• 제목/요약/키워드: $1,2,3,4-tetrahydro-{\beta}-carboline$

검색결과 6건 처리시간 0.018초

더덕의 품질 관리에 관한 연구 (Quality Control of Dried Roots of Codonopsis lanceolata)

  • 유혜현;백승훈;박연경;이승호;김창민;이경순;박만기;박정일
    • 생약학회지
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    • 제33권2호통권129호
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    • pp.85-87
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    • 2002
  • This study is to establish the quality control method of Codonopsis Radix, the root of Codonopsis lanceolata (S. et Z.) Trautv. $1,2,3,4-tetrahydro-{\beta}-carboline-3-carboxylic\;acid$ (1) isolated from this plant was adequate as an analytical marker. Content of 1 in Codonopsis Radix, determined by HPLC, was $0.0012{\pm}0.0005%$ (n=13). Total ash was $5.0{\pm}2.7%$, and loss on drying was $11.9{\pm}1.3%$.

야생 식용식물의 약물대사 활성성분에 관한 연구 (Studies on the Active Principles of Wild Vegetables on Biotransformation of Drug)

  • 최재수;박시향;김일성
    • 생약학회지
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    • 제20권2호
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    • pp.117-122
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    • 1989
  • The effect of wild vegetables such as Allium tuberosum, Allium monanthum, Sedum sarmentosum, Ixeris dentata and Capsella-bursa pastoris on hexobarbital induced hypnosis was tested in mice. Among them, the methanol extract of Allium tuberosum exhibited significant lengthening of the barbiturate hypnosis. When various fractions prepared from the methanol extract of the Allium tuberosum were administered, the chloroform, ethylacetate and butanol extracts caused a significant activity. Through systematic fractionation by $SiO_2$ column monitoring by bioassays, $1,2,3,4-tetrahydro-{\beta}-carboline$ 3-carboxylic acid from the butanol extract was isolated as one of the active principles of this plant.

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Synthesis of 1-(N-carbobenzoxythiazolidinyl)-2-hydroxy-3-ethoxycarbonyl-1,2,3,4-tetrahydro-${\beta}$-carboline

  • Byung Hee Yoon;Hak Soo Lyu;Jee Hyun Hahn;Chan Mug Ahn
    • Bulletin of the Korean Chemical Society
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    • 제12권4호
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    • pp.380-382
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    • 1991
  • Pictet-Spengler reaction of the N-hydroxytryptophan ethyl ester (4) with N-protected thiazolidine aldehyde (8) has been carried out. The product, compound (9b), might be a possible precursor for the eudistomins C, E, K, and L.

Isolation of Phenolics, Nucleosides, Saccharides and an Alkaloid from the root of Aralia cordata

  • Hyun, Sook-Kyung;Jung, Hyun-Ah;Min, Byung-Sun;Jung, Jee-H.;Choi, Jae-Sue
    • Natural Product Sciences
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    • 제16권1호
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    • pp.20-25
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    • 2010
  • Fourteen compounds were isolated from the n-BuOH fraction of the roots of Aralia cordata (syn. = A. continentalis). Through spectroscopic method, the chemical structures were elucidated as: caffeic acid (1), protocatechuic acid (2), thymidine (3), uridine (4), methyl-$\alpha$-D-fructofuranoside (5), a mixture (3 : 1) of $\beta$-D-fructopyranoside and $\beta$-D-fructofuranoside (6), 1-methyl 1,2,3,4-tetrahydro-$\beta$-carboline-3-carboxylic acid (7), methyl-$\beta$-D-fructofuranoside (8), sucrose (9), 5-caffeoylquinic acid (chlorogenic acid) (10), 3-caffeoylquinic acid (neochlorogenic acid) (11), 4-caffeoylquinic acid (cryptochlorogenic acid) (12), 3,5-di-O-caffeoylquinic acid (13), and 1-kestose [$\beta$-D-fructofuranosyl-($2{\rightarrow}1$)-$\beta$-D-fructofuranosyl-($2{\rightarrow}1$)-$\alpha$-D-glucopyranoside] (14). Among them, compounds 5, 7, 8, and 10 - 14 were isolated from this plant for the first time.

Quality Control of Codonopsis Radix

  • Yoo, Hye-Hyun;Baek, Seung-Hoon;Park, Yun-Kyung;Lee, Seung-Ho;Kim, Chang-Min;Lee, Kyung-Soon;Park, Man-Ki;Park, Jeong-Hill
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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    • pp.222.3-223
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    • 2003
  • Codonopsis radix, a root of Codonopsis lanceolata (S. et Z.) Trautv., is a source of the traditional medicine and health foods. However quality control method is not established yet. This research is to establish the standard for the quality control of Codonopsis radix. From the root of this plant, 1,2,3,4-tetrahydro-${\beta}$-carboline -3-carboxylic acid (1) was isolated. This alkaloid was adequate as a marker compound for quality control, since it is a unique constituent of Codonopsis radix. In particular, (1) was not found in Adenophorae radix, a common adulterants of Codonopsis radix. (omitted)

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β-카볼린 화합물의 합성 및 구조분석 (Synthesis and Structural Characterization of β-Carboline Compounds)

  • 변홍주;한민희;문기성;정경환;이향렬
    • 한국응용과학기술학회지
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    • 제36권2호
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    • pp.676-684
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    • 2019
  • 자연에서도 생합성이 되는 테트라하이드로-${\beta}$-카볼린 화합물은 Pictet-Spengler반응을 통해서 화학적으로도 합성된다. 본 연구에서는 ${\beta}$-카볼린 화합물을 쉽고 효과적으로 합성할 수 있는 친환경 합성법을 개발하여 유기용매가 아닌 물을 사용하여 합성하였다. 이 화합물은 투명한 결정형의 생성물로 얻어지므로 복잡한 분리과정이 필요하지 않다. 합성된 화합물은 NMR 및 UPLC/MS를 이용하여 구조를 확인하였다. 화합물 1의 이론적 분자량($C_{17}H_{17}N_2$ 249.1392), 화합물 2 ($C_{17}H_{23}N_2$ 255.1861), 화합물 3($C_{19}H_{21}N_2O_3$ 325.1552), 화합물 4($C_{19}H_{19}N_2O$ 279.1497)과 측정된 화합물들의 질량과 비교하였다. 그 결과 측정된 화합물 1의 분자량 ($[M+H]^+m/z$ detected 249.1315), 2 (detected 255.1789), 3 (detected 325.1460) 그리고 4 (detected 279.1364)와 거의 일치함으로써 생성된 화합물이 1~4의 구조를 가지고 있음을 확인하였다. 합성된 화합물들을 그람 음성균인 E. coli $DH5{\alpha}$를 대상으로 항균효과를 조사한 결과 강한 저해효과를 확인할 수 있었다.