• Korean Journal of Pharmacognosy
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• v.33 no.2 s.129
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• pp.85-87
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• 2002

This study is to establish the quality control method of Codonopsis Radix, the root of Codonopsis lanceolata (S. et Z.) Trautv. $1,2,3,4-tetrahydro-{\beta}-carboline-3-carboxylic\;acid$ (1) isolated from this plant was adequate as an analytical marker. Content of 1 in Codonopsis Radix, determined by HPLC, was $0.0012{\pm}0.0005%$ (n=13). Total ash was $5.0{\pm}2.7%$, and loss on drying was $11.9{\pm}1.3%$.

• Korean Journal of Pharmacognosy
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• v.20 no.2
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• pp.117-122
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• 1989

The effect of wild vegetables such as Allium tuberosum, Allium monanthum, Sedum sarmentosum, Ixeris dentata and Capsella-bursa pastoris on hexobarbital induced hypnosis was tested in mice. Among them, the methanol extract of Allium tuberosum exhibited significant lengthening of the barbiturate hypnosis. When various fractions prepared from the methanol extract of the Allium tuberosum were administered, the chloroform, ethylacetate and butanol extracts caused a significant activity. Through systematic fractionation by $SiO_2$ column monitoring by bioassays, $1,2,3,4-tetrahydro-{\beta}-carboline$ 3-carboxylic acid from the butanol extract was isolated as one of the active principles of this plant.

• Bulletin of the Korean Chemical Society
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• v.12 no.4
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• pp.380-382
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• 1991

Pictet-Spengler reaction of the N-hydroxytryptophan ethyl ester (4) with N-protected thiazolidine aldehyde (8) has been carried out. The product, compound (9b), might be a possible precursor for the eudistomins C, E, K, and L.

• Natural Product Sciences
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• v.16 no.1
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• pp.20-25
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• 2010

Fourteen compounds were isolated from the n-BuOH fraction of the roots of Aralia cordata (syn. = A. continentalis). Through spectroscopic method, the chemical structures were elucidated as: caffeic acid (1), protocatechuic acid (2), thymidine (3), uridine (4), methyl-$\alpha$-D-fructofuranoside (5), a mixture (3 : 1) of $\beta$-D-fructopyranoside and $\beta$-D-fructofuranoside (6), 1-methyl 1,2,3,4-tetrahydro-$\beta$-carboline-3-carboxylic acid (7), methyl-$\beta$-D-fructofuranoside (8), sucrose (9), 5-caffeoylquinic acid (chlorogenic acid) (10), 3-caffeoylquinic acid (neochlorogenic acid) (11), 4-caffeoylquinic acid (cryptochlorogenic acid) (12), 3,5-di-O-caffeoylquinic acid (13), and 1-kestose [$\beta$-D-fructofuranosyl-($2{\rightarrow}1$)-$\beta$-D-fructofuranosyl-($2{\rightarrow}1$)-$\alpha$-D-glucopyranoside] (14). Among them, compounds 5, 7, 8, and 10 - 14 were isolated from this plant for the first time.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.222.3-223
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• 2003

Codonopsis radix, a root of Codonopsis lanceolata (S. et Z.) Trautv., is a source of the traditional medicine and health foods. However quality control method is not established yet. This research is to establish the standard for the quality control of Codonopsis radix. From the root of this plant, 1,2,3,4-tetrahydro-${\beta}$-carboline -3-carboxylic acid (1) was isolated. This alkaloid was adequate as a marker compound for quality control, since it is a unique constituent of Codonopsis radix. In particular, (1) was not found in Adenophorae radix, a common adulterants of Codonopsis radix. (omitted)

• Journal of the Korean Applied Science and Technology
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• v.36 no.2
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• pp.676-684
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• 2019

The Pictet-Spengler reactions have widely known for the organic synthesis or biosynthesis of biologically active compounds, tetrahydro-${\beta}$-carbolines. We have developed the simple and efficient synthetic method for the synthesis of ${\beta}$-carbolines in water. Their chemical structures were characterized by nmr and UPLC/MS/QTOF. Calculated masses of compound 1 ($C_{17}H_{17}N_2$ 249.1392), 2 ($C_{17}H_{23}N_2$ 255.1861), 3 ($C_{19}H_{21}N_2O_3$ 325.1552) and 4 ($C_{19}H_{19}N_2O$ 279.1497) were almost identical with the detected masses of compound 1 (249.1315), 2 (255.1789), 3 (325.1460) and 4 (279.1364) respectively. Those synthesized four compounds showed strong antibiotic activity against the common E. coli.