponin component glycolipoprotein isolated from ginseng root. This study examined the effect of GEF on age-related sarcopenia in old C57BL/6J mice. Methods: Young (3-6 months) and old (20-24 months) C57BL/6J mice received oral GEF (50 mg/kg/day or 150 mg/kg/day) daily for 5 weeks. During the oral administration period, body weight and grip strength were measured weekly. After sacrifice, muscles from the hindlimb were excised and used for hematoxylin and eosin staining and western blotting to determine the effects of GEF on sarcopenia. The thymus was photographed to compare size, and flow cytometry was performed to examine the effect of GEF on immune homeostasis in the thymus and spleen. Blood samples were collected, and the concentrations of pro-inflammatory cytokines and IGF-1 were measured. Results: GEF caused a significant increase in muscle strength, mass, and fiber size in old mice. GEF restored age-related disruption of immune homeostasis by maintaining T cell compartments and regulating inflammatory biomarkers. Thus, GEF reduced common low-grade chronic inflammatory parameters, which are the main cause of muscle loss. Conclusion: GEF maintained immune homeostasis and inhibited markers of chronic inflammation, resulting in anti-sarcopenia effects in aged C57BL/6J mice. Thus, GEF is a potential therapeutic agent that slows sarcopenia in the elderly.

• Nuclear Engineering and Technology
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• v.56 no.5
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• pp.1813-1821
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• 2024

Beam shaping assembly (BSA) is a vital component in Boron Neutron Capture Therapy (BNCT) for obtaining epithermal neutron beams. Several feasible designs of BSA for accelerator-based BNCT (AB-BNCT) neutron source are carried out based on neutrons by bombarding a natural lithium target with 10 mA, 2.8 MeV proton beams. The calculation results demonstrate that a thickness of 45 cm is appropriate for general moderators referring to the therapeutic parameter of Advanced Depth (AD). A series of optimizations are performed and two results are confirmed: One is that employing the configuration of MgF₂ and FLUENTAL combined by 1:1 could improve the therapeutic rate (TR) of tumors at a depth of middle region, and the other one is that the TR of superficial tumors can be increased by adding a 5 cm thick boron-11 secondary moderator at the end of general moderators. As a result, an innovative conception of an adjustable moderator is recommended to BNCT. Compared to the MgF₂ moderator with a fixed thickness of 45 cm, the TR value can be improved by a maximum of 47.7 % by using the adjustable moderator. Furthermore, the configuration of adjustable moderator has been designed with regulation method for treating tumors of different depths.

• Proceedings of the KSME Conference
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• 2001.06b
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• pp.235-240
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• 2001

This paper introduces developed prototype intelligent pig which detects corrosion on pipeline by using Magnetic Flux Leakage technology. The 8 inch developed MFL(Magnetic Flux Leakage) pig is composed of 5 yokes which magnetize pipeline wall and 45 Hall sensors which detect MFL signal. The designed MFL modules are analyzed by using magnetic circuit method in order to confirm whether pipeline wall is fully saturated. A variety of artificial defects are manufactured on 8 inch diameter steel pipeline in order to acquire MFL signals. So leakage flux of the axial, radial and circumferential component was acquired as defects. The results of this paper show that design technique for 8 inch MFL pig can be applied to large diameter MFL pig and 0.5mm defect depth can be detected.

• Journal of the korean Society of Automotive Engineers
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• v.8 no.3
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• pp.37-45
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• 1986

열교환기의 확장 표면이 2가지 또는 3가지의 서로 다른 재질들로써 구성되는 경우, 직선 및 환상 의 Composit Fin Assembly에서 구성 재질들의 열전도율들이 각 Assembly 에서의 온도 분포와 열유동량에 미치는 영향을 조사하였다. Composite Fin Assembly에서의 온도 분포를 구하기 위 하여 유한 요소법을 사용하여 수치 계산하였다. Composite Fin Assembly를 구성하는 재료들의 열전도율들이 열유동량에 미치는 효과는 상당히 크며, 따라서 확장 표면의 설계 계산에 있어서 이러한 효과들을 필수적으로 고려하여야 함이 밝혀졌다.

• 한국전산유체공학회:학술대회논문집
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• 2004.10a
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• pp.137-139
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• 2004

The monopropellant hydrazine thrusters are widely used for the satellite on-board propulsion system fulfilling various missions in space. They have outstanding features caused by the nearly unlimited restart capability and the very high credibility. The sole monopropellant thruster used at precent in nation is MRE-1 that is a standard component of NASA. It can produce 4.45 N of nominal thrust. Due to the glowing complexity with a satellite mission, the needs for thrusters of the diverse performance are being increased. The numerical simulation could give useful information to develop a new type thruster instead of the experiments performed previously. Therefore it is critical to make a reliable computer code to prepare design change of a thruster. In this paper, the performance analysis and validation of the satellite monopropellant hydrazine thruster currently used is accomplished as the preliminary study to serve valuable data for future design change.

• Proceedings of the KSME Conference
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• 2000.04b
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• pp.434-440
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• 2000

The atomization characteristics of air-assist atomizer which is surrounded by a coflowing airstream is investigated. The air-assist, coflow air stream had swirl imparted to them in the same direction with 45 degree's angle swillers. The fuel and air entered the combustor at ambient temperature and the combustor was operated in an unconfined environment. Diesel fuel was used for all the experiments. Drop size and mean velocity are reported for certain distances downstream from the nozzle. The droplet size and velocity measurements were performed using a two-component phase/Doppler particle analyzer and velocity profiles across the entire flowfield are presented.

• Journal of Ginseng Research
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• v.45 no.2
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• pp.199-210
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• 2021

Ginseng has been used as a traditional herb in Asian countries for thousands of years. It contains a large number of active ingredients including steroidal saponins, protopanaxadiols, and protopanaxatriols, collectively known as ginsenosides. In the last few decades, the antioxidative and anticancer effects of ginseng, in addition to its effects on improving immunity, energy and sexuality, and combating cardiovascular diseases, diabetes mellitus, and neurological diseases, have been studied in both basic and clinical research. Ginseng could be a valuable resource for future drug development; however, further higher quality evidence is required. Moreover, ginseng may have drug interactions although the available evidence suggests it is a relatively safe product. This article reviews the bioactive compounds, global distribution, and therapeutic potential of plants in the genus Panax.

• Asian-Australasian Journal of Animal Sciences
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• v.15 no.11
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• pp.1553-1558
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• 2002

This study was carried out to obtain informations regarding the effect of N-acetyl-D-glucosamine in the LEY (lactoseegg yolk) diluent according to incubation time in 5 ml maxi-straw and the effects of freezing rate, thawing temperature and thawing time in the LEN (lactose-egg yolk and N-acetyl-D-glucosamine) diluent on acrosome morphology and motility of frozen-thawed boar sperm. The study showed that the LEN diluent was higher post-thaw NAR (normal apical ridge) acrosome than the LEY diluent for 0.5 h incubation at 37$^{\circ}C$. However, there were no differences between the LEN and LEY diluents on post-thaw sperm motility according to incubation time. The straws frozen from 5.0 cm (20$^{\circ}C$/min) to 17.0 cm (1$^{\circ}C$/min) above the liquid nitrogen surface did not show any significant differences on post-thaw sperm motility. However, the straws frozen above 5.0 cm from the liquid nitrogen surface were higher NAR acrosome than those frozen above 17.0 cm. The post-thaw percentages of motile sperm and NAR acrosome were significantly higher (p<0.05) for the maxi-straws submerged for 40 or 45 sec in a 52$^{\circ}C$ water bath than for 30, 35, 50 or 55 sec. The mean sample temperatures of maxi-straws after 40 or 45 sec submersion were 20.7 or 26.4$^{\circ}C$. In conclusion, the sample temperature of the thawed semen was very important for post-thaw sperm survival in the LEN diluent of 5 ml maxi-straw. When the temperature of the thawed semen was 20.7$^{\circ}C$, the percentages of motile sperm and NAR acrosome were highest.

• Journal of the Korean Institute of Gas
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• v.6 no.1 s.17
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• pp.10-16
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• 2002

This paper introduces developed prototype intelligent pig which detects corrosion on pipeline by using Magnetic Flux Leakage technology. The 8 inch developed MFL(Magnetic Flux Leakage) pig is composed of 5 yokes which magnetize pipeline wall and 45 Hall sensors which detect MFL signal. The designed MFL modules are analyzed by using magnetic circuit method in order to confirm whether pipeline wall is fully saturated. A variety of artificial defects are manufactured on 8 inch diameter steel pipeline in order to acquire MFL signals. So leakage flux of the axial, radial and circumferential component was acquired as defects. The results of this paper show that design technique for 8 inch MFL pig can be applied to large diameter MFL pig and 0.5mm defect depth can be detected.

• Membrane Journal
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• v.15 no.1
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• pp.52-61
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• 2005

Permeate flux decline in a microfiltration was analyzed by measuring the permeability of bentonite colloidal solution through polyethylene capillary membranes. The flux decline with time was due to the growth of cake layer on the membrane surface and to the pore blocking by particles. As the time approaches to steady state, the permeate flux is almost controlled by the cake filtration model. Faster flux decline at high trans-membrane pressure was attributed to the formation of denser packed cake layer and pore blocking. The ratio of permeate flux to the initial permeate flux, J/J₁, decreased with increasing the trans-membrane pressure, from 45% for 0.5 kg/sub f//㎠ to 38% for 2.0 kg/sub f//㎠. In comparing the ratio of each fouling component to the total fouling for the 0.5 kg/sub f//㎠ TMP condition, complete blocking was 23.4%, standard blocking was about 14.6% and cake filtration was 62.0%, respectively. Permeate flux through the membrane increases with cross flow velocity, and the effect of the variation of velocity is more significant at 1.0 kg/sub f//㎠ rather than at 2.0 kg/sub f//㎠ of the operation pressure. Permeate flux for the membrane having the average pore diameter of 0.34 ㎛ was higher than that for the membrane of 0.24 ㎛ pore size, with the higher flux with the low concentration of feed. On the operation using the membrane of 0.34 ㎛ pore, the pore blocking in the low concentration of 200 ppm is negligible relative to the pore blocking in the 1000 ppm feed.