• Journal of Chest Surgery
• /
• v.33 no.1
• /
• pp.1-6
• /
• 2000

Background: TNF-$\alpha$ plays a major role in producing left ventricular dysfunction cardio-myopathy pulmonary edema and inhibits the compensatory mechanism of congestive heart failure. IL-6 is an acute reactant of immune reaction and also known to control immune reaction but its function in the myocyte was not clearly investigated. Author's performed this experiment to investigate the contents of TNF-$\alpha$ and IL-6 on the assumption that TNF-$\alpha$ and IL-6 may reside in nonfailing heart that has gone cardiac surgery and play some role in cardiac function. Material and Method : Right auricular tissues were sampled from 12 patients who had undergone total corrective surgery for both congenital and acquired heart diseases from January 1998 to June 1998 in Kosin Universcfy Gospel hospital. The quantitive analysis of TNF-$\alpha$ and IL-6 were assessed by ELISA method in right auricular tissue. Hemodynamic values about the pressure of ventricle atrium aorta pulmonary artery and cardiac index pulmonary and systemic vascular resistance and cardiac output were measured by echocardiography and cardiac catheterization and biochemical analyses of LDH & AST were done before operation. statistical analysis was by Paired Student t-test. Patients were divided into children(under 15 years olds) and adults groups and the data was compared beween two groups. Conclusion: Mild pulmonary hypertension and increased pulmonary vascular resistance were existed in both group. The contents of tissue TNF-$\alpha$ IL-6 in each group were independent of each data.

• Journal of the Institute of Electronics and Information Engineers
• /
• v.51 no.5
• /
• pp.35-43
• /
• 2014

In this paper, we propose a performance enhancement method of the target tracking system for communication signal using the monopulse and the ${\alpha}{\beta}$ filter to keep the connection of the communication system between the airplane and the ground. We suggest the minimum distance measurement method for tracking error angle of the monopulse signal instead of the generally used method of MR(Monopulse Ratio) curve, and the ${\alpha}{\beta}$ filter with variable gain for enhancement of the tracking accuracy and the probability of re-tracking the monopulse signal under the disconnection of link. We show the performance enhancement of the proposed method of monopulse system using the measured MR Curve results of the prototype system. And also, the comparison of simulation results between the ${\alpha}{\beta}$ filter with variable gain and the ${\alpha}{\beta}$ filter with fixed gain shows the performance enhancement of the proposed ${\alpha}{\beta}$ filter. Using the proposed methods, we expect the enhanced performance of the existing target tracking system for communication signal only by changing the algorithm without hardware changes.

• Journal of radiological science and technology
• /
• v.46 no.5
• /
• pp.379-394
• /
• 2023

Targeted Alpha Therapy (TAT) is a new method of cancer treatment that protects normal tissues while selectively killing tumor cells using high cytotoxicity and short range of alpha particles, and target alpha therapy is a highly specific and effective cancer treatment strategy, and its potential has been proven through many clinical and experimental studies. This treatment method accurately delivers alpha particles by selecting specific molecules present in cancer tissue, which has an effective destruction and tumor suppression effect on cancer cells, and one of the main advantages of target alpha treatment is the physical properties of alpha particles. Alpha particles have a very high energy and short effective distance, interacting with target molecules in cancer tissues and having a fatal effect on cancer cells, which is known to cause DNA damage and cell death in cancer cells. TAT has shown positive results in preclinical and clinical studies for various types of cancers, especially those that resist or are unresponsive to existing treatments, but there are several challenges and limitations to overcome for successful clinical transition and application. These include the provision and production of suitable alpha radioisotopes, optimization of target vectors and delivery formulations, understanding and regulation of radiological effects, accurate dosage calculation and toxicity assessment. Future research should focus on developing new or improved isotopes, target vectors, transfer formulations, radiobiological models, combination strategies, imaging techniques, etc. for TAT. In addition, TAT has the potential to improve the quality of life and survival of cancer patients due to the possibility of a new treatment for overcoming cancer, and to this end, prospective research on more carcinomas and more diverse patient groups is needed.

• Proceedings of the Korean Reliability Society Conference
• /
• 2004.07a
• /
• pp.161-166
• /
• 2004

A method of estimating B$_{\alpha}$ life of crack growth is proposed based on the linear elastic fracture mechanic model. It is assumed that the coefficients in the Paris-Erdogan equation are random variables and their distributions are estimated by the method of 2-stage estimation from the fatigue crack growth data. A case study is also given. is also given.

