• Journal of Marine Bioscience and Biotechnology
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• v.5 no.4
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• pp.33-39
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• 2011

As a rapid and quick bioactive compound evaluation technique, we utilized an automatic system of high throughput screening (HTS) to investigate ${\alpha}$-glucosidase inhibitory efficacy of seaweeds, collected from Jeju Island in Korea. In this study, different extracts with methanol at $20^{\circ}C$ and $70^{\circ}C$ from 23 species of brown seaweeds and 22 species of red seaweeds and 9 species of green seaweeds were subjected to HTS. Of the brown seaweeds tested, Myelophycus simplex (20B3), Ishige sinicola (20B5, 70B5), Colpomenia sinuosa, (20B14, 70B14), Hizikia fusiforme (20B21), Ishige okamurai (70B22) and Ecklonia cava (70B23) showed significantly high ${\alpha}$-glucosidase inhibitory activity with 96.52%, 98.34%, 98.37%, 80.49%, 96.16%, 76.32%, 98.32% and 98.12%. Schizymenia dubyi (20R15), Gelidium amansii (20R16) and Polysiphonia japonica (70R22) amomng the red seaweeds showed remarkable ${\alpha}$-glucosidase inhibitory activity more than 95%. On the other hand, the green seaweeds showed poor ${\alpha}$-glucosidase inhibitory activities (less the10%) at 1 mg/ml.

• Journal of Digital Convergence
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• v.18 no.6
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• pp.513-522
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• 2020

The purpose of this study is to analyze the auto-regression effect between the elderly's assets and depression and life satisfaction, and to approach the influence of assets and depression on the elderly's life from a longitudinal perspective. For this purpose, the data for the 9th year (2014), 11th year (2016), and 13th year (2018) of the Korea Welfare Panel were used. As a result of the analysis, First, the assets, depression and life satisfaction of the elderly have a lasting effect on the passage of time, and the assets, depression and life satisfaction of the previous point in time (B=.694, B=.725, p<.001), depression (B=.258, B=.331 and p<.001) and life satisfaction (B=.264, B=.265, p<.001). Second, cross-recursion coefficients show how the relationship between the assets of the elderly and depression and the satisfaction of life affects each other over time, and the assets of the older person at the previous point in time (B=.010, B=.011, p<.001), the assets of the older persons at previous times are subsequently satisfied with their lives (B=.128, B=.124, p<.001). Based on the results of the above analysis, it is necessary to support the elderly's asset management service and education to prevent depression, such as continuous asset utilization education.

• Fisheries and Aquatic Sciences
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• v.21 no.9
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• pp.21.1-21.8
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• 2018

In the present study, we first evaluated the melanin inhibitory effect of four crude 70% ethanol extracts separated from soft corals abundantly growing along the seawaters of Jeju Island, South Korea, including Dendronephthya castanea (DC), Dendronephthya gigantea (DG), Dendronephthya puetteri (DP), and Dendronephthya spinulosa (DS). Among the four ethanol extracts, the ethanol extract of DP (DPE) did not possess any cytotoxic effect on B16F10 cells. However, all other three extracts showed a cytotoxic effect. Also, DPE reduced the melanin content and the cellular tyrosinase activity without cytotoxicity, compared to the ${\alpha}-MSH$-stimulated B16F10 cells. Specifically, DPE downregulated the expression levels of tyrosinase and microphthalmia-associated transcription factor by activating the ERK signaling cascade in ${\alpha}-MSH$-stimulated B16F10 cells. Interestingly, the melanin inhibitory effect of DPE was abolished by the co-treatment of PD98059, an ERK inhibitor. According to these results, we suggest that DPE has whitening capacity with the melanin inhibitory effects by activating ERK signaling and could be used as a potential natural melanin inhibitor for cosmeceutical products.

• IMMUNE NETWORK
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• v.14 no.1
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• pp.14-20
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• 2014

CD28/T cell receptor ligation activates the NF-${\kappa}B$ signaling cascade during CD4 T cell activation. NF-${\kappa}B$ activation is required for cytokine gene expression and activated T cell survival and proliferation. Recently, many reports showed that NF-${\kappa}B$ activation is also involved in T helper (Th) cell differentiation including Th17 cell differentiation. In this review, we discuss the current literature on NF-${\kappa}B$ activation pathway and its effect on Th17 cell differentiation.

• Journal of the Korea Society of Computer and Information
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• v.17 no.6
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• pp.201-209
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• 2012

This study was conducted in order to empirically analyze factors affecting the quality of life in the elder resulting from the use of elderly leisure facilities in the community. For this purpose, we surveyed the elder using the senior health town of Gwang-ju Metropolitan City to see whether the quality of life in the elder is influenced by factors such as facilities' environment within the health town, the capacity for the staff and instructors, and the elders' satisfaction with programs. The results of this study are expected to provide practical solutions for enhancing the quality of life in senior users. The survey was performed with 1,038 elders aged over 60 who were using the senior health town of Gwang-ju Metropolitan City by using a self-administered questionnaire and being interviewed with surveyors. The period of the survey was from the 10th to 15th of December, 2010. According to the results of this study, variables affecting the elders' quality of life were academic qualification (B= .074, p<0.05), instructors satisfaction (B=.172, p<0.001), staff satisfaction (B=.104, p<0.01), and facilities and environment satisfaction (B=.217, p<0.001). That is, the lower academic background they have, the higher instructors', staff's, facilities and environment's satisfaction are, the quality of life in the elder was positively affected. In particular, facilities and environment's satisfaction show a relatively high effect and this suggests the necessity to modernize cultural and leisurely facilities in community for senior citizens and create pleasant environment in order to improve the quality of life in the elder.

• Journal of the Korean Society of Propulsion Engineers
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• v.18 no.3
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• pp.17-25
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• 2014

The purpose of this paper is to present a method to estimate the storage life of propellant bag for degradation of breaking load with storage time by using gamma process model. The nitrogen compound generated by natural decomposition of propellants degrades the breaking load of propellant bag with time. The statistical distributions of condition and lifetime with time were shown from the results of accelerated life test of propellant bag cloth at $80^{\circ}C$. It was found that the use of median for life was highly appropriate and the $B_1$ or $B_5$ life should be selectively applied to the quality assurance policy.

• The Plant Pathology Journal
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• v.32 no.3
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• pp.228-241
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• 2016

In our previous study, we reported that a novel endophytic bacterium Bacillus oryzicola YC7007 has suppressed bacterial diseases of rice via induced systemic resistance and antibiotic production. This endophytic strain, B. oryzicola YC7007 was used as a biological control agent against bakanae disease of rice caused by Fusarium fujikuroi, and its mechanism of interaction with the pathogen and the rice was further elucidated. Root drenching with B. oryzicola YC7007 suspension reduced the disease severity of bakanae significantly when compared with the untreated controls. The treatments of B. oryzicola YC7007 suspension ($2.0{\times}10^7cfu/ml$) to the rice rhizosphere reduced bakanae severity by 46-78% in pots and nursery box tests containing autoclaved and non-autoclaved soils. Moreover, in the detached rice leaves bioassay, the development of necrotic lesion and mycelial expansion of F. fujikuroi were inhibited significantly by spraying the culture filtrate of B. oryzicola YC7007. Drenching of ethyl acetate extracts of the culture filtrate to the rhizosphere of rice seedlings also reduced the bakanae disease severity in the plant culture dish tests. With the root drenching of B. oryzicola YC7007 suspension, the accumulation of hydrogen peroxide was observed at an early stage of rice seedlings, and a hormonal defense was elicited with and without pathogen inoculation. Our results showed that the strain B. oryzicola YC7007 had a good biocontrol activity against the bakanae disease of rice by direct inhibition, and was also capable of inducing systemic resistance against the pathogen via primed induction of the jasmonic acid pathway.

• Journal of Navigation and Port Research
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• v.39 no.6
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• pp.473-478
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• 2015

In this paper, we suggest a flexible multiband antenna which can be equipped on an inflatable life-jacket. The antenna can send distress alert and location data of survivors to assist rescue operation when crew or people are in distress. The antenna operate in three frequency bands such as VHF-DSC band (156MHz), COSPAS-SARSAT band (406MHz) and GPS band (1,575MHz). The GPS band is implemented with a square ring-slot planar antenna, the COSPAS-SARSAT band and the VHF-DSC band antenna is implemented by monopole type. In order to give flexibility of substrate to be equipped on life-jacket, FR4-epoxy substrate of thickness 0.2mm is used to make antenna. The reflection coefficients of the fabricated antenna are -8.8dB, -20.4dB and -10.7dB at each bandwidth like VHF-DSC, COSPAS-SARSAT and GPS band, respectively, when people are wearing life-jacket integrated multiband antenna.

• BMB Reports
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• v.45 no.5
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• pp.293-298
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• 2012

The p38 mitogen-activated protein kinase (MAPK) is involved in various processes, including stress responses, development, and differentiation. However, little information on p38 MAPK in insects is available. In this study, a p38 MAPK gene, $Accp38b$, was isolated from $Apis$ $cerana$ $cerana$ and characterized. The quantitative real-time PCR (Q-PCR) analysis revealed that $Accp38b$ was induced by multiple stressors. Notably, the expression of $Accp38b$ was relatively higher in the pupae phase than in other developmental phases. During the pupae phase, Accp38b expression was higher in the thorax than in the head and abdomen and higher in the fat body than in the muscle and midgut. Immunohistochemisty showed significant positive staining of Accp38b in sections from the brain, eyes, fat body, and midgut of $A.$ $cerana$ $cerana$. These results suggest that Accp38b may play a crucial role in stress responses and have multiple aspects function during development.

• Journal of Life Science
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• v.26 no.2
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• pp.259-264
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• 2016

Metastatic cancer is one of the main causes of cancer-related death since they rarely respond to available treatments. There is epidemiologic evidence that high garlic consumption decreases the incidence of cancer. Recent studies of our laboratory have revealed that a garlic-extracts is effective in suppressing metastasis. For experimental metastasis, C57BL/6 mice were injected intravenously with melanoma B16F10 cells in the tail vein, and were orally administered various concentrations (0, 50, 100 or 200 mg/kg body weight) of garlic hexane extract (GHE) for 21 days. The incidence and the area of the melanoma cell colony occupied by the poorly differentiated carcinoma were significantly lower in dose-dependent in 50, 100 and 200 mg/kg BW GHE - treated mice compared with control mice. In conclusion, the results of the present study show that GHE administration prevents lung metastasis in C57BL/6 mice.