• Nutrition Research and Practice
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• 제7권1호
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• pp.15-21
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• 2013

Leaf of Sasa borealis, a species of bamboo, has been reported to exhibit anti-hyperglycemic effect. However, its antidiabetic mechanism is not fully understood. In this study, we examined whether an extract of S. borealis activates AMP-activated protein kinase (AMPK) and exerts anti-hyperglycemic effects. Treatment with the S. borealis extract increased insulin signaling and phosphorylation of AMPK and stimulated the expression of its downstream targets, including $PPAR{\alpha}$, ACO, and CPT-1 in C2C12 cells and $PPAR{\alpha}$ in HepG2 cells. However, inhibition of AMPK activation attenuated insulin signaling and prevented the stimulation of AMPK target genes. The S. borealis extract increased glucose uptake in C2C12 cells and suppressed expression of the gluconeogenic gene, PEPCK in HepG2 cells. The extract significantly reduced blood glucose and triglyceride levels in STZ-induced diabetic mice. The extract enhanced AMPK phosphorylation and increased Glut-4 expression in the skeletal muscle of the mice. These findings demonstrated that the S. borealis extract exerts its anti-hyperglycemic effect through activation of AMPK and enhancement of insulin signaling.

• 한국식품영양과학회지
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• 제27권4호
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• pp.609-617
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• 1998

A microorganism capable of producing high level of extracellular cyclodextrin glucanotransferase(EC 2.4.1.19 ; CGTase) was isolated from Kimchi. 2-O-$\alpha$-D-glucopyranosyl L-ascorbic acid(AA-2G) was synthesized by transglycosylation reaction of CGTase using starch as a donor and L-ascorbic acid as an acceptor. The isolated strain S-6 was identified as Bacillus sp. S-6. The maximal CGTase production was observed in a medium containing 0.5% soluble starch, 1% yeast extract, 1% NaCO3, 0.1% K2HPO4, and 0.02% MgSO4 with initial pH 8.0. The strain was cultured at 37$^{\circ}C$ for 40 hr with reciprocal shaking. Using the culture supernatant as crude enzyme, the optimal pH and temperature of the CGTase activity of this strain were 7.0 and 4$0^{\circ}C$. In the effects of pH and temperature on the stability of the enzyme, the enzyme was stable in the range of pH 6.0~10.0 and up to 45$^{\circ}C$, respectively.

• 천문학회보
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• 제40권2호
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• pp.28.3-29
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• 2015

$Ly{\alpha}$ nebulae, or "$Ly{\alpha}$ blobs", are extended (~100 kpc), bright (L[$Ly{\alpha}$] ~ 1044 erg/s) clouds of $Ly{\alpha}$-emitting gas. The origin of the $Ly{\alpha}$ emission remains unknown, but recent theoretical work suggests that measuring the polarization could discriminate among powering mechanisms. we will discuss current status of $Ly{\alpha}$ polarization observations at high-redshift and our on-going survey program. We will present the first narrow-band, imaging polarimetry of a $Ly{\alpha}$ blob, B3 J2330+3927 at z=3.09, with an embedded, radio-loud AGN (C. You et al. in prep.). The AGN lies near the blob's $Ly{\alpha}$ emission peak and its radio lobes align roughly with the blob's semi-major axis. With the SPOL polarimeter on the MMT telescope, we map the polarization in a grid of circular apertures of radius 0.6" (4.4 kpc), detecting a significant (>$2{\sigma}$) polarization fraction P% in 10 apertures and achieving strong upper-limits (as low as 2%) elsewhere. The degree of the polarization map increases from P% ~ 5% at ~5 kpc from the blob center to ~20% at the outer part (~30 kpc). The detections are distributed asymmetrically, roughly along the blob's major axis. The polarization angles (${\Theta}$) are mostly perpendicular to this axis. These results are consistent with the picture that $Ly{\alpha}$ photons produced at the AGN (or the host galaxy) are resonantly scattered away from the center. Higher polarization fraction on the radio jet suggests that the gas is more optically thin along the jet than the off-axis region.

