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검색결과 586건 처리시간 0.029초

소아 막성 신병증의 원인에 따른 빈도 및 임상양상의 차이 (The Differences in Frequencies and Clinical Manifestations According to the Causes of Membranous Nephropathy in Children)

  • 문윤희;김세진;김성도;조병수
    • Childhood Kidney Diseases
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    • 제10권2호
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    • pp.162-173
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    • 2006
  • Purpose : To report the decreasing indicence of HBV(Hepatitis B virus)-associated membranous nephropathy in children after HBV vaccination and to elucidate the clinical course and treatment strategies of IMN(Idiopathic membranous nephropathy). Methods : We retrospectively reviewed the clinico-pathological findings of HBV-MN and IMN patients who underwent a renal biopsy from 1986 to 2005. We compared the HBV-MN and the IMN groups and the remission and the non-remission groups of patients with IMN. Results : Among 24 cases of MN patients, HBV-MN comprised 6 cases(25%) and IMN 18 cases(75%). Clinical masnifestations were nephrotic syndrome(3 cases, 50%), nephritic syndrome(1 case, 16.7%), asymptomatic(2 cases, 33.4%) in the HBV-MN group, asymptomatic(10 cases, 55.5%), nephrotic syndrome(5 cases, 27.8%), and gross hematuria(3 cases, 16.7%) in the IMN groups. From 1996 to 2000, there were 2 cases(28%) of HBV-MN and 5 cases(72%) of IMN. After 2001 all 10 cases were IMN. In the HBV-MN group, 4 cases(66.7%) received interferon and 1 cases received methylprednisolone pulse therapy. In the IMN group, 16 cases(88.9%) received methylprednisolone, 8 cases(44.4%) were in complete remission, 2 cases(11.1%) were in partial remission, 2 cases(11.1%) were in chronic renal failure, and 5 cases(27.8%) were lost to follow-up with sustained proteinuria, 1 case(5.6%) continued to have frequent relapse of nephrotic syndrome without renal insufficiency. In the comparison between remission and non-remission groups, nephrotic range proteinuria and hypertension were more significantly common in the non-remission group(P<0.05). Conclusion : With HBV vaccination, HBV-MN has decreased markedly. IMN is a rare glomerular disease in children. Because the prognosis for patients with nephrotic range proteinuria is poor this group needs more aggressive treatment.

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음양곽(淫羊藿)이 실험적으로 유발된 갑상선 기능저하증 동물모델에 미치는 영향과 안전성 (The Effects of Epimedii Herba on a Hypothyroidism Rat Model induced by PTU(6-Propyl, 2-thiouracil))

  • 홍민진;이병철;안영민;안세영
    • 대한약침학회지
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    • 제14권4호
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    • pp.13-22
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    • 2011
  • Objectives: The symptoms of hypothyroidism are fatigue, cold intolerance, arthralgia, muscle cramps, dry skin and etc. Although hypothyroidism is a relatively common endocrinical disease, we do have many difficulties treating it effectively. The symptoms of hypothyroidism are similar to those of Yang-deficiency in Oriental medicine. Epimedii Herba is a popular herb that has the effect of tonifying the kidney and strengthening Yang in Oriental medicine. In this study, we investigated the therapeutic effects of Epimedii Herba on a hypothyroidism rat model induced by PTU(6-Propyl, 2-thiouracil). Methods: 24 two-month-old Spargue-Dawley(SD) rats were divided into 4 groups: 1) normal(n=6), 2) PTU-induced hypothyroidism control(n=6), 3) hypothyroidism rat treated with Epimedii Herba(n=6), 4) hypothyroidism rat treated with levothyroxine(n=6). PTU was administered for 4 weeks, Epimedii Herba and levothyroxine was administered for 2 weeks after PTU was initiated for a total duration of 2 week. At the end of the experiment, blood samples from all the rats were taken from their hearts and were analyzed. Results: In comparison with normal group, the PTU-induced control group significantly showed hypothyroidism with low T3, T4 and high TSH. In Epimedii Herba group, T4 was significantly increased(p<0.05). There was no significant difference in TSH between the Epimedii Herba treatment group and the control group. And no significant differences were observed in biochemical labs and weight between the Epimedii Herba group and the control group. Conclusions: These results suggest that Epimedii Herba could help thyroid cells to produce thyroid hormones. And no significant side effects related with Epimedii Herba were found, suggesting that it is safe to administer. According to these results, Epimedii Herba may be a safe alternative medicine for hypothyroidism.

