• Genomics & Informatics
• /
• v.18 no.4
• /
• pp.39.1-39.8
• /
• 2020

Alzheimer's disease (AD) is a chronic, progressive brain disorder that slowly destroys affected individuals' memory and reasoning faculties, and consequently, their ability to perform the simplest tasks. This study investigated the hub genes of AD. Proteins interact with other proteins and non-protein molecules, and these interactions play an important role in understanding protein function. Computational methods are useful for understanding biological problems, in particular, network analyses of protein-protein interactions. Through a protein network analysis, we identified the following top 10 hub genes associated with AD: PTGER3, C3AR1, NPY, ADCY2, CXCL12, CCR5, MTNR1A, CNR2, GRM2, and CXCL8. Through gene enrichment, it was identified that most gene functions could be classified as integral to the plasma membrane, G-protein coupled receptor activity, and cell communication under gene ontology, as well as involvement in signal transduction pathways. Based on the convergent functional genomics ranking, the prioritized genes were NPY, CXCL12, CCR5, and CNR2.

• The Bulletin of The Korean Astronomical Society
• /
• v.44 no.1
• /
• pp.46.1-46.1
• /
• 2019

We present an accurate and efficient method to calculate the gravitational potential of an isolated system in three-dimensional Cartesian and cylindrical coordinates subject to vacuum (open) boundary conditions. Our method consists of two parts: an interior solver and a boundary solver. The interior solver adopts an eigenfunction expansion method together with a tridiagonal matrix solver to solve the Poisson equation subject to the zero boundary condition. The boundary solver employs James's method to calculate the boundary potential due to the screening charges required to keep the zero boundary condition for the interior solver. A full computation of gravitational potential requires running the interior solver twice and the boundary solver once. We develop a method to compute the discrete Green's function in cylindrical coordinates, which is an integral part of the James algorithm to maintain second-order accuracy. We implement our method in the {\tt Athena++} magnetohydrodynamics code, and perform various tests to check that our solver is second-order accurate and exhibits good parallel performance.

• Bulletin of the Korean Chemical Society
• /
• v.15 no.3
• /
• pp.214-221
• /
• 1994

We present some results obtained from theoretical study on a non-symmetrical A/BC polymeric system including solvent which consists of two phases, a polymeric phase A on one side and a mixture of polymers B (as a compatibilizer) and C on the other in the presence of a solvent. By employing the functional integral techniques we derive the mean-field equations and solve them numerically to deduce the physical properties of the interface involving the polymers and solvent concentration profiles in the limit that molecular weights of all the polymers involved tend to infinity. The calculations are performed for typical values of the Flory interaction parameters and for the volume fraction of polymer B in the asymptotic phase and of solvent. In the polymers/solvent blend under consideration the interfacial adsorption of polymer B, the solvent concentration, and degrees of the specific interaction between the polymers are found to play important roles in modification of the interfacial properties.

• Nonlinear Functional Analysis and Applications
• /
• v.27 no.1
• /
• pp.99-110
• /
• 2022

The main object of this paper is to provide necessary and sufficient conditions for the generalized Struve functions of first kind to be in the classes 𝒮(k, λ) and 𝒞(k, λ). Furthermore, we give conditions for the integral operator 𝓛(m, c, z) = ∫^z₀(2 - u_p(t))dt to be in the class 𝒞^*(k, λ). Several corollaries and consequences of the main results are also considered.

• Communications of the Korean Mathematical Society
• /
• v.37 no.2
• /
• pp.551-566
• /
• 2022

We apply Fourier-Legendre-based integration methods that had been given by Campbell in 2021, to evaluate new rational double hypergeometric sums involving ${\frac{{1}}{\pi}}$. Closed-form evaluations for dilogarithmic expressions are key to our proofs of these results. The single sums obtained from our double series are either inevaluable $_2F_1({\frac{4}{5}})$- or $_2F_1({\frac{1}{2}})$-series, or Ramanujan's ₃F₂(1)-series for the moments of the complete elliptic integral K. Furthermore, we make use of Ramanujan's finite sum identity for the aforementioned ₃F₂(1)-family to construct creative new proofs of Landau's asymptotic formula for the Landau constants.

• Journal of the Chungcheong Mathematical Society
• /
• v.23 no.3
• /
• pp.523-534
• /
• 2010

In this paper, we consider the weighted Bloch spaces ${\mathcal{B}}_q$(q > 0) on the open unit ball in ${\mathbb{C}}^n$. We prove a certain integral representation theorem that is used to determine the degree of growth of the functions in the space ${\mathcal{B}}_q$ for q > 0. This means that for each q > 0, the Banach dual of $L_a^1$ is ${\mathcal{B}}_q$ and the Banach dual of ${\mathcal{B}}_{q,0}$ is $L_a^1$ for each $q{\geq}1$.

