• Title/Summary/Keyword: $21{\alpha}-\

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Setting Time, Compressive Strength and Drying Shrinkage of Mortar with Alpha-Calcium Sulfate Hemihydrate (α형 반수석고를 치환한 모르타르의 응결 및 압축강도, 건조수축 특성)

  • Lee, Kye-Hyouk;Kim, Gyu-Yong;Lee, Bo-Kyeong;Shin, Kyoung-Su;Nam, Jeong-Soo
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.21 no.5
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    • pp.117-124
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    • 2017
  • In this study, to evaluate the setting time, compressive strength and drying shrinkage of ordinary Portland cement and Portland blast-furnace slag cement mortar with 0, 10, 20, 30 wt.% alpha-calcium sulfate hemihydrate. As a results, as the replacement ratio of alpha-calcium sulfate hemihydrate increased, the initial setting time of ordinary Portland cement and Portland blast-furnace slag cement mortar was faster. In addition, the compressive strength decreased with increasing replacement ratio of alpha-calcium sulfate hemihydrate in both ordinary Portland cement mortar and Portland blast-furnace slag cement mortar. The strength development of Portland blast-furnace slag cement mortar with alpha-calcium sulfate hemihydrate was effective than that of ordinary Portland cement mortar. On the other hand, in the case of the mortar with alpha-calcium sulfate hemihydrate, it was confirmed that shrinkage deformation was reduced at the early age by growth pressure of needle-shaped ettringite crystals produced by incorporation of alpha-calcium sulfate hemihydrate. However, the effect of inhibiting shrinkage deformation of mortar with alpha-calcium sulfate hemihydrate was not significant as the age passed. Therefore, it is considered that the alpha-calcium sulfate hemihydrate is useful as a construction material.

Synergistic efficacy of LBH and αB-crystallin through inhibiting transcriptional activities of p53 and p21

  • Deng, Yun;Li, Yongqing;Fan, Xiongwei;Yuan, Wuzhou;Xie, Huaping;Mo, Xiaoyang;Yan, Yan;Zhou, Junmei;Wang, Yuequn;Ye, Xianli;Wan, Yongqi;Wu, Xiushan
    • BMB Reports
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    • v.43 no.6
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    • pp.432-437
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    • 2010
  • LBH is a transcription factor as a candidate gene for CHD associated with partial trisomy 2p syndrome. To identify potential LBH-interacting partners, a yeast two-hybrid screen using LBH as a bait was performed with a human heart cDNA library. One of the clones identified encodes ${\alpha}B$-crystallin. Co-immunoprecipitation and GST pull-down assays showed that LBH interacts with ${\alpha}B$-crystallin, which is further confirmed by mammalian two-hybrid assays. Co-localization analysis showed that in COS-7 cells, ${\alpha}B$-crystallin that is cytoplasmic alone, accumulates partialy in the nucleus when co-transfected with LBH. Transient transfection assays indicated that overexpression of LBH or ${\alpha}B$-crystallin reduced the transcriptional activities of p53 and p21, respectively, Overexpression of both ${\alpha}B$-crystallin and LBH together resulted in a stronger repression of the transcriptional activities of p21 and p53. These results showed that the interaction of LBH and ${\alpha}B$-crystallin may inhibit synergistically the transcriptional regulation of p53 and p21.

The Availability of Amplitude, Asymmetry and Mean Frequency of Alpha Intrinsic Rhythm in Old Age as Brain Health Indicators (노년기 알파 고유리듬 진폭, 비대칭 및 평균 주파수의 뇌건강 지표로써 활용 가능성 연구)