농업용 저수지의 점오염원 바이패스 효과 평가를 위한 EFDC 모델의 적용 (Application of EFDC Model to an Agricultural Reservoir for Assessing the Effect of Point Source Bypassing)

  • 김동민;박형석;정세웅
    • 한국농공학회논문집
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    • 제58권6호
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    • pp.9-21
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    • 2016
  • Agricultural reservoirs in Korea have been recognized as an emerging resource for recreational and cultural activities for residents. However, most of the reservoirs are eutrophic and showing high level of contamination with nuisance algal bloom and offensive odor during the summer. For better management and restoration of the reservoirs' water quality, scientific modeling approaches could be used to diagnose the problems and evaluate the efficacy of alternative control measures. The objectives of this study were to validate the performance of a three-dimensional (3D) hydrodynamic and water quality model (Environmental Fluid Dynamics Code, EFDC) for a eutrophic agricultural reservoir and assess the effect of bypassing of the effluent from a wastewater treatment plant on the reservoir water quality. The 3D model successfully simulated the temporal variations of water temperature, DO, TOC, nitrogen and phosphorus species and Chl-a observed in 2014 and also captured their spatial heterogeneity in the reservoir. The simulation results indicated that the point source bypassing may reduce the T-N and T-P concentrations of the reservoir by 6.6 ~ 8.2 %, and 1.7 ~ 16.8 %, respectively. The bypassing, however, showed a marginal effect on the control of TOC due to the increased algal biomass associated with the increased water retention time after bypassing as well as the lower TOC level of the effluent compared to the ambient reservoir water.

Incoterms$^{(R)}$ 2010 Rules의 문제점과 대안 (A Study on Problems and Attentive of Incoterms$^{(R)}$ 2010 Rules)

  • 오세창
    • 무역상무연구
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    • 제51권
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    • pp.3-54
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    • 2011
  • The important and main purpose of revision of Incoterms rules are to adapt it to contemporary commercial practice in world trade, and to contribute to great service to foreign trade. Incoterms$^{(R)}$ 2010 revision basically focuses on trade terms to be used for any mode or modes of transport at compared Incoterms 2000 gouping in four basically different categories, and presents trade terms to be used for traditionally seaborn trade. Therefore the former is for trading in manufactured goods involved in containerization, the latter is for trading in community. This study focuses on a motive of revisions and main features of the Incoterms$^{(R)}$ 2010 rules, an outline, the problems and alternative of them. In conclusion, I would like present as follows; (1) Although they only concerned the models of delivery and critical point, they only say a few of the many factors of a sale contract, that is to say for the devision of fuctions, costs and risks between the contracting parties as supplement law, but the guestion of the legal position of Incoterms rules is various in different countries and scholars. in spite of that, it must focus on the practical application and the wide acceptance of Incoterms rules in world trade. (2) Although they present more simple and clear, unfricative, than Incoterms 2000 rules, in order to help users, the need to unify consistently and fully explanate in contents and expression. (3) Introduction and guidance note of Incoterms$^{(R)}$ 2010 rules basically focuses on the understanding of a motive of revisions as compared Incoterms 2000 rules. But it is well advised to do this on the assumption of understanding the various basic meaning of terms. (4) finally, trade concerned regulations take account of the reflection for the application to domestic and international trade according to formally reconization of availability for both trade.

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무증상 송과체 낭종의 임상적 양상 및 자기공명영상 소견 (The Magnetic Resonance Images and Clinical Features of the Asymptomatic Pineal Cysts)

  • 임강택;박세혁;신동익;조병문;오세문;황도윤
    • Journal of Korean Neurosurgical Society
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    • 제29권1호
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    • pp.113-117
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    • 2000
  • Objective : Asymptomatic cyst of the pineal gland is a common incidental finding in adults on computerized tomography or magnetic resonance image(MRI) or at postmortem examination. This study was conducted to identify MRI findings of the benign pineal cysts and to determine the proper management of asymptomatic pineal cysts. Methods : From January 1995 to March 1999, 13 cases of asymptomatic pineal cysts were diagnosed incidentally on MRI. The mean age of the patients at diagnosis was 43 years(ranged 8 to 69 years). Five patients were females and eight patients were males. We analyzed the clinical presentations and MRI findings. Results : Clincal features were not related to pineal cysts in all 13 cases included posttraumatic headache in seven cases, headache related to brain tumor in two cases, one of facial palsy, one of diabetic neuropathy, and two of other diseases. MRI demonstrated a well-demarcated mass lesion(mean 1.3cm in diameter) of low signal intensity on T1-weighted images and high signal intensity on T2-weighted images. Gadolinium-enhanced MRI, performed in 10 cases, demonstrated a rim enhancement. Hydrocephalus was not present in all cases. Follow-up MRI(ranged 12 to 36 months) obtained in 3 of the 13 patients showed stability of cyst size. After symptomatic treatment, presenting symptoms were resolved in all patients and symptom related to pineal cysts have not been developed during follow up period(mean 27 months). Conclusion : The long-term behavior of asymptomatic pineal cysts is still unknown. But we advocate conservative management of these benign pineal cysts that may be developmental variants of normal pineal gland.

