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Cyclophosphamide in the Treatment of Idiopathic UIP and NSIP (통상성 간질성 폐렴과 비특이성 간질성 폐렴의 치료에 있어 Cyclophosphamide의 역할)

  • Jeon, Kyeongman;Chung, Man Pyo;Shin, Sung-Chul;Yu, Chang Min;Koh, Won-Jung;Suh, Gee Young;Kim, Hojoong;Kwon, O Jung;Kim, Tae Sung;Lee, Kyung Soo;Han, Joungho
    • Tuberculosis and Respiratory Diseases
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    • v.55 no.2
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    • pp.175-187
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    • 2003
  • Background : Although corticosteroid and cytotoxic agent such as cyclophosphamide have been used for the treatment idiopathic interstitial pneumonia (IIP), efficacy of these toxic drugs are unclear because previous reports included the patients who did not undergo surgical lung biopsy and none evaluated the response according to histopathologic entities of IIP. To answer this, we retrospectively analyzed the treatment response and side effects of corticosteroids and cyclophosphamide therapy in patients with idiopathic UIP and NSIP. Methods : Among 61 patients with UIP and 26 patients with NSIP diagnosed by surgical lung biopsy at Samsung Medical Center from July 1996 to June 2002, those who received corticosteroid or cyclophosphamide therapy for at least 6 months and were followed for at least one year after the initiation of treatment were enrolled (32 UIP, 23 NSIP). Treatment response of 55 patients was assessed by ATS response criteria (clinical symptoms, pulmonary function test and radiological findings). Adverse reactions to either agent (42 cases of cyclophosphamide${\pm}$low-dose prednisolone, 49 cases of prednisolone alone) were also analyzed. Results : Irrespective of treatment regimen, NSIP showed more favorable response than UIP (6 months: 78.3% vs. 9.4%, 12 months: 69.6% vs. 9.4%, p<0.001). Cyclophosphamide showed comparable response to corticosteroid in NSIP while its efficacy was as poor as those of corticosteroid therapy in UIP. Significant adverse reaction to drug more frequently occurred in corticosteroid group (35.7%) than cyclophosphamide group (14.3%) (p=0.017). Conclusion : Cyclophosphamide is effective and more tolerable than corticosteroids in the treatment of idiopathic nonspecific interstitial pneumonia.

Effects of Stocking Density on Performance and Blood Characteristics of Broiler in Summer (혹서기 사육 밀도가 육계의 생산성 및 혈액 성상에 미치는 영향)

  • Yu, D.J.;Na, J.C.;Jang, B.G.;Lee, D.S.;Kim, S.H.;Kim, J.H.;Kang, K.H.;Kang, H.G.;Suh, O.S.;Kang, H.S.
    • Korean Journal of Poultry Science
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    • v.34 no.2
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    • pp.105-110
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    • 2007
  • This experiment was conducted to investigate the effects of stocking density on performance and blood characteristics of broiler chicken in summer. One day-old 648 male commercial broiler chicks(Ross strain) were divided into 3 groups with 4 replicates(12 pens), 41 to 69 birds per pen, to compare the stocking density difference on growth performance and blood characteristics. Birds in T1, T2 and T3 were reared in different size 0.050, 0.066, 0.083 $m^2$/bird floor, respectively. The birds were fed the same experimental diet ad libitum for 5 weeks. Chickens were weekly weighed and one bird was selected from each pen to measure blood characteristics at the end of experiment. Body weight and feed intake increased significantly in low density treatment(T3) compare to that of high density treatment(P<0.05). Feed conversion was significantly improved in customary treatment(T2) relative to that of other treatments(P<0.05). No significant difference was observed in moisture contents of bedding among treatments. In blood characteristics, low density treatment(T3) decreased the total protein, cholesterol and albumin, but were no significant difference. From the result of this study, it could be concluded that the higher stocking density might give more stress to the birds from physical stimuli and thus were harmful environment causing lower productions compared to the lower ones

University students' eating behavior and consumer attitude in social commerce service (소셜커머스 이용 대학생의 외식 행동 및 태도 분석)

