• 환경생물
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• 제31권4호
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• pp.376-382
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• 2013

[6]-Gingerol, a major polyphenol of ginger (Zingiber officinale), exhibits a variety of biological properties including anti-oxidant, anti-inflammatory and anti-cancer activity. However, the radioprotective effect of [6]-gingerol is still unknown. The aim of this study was to investigate the radioprotective effect of [6]-gingerol against radiation-induced cell cytotoxicity and oxidative stress in HepG2 cells. [6]-Gingerol pretreatment attenuated radiation-induced cell cytotoxicity caused by 5Gy (half lethal dose, $LD_{50}$ of HepG2 cells). The measurements of superoxide dismutase (SOD) and catalase (CAT) activity were also performed. The results showed that [6]-gingerol pretreatment reduced increasing SOD and CAT activity after exposure of IR, indicating that [6]-gingerol protected oxidative stress by regulating cellular antioxidant enzyme (SOD and CAT) activity. These findings suggest that [6]-gingerol acts as a radioprotector by attenuating cell cytotoxicity and oxidative stress.

• Bulletin of the Korean Chemical Society
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• 제35권8호
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• pp.2311-2316
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• 2014

Conformations and vibrational frequencies of the racemic (2RS,3RS)-5-amino-3-(4-phenylpiperazin-1-yl)-1,2,3,4-tetrahydronaphthalen-2-ol-(I) [(2RS,3RS)-(I)], a precursor of benzovesamicol analogues, have been carried out using various DFT methods (M06-2X, B3LYP, B3PW91, PBEPBE, LSDA, and B3P86) with basis sets of 6-31G(d), 6-31+G(d,p), 6-311+G(d,p), 6-311++G(d,p), cc-pVTZ, and TZVP. The LSDA/6-31G(d) level of theory shows the best performance in reproducing the X-ray powder structure. However, the PBEPBE/cc-pVTZ level of theory is the best method to predict the vibrational frequencies of (2RS,3RS)-(I). The potential energy surfaces of racemic pairs (2RS,3RS)-(I) and -(II) are obtained at the LSDA/6-31G(d) level of theory in the gas phase and in water. The results indicate that (2RS,3RS)-(I) are more stable by ~0.75 kcal/mol in energy than (2RS,3RS)-(II) in water, whereas conformer AIIg and BIIg are more stable by ~0.04 kcal/mol than AIg in gas phase. In particular, the hydrogen bond distances between the N of piperazine and the OH of tetrahydronaphthalen become longer in gas, compared with those in the water phase. Vibrational frequencies calculated at the PBEPBE/cc-pVTZ level of theory in the gas phase are larger than those in water, whereas their intensities in the gas phase are weaker than those in water.

• 한국수산과학회지
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• 제53권4호
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• pp.620-627
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• 2020

Oxygen consumption and blood physiology of olive flounder Paralichthys olivaceus (mean body weight 106.6±6.8 g, mean±SD) was investigated at salinities of 34.0 (control), 33.7, 33.3, 32.6, 31.3, 28.6, 23.1, 12.2 and 0.0 psu at 20.0℃, respectively. Stepwise salinity changes (34.0→33.7→33.3→32.6→31.3→28.6→23.1→12.2→0.0 psu) with an interval of 24 h for each salinity induced a significant (P<0.05) increase of oxygen consumption rate (OCR) in fish exposed from 31.3 to 0.0 psu compared to that of control fish. The maximum OCR was found in fish exposed to 23.1 psu, which was accompanied by 36.2% higher energy consumption than the control fish. Fish exposed to each salinity for 24 h induced a significant decrease of blood plasma Na⁺ in 0.0 psu and Cl^- in 12.2 and 0.0 psu (P<0.05), and increase of plasma glutamic oxaloacetic transaminase (GOT) in 0.0 psu compared to the control fish (P<0.05). The results of this experiment show that P. olivaceus exposed to concentrations below 31.3 psu requires more energy costs to adapt to salinity changes than 34.0 psu under our experimental conditions.