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무선통신기술과 MAA 알고리즘을 이용한 휴대형 혈압측정 시스템 구현 (Implementation of the Potable Blood Pressure Measurement System Using Wireless Communication Technology and MAA Algorithm)

  • 김보성;김세진;정도운
    • 한국정보통신학회:학술대회논문집
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    • 한국해양정보통신학회 2007년도 춘계종합학술대회
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    • pp.678-681
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    • 2007
  • 본 연구에서는 오실로메크릭법에 의한 혈압측정을 위하여 비관혈적인 방법으로 보다 정확하게 혈압을 추정할 수 있는 시스템을 구현하였다. 구현된 혈압 측정 시스템은 압력 제어부, 신호 측정부 그리고 혈압 신호처리부, 무선센서네트워크부 등으로 구성하였다. 구현된 혈압측정 실험 시스템의 타당성을 검증하기 위하여 압력 측정부의 특성 평가 실험, 혈압 추정을 위한 특성비율 산출 실험, 오실로 메트릭법에 의한 혈압 추정 및 평가 실험을 수행하였다. 본 연구에서 구현된 혈압 측정 실험 시스템으로 성인남성 5명을 실험 대상군으로 선정하여 데이터를 계측하고 혈압을 추정하는 실험을 한 결과 오실로메트릭에 의한 혈압 추정 및 평가 실험에서 청진법과의 평균동맥압, 수축기 혈압, 그리고 이완기 혈압에서 최대 절대편차 비율이 각각 1.38 %, 1.63 그리고 2.97 % 이었고 최대 표준오차가 각각 5.00, 3.72, 그리고 4.34인 혈압 측정 시스템을 구현하였다.

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선미유동 제어용 수직판 제원 변화에 따른 유동특성 연구 (A Study on Flow Characteristics due to Dimension Variations of the Vertical Plate for Controlling the Ship Stern Flow)

  • 김도정;오우준;박제웅;정세민
    • 해양환경안전학회지
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    • 제22권5호
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    • pp.576-582
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    • 2016
  • 이산화탄소 배출량 제한을 의무화하는 EEDI, SEEMP 등의 국제협약에 대응하기 위하여 선박의 에너지 절감장치(ESD, Energy Saving Device) 관련 국내기술 대응이 절실하다. 본 연구는 국내 중소형 조선소의 주력선종 효율 향상의 ESD를 설계하기 위하여 유동특성 분석에 대한 연구이다. 프로펠러 상단으로 유입되는 유동을 개선하기 위하여 bare hull의 선미벌브 및 빌지 주변의 유동특성을 수치해석과 모형시험을 통하여 정성적으로 분석하였으며, 선저압력 지점의 개선 및 프로펠러 상단 유입의 선미 빌지 유동 제어를 위하여 선미벌브와 빌지 사이에 수직평판을 부착하였다. 선미 선체표면 압력회복으로 전저항이 약 3.04 % 감소하였으며, 프로펠러 상단 유동 제어를 통해 평균 공칭반류가 약 18.8 % 감소하였다.

Immunomodulatory Effects of Supplementation with Extracts from the Marine Brown Alga Eisenia bicyclis on Macrophages

  • NamKoong, Seung;Kang, Se-Chan;Do, Hang;Jang, Ki-Hyo;Jang, Seon-A;Choung, Myoung-Gun;Sohn, Eun-Hwa
    • 한국자원식물학회지
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    • 제24권3호
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    • pp.298-303
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    • 2011
  • A large number of edible seaweeds are consumed by the coastal peoples of Asia. Some of them are used in traditional remedies in many parts of the world. In this study we investigated effects of supplementation with ethyl acetate extracts of the brown alga Eisenia bicyclis (EBE) on rat macrophage to evaluate the possibilities as immune-modulators. Twelve male SD rats were divided into two groups and the treatments were as follows: A, no Eisenia bicyclis extract (EBE) intake and distilled water ; B, oral supplemented with EBE 200 mg/kg. After 5 weeks of supplementation, rats were sacrificed to assess the effect on peritoneal macrophage functions. We showed no increasing effects on tumoricidal activity, phagocytic activity and NO production in macrophages in EBE supplementation group. However, EBE supplementation suppressed NO-iNOS production and p65 translocation into the nucleus in LPS-stimulated macrophages. Overall, these results suggest that the supplementation of EBE might have an anti-inflammatory effects on NO-iNOS production in macrophages throughout the inhibition of NF-${\kappa}B$ activation.

275 GHz 이상 전파천문대역과 관련된 APG-11 2차 회의 결과

  • 정현수;제도흥;오세진;노덕규;손봉원;이상성;김효령
    • 천문학회보
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    • 제35권1호
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    • pp.46.1-46.1
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    • 2010
  • APT(Asian-Pacific Telecommunity)는 아시아-태평양지역 국가의 공동이익을 도모하기 위하여 결성된 아-태지역 전파협의체 조직으로, WRC(세계전파통신회의)회의에서의 아-태지역 주관청의 공동이익을 얻기 위해 APG(APT Conference Preparatory Group for WRC)회의를 연간 1회의 비율로 개최하고 있다. WRC-12회의에 대비하여 결성된 APG-12 회의가 2010년 3월 태국 방콕에서 개최되었으며, 전파천문업무 보호 및 22 GHz 대역 달탐사, 38 GHz 대역 Space-VLBI운용대역과 관련된 WRC-12 의제 1.6, 1.11, 1.12 등에 대해 활발한 토론이 있었다. WRC-12 의제 1.6은 수동업무(전파천문업무, 지구탐사위성 및 우주연구업무)를 능동업무의 유해혼신으로부터 보호하기 위하여 제정한 전파규칙 각주 5.565조의 개정 검토와 관련된 의제이다. 따라서 한국천문연구원에서는 275 GHz 이상 대역에서의 전파천문업무의 원활한 운용을 위해, WRC회의에서 최종적인 규정개정을 함에 있어서 필요한 아-태지역 국가의 공동의견을 창출하기 위한 APT회의에서 주도적인 역할을 담당하고 있다. 본 발표에서는 APG-12 3차 회의에 제출한 우리나라의 기고서 제출 결과 및 동 회의에서의 최종결과 및 향후 대응책에 대해서도 알아보고자 한다.

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철 프탈로시아닌 유도체에 의한 아민 및 황 화합물의 흡착 (Adsorption of Amine and Sulfur Compounds by Iron Phthalocyanine Derivatives)

  • 이정세;박진도;이학성
    • 한국대기환경학회지
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    • 제23권5호
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    • pp.575-584
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    • 2007
  • The adsorption capability of iron phthalocyanine derivatives were investigated by means of X-ray diffractometor (XRD), IR (infrared) spectroscopy, scanning electron microscopy (SEM) and temperature programmed desorption (TPD). According to TPD results, iron phthalocyanine derivatives showed two desorption peaks at low temperature ($100{\sim}150^{\circ}C$) and high temperature ($350{\sim}400^{\circ}C$) indicating that there were two kinds of acidities. Tetracarboxylic iron phthalocyanine (Fe-TCPC) have a stronger desorption peak (chemical adsorption) at the high temperature and a weaker desorption peak (physical adsorption) at the low temperature than iron phthalocyanine (Fe-PC). The specific surface areas of Fe-TCPC and Fe-PC were $26.46\;m^2/g\;and\;11.77\;m^2/g$, respectively. The pore volumes of Fe-TCPC and Fe-PC were $0.14\;cm^3/g\;and\;0.06\;cm^3/g$, respectively. The adsorption capability of triethyl amine calculated by breakthrough curve at 220 ppm of equilibrium concentration was 29.2 mmoL/g for Fe-TCPC and 0.8 mmoL/g for Fe-PC. The removal efficiency of dimethyl sulfide of Fe-TCPC and Fe-PC in batch experiment of 225 ppm of initial concentration were 44.9% and 28.9%, respectively. The removal efficiency of trimethyl amine of Fe-TCPC and Fe-PC in batch experiment of 118 ppm of initial concentration were approximately 100.0% and 33.9%, respectively.