• IMMUNE NETWORK
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• 제11권1호
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• pp.59-67
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• 2011

Background: Insulin resistance is an integral feature of metabolic syndromes, including obesity, hyperglycemia, and hyperlipidemia. In this study, we evaluated whether the aloe component could reduce obesity-induced inflammation and the occurrence of metabolic disorders such as blood glucose and insulin resistance. Methods: Male C57BL/6 obese mice fed a high-fat diet for 54 days received a supplement of aloe formula (PAG, ALS, Aloe QDM, and Aloe QDM complex) or pioglitazone (PGZ) and were compared with unsupplemented controls (high-fat diet; HFD) or mice fed a regular diet (RD). RT-PCR and western blot analysis were used to quantify the expression of obesity-induced inflammation. Results: Aloe QDM lowered fasting blood glucose and plasma insulin compared with HFD. Obesity-induced inflammatory cytokine (IL-$1{\beta}$, -6, -12, TNF-${\alpha}$) and chemokine (CX3CL1, CCL5) mRNA and protein were decreased markedly, as was macrophage infiltration and hepatic triglycerides by Aloe QDM. At the same time, Aloe QDM decreased the mRNA and protein of $PPAR{\gamma}/LXR{\alpha}$ and $11{\beta}$-HSD1 both in the liver and WAT. Conclusion: Dietary aloe formula reduces obesity-induced glucose tolerance not only by suppressing inflammatory responses but also by inducing anti-inflammatory cytokines in the WAT and liver, both of which are important peripheral tissues affecting insulin resistance. The effect of Aloe QDM complex in the WAT and liver are related to its dual action on $PPAR{\gamma}$ and $11{\beta}$-HSD1 ression and its use as a nutritional intervention against T2D and obesity-related inflammation is suggested.

• 대한조선학회지
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• 제27권4호
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• pp.15-26
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• 1990

본 연구는 표면 양력관 이론을 이용하여 초월 공동이 발생한 2차원 날개의 유동해석을 위한 제반 경계 조건을 검증하고 공동 뒷부분의 모형을 비교 검토한다. 해석해가 존재하는 2차원 대칭 스트럿 주위의 초월 공동 현상을 수치적으로 해석하여 그 결과를 해석해와 비교함으로써 표면 양력판 이론에 의한 프로펠러 공동 문제 해석의 가능성을 입증하였다. 특히, 공동 뒷부분의 비 선형 닫힘 모형, 타원형 닫힘 모형, 그리고 선형 닫힘 조건을 서로 비교 분석함으로써 공동 문제 해결에서 가장 중요한 공동 닫힘 조건의 영향을 보였다.

• 대한조선학회논문집
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• 제28권2호
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• pp.146-158
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• 1991

2차원 날개 단면 주위의 유동을 레이저 유속계측장치(LDV)를 이용하여 계측하였다. 레이저 유속계측장치는 주위 유동에 영향을 주지 않으면서 물체 주위의 유속을 정밀하게 계측할 수 있는 장비로서 본 논문에서는 2W Ar-Ion 레이져 광선을 이용한 2색 3선형 레이저 시스템을 사용하여 2방향 속도를 동시에 계측하였다. 레이저유속 계측장치를 사용하여 NACA0012 단면 주위의 유동을 계측한 후 난류경계층, 박리현상(Separation) 및 날개 뒷날에서의 유동 현상등에 대한 해석을 수행하였다. 계측된 유동장의 해석 결과를 Head의 운동량 적분법에 의한 계산결과와 비교하였다. 입사각이 작고 레이놀드수가 비교적 큰 경우에는 계측결과에 의한 경계층 특성과 운동량 적분법에 의한 계산결과가 잘 일치함을 보였다. 2차원 날개단면 주위 유동을 정밀 계측하여 수치계산 방법에 의한 결과와의 비교를 위한 유동계측 자료를 확보하였으며 캐비테이션 특징 및 양력특성이 우수한 새로운 날개단면 개발에 응용될 수 있는 2차원 단면시험법을 개발하였다.

• 조명전기설비학회논문지
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• 제29권10호
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• pp.73-82
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• 2015

This paper proposes an ripple reduction algorithm and analyzes the effects of offset and scale errors generated by voltage sensor while measuring grid voltage in grid-tied single-phase inverters. Generally, the grid-connected inverter needs to detect the phase angle information by measuring grid voltage for synchronization, so that the single-phase inverter can be accurately driven based on estimated phase angle information. However, offset and scale errors are inevitably generated owing to the non-linear characteristics of voltage sensor and these errors affect that the phase angle includes 1st harmonic component under using SRF-PLL(Synchronous Reference Frame - Phase Locked Loop) system for detecting grid phase angle. Also, the performance of the overall system is degraded from the distorted phase angle including the specific harmonic component. As a result, in this paper, offset and scale error due to the voltage sensor in single-phase grid connected inverter under SRF-PLL is analyzed in detail and proportional resonant controller is used to reduce the ripples caused by the offset error. Especially, the integrator output of PI(Proportional Integral) controller in SRF-PLL is selected as an input signal of the proportional resonant controller. Simulation and experiment are performed to verify the effectiveness of the proposed algorithm.

• 조명전기설비학회논문지
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• 제27권3호
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• pp.100-106
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• 2013

In this paper, in order to analyze lightning impulse response characteristics in combined installations of SPDs and RCDs, surge protection coordination between SPDs and RCDs are experimentally investigated by using the combination wave generator. Six different types of single-phase residual current operated circuit-breakers with integral overcurrent protection for household and similar uses(RCBOs) being present on the domestic market are tested according to KS C IEC 61009-1 standard. As a result, when a class I SPD is located on the source side of an RCBO, all kinds of specimens are able to provide the proper coordination between the SPD and RCBOs without nuisance tripping, unintended operation or damage due to test impulse currents. However, in the case that the class II SPD is located on the load side of RCBOs, a lot of L-N mode injected currents is split into the RCBO, and a few RCBOs are damaged. Coordination between SPDs and RCDs is not valid and a role of SPDs is of no use. When combining SPDs with RCDs, it is necessary to select SPDs and RCDs in consideration of the protection voltage level of metal oxide varistor embedded in RCDs.

• Journal of Microbiology
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• 제37권4호
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• pp.256-262
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• 1999

Latent membrane protein 1 (LMP1) of the Epstein-Barr virus (EBV) is an integral membrane protein with six transmembrane domains, which is essential for EBV-induced B cell transformation. LMP1 functions as a constitutively active tumor necrosis factor receptor (TNFR) like membrane receptor, whose signaling requires recruitment of TNFR-associated factors (TRAFs) and leads to NF-${\kappa}B$ activation. NF-${\kappa}B$ activation by LMP1 is critical for B cell transformation and has been linked to many phenotypic changes associated with EBV-induced B cell transformation. Deletion analysis has identified two NF-${\kappa}B$ activation regions in the carboxy terminal cytoplasmic domains of LMP1, termed CTAR1 (residues 194-232) and CTAR2 (351-386). The membrane proximal C-terminal domain was precisely mapped to a PXQXT motif (residues 204-208) involved in TRAF binding as well as NF-${\kappa}B$ activation. In this study, we dissected the CTAR2 region, which is the major NF-${\kappa}B$ signaling effector of LMP1, to determine a minimal functional sequence. A series of LMP1 mutant constructs systematically deleted for the CTAR2 region were prepared, and NF-${\kappa}B$ activation activity of these mutants were assessed by transiently expressing them in 293 cells and Jurkat T cells. The NF-${\kappa}B$ activation domain of CTAR2 appears to reside in a stretch of 6 amino acids (residues 379-384) at the end of the carboxy terminus.

• 한국정밀공학회지
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• 제22권5호
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• pp.130-137
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• 2005

Recently, the importance of CAE research is growing with the advances of the automotive and computer industry. In addition, multi-body dynamics and powertrain analysis are the most important factors in improving the vehicle design. Since engine torque with curve-data was used for analyzing full car simulation in the multi-body dynamics system for many years, it is impossible to assess the concurrent analysis of the engine and powertrain element included in a real full car system. In powertrain, since vehicle are usually modeled as a simple mass and a inertia, they can not be seen as real cars. Moreover, it is hard to obtain additional dynamics data other than the longitudinal velocity value in movement. Because of the reason that was previously discussed, it is necessary to consolidate the two parts as one routine program for design and development through the coordinate system connectivity, and presented here is a program named O-DYN. Using an object-oriented language C++, this program has a good structure with the valuable characteristics of objectivity, inheritance, and reusability. The reliability of this multi-body dynamics program is examined by DADS, which is the general dynamics program, using DAE solver and PECE integral function with the common coordinator separation method. As a result, we can obtain a better solution and total dynamics data in either area through this process. This program will be useful for analyzing full car simulation with powertrain.

• 대한조선학회논문집
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• 제32권4호
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• pp.55-63
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• 1995

본 논문은 경계적분법에 의해 날개끝판이 부착된 프로펠러(EPP)의 성능을 해석하는 방법을 기술하고 있다. 나선 프로펠러 날개와 날개끝판을 사각형 판요소로 치환하고, 균일 세기의 쏘오스와 법선 다이폴을 분포하여 해석한다. 포텐셜을 기저로 하는 정식화 과정을 통해 적분방정식을 구하고, 나선날개와 날개끝판에서 동시에 법선방향 비침투조건을 만족시킴으로써 섭동 속도 포텐셜을 구하였다. Kutta조건은 반복작업을 통해 나선날개와 날개끝판의 뒷날에서 압력점프가 없어지도록 함으로써 만족시켰다. 예제계산을 통하여 날개끝판이 나선날개의 날개끝 부근의 하중을 증가시킴을 보였고, 동시에 날개끝판의 뒷날에 걸쳐 후연 보오텍스를 분산시킴으로써 강력한 날개끝 보오텍스의 형성을 피할 수 있음을 확인하였다. EPP의 성능을 추정한 결과는 실험결과와 좋은 일치를 보인다. 에너지절약 추진장치로 채택될 수 있는 EPP의 설계 및 해석을 위하여 본 연구에서 확립된 방법이 적용가능하리라 판단된다.

• 한국분말재료학회지
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• 제26권2호
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• pp.146-155
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• 2019

Rare earth magnets are the strongest type of permanent magnets and are integral to the high tech industry, particularly in clean energies, such as electric vehicle motors and wind turbine generators. However, the cost of rare earth materials and the imbalance in supply and demand still remain big problems to solve for permanent magnet related industries. Thus, a magnet with abundant elements and moderate magnetic performance is required to replace rare-earth magnets. Recently, $a^{{\prime}{\prime}}-Fe_{16}N_2$ has attracted considerable attention as a promising candidate for next-generation non-rare-earth permanent magnets due to its gigantic magnetization (3.23 T). Also, metastable $a^{{\prime}{\prime}}-Fe_{16}N_2$ exhibits high tetragonality (c/a = 1.1) by interstitial introduction of N atoms, leading to a high magnetocrystalline anisotropy constant ($K_1=1.0MJ/m^3$). In addition, Fe has a large amount of reserves on the Earth compared to other magnetic materials, leading to low cost of raw materials and manufacturing for industrial production. In this paper, we review the synthetic methods of metastable $a^{{\prime}{\prime}}-Fe_{16}N_2$ with film, powder and bulk form and discuss the approaches to enhance magnetocrystalline anisotropy of $a^{{\prime}{\prime}}-Fe_{16}N_2$. Future research prospects are also offered with patent trends observed thus far.

• Steel and Composite Structures
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• 제42권2호
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• pp.243-256
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• 2022

A coupled finite element method (FEM)-boundary element method (BEM) for analyzing the hydroelastic response of functionally graded carbon nanotube-reinforced composite (FG-CNTRC) floating plates under moving loads is firstly introduced in this article. For that aim, the plate displacement field is described utilizing a generalized shear deformation theory (GSDT)-based FEM, meanwhile the linear water-wave theory (LWWT)-relied BEM is employed for the fluid hydrodynamic modeling. Both computational domains of the plate and fluid are coincidentally discretized into 4-node Hermite elements. Accordingly, the C1-continuous plate element model can be simply captured owing to the inherent feature of third-order Hermite polynomials. In addition, this model is also completely free from shear correction factors, although the shear deformation effects are still taken into account. While the fluid BEM can easily handle the free surface with a lower computational effort due to its boundary integral performance. Material properties through the plate thickness follow four specific CNT distributions. Outcomes gained by the present FEM-BEM are compared with those of previously released papers including analytical solutions and experimental data to validate its reliability. In addition, the influences of CNT volume fraction, different CNT configurations, water depth, and load speed on the hydroelastic behavior of FG-CNTRC plates are also examined.