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Nutrikinetic study of fermented soybean paste (Cheonggukjang) isoflavones according to the Sasang typology

  • Kim, Min Jung;Lee, Da-Hye;Ahn, Jiyun;Jang, Young-Jin;Ha, Tae-Youl;Do, Eunju;Jung, Chang Hwa
    • Nutrition Research and Practice
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    • v.14 no.2
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    • pp.102-108
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    • 2020
  • BACKGROUND/OBJECTIVES: In Oriental medicine, certain foods may be beneficial or detrimental based on an individual's constitution; however, the scientific basis for this theory is insufficient. The purpose of this study was to investigate the effect of body constitution, based on the Sasang type of Korean traditional medical classification system, on the bioavailability of soy isoflavones of Cheonggukjang, a quick-fermented soybean paste. SUBJECTS/METHODS: A pilot study was conducted on 48 healthy Korean men to evaluate the bioavailability of isoflavone after ingestion of food based on constitution types classified by the Sasang typology. The participants were classified into the Taeeumin (TE; n = 15), Soyangin (SY; n = 15), and Soeumin (SE; n = 18) groups. Each participant ingested 50 g of Cheonggukjang per 60 kg body weight. Thereafter, blood was collected, and the soy isoflavone metabolites were analyzed by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry. Ntrikinetic analysis of individual isoflavone-derived metabolites was performed. RESULTS: Our nutrikinetic analysis identified 21 metabolites derived from isoflavones in the blood samples from 48 healthy Korean men (age range, 21-29 years). Significant differences were observed in the time to maximum concentration (Tmax) and elimination half-life (t1/2) for nine metabolites among the three groups. The Tmax and t1/2 of the nine metabolites were higher in the SE group than in the other groups. Moreover, the absorption rates, as determined by the area under the plasma-level curve (AUC) values of intact isoflavone, were 5.3 and 9.4 times higher in the TE group than in the SY and SE groups, respectively. Additionally, the highest AUC values for phase I and II metabolites were observed in the TE group. CONCLUSIONS: These findings indicate that isoflavone bioavailability, following Cheonggukjang insgestion, is high in individuals with the TE constitution, and relatively lower in those with the SE and SY constitutions.

PERFORMANCE EVALUATION OF DIGITAL DATA PROCESSING SYSTEM FOR KOREAN VLBI NETWORK(KVN) (KVN을 위한 디지털 데이터 처리 시스템의 성능평가)

  • Oh, Se-Jin;Roh, Duk-Gyoo;Yeom, Jae-Hwan;Byun, Do-Young;Lee, Chang-Hoon;Chung, Hyun-Soo;Je, Do-Heung;Wajima, Kiyoaki;Kawakami, Kazuyuki
    • Publications of The Korean Astronomical Society
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    • v.22 no.3
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    • pp.63-73
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    • 2007
  • In this paper, we introduce the performance test results of digital data processing system for KVN (Korean VLBI Network). The digital data processing system for KVN consists of DAS (Data Acquisition System) and high-speed recorder which called Mark5B system. DAS system performs the digitalization of analog radio signal through ADS-1000 gigabit sampler with 1 Gsps/2-bit and process the digital filtering of digital signal. Mark5B system records the output data of DFB (Digital Filter Bank) with about 1 Gbps. In this paper, we carried out the preliminary evaluation experiments of the KVN digital data processing system connected between DAS system and Mark5B with VSI (VLBI Standard Interface) interface which is designed for compatible in each VLBI system. We first performed all of the KVN digital data processing system connected by VSI interface in the world. In factory inspection phase, we found that the DAS system has a memory read/write error in DSM (Digital Spectrometer) by analyzing the recorded data in Mark5B system. We confirmed that the DSM memory error has been correctly solved by comparing DSM results with Mark5B results. The effectiveness of KVN digital data processing system has been verified through the preliminary experiments such as data transmission, recording with VSI interface connection and data analysis between DSM and Mark5B system. In future work, we will perform the real astronomical observation by using the KVN 21m radio telescopes so as to verify its stability and performance.

