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http://dx.doi.org/10.4110/in.2014.14.1.14

NF-${\kappa}B$ Activation in T Helper 17 Cell Differentiation  

Park, Sang-Heon (School of Life Sciences, Gwangju Institute of Science and Technology (GIST))
Cho, Gabi (School of Life Sciences, Gwangju Institute of Science and Technology (GIST))
Park, Sung-Gyoo (School of Life Sciences, Gwangju Institute of Science and Technology (GIST))
Publication Information
IMMUNE NETWORK / v.14, no.1, 2014 , pp. 14-20 More about this Journal
Abstract
CD28/T cell receptor ligation activates the NF-${\kappa}B$ signaling cascade during CD4 T cell activation. NF-${\kappa}B$ activation is required for cytokine gene expression and activated T cell survival and proliferation. Recently, many reports showed that NF-${\kappa}B$ activation is also involved in T helper (Th) cell differentiation including Th17 cell differentiation. In this review, we discuss the current literature on NF-${\kappa}B$ activation pathway and its effect on Th17 cell differentiation.
Keywords
NF-${\kappa}B$; Th17; T cell receptor; Autoimmune;
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