• 대한영상의학회지
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• 제84권1호
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• pp.253-262
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• 2023

목적 정상 면역 환자에서 폐 크립토코쿠스증의 컴퓨터단층촬영 영상 소견과 임상 양상에 대하여 분석해 보고자 하였다. 대상과 방법 2008년 1월부터 2019년 11월까지 흉부 컴퓨터단층촬영을 시행하였으며, 조직병리 학적 검사로 진단된 정상 면역 폐 크립토코쿠스 환자를 대상으로 후향적 분석을 시행하였다. 영상 소견은 주 영상 형태, 병변의 분포, 보조적 영상 소견으로 구분하였다. 혈청 크립토코쿠스 항원의 유무에 따른 임상 및 방사선학적 특징을 확인하기 위해 단변수 분석을 시행하였다. 결과 총 31명의 환자를 분석하였다(평균 연령: 60세, 범위 19-78세). 단일 폐엽에 국한된 단일 결절성 병변이 가장 흔한 주된 영상 소견이었다(14/31, 45.2%). 19명의 환자에서 혈청 크립토코쿠스 항원 검사를 시행하였다(19/31, 61.3%). 6명의 환자에서 혈청 크립토코쿠스 항원이 검출됐으며(6/19, 31.6%), 이들 모두 폐경결 우세 형태를 보였다. 혈청 크립토코쿠스 항원은 결절 우세 형태보다 폐경결 우세 형태에서 보다 유의미하게 검출되었다(p = 0.011). 결론 폐경결 형태의 CT 영상 소견을 보이고 혈청 크립토코쿠스 항원 검사가 양성을 보이는 조합은 정상 면역 폐 크립토코쿠스 환자의 진단에 도움이 될 수 있다.

• 한국축산식품학회지
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• 제43권5호
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• pp.877-888
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• 2023

We studied the proteolysis and conducted a sensory evaluation of fermented sausages using strains derived from Kimchi [Pediococcus pentosaceus-SMFM2021-GK1 (GK1); P. pentosaceus-SMFM2021-NK3 (NK3)], Doenjang [Debaryomyces hansenii-SMFM2021-D1 (D1)], and spontaneous fermented sausage [Penicillium nalgiovense-SMFM2021-S6 (S6)]. Fermented sausages were classified as commercial starter culture (CST), mixed with GK1, D1, and S6 (GKDS), and mixed with NK3, D1, and S6 (NKDS). The protein content and pH of GKDS and NKDS were significantly higher than those of CST on days 3 and 31, respectively (p<0.05). Sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed that the NKDS had higher molecular weight proteins than the GKDS and CST. The myofibrillar protein solubility of the GKDS and NKDS was significantly higher than that of the CST on day 31 (p<0.05). The GKDS displayed significantly higher pepsin and trypsin digestion than the NKDS on day 31 (p<0.05). The hardness, chewiness, gumminess, and cohesiveness of the GKDS were not significantly different from those of the CST. The GKDS exhibited the highest values for flavor, tenderness, texture, and overall acceptability. According to this study, sausages fermented using lactic acid bacteria (GK1), yeast (D1), and mold (S6) derived from Korean fermented foods displayed high proteolysis and excellent sensory evaluation results.

• 한국식품영양과학회지
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• 제39권11호
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• pp.1710-1714
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• 2010

CLA가 함유된 사료를 섭취하고 성장한 고등어에 함유된 EPA, DHA 등의 고도불포화지방산을 포함한 여러 종류의 지방산이 여러 가지 방법으로 요리하였을 때의 어떠한 변화를 나타내는가를 조사함으로써 소비자에게 양식 고등어의 적절한 조리방법을 제공하고자 하였다. 조리 후 포화산 및 모노엔산은 생육의 Control 27.5%, CA25 28.8%와 차이가 없었다. 폴리엔산 역시 RO-8GM, RO-8CM이 31.2%, 30.7%, BO-8GM, BO-8CM은 27.1%, 31.5%, CA-8GM, CA-8CM은 25.4%, 28.4%를 나타내어 생육의 Control 29.4%, CA25의 31.9%와 비교하였을 때 된장조림 및 통조림의 경우 CLA 무첨가구에서 함량이 감소하였지만, CLA 첨가구에서는 통조림구에서만 감소하는 경향을 보였다. 조리된 고등어 중 n-6/n-3의 비는 구이의 경우 Control 및 CA25구 각각에서 0.29, 0.24, 된장조림의 경우 각각 0.28, 0.27 그리고 통조림의 경우 각각 0.28, 0.31로 나타났다.