A Study on Network based Intelligent Intrusion Prevention model by using Fuzzy Cognitive Maps on Denial of Service Attack (서비스 거부 공격에서의 퍼지인식도를 이용한 네트워크기반의 지능적 침입 방지 모델에 관한 연구)

  • Lee, Se-Yul;Kim, Yong-Soo;Sim, Kwee-Bo
    • Journal of the Korean Institute of Intelligent Systems
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    • v.13 no.2
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    • pp.148-153
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    • 2003
  • A DoS(Denial of Service) attack appears in the form of the intrusion attempt and Syn Flooding attack is a typical example. The Syn Flooding attack takes advantage of the weak point of 3-way handshake between the end-points of TCP which is the connection-oriented transmission service and has the reliability This paper proposes a NIIP(Network based Intelligent Intrusion Prevention) model. This model captures and analyzes the packet informations for the detection of Syn Flooding attack. Using the result of analysis of decision module, the decision module, which utilizes FCM(Fuzzy Cognitive Maps), measures the degree of danger of the DoS and trains the response module to deal with attacks. This model is a network based intelligent intrusion prevention model that reduces or prevents the danger of Syn Flooding attack.

Implementing Medical Education Continuous Quality Improvement Using Design-Based Research (설계기반 연구를 통한 의학교육 Continuous Quality Improvement 운영 경험)

  • Lee, Aehwa;Park, Hye Jin;Kim, Soon Gu;Kim, Jin Young;Kang, Yu Na;Lee, Se Youp;Baek, Won-Ki
    • Korean Medical Education Review
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    • v.22 no.3
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    • pp.189-197
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    • 2020
  • The goal of this study is to present efficient measures to improve the quality of medical education through using a developed and applied continuous quality improvement (CQI) model suitable for medical education. To achieve this purpose, we developed a theoretical CQI model through a review of the literature according to the design-based research method. Through repetitive productive cyclical processes and professional reviews, we finally deduced an appropriate CQI model for medical education. The most important results of this study are as follows: First, the CQI model for medical education is defined as a quality management system with a cyclical course of planning, implementation, evaluation, and improvement of medical education. Second, the CQI model for medical education is composed of quality management activities of educational design, work, and evaluation. In addition, each activity has the implementation strategies of planning, doing, checking, and improving based on the PDCA model (Plan-Do-Check-Act model). Third, the CQI model for medical school education is composed of committees related to medical education doing improvement activities, as well as planning, implementing and evaluating it with CQI. As a result, we can improve teaching by using the CQI model for medical education. It is more meaningful because this gives us organized and practical measures of quality management and improvement in medical education as well as in the educational process.

Isolation and Physiological Functionality of Yeasts from Wild Flowers in Seonyudo of Gogunsanyeoldo, Jeollabuk-do, Korea (전라북도 고군산열도의 선유도 일대 야생화들로부터 효모의 분리 및 생리기능성)

  • Hyun, Se-Hee;Han, Sang-Min;Lee, Jong-Soo
    • The Korean Journal of Mycology
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    • v.42 no.3
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    • pp.201-206
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    • 2014
  • Sixty one yeast strains of 21 species were isolated from wild flowers in Gogunsanyeoldo, including Seonyudo of Jeollabuk-do, Korea, and identified by comparison of nucleotide sequences for PCR-amplified D1/D2 region of 26S rDNA using BLAST. Among them, Cryptococcus sp. including C. aureus SY1-4 were found to be dominant, and Metschnikowia sp. including M. reukaufii SY20-1 and Rhodotnula sp. such as R. ingeniosa SY1-1 were also abundantly isolated. Some physiological functionalities of the culture broth and cell-free extracts from 61 yeast strains were determined. Supernatant from Metschnilowia reukaufii SY44-6 showed anti-gout xanthine oxidase inhibitory activity of 49.6% and whitening tyrosinase inhibitory activity of 38.4%, respectively.

Analysis of Elementary School Children's Concepts in Evolution Based on Science History (과학사적 진화개념 발달 단계에 기초한 초등학생들의 진화 개념 분석)

  • Lee Mi-Sook;Oh Se-Pyoung;Lee Kil-Jae
    • Journal of Korean Elementary Science Education
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    • v.24 no.2
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    • pp.145-159
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    • 2005
  • Students' alternative concepts of evolution are similar to misconcepts and disputes which scientists had in science history. The aims of this study are to analyze the elementary children's concept in evolution based on science history. Lee (2004)'s two tests were applied to 6th grade to investigate the children's evolution concepts and genetic concepts related to the historical development of the evolution concepts. The test results were analyzed in accordance with 4 stages of science history based on Lee (2004)'s method. These stages are divided to stage 1 (Before Lamarck), stage 2 (Lamarck), stage 3 (Darwin), stage 4 (After Darwin). The major results are as follows. Most of elementary school children are fixed to the stage 2. They usually do not show the consistency of evolution concepts in the three dimensional aspects such as mechanism, time, and subjects. Many children do not have concrete meaning of gene, inheritance, sexual reproduction, mutation and could not connect these concetps and process of evolution. Also, they believe the inheritance of acquired traits and spontaneous generation. Therefore it is confirmed that they still have similar misconcepts and disputes which scientists had in transition time between stage 2 and 3 and most of children already have strong Lamarckian thought acquired from daily life experience before learning about natural selection and evolution.

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Scale-up Polymerization of L -Lactide in Supercritical Fluid (초임계 유체에서 L-Lactide의 Scale-up 중합)

  • Prabowo, Benedictus;Kim, Se-Yoon;Choi, Dong-Hoon;Kim, Sao-Hyun
    • Polymer(Korea)
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    • v.35 no.4
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    • pp.284-288
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    • 2011
  • For the purpose of the pre-industry production of poly(L-lactide) (PLLA) and full understanding of the supercritical polymerization system, large scale polymerization of L-iactide initiated by 1-dodecano/stannous 2-ethyl-hexanoate (DoOH/Sn(Oct)$_2$) was carried out in supercritical chlorodifluoromethane under various reaction conditions (time, temperature and pressure)and reactants (monomer and supercritical solvent) concentrations. A 3 L sized-reactor system was used throughout this study. The monomer conversion increased to 72% on increasing reaction time to 5 h. The molecular weight of PLLA product also increased to 68000 g/moi over the same period. An increase in monomer concentration resulted in a higher molecular weight, up to 144000 g/mol and 97% of monomer conversion. Raising the reaction pressure from 130 to 240 bar also resulted in an increased monomer conversion and molecular weight. To increase heat resistivity of PLLA, methanol treatment and heat-vacuum methods were evaluated. Both of them successfully improved the heat resistivity property of PLLA.

Mental Health of Physical Therapy Students in Clinical Practice during the COVID-19 Pandemic: A Cross-sectional Survey in Gwangju and Jeollanam-do, South Korea

  • Park, Se Ju;Yeo, Seong Geun;Kim, Byeong Geun
    • The Journal of Korean Physical Therapy
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    • v.33 no.3
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    • pp.131-135
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    • 2021
  • Purpose: The purpose of this study was to investigate the mental health of physical therapy students in clinical practice during the COVID-19 pandemic. Methods: A cross-sectional survey was conducted during the pandemic and was completed by 100 physical therapy students in two universities in Gwangju and Jeollanam-do, South Korea. The Generalized Anxiety Disorder-7 (GAD-7) scale and the Patient Health Questionnaire-9 (PHQ-9) were used to evaluate their anxiety and depression status. A Chi-square test was conducted to evaluate the association of participant characteristics with the risk of having anxiety and depression. Logistic regression models were used to identify the general characteristic factors related to anxiety or depression. Results: Anxiety was found in 28 (28%) of the participants, and depression in 24 (24%). The risk of anxiety and depression in male physical therapy students was 0.189 and 0.211 times lower, respectively, than those female students (p<0.05). The risk of anxiety and depression in physical therapy students with a history of disease was 11.721 and 7.056 times higher, respectively, than those with a history of disease (p<0.05). The risk of anxiety in physical therapy students in clinical practice was 11.721 times higher than that in students who were not in clinical practice (p<0.05). Conclusion: The COVID-19 pandemic has led to a high risk of anxiety and depression among many physical therapy students. More attention and improvements are needed so that physical therapy students can study in a safe environment.

An Analysis of Spatial Characteristics of Environmental-Friendly Certified Farms - Focused on Jeollanam-do - (친환경 인증 농경지의 공간적 특성 분석 - 전라남도를 대상으로 -)

  • Park, Yujin;Gu, Jeong-Yoon;Lee, Sang-Woo;An, Kyungjin;Choi, Jinah;Kim, Sangbum;Park, Se-Rin
    • Journal of Korean Society of Rural Planning
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    • v.29 no.3
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    • pp.79-89
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    • 2023
  • As the demand for environmental-friendly agricultural products continues to rise due to increased concerns regarding food safety and ecosystem conservation, it is becoming important to identify regions and spatial locations where environmental-friendly should be intensively established for production integration. This study aims to analyze the spatial distribution of environmental-friendly certified farms in Jeollanam-do, South Korea. Spatial statistical analysis based on Local Moran's I and Getis-Ord Gi* were used to identify spatial cluster characteristics and landscape indices were utilized to analyze spatial patterns of environmental-friendly certified farms. The results indicated that Haenam-gun, Gangjin-gun, Muan-gun, and Jindo-gun were identified as hotspots, while Muan-gun, Goheung-gun, and Jindo-gun exhibited high connectivity. This suggests that environmental-friendly certified farms in Muan-gun and Jindo-gun were clustered and closely connected to one another. Based on the results of the spatial distribution of environmental-friendly certified farms, areas belonging to the hotspot and with high connectivity should be managed as clustered districts to secure the foundation and system of environmental-friendly certified farms. Areas that belong to cold spots and have low connectivity should be preceded by measures to promote conversion to environmental-friendly agriculture. In addition, it is necessary to make it possible to create a large-scale cluster district through a long-term spatial planning strategy to expand the environmental-friendly certified farms. The findings of this study can provide quantitative data on policies and discussions for developing a model for rural spatial planning.

Seed Morphological Characteristics and Dormancy type of Eranthis stellata Maxim., Korea Rare Plant. (희귀식물 너도바람꽃(Eranthis stellata Maxim.) 종자의 형태특성 및 휴면유형 분석)

  • Inhwan Chae;Geon Hui Ryu;Se-kyu Song;Jin-Woo Kim;Gi Ho Kang;Hayan Lee
    • Proceedings of the Plant Resources Society of Korea Conference
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    • 2020.08a
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    • pp.20-20
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    • 2020
  • Eranthis stellata Maxim. is a perennial plant that grows around the valley. E. stellata is concerned about the decline in natural habitats due to climate change in KOREA, continues to be observed and protected as an endangered species (Least Concrned, LC). Nevertheless, studies on the characteristics of the seeds of E. stellata are insufficient. So, this study analyzed the morphological characteristics and dormancy types of seeds. Seeds of E. stellata was collected in April at Gyeongsangbuk-do Arboretum and kept at 5 ℃ until using. To investigate the morphology of seeds, an optical microscope and a scanning electron microscope (SEM) were used. GA3 treated or untreated seeds (4 replicates of 25 seeds each) were observed germination and embryo growth for 1 month at 5 ℃ and 25/15 ℃ (12h day/12h night). The seed surface of E. stellata, light brown, was observed as a common characteristic of Eranthis genus, reticulate. The short axis of seeds was 1.11~1.77mm (average 1.44mm), and the long axis was 1.27~1.91mm (average 1.63mm), which was investigated in a slightly round shape (subglose). While no germination was observed at all conditions, Embryo growth was observed at 5 ℃ both in the control group and with GA3treated groups. Thus, seeds of E. stellata are classified as morphological physiological dormancy (MDP), which requires embryonic development and dormant break at the same time. These results can be useful information for determining morphological physiological seed dormancy and germination, and will be an important basic data for seed propagation of E. stellata as a resource.

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