• Bulletin of the Korean Chemical Society
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• 제2권4호
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• pp.142-147
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• 1981

A blend polymeric system composed of poly(methyl methacrylate) (PMMA or PM) and polystyrene (PS) dissolved in chloroform was rheologically studied. The viscosities ${\eta}_{bl}$ of the blend system with various blending ratios ${\chi}$ changing from zero (pure PS solution) to unity (pure PMMA solution) were measured at $25{\circ}C$ as a function of shear rates ${\dot{s}}$ by using a Couette type viscometer. ${\eta}_{bl}$ at a given ${\dot{s}}$ decreased exponentially with ${\chi}$ reaching asymptotic constant value of ${\eta}_{bl}$ ; ${\eta}_{bl}$ at a given ${\chi}$ is greater at a smaller ${\dot{s}}$. These results are explained by using Ree-Erying's theory of viscosity, ${\eta}_{bl}=(x_1{\beta}_1/{\alpha}_1)_{b}_1＋ (x_2{\beta}_2/{\alpha}_2)_{bl}[sinh^{-1}{\beta}_2(bl) {\dot{s}}]/{\beta}_2(bl){\dot{s}}$. The Gibbs activation energy ${\Delta}G_i^\neq$(i = 2 for non-Newtonian units) entering into the intrinsic relaxation time ${\beta}$ is represented by a linear combination ${\Delta}G_i^\neq(bl) ={\chi}{\Delta}G_i^{\neq}_{iPM}+(1-{\chi}){\Delta}G_i^{\neq}_{iPS}$;the intrinsic shear modulus$[[\alpha}_i]^{-1}$ is also represented by $[{\alpha}_i(bl)]^{-1}={\chi}[{\alpha}_{iPM}]^{-1}+(1-{\chi})[{\alpha}_{iPS}]^{-1}$ and the fraction of area on a shear surface occupied by the ith flow units $x_i(bl)$ is similarly represented, i.e., $x_i(bl) = {\chi}x_{iPM}+(1-{\chi})x_{iPS}$. By using these ideas the Ree-Eyring equation was rewritten which explained the experimental results satisfactorily.

• 대한수학회보
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• 제25권2호
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• pp.167-170
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• 1988

Versions of Tannaka duality in operator algebraic context have been obtained in [6], [8] etc. Suppose .sigma.is an automorphism of a von Neumann algebra M, on which there is an action .alpha. of a compact group G such that .sigma. vertical bar $M^{\alpha}$=id, where $M^{\tau}$is the fixed point algebra under the action .alpha.. Then it is shown that if there is an action .tau. of a group H which commutes with .alpha., and which is ergodic in the sense that the fixed point algebra $M^{\tau}$ is trivial, then there exists g.mem.G such that .sigma.=.alpha.(g). Recently Evans and Kishimoto ([4]) showed the versions of Tannaka duality in $C^{*}$-settings under some conditions.s.

• 대한화학회지
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• 제29권3호
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• pp.277-282
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• 1985

N-benzylideneaniline 유도체의 C-phenyl group 파라위치에 치환기가 변화함에 따라 imidoyl양성자의 화학적 이동 (H${\alpha}$-SCS)에 미치는 자유에너지 직선관계(LFER)를 검토하기 위하여 치환기별 H$_{\alpha}$-SCS와 ${\sigma}$,${\sigma}^+$, ${\sigma}_I$,${\sigma}_R$, F 및 R등의 여러가지 자유에너지 관계 파라미터를 Hammett, Okamoto-Brown식과 그리고 Taft, Swain-Lupton의 DSP식에 적용한 바, 2.8∼3.2의 섞임계수(blending coefficient values, ${\lambda}$)값을 얻음으로써 공명효과(R)가 유발효과(I)나 장효과(F)보다 H_${\sigma}$-SCS에 크게 영향을 미친다는 사실을 알 수 있었으며 Swain-Lupton의 식으로 구한 %R = 66.6 and %F = 33.4의 값으로 부터 H$_{\sigma}$-SCS에 미치는 공명효과(R)와 장효과(F)의 비가 2:1이라는 정량적인 관계를 알았다.

• 대한치과기공학회지
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• 제19권1호
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• pp.21-35
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• 1997

Au 함량이 20% 미만인 Au-Ag-Pd합금의 기초합금인 Ag-Pd-Cu 3원계 합금의 시효경화 특성을 규명할 목적으로 20wt% Pd 및 20wt% Cu의 용질농도구성비가 1이 되는 3원 합금과 여기에 2wt% Au의 첨가합금에 미치는 석출상의 영향을 분석, 조사하여 아래와 같은 결론을 얻었다. Ag-20wt% Pd-20wt% Cu 3원 함금은 ${\alpha}$의 단일상에서 Ag-rich의 ${\alpha}2$상 및 PdCu규칙상에 의하여 경화반응이 진행되며 연속승온과정에서 $100{\sim}300^{\circ}C$의 경도증가와 $300{\sim}500^{\circ}C$의 경도감소의 2단계 경화특성이 얻어졌다. 연속승온시효과정은 Au첨가에 관계없이 2단계의 석출반응이 저온영역에서는 stage I, stage II로 나타나고 stage I은 고온에서의 소입에 의해 도입된 과잉공공의 이동 및 소멸에 의한 반응이고 stage II는 평형농도의 공공확산에 의한 반응에 대응하였다. 또한 본 합금의 시효석출과정은 ${\alpha}\to{\alpha}+{\alpha}2+PdCu\to{\alpha}_1+{\alpha}_2+PdCu$이고 최대 경화는 ${\alpha}_1,\;{\alpha}_2$, PdCu의 3상공존구역에서 나타났다. 이들 석출반응은 입계반응이고 반응의 진행과 함께 경도값은 상승하며 경화능에 직접적으로 기여하였다. 또한 석출상은 미세한 lamella조직의 nodule을 나타내고 이들 ${\alpha}_1,\;{\alpha}_2$ 및 PdCu상과의 미세한 혼합상의 형성이 시효경화능에 기여하는 주된 원인이 되었다. 과시효는 lamella의 조대화와 PdCu상의 ${\alpha}_2$상으로의 용해에 따른 정량적 감소에 대응하였다. 본 합금의 시효열처리 온도는 $450^{\circ}C$가 적절하며 $1{\sim}120min$ 시효시간에 걸쳐서 소정의 경화특성을 얻을 수 있었다.

• 소성∙가공
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• 제8권3호
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• pp.259-259
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• 1999

TiC ceramic particulate-reinforced titanium matrix composites were fabricated and the resultant densification, microstructure, and static and dynamic mechanical properties were studied. Comparing Ti with TiH₂powders as host materials for TiC ceramic reinforcement by pressureless vacuum sintering, TiH₂-started composites showed better sinterability and resistance to both elastic and plastic deformation than Ti-started ones. When TiH₂and TiH₂-45 vol.%TiC samples were hot pressed, TiH₂matrices transformed to alpha prime Ti and alpha Ti phase, respectively. It is interpreted that the diffusion of an alpha stabilizer carbon from TiC into the matrix is one of the plausible reasons far such a microstructural difference. The 0.2% offset yield strengths of the hot pressed TiH₂and TiH₂-45 vol.%TiC samples were 1008 and 1446 MPa, respectively, in a static compressive mode (strain rate of 1×$10^{-3}$/s). Dynamic compressive strengths of the samples were 1600 and 2060 MPa, respectively, at a strain rate of 4×10³/s.

• Archives of Pharmacal Research
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• 제11권1호
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• pp.74-79
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• 1988

Crystals of tolazamide, $C_{14}H_{21}N_3O_3S$, are triclinic space group $P{\bar{1}}$ with cell dimensions of a = 6.355 (2), b = 9.223 (2), c = 13.510 (3) A, ${\alpha}\;=\;101.04\;(8),\;{\beta}=92.80(5),\;{\gamma}\;=\;85.72\;(6)^{\circ}$ and Z = 2. Intensities were collected on an automated four-circle diffractometer using graphite-monochromated Cu K ${\alpha}$ radiations. The structure was solved by direct method and refined by full-matrix least-squares to an R factor of 0.058 for 1184 observed reflections. The molecules are dimerized by the $N-H{\cdots}O$ hydrogen bonds. There are only van der Waals interactions between these molecular dimers.

• 한국미생물·생명공학회지
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• 제30권4호
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• pp.293-297
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• 2002

효모 S. cerevisiae에서 B. stearothermophilus 유래의 CGTase를 발현 생산하였으며, 분비, 생산된 단백질을 정제하여 그 특성을 조사하였다. 재조합 효모 S. cerevisiae 2805/pVT- CGTS가 생산하는 CGTase의 분자량은 효모에서 발현될 때 고당쇄가 부가되어 야생형의 68kDa에 비해 15-160% 증가된 약 78-178 kDa으로 나타났다. 효모 S. cerevisiae에서 발현된 CGTase의 효소반응 최적활성조건은 pH7.0, $65^{\circ}C$였고, 열안정성에 있어서 $75^{\circ}C$에서 약 90%의 잔존활성을 가질 정도로 내열성이 개선되었다. 효모 S. cerevisiae에서 발현된 CGTase는 5% soluble starch를 기질로 약 40.2%의 CD 전환율 및 3 : 6 : 1의 $\alpha$-, $\beta$-, ${\gamma}$-CD의 생산 비율을 나타내어 야생형과 별다른 변화가 없었다.