• Journal of the East Asian Society of Dietary Life
• /
• v.5 no.3
• /
• pp.239-246
• /
• 1995

This study was prepared to optimize $\alpha$-azuki bean powder content by sensory evaluation method when manufacturing bread with added $\alpha$-azuki bean powder. These sensory characteristics were designed to investigate sensory evaluation about appearance, color, texture, taste and overall acceptability of small red bean bread by balanced incomplete block design. According to evaluated mean of adjusted treatments, appearance was represented high value in bread with added 3% and 6% $\alpha$-azuki bean powder than bread without $\alpha$-azuki bean powder. Bread without $\alpha$-azuki bean powder was revealed maximum sensory score value of color among whole treatments and vread with added 6% $\alpha$-azuki bean powder was revealed second highest sensory value. As $\alpha$-azuki bean powder content increased, sensory score of texture, taste and overall acceptability increased. and bread added 12% $\alpha$-azuki bean powder revealed maximum sensory score. On the results of this research about sensory characteristics for manufacturing bread with added $\alpha$-azuki bean powder, bread with added $\alpha$-azuki bean powder was considered optimum when12% $\alpha$-azuki bean powder was added wheat flour because of highest score of texture, taste and overall acceptability in spite of lower score of appearance and color.

• Proceedings of the KSR Conference
• /
• 2006.11b
• /
• pp.593-605
• /
• 2006

We have developed a catenary-pantograph dynamic simulation program by using the finite element method and verified the accuracy according to the EN 50319. During the validation process, we have reviewed which the time integration methods is proper for this application. among the Newmark method, Wilson theta method and alpha method. We conclude that the alpha method is the best in terms of computation time and accuracy.

• Analytical Science and Technology
• /
• v.14 no.4
• /
• pp.1075-1081
• /
• 2001

Instrumental Neutron Activation Analysis as a representative method of nuclear analytical technique, has advantages of non-destructive, simultaneous multi-element analysis with the characteristics of absolute measurement method. Up to date, $k_0$-quantitative method which is accurate, convenient and user-friendly, has been generalized world-widely. In this study, it is intented to introduce the general concept of $k_0$-method and to measure $k_0$-parameters for the future implementation to our NAA system. For this objectives, the definition of relevant factors for the quantitative analysis and the equation for the experimental determination of parameters such as $Q_0$(${\alpha}$) and f were summarized. Furthermore, a foundation for the $k_0$-standardization method was prepared through the measurement of ${\alpha}$ and f-value which depend on the specific character of irradiation hole at NAA#1-hole of HANARO research reactor.

• Food Science of Animal Resources
• /
• v.18 no.1
• /
• pp.9-18
• /
• 1998

This study was performed to obtain a large quantity of $\alpha$-lactalbumin ($\alpha$-LA) from milk by an improved separation and purification method. Functional properties-solubility viscosity, emulsifying activity, foamability surface hydrophobicity and gelation-of the purified $\alpha$-LA were investigated, $\alpha$-LA was purified in a large quantity by DEAE-Sephacel chromatography using 0.15M NaCl in 20mM Tris-HCl buffer(pH 7.2), as an eluent. The yield and purity of the purified $\alpha$-LA were 23.6%, 92.5%, respect-ively. The solubility viscosity and emulsifying activity of the purified $\alpha$-LA were 92.2$\pm$2% 3.46$\pm$0.19 cP and 345$\pm$5.0m^2$-/g respecively. The foamability of $\alpha$ -LA was 762 after 5min whipping which was lower than that of WPC and showed decreasing tendency with whipping time. The relative surface hydrophobicity of the $\alpha$-LA was formed when a 10% $\alpha$-LA solution containing 100mM NaCl and 20 mM $CaCl_2$ was heated at 92$^{\circ}C$for 40min. The $\alpha$-LA gel showed 31.5 as hardness and showed low springiness and cohesiveness.

• Journal of applied mathematics & informatics
• /
• v.26 no.3_4
• /
• pp.767-778
• /
• 2008

Comparison between two or more fuzzy numbers, along with their ranking, is an important subject discussed in scholarly articles. We endeavor in this paper to present a simple yet effective parametric method for comparing fuzzy numbers. This method offer significant advantages over similar methods, in comparing intersected fuzzy numbers, rendering the comparison between fuzzy numbers possible in different decision levels. In the process, each fuzzy number will be given a parametric value in terms of $\alpha$, which is dependent on the related $\alpha$-cuts. We have compared this method to Cheng's centroid point method [5] (The relation of calculating centroid point of a fuzzy number was corrected later on by Wang [12]). The proposed method can be utilized for all types of fuzzy numbers whether normal, abