• Biomolecules & Therapeutics
• /
• v.24 no.5
• /
• pp.517-522
• /
• 2016

${\beta}$-Arrestins are one of the protein families that interact with G protein-coupled receptors (GPCRs). The roles of ${\beta}$-arrestins are multifaceted, as they mediate different processes including receptor desensitization, endocytosis, and G protein-independent signaling. Thus, determining the GPCR regions involved in the interactions with ${\beta}$-arrestins would be a preliminary step in understanding the molecular mechanisms involved in the selective direction of each function. In the current study, we determined the roles of the N-terminus, intracellular loops, and C-terminal tail of a representative GPCR in the interaction with ${\beta}$-arrestin2. For this, we employed dopamine $D_2$ and $D_3$ receptors ($D_2R$ and $D_3R$, respectively), since they display distinct agonist-induced interactions with ${\beta}$-arrestins. Our results showed that the second and third intracellular loops of $D_2R$ are involved in the agonist-induced translocation of ${\beta}$-arrestins toward plasma membranes. In contrast, the N- and C-termini of $D_2R$ exerted negative effects on the basal interaction with ${\beta}$-arrestins.

• Journal of applied mathematics & informatics
• /
• v.39 no.1_2
• /
• pp.155-163
• /
• 2021

For a connected graph G of order n, a set S of vertices is called a double geodetic set of G if for each pair of vertices x, y in G there exist vertices u, v ∈ S such that x, y ∈ I[u, v]. The double geodetic number dg(G) is the minimum cardinality of a double geodetic set. Any double godetic set of cardinality dg(G) is called a dg-set of G. A connected double geodetic set of G is a double geodetic set S such that the subgraph G[S] induced by S is connected. The minimum cardinality of a connected double geodetic set of G is the connected double geodetic number of G and is denoted by dgc(G). A connected double geodetic set of cardinality dgc(G) is called a dgc-set of G. Connected graphs of order n with connected double geodetic number 2 or n are characterized. For integers n, a and b with 2 ≤ a < b ≤ n, there exists a connected graph G of order n such that dg(G) = a and dgc(G) = b. It is shown that for positive integers r, d and k ≥ 5 with r < d ≤ 2r and k - d - 3 ≥ 0, there exists a connected graph G of radius r, diameter d and connected double geodetic number k.

• Proceedings of the SCSK Conference
• /
• 2003.09a
• /
• pp.719-732
• /
• 2003

A kojic acid derivative, kojic acid 7-O-$\beta$-D-tetraacetylglucopyranoside(KTG) was synthesized. Regio-and stereo-selective glycosylation at 7-postion in kojic acid with $\beta$-D-pentaacetylglucose was achieved with high yield(80％) by the use of Lewis acid and organic base in nonpolar solvent. KTG was hydrolyzed in methanol by the aid of sodium methoxide to give kojic acid 7-O-$\beta$-D-glucopyranoside(KGP). KGP is freely soluble in water and soluble in methanol and ethanol. Its structure was comfirmed by $^1$H-NMR and $^{13}$ C-NMR. Tyrosinase activity inhibition of KGP was measured with mushroom tyrosinase compared with ascorbic acid, kojic acid and arbutin. KGP showed higher tyrosinase inhibition activity($IC_{50}$/=33.3 $\mu\textrm{g}$/ml) than ascorbic acid(63.2 $\mu\textrm{g}$/ml) and arbutin(91.8 $\mu\textrm{g}$/ml) but lower inhibition activity than kojic acid(8.3 $\mu\textrm{g}$/ml). To test free-radical scavenging activity, we used 1, 1-diphenyl-2-picrylhydrazyl(DPPH) as a free-radical source. Free-radical scavenging activity of KGP was very low($SC_{50}$/>1000 $\mu\textrm{g}$/ml) compared with ascorbic acid($SC_{50}$/=2.68 $\mu\textrm{g}$/ml) and arbutin($SC_{50}$/=180$\mu\textrm{g}$/ml). Melanin formation inhibition of KGP was measured in B16 melanoma, compared with kojic acid, arbutin and Vitamin C. Inhibition activity of KGP for melanin formation was not found within test concentrations.

• Journal of the Chungcheong Mathematical Society
• /
• v.20 no.2
• /
• pp.183-190
• /
• 2007

In this paper, we will introduce the noetherian quotients in R-groups, and then investigate the related substructures of the near-ring R and G and the R-group G. Also, applying the annihilator concept in R-groups and d.g. near-rings, we will survey some properties of the substructures of R and G in monogenic R-groups and faithful R-groups.

• Journal of applied mathematics & informatics
• /
• v.26 no.1_2
• /
• pp.401-406
• /
• 2008

In this paper, we will introduce the noetherian quotients in R-groups, and then investigate the related substructures of the near-ring R and G and the R-group G. Also, applying the annihilator concept in R-groups and d.g. near-rings, we will survey some properties of the substructures of R and G in monogenic Rgroups, and show that R becomes a ring for faithful monogenic R-groups with some condition.

• Proceedings of the PSK Conference
• /
• 2001.04a
• /
• pp.219.3-220
• /
• 2001

• Bulletin of the Korean Chemical Society
• /
• v.31 no.4
• /
• pp.874-880
• /
• 2010

A series of 13- and 14-membered cyclic enkephalin analogs based on the moderately $\mu$ selective prototype compound Tyr-C[D-$A_2bu$-Gly-Phe-Leu] 8a were synthesized to investigate the structure-activity relationship. The modifications of sequence were mainly focused on two positions 3 and 5, critical for the selective recognition for $\mu$ and $\delta$ opioid receptors. The substitution of hydrophobic $Leu^5$ with hydrophilic $Asp^5$ derivatives led to Tyr-C[D-$A_2bu$-Gly-Phe-Asp(N-Me)] 7 and Tyr-C[D-Glu-Phe-gPhe-rAsp(O-Me)] 5, the peptides with a large affinity losses at both $\mu$ and $\delta$ receptors. The substitution of $Phe^3$ with $Gly^3$ led to Tyr-C[D-Glu-Gly-gPhe-rLeu] 3 and Tyr-C[D-Glu-Gly-gPhe-D-rLeu] 4, the peptides with large affinity losses at $\mu$ receptors, indicating the critical role of phenyl ring of $Phe^3$ for $\mu$ receptor affinities. One atom reduction of the ring size from 14-membered analogs Tyr-C[D-Glu-Phe-gPhe-(L and D)-rLeu] 6a, 6b to 13-membered analogs Tyr-C[D-Asp-Phe-gPhe-(L and D)-rLeu] 1, 2 reduced the affinity at both $\mu$ and $\delta$ receptors, but increased the potency in the nociceptive assay, indicating the ring constrain is attributed to high nociceptive potency of the analogs. For the influence of D- or L-chirality of $Leu^5$ on the receptor selectivity, regardless of chirality and ring size, all cyclic diastereomers displayed marked $\mu$ selectivity with low potencies at the $\delta$ receptor. The retro-inverso analogs display similar or more active at $\mu$ receptor, but less active at $\delta$ receptor than the parent analogs.

• Progress in Superconductivity and Cryogenics
• /
• v.22 no.4
• /
• pp.31-39
• /
• 2020

Power cables made of high temperature superconductors (HTS) are considered as most advanced applications of superconductivity for electro-energetics. Several cables made of the First Generation (1G) HTS wires have been produced and installed to electrical grids worldwide. Power cables made of the Second Generation HTS wires (2G or Coated Conductors) are in active development. Most basic principles of HTS power cables development have been published in many works since 90-ties. In this Review we would like to present our new developments mostly directed to 2G HTS compact power cables. We are presenting the methods to optimize a design of 2G AC compact power cable providing uniform current distribution among cable layers and the production technology approaches to implement such a design. AC losses measurements in such cables and other test methods are described. Some problems of the development 2G HTS power cables with small diameters are discussed. We presented as examples designs, developments and test results of two major coaxial cables designs: single-phase (cable core and a shield) and three-phase (triaxial: with three coaxial phases).

• Journal of Information Display
• /
• v.11 no.1
• /
• pp.24-27
• /
• 2010

A novel stereo 3D LCD for passive interference filter glasses is presented. A demonstrator based on a standard 120Hz LCD was set up. Stereoscopic image separation was realized in a time-sequential mode using a LED-based scanning backlight with two complementary spectra. A stereo brightness of 3 cd/$m^2$ and a channel separation of 30:1 were achieved.

• Journal of Ginseng Research
• /
• v.39 no.2
• /
• pp.94-104
• /
• 2015

Background: Ginseng (Panax ginseng Meyer) is an important medicinal herbs in Asia. However, ginseng varieties are less developed. Method: To developed ginseng varieties, a pure line selection method was applied in this study. Results: Gumpoong was testing of 4-yr-old specimens in 2002, the proportions of the below-ground roots that were rusty colored for Gumpoong was 1.29 in Daejeon and 1.45 in Eumseong, whereas the proportions for its yellow berry variant were 2.60 and 2.45 in the two regions, respectively. Thus the Gumpoong was resistant to root rust. Sunpoong has a high yielding property. Its average root weight is 70.6 g for 6-yr-old roots. Its yield is 2.9 kg/$1.62m^2$ and the rate of heaven- and earth-grade product is 20.9%, which is very high compared to 9.4% for Yunpoong. Sunone is resistance to root rot and the survival rate of 4-yr-old roots was 44.4% in 1997, whereas that of the violet-stem variant landrace was 21.7%. Sunhyang has content of arginyl-fructosyl-glucose (AFG), which produces the unique scent of red ginseng, is $95.1{\mu}mol/g$ and greater than the $30.8{\mu}mol/g$ of Chunpoong in 6-yr-old plants. Sunun and Cheongsun are being nurtured to protect genetic resources. Conclusion: Developed ginsneg varieties will be used as the basis for the protection of genetic resources and breeding.