[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.11626/KJEB.2013.31.4.376

[6]-Gingerol Attenuates Radiation-induced Cytotoxicity and Oxidative Stress in HepG2 Cells

Chung, Dong-Min (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute)
Uddin, S.M. Nasir (University of Science & Technology)
Kim, Jin Kyu (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute)

Publication Information

Korean Journal of Environmental Biology / v.31, no.4, 2013 , pp. 376-382 More about this Journal

Abstract

[6]-Gingerol, a major polyphenol of ginger (Zingiber officinale), exhibits a variety of biological properties including anti-oxidant, anti-inflammatory and anti-cancer activity. However, the radioprotective effect of [6]-gingerol is still unknown. The aim of this study was to investigate the radioprotective effect of [6]-gingerol against radiation-induced cell cytotoxicity and oxidative stress in HepG2 cells. [6]-Gingerol pretreatment attenuated radiation-induced cell cytotoxicity caused by 5Gy (half lethal dose, $LD_{50}$ of HepG2 cells). The measurements of superoxide dismutase (SOD) and catalase (CAT) activity were also performed. The results showed that [6]-gingerol pretreatment reduced increasing SOD and CAT activity after exposure of IR, indicating that [6]-gingerol protected oxidative stress by regulating cellular antioxidant enzyme (SOD and CAT) activity. These findings suggest that [6]-gingerol acts as a radioprotector by attenuating cell cytotoxicity and oxidative stress.

Keywords

antioxidant defense system; apoptosis; HepG2 cell; oxidative stress; radiation; radioprotector;

Citations & Related Records

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