  • Shim, Jun-Young
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.21 no.2
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    • pp.124-132
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    • 2020
  • This study examines the clinical availability of alpha amplitude, asymmetry and mean frequency in old age as EEG indexes reflecting brain health condition. The EEGs of prefrontal lobes in eye closure state were measured for 4 minutes with 72 male and female elderly people aged 73. Subjects were divided into higher and lower groups based on average values of alpha amplitude, asymmetry and mean frequency. The results of correlations and t-test among EEG indexes were as follows. First, the higher Alpha altitude was, the higher physical and mental stress resistance and left-to-right brain communication were, and the lower mean Alpha mean frequency location was. The higher Alpha asymmetry was, the lower left-to-right communication level was. Second, as Alpha power of right brain was higher than that of left brain, Alpha amplitude and mental stress resistance and left-to-right brain communication level were higher. Third, as Alpha mean frequency location was higher, Alpha amplitude and mental anti-stress level were lowered and arousal level was enhanced. These high correlations and complementary meaning among quantitative EEG indicators demonstrated the possibility of biomarkers reflecting brain health state in old age.

Expression and Localization of 20α-Hydroxysteroid Dehydrogenase in Immature Pig Testis (미니돼지 정소에서 20α-HSD의 발현 및 특성화)

  • Kim, Jeong-Soo;Seong, Hun-Ki;Byambaragchaa, Munkhzaya;Sim, Bo-Woong;Her, Chang-Gi;Kang, Myung-Hwa;Min, Kwan-Sik
    • Journal of Life Science
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    • v.27 no.7
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    • pp.739-745
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    • 2017
  • In all mammalian species, progesterone is essential in the preparation for and maintenance of pregnancy. $20{\alpha}$-hydroxysteroid dehydrogenase ($20{\alpha}$-HSD) predominantly converts progesterone into its biologically inactive form $20{\alpha}$-hydroxyprogesterone ($20{\alpha}$-OHP), and plays a crucial role in the termination of pregnancy and initiation of parturition. In this study, we characterized the expression and localization of $20{\alpha}$-HSDinthe testis of MediKinetics $Micropigs^{(R)}$. The testes were collected at days 6, 9, 12, 18, and 21 after birth. The $20{\alpha}$-HSD mRNA was found to be expressed in the testis at day 6 after birth by RT-PCR. The highest level of mRNA expression in the testis was detected on day 21 after birth. However, the mRNA was not detected in the placenta after parturition. Western blot for $20{\alpha}$-HSD reveal that the specific 37-kDa band was detected in immature pig testis. However, this band was not detected in testis tissue at day 6 after birth. In the immunohistochemical analysis of the testis, $20{\alpha}$-HSD was detected in the Sertoli cells and Leydig cells. Taken together, our study shows for the first time that the $20{\alpha}$-HSD mRNA and protein are expressed in pig testis after birth. Further investigation is required to elucidate the functional mechanisms of $20{\alpha}$-HSD in pig testis after birth.

Construction of a Temperature Controlled Expression Ve e tor in Saccharumy ces cerevisiae (Saccharomyces cerevisiae를 이용한 온도조절형 발현 Vector의 개발)

  • 최진옥;황용일
    • Microbiology and Biotechnology Letters
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    • v.21 no.3
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    • pp.214-220
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    • 1993
  • The mating type a of yeast, Saccharomyces cerevisiae mutant with hmla2-102 and sir3-8ts was changed to type alpha by changing the growth temperature from 25C to 35C. A temperature-sensitive expression vector system was constructed using mating factor alpha1 (Mfalpha1) gene encoding alpha factor which is expressed in the type alpha cells. Vectors with different copy numbers were constructed by joining the promoter and pre or prepro-secretion single sequence of Mfalpha1 to promoterless PHO5' gene as a reporter gene.

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PRIME IDEALS IN LIPSCHITZ ALGEBRAS OF FINITE DIFFERENTIABLE FUNCTIONS

  • EBADIAN, ALI
    • Honam Mathematical Journal
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    • v.22 no.1
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    • pp.21-30
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    • 2000
  • Lipschitz Algebras Lip(X, ${\alpha}$) and lip(X, ${\alpha}$) were first studied by D. R. Sherbert in 1964. B. Pavlovic in 1995 shown that in these algebras, the prime ideals containing a given prime ideal form a chain. In this paper, we show that the above property holds in $Lip^n(X,\;{\alpha})$ and $lip^n(X,\;{\alpha})$, the Lipschitz algebras of finite differentiable functions on a perfect compact place set X.

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