• Communications of the Korean Mathematical Society
• /
• v.38 no.1
• /
• pp.21-38
• /
• 2023

Let R be a commutative ring with identity. Let R be an integral domain and M a torsion-free R-module. We investigate the relation between the notion of e-exactness, recently introduced by Akray and Zebari [1], and generalized the concept of homology, and establish a relation between e-exact sequences and homology of modules. We modify some applications of e-exact sequences in homology and reprove some results of homology with e-exact sequences such as horseshoe lemma, long exact sequences, connecting homomorphisms and etc. Next, we generalize two special drived functor T or and Ext, and study some properties of them.

• Journal of Korean Port Research
• /
• v.5 no.1
• /
• pp.71-81
• /
• 1991

This study deals with the analytical and numerical solution for the combined wave reflection and diffraction near the impermeable rigid upright breakwater, subject to the excitation of a plane simple harmonic wave coming from infinity. Three cases are presented : a) the analytical solution near a thin semi-infinite breakwater, b) the analytical solution near the semi-infinite breakwaters of arbitrary edge angles, $30^{\circ},\;45^{\circ},\;and\;90^{\circ}$, c) the numerical solution near a detached thin breakwater the results are presented in amplification factor and wave height diagrams. Moreover, the amplification factors near the structure(2 wavelength before and behind the structure) are compared for the given cases. A finite difference technique for the numerical solution was applied to the integral equation obtained for the wave potential.

• The Korean Journal of Food & Health Convergence
• /
• v.10 no.2
• /
• pp.7-11
• /
• 2024

Glutathione (GSH) is a vital compound composed of glutamic acid, cysteine, and glycine, crucial for cellular functions including oxidative stress defense and detoxification. It has widespread applications in pharmaceuticals, cosmetics, and food industries due to its antioxidant properties and immune system support. Two primary methods for GSH synthesis are enzymatic and microbial fermentation. Enzymatic synthesis is efficient but costly, while microbial fermentation, particularly using yeast strains like Candida albicans, offers a cost-effective alternative. This study focuses on genetically modifying C. albicans mutants, specifically targeting glutathione reductase (GLR1) and gamma-glutamylcysteine synthetase (GCS1) genes, integral to GSH synthesis. By optimizing these mutants, the research aims to develop a model for efficient GSH production, potentially expanding its applications in the food industry.

• The Korean Journal of Nuclear Medicine Technology
• /
• v.19 no.2
• /
• pp.87-92
• /
• 2015

Purpose When the patients takes myocardial perfusion SPECT using $^{201}Tl$, the operator gives the patients an injection of $^{201}Tl$. But the uniformity correction map in SPECT uses $^{99m}Tc$ uniformity correction map. Thus, we want to compare the image quality when it uses $^{99m}Tc$ uniformity correction map and when it uses $^{201}Tl$ uniformity correction map. Materials and Methods Phantom study is performed. We take the data by Asan medical center daily QC condition with flood phantom including $^{201}Tl$ 21.3 kBq/mL. After postprocessing with this data, we analyze CFOV integral uniformity(I.U) and differential uniformity(D.U). And we take the data with Jaszczak ECT Phantom by American college of radiology accreditation program instruction including $^{201}Tl$ 33.4 kBq/mL. After post processing with this data, we analyze spatial Resolution, Integral Uniformity(I.U), coefficient of variation(C.V) and Contrast with Interactive data language program. Results In the flood phantom test, when it uses $^{99m}Tc$ uniformity correction map, Flood I.U is 3.6% and D.U is 3.0%. When it uses $^{201}Tl$ uniformity correction map, Flood I.U is 3.8% and D.U is 2.1%. The flood I.U is worsen about 5%, but the D.U is improved about 30% inversely. In the Jaszczak ECT phantom test, when it uses $^{99m}Tc$ uniformity correction map, SPECT I.U, C.V and contrast is 13.99%, 4.89% and 0.69. When it uses $^{201}Tl$ uniformity correction map, SPECT I.U, C.V and contrast is 11.37%, 4.79% and 0.78. All of data are improved about 18%, 2%, 13% The spatial resolution was no significant changes. Conclusion In the flood phantom test, Flood I.U is worsen but Flood D.U is improved. Therefore, it's uncertain that an image quality is improved with flood phantom test. On the other hand, SPECT I.U, C.V, Contrast are improved about 18%, 2%, 13% in the Jaszczak ECT phantom test. This study has limitations that we can't take all variables into account and study with two phantoms. We need think about things that it has a good effect when doctors decipher the nuclear medicine image and it's possible to improve the image quality using the uniformity correction map of other radionuclides other than $^{99m}Tc$, $^{201}Tl$ when we make other nuclear medicine examinations.