• 한국작물학회지
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• 제65권1호
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• pp.47-55
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• 2020

북한 콩 22 품종의 개화기 특성을 평가하기 위하여 2017년부터 2019년 3년간 고려대학교 실험농장에서 5월 31일, 6월 19일, 6월 30일, 7월 3일, 7월 4일의 파종기에 따른 개화기와 개화일수를 조사하였고, 이를 이용하여 개화기 군을 분류하여 개화기 반응을 분석하였다. 1. 5월 31일 파종한 한국 조생종인 '연풍콩'의 개화기는 7월 18일, 개화일수 48일 보였으며, 중만생종 '대원콩'은 7월 30일의 60일이었다. 2. 5월 31일 파종기에서 개화기가 '연풍콩'보다 빠른 북한 품종의 개화기는 7월 2일~15일로 분포하였으며, 'Brekkhat'을 포함한 8개 조생종 품종이 분류되었다. 3. 5월 31일 파종기에서 '대원콩'과 비슷하거나 늦은 북한 품종의 개화기는 7월 24일~30일로 분포되었으며, 'Chang Dan Bac Mok'을 포함한 12품종을 중·만생종 품종으로 분류하였다. 4. 콩 품종의 개화기 조만성은 년차 간 또는 파종기 간 차이가 나타나지 않았으며, 품종의 개화기 군 분류에 영향을 미치지 못하였다. 5. 한국 조생종 '연풍콩'과 중만생종 '대원콩'의 개화기를 기준으로 북한 콩 품종의 개화기를 6개 군으로 분류하였다. 6. 북한 중·만생종 콩 품종은 모두 '감광성 중·만생종'으로 분석되었으며, 조생종 품종의 경우, '감온성 조생종'과 '감광성 조생종'의 2 형태로 분류되었음을 제시하였다.

• 한국표면공학회지
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• 제46권2호
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• pp.80-86
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• 2013

Magnesium alloys of AZ31 containing (0.5, 1, 1.5) wt.% of initially added CaO particles were cast in air, and their oxidation behavior was studied at $450-650^{\circ}C$ in air. The initially added CaO particles either decomposed to dissolve in the ${\alpha}$-Mg matrix or precipitated as $Al_2Ca$ along the grain boundaries of the matrix during casting. The ignition temperatures were $565.4^{\circ}C$ for AZ31, $608.6^{\circ}C$ for AZ31+0.5 wt.%CaO, and $689.7^{\circ}C$ for AZ31+1 wt.%CaO. No ignition occurred for AZ31+1.5 wt.%CaO up to $700^{\circ}C$, displaying good oxidation resistance. The CaO-rich oxide scales that formed on the surface of the AZ31+(0.5, 1, 1.5) wt.%CaO alloys improved the oxidation resistance of AZ31 alloys.

• 열처리공학회지
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• 제28권6호
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• pp.315-321
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• 2015

Friction stir processing (FSP) was applied to fabricate AZ31/CNT (Carbon Nano Tube) surface composite for improvement of surface hardness of AZ31 Mg-based alloy. The effects of traverse speed of rotating tool and volume fraction of CNT (i.e., groove depth of 3 mm and 4 mm) on the soundness and hardness of the composite layer were investigated. Multi-walled CNTs were fully filled in a machined groove and stirring tool was rotated at the speed of 1400 rpm. Only under the tool traverse speed of 25 mm/min for the specimen with a groove depth of 3 mm, surface composite layer with no defect was successfully produced. Increased hardness of about 35% was observed in the composite layer.

• 한국표면공학회지
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• 제44권6호
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• pp.239-245
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• 2011

Magnesium alloys is the lightest by structural metals, but it is not good corrosion resistant because of pit, void. Particularly, AZ31B magnesium alloy sheets that have slag, scratch by rolling process indicate some defects. The objective of this research is to perform uniform plating on AZ31B by studying etching and zincate process. Especially, zincate treatment by zinc salt and pyrophosphate is the most important in the decoration plating. Dissolution of magnesium is reduced by the formation of uniform zinc conversion layer during strick and post process, which decreases defects for plating process.