  • Kim, Hyun-Ah
    • Journal of Nutrition and Health
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    • v.47 no.6
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    • pp.426-434
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    • 2014
  • Purpose: The purposes of this study were to investigate eating behavior of university students through social commerce and to analyze factors affecting university students' attitude regarding social commerce. Methods: Questionnaires were distributed to 445 university students in Changwon, Korea from March 28 to April 28, 2013. A total of 339 questionnaires were used for the final analysis, which excluded improperly-completed questionnaires. Results: The major factor considered for eating behavior through social commerce was price (37.2%). Purchasing experiences of foodservice products according to types of foodservice were 64.9% for coffee shop, 59.3% for fast food restaurant, 53.4% for family restaurant, 46.0% for specialty restaurant, 35.7% for pizza restaurant, 35.4% for buffet, and 31.9% for bakery. Factors affecting satisfaction with social commerce for purchasing foodservice products were 'service quality of foodservice company', 'communication of social commerce', and 'discount rate of social commerce'. Factors affecting repurchasing intention of foodservice products through social commerce were 'service quality of foodservice company', 'site design of social commerce', and 'discount rate of social commerce'. Conclusion: In order to increase satisfaction with social commerce, 'service quality of foodservice company', 'communication of social commerce', and 'discount rate of social commerce' should be increased. And, to increase repurchasing intention of social commerce, 'service quality of foodservice company', 'site design of social commerce', and 'discount rate of social commerce' should be increased. In addition, two factors 'service quality of foodservice' and 'discount rate of social commerce' were found to have an effect on satisfaction and repurchasing intention of social commerce. For development of social commerce and foodservice industry, cooperative relationship between social commerce and foodservice industry is needed, and a reasonable price strategy should be established. The university students considered price as a major factor of eating behaviors and did not consider menu and taste as a major factor. From a longer perspective, such an eating behavior would have an effect on university students' dietary life and it would cause nutrition and health problems for university students. Thus, it implied that further studies from the perspectives of nutrition and health regarding eating behavior through social commerce service should be conducted.

Survey on sanitary knowledge level and degree of HACCP practice in culinary staff employed in elementary, middle, and high schools in Chungnam province (충남지역 초.중.고 학교급식 조리원의 위생지식 및 HACCP 수행도 조사)

  • Lee, Young Joong;Kim, Sun Hyo
    • Journal of Nutrition and Health
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    • v.47 no.4
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    • pp.300-312
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    • 2014
  • Purpose: This study was performed to examine the sanitary knowledge level and degree of HACCP (hazard analysis critical control point) practice in school culinary staff in order to provide basic information for improving hygiene of school meals. Methods: Exactly 305 culinary staff members were selected from elementary, middle, and high schools in 14 cities and rural areas, including whole administrative districts in Chungnam province. Surveyed schools were selected by convenience sampling, and one subject was selected randomly from each school. Surveys were taken by self-administered questionnaires developed by researchers and questionnaire were distributed and collected by postal mail. Results: Sanitary education administered by school dietitians to culinary staff was more frequent and longer in elementary schools, followed by middle and high schools (p < 0.001). Sanitary knowledge level and degree of HACCP practice, except for a few CCP or CP of culinary staff, were highest in elementary schools and middle school followed by high schools (p < 0.05), respectively. School class was negatively correlated with sanitary knowledge level of culinary staff (p < 0.01), and frequency of sanitary education was positively correlated with sanitary knowledge level of culinary staff (p < 0.01). Sanitary knowledge level of culinary staff was positively correlated with degree of HACCP practice (p < 0.01). School class, daily frequency of meal service, work experience, rice washing machine, and total score of sanitary knowledge were significant variables influencing degree of HACCP practice in culinary staff. Conclusion: The above results show that the following points should be considered to improve hygiene of school meals. Sanitary education should be administered more frequently by school dietitians to culinary staff, especially to those in high schools, which showed the lowest sanitary knowledge level and degree of HACCP practice. In addition, facilities and equipment required for HACCP practice should be supported in small-sized elementary schools.

First Report of the Virus Diseases in Victory Onion (Allium victorialis var. platyphyllum) (산마늘(Allium victorialis var. platyphyllum)에서 바이러스병의 최초보고)

  • Park, Seok-Jin;Nam, Moon;Kim, Jeong-Seon;Lee, Yeong-Hoon;Lee, Jae-Bong;Kim, Min-Kyeong;Lee, Jun-Seong;Choi, Hong-Soo;Kim, Jeong-Soo;Moon, Jae-Sun;Kim, Hong-Gi;Lee, Su-Heon
    • Research in Plant Disease
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    • v.17 no.1
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    • pp.66-74
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    • 2011
  • In 2005, a survey was conducted to identify virus diseases on victory onion, Allium victorialis var. platyphyllum grown in Ulleung island located in the East Sea. A total of 61 samples were collected from victory onion in the neighborhood of Seonginbong. The identification of viruses from the samples were carried out by electron microscopy and RT-PCR using primers species specific to GCLV, LYSV, SLV, OYDV and genus specific to Allexivirus, respectively. From sixty-one samples, filamentous rod particles (600-900 nm) were detected from four victory onion samples in EM, three samples containing SLV and one sample containing both SLV and Allexivirus in RT-PCR analysis, respectively. Victory onions naturally infected by the viruses were asymptomatic apparently. The viruses detected by RT-PCR were further characterized by the nucleotide sequence analysis of the coat protein region. Three isolates of SLV showed approximately 99% identities in the nucleotide and amino acid sequences, suggesting that they were likely to be the same strain. On the other hand, they showed approximately 75.7~83.7% identities in the nucleotide and 89.2~97.0% in amino acid sequences compared with the previously reported SLV isolates in Allium. The CP gene of the Allexivirus showed approximately 99.2% nucleotide identities and 98.8% amino acid identities with Garlic virus A. However, there was relatively low homology ranging from 60.6% to 81.5% compared with other Allexiviruses (GarV-C, GarV-E, GarV-X, GMbMV, and Shal-X). These data suggested that two viruses, SLV and GarV-A identified from victory onion, are named SLV-Ulleungdo and GarV-A-Ulleungdo, respectively. This is the first report of viruses infecting victory onion.

Effect of Film Layers and Storing Period on the Fermentation Quality of Whole Crop Barley Silage (청보리 사일리지의 비닐겹수 및 저장기간에 따른 발효품질)

  • Song, Tae-Hwa;Park, Tae-Il;Park, Hyong-Ho;Yoon, Chang;Kim, Yang-Kil;Park, Jong-Chul;Kang, Chon-Sik;Son, Jae-Han;Kim, Kyong-Ho;Cheong, Young-Keun;Oh, Young-Jin
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.35 no.1
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    • pp.6-11
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    • 2015
  • This study was undertaken to characterize feed value and silage quality according to storage period and film layers for whole-crop barley silage. The crude protein (CP) content increased in all silage during the storage periods compared to those before silage, this content slightly increased over the prolonged storage period but it was not significant (p>0.05). Depending on the film layers of silage, 6 layers were higher than 4 layers. The neutral detergent fiber (NDF) and acid detergent fiber (ADF) contents also increased in all silage during storage periods compared to those before silage (P<0.05), but they were maintained at similar levels during the storage period. Depending on the film layers of silage, 6 layers were higher than 4 layers. The total digestible nutrients (TDN) content decreased in all silage during the storage periods. However, it was maintained at a similar level for the duration of each storage period. Depending on the film layers of silage, 6 layers were lower than 4 layers. The pH value was decreased during the prolonged storage period and depending on the film layers, 6 layers were lower than 4 layers. In the organic acid contents during the prolonged storage period, lactic acid increased, acetic acid was lower, and butyric acid was significantly higher (p<0.05). Depending on the film layers, 6 layers showed higher levels of lactic acid and lower levels of butyric acid (p<0.05). Therefore, these results showed that 6 layer wrapping was advantageous for long term storage of whole crop barley silage, while also indicating that it is desirable to use 4 layer wrapping within a six month period.

Dry Matter Yield and Forage Quality at Mixture of Annual Legumes and Italian ryegrass on Paddy Field (논에서 이탈리안 라이그라스와 두과 사료작물 혼파에 따른 생산성 및 사료가치 비교)

  • Kim, Won-Ho;Kim, Ki-Young;Jung, Min-Woong;Ji, Hee-Chung;Lim, Young-Chul;Seo, Sung;Kim, Jong-Duk;Yoon, Bong-Ki;Lee, Hyo-Won
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.31 no.1
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    • pp.33-38
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    • 2011
  • This experiment was conducted to compare the dry matter yield and forage quality according to the seed mixture of annual legumes and Italian ryegrass (Lolium multiflorum, IRG) on paddy field at the experimental field of Jeollanam-Do Agricultural Research and Extension Services from 2007 to 2008. The five treatments used in this experiment were IRG single (cv. Kowinearly), IRG+Chinese milk vetch mixture, IRG + Crimson clover (cv. Linkarus) mixture, IRG + Austrian winter pea (Pisum sativum subsp. arvense cv. forage Pea) mixture and IRG + Hairy vetch (Vicia villosa. cv. Oregon Common) mixture. And the mixing ratio of Italian ryegrass + annual legumes were 70 : 30 as based mono seed rate. The dry matter (DM) percentage at harvest was 23.6~26.8%. The DM percentage among IRG single and mixture treatments were similar. The yields of fresh and CP were high in IRG + Forage pea mixtures as a 40,100 kg and 625 kg per ha, respectively (p<0.05). The yields of dry matter were high in IRG + Forage pea and IRG + hairy vetch pea mixtures as a 9,470 kg and 9,500 kg per ha, respectively (p<0.05). But the forage quality did not show difference between Italian ryegrass mono-culture and annual legumes mixture. The Av. $P_2O_5$ in IRG+Forage pea mixture was 78 mg/kg and concentration of K were 0.52~0.88. In conclusion, the mixture of IRG and Forage pea, dry matter yield, protein yield increased, and was effective in enhancing the stability of cultivation.

Study on Manufacture of Square Baled Corn Silage Using Square Silage Wrapping Compressor (소형 사각 곤포기를 이용한 옥수수 사각 압축곤포 사일리지 조제에 관한 연구)

  • Choi, Ki-Choon;Cho, Nam-Chul;Jung, Min-Woong;Kim, Jong-Geun;Shin, Jae-Soon;Lee, Kyung-Dong;Lim, Young-Chul;Kim, Won-Ho;Oh, Young-Keun;Kim, Cheon-Man;Kim, Hyuk-Gi;Han, Dong-Bae
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.31 no.1
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    • pp.75-84
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    • 2011
  • This study was conducted to investigate the effect of harvest stage of corn on the quality of square baled corn silage manufactured with corn grown in paddy land of Department of Animal Resources Development, National Institute of Animal Science, RDA from 2009 to 2010. Corn "Kwangpyungok" was harvested at three different growth stages (milk, yellow ripen and ripen stage) and ensiled at each harvest time. Square baled corn silage was manufactured by use of square silage wrapping compressor. Each treatment was replicated three times. The content of crude protein (CP) of corn in square baled corn silage decreased with delayed maturity, but the content of ADF (acid detergent fiber), NDF (neutral detergent fiber), TDN (total digestible nutrient) and in vitro dry matter digestibility (IVDMD) were not changed. The content of moisture, pH and the nutritive values at three different harvest stages were not influenced by the method of silage manufacture and inoculant. The content of lactate of square baled corn silage harvested in milk stage of corn was significantly increased, as compared with that of round baled corn silage (P<0.05), but in stage of yellow ripen was significantly decreased (P<0.05). The content of acetate in square baled corn silage significantly decreased with delayed harvest maturity, as compared with that of round baled corn silage (P<0.05). Flieg's score of square baled corn silage harvested in milk stage of corn was slightly higher than that of round baled corn silage, but Flieg's scores in yellow ripen stage and ripen stage were not influenced by the method of silage manufacture. Flieg's score with delayed maturity was not influenced by the method of silage manufacture and inoculant. The manufacture of square baled corn silage was proved to be suitable for the fermentation of corn silage. Therefore, this study suggest that square baled corn silage can be a way of new silage manufacture technique.

Effect of Nitrogen Application Level and Regrowth Period on Composition of Fatty Acid in Tall fescue and Bermudagrass (질소시비 수준 및 재생기간이 톨페스큐와 버뮤다그라스의 지방산조성에 미치는 영향)

  • Park, Hyung-Soo;Hwang, Kyung-Jun;Park, Nam-Gun;Kim, Young-Jun;Jeong, Ha-Yeon;Jo, Nam-Chul;Ko, Moon-Suck
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.29 no.1
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    • pp.43-50
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    • 2009
  • Two experiments were conducted to evaluate the effects of nitrogen (N) application level and regrowth period on the fatty acid (FA) concentration and forage production of tall fescue (Festuca arundinacea Schr.) and bermudagrass (Cynodon dactylon (L.) Pers.). N was applied at 0, 50 and 100 kg/ha, and swards were cut after regrowth periods (15d, 30d and 45d). Concentrations of Individual FA were determined by gas chromatography. FA composition of tall fescue contains a high proportion ($87{\sim}88%$) of total FA contents as palmitic (C16:0), linoleic (C18:2) and linolenic acid (C18:3). The FA composition was not affected by N application, but a longer regrowth period significantly (p<0.05) decreased the composition of linolenic acid (C18:3) and increased those of linoleic acid (C18:2). The FA composition of bermudagrass was not affected by N application, but a longer regrowth period significantly (p<0.001) decreased the composition of linoleic (C18:2) and linolenic acid (C18:3). Linoleic and linolenic acfd of tall fescue were higher than those of bermudagrass. Dry matter (DM) yield of bermudagrass was significantly (P<0.05) affected by N application level and regrowth period. DM yield was higher at high N application and was higher at longer regrowth period. The crude protein concentration was higher at high N application and was low at longer regrowth period. Application of nitrogen fertilizer Increases dry matter (DM) yield and crude protein (CP) content of bermudagrass. These studies demonstrate opportunities to affect the FA concentration and composition of FA in forage through management strategies, which could affect milk FA composition.

Effects of Extruded Linseed Supplementation on Methane Production in Holstein Steers (Extruded linseed 첨가가 홀스타인 거세우 장내발효 메탄발생량에 미치는 효과)

  • Woo, Yang Won;Lee, Chang Hyun;Rajaraman, Bharanidharan;Yeo, Joon Mo;Lee, Won Young;Kim, Do Hyung;Jang, Seon-Sik;Kim, Kyoung Hoon
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.37 no.4
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    • pp.315-321
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    • 2017
  • The present experiment was designed to investigate the effects of extruded linseed supplementation on methane production in Holstein steers. Four Holstein steers fitted with permanent cannulas were assigned to two dietary treatments in a duplicated $2{\times}2$ Latin square design: a control diet consisting of tall fescue straw (65%) and concentrate (35%), and a treatment diet supplemented with 3.8% extruded linseed by replacing a part of ingredients in the concentrate of the control diet. The concentrates of the control and the treatment diet were isoenergetic and isonitrogenous. Extruded linseed supplementation did not affect dry matter intake but significantly (P<0.05) increased the intake of lipid. Rumen pH was significantly (P<0.05) lower for control than for treatment. Although there was no significant difference between treatments, the concentration of total VFA in control was 21% higher than in treatment. The concentrations of acetic acid, propionic acid and butyric acid were not different between treatments. Extruded linseed supplementation significantly (P<0.05) reduced methane output(g/d) and emission factor. Methane conversion rate was lower for treatment than for control but no significant difference was found. The results of the present study showed that extruded linseed supplementation in the diet of Holstein steers could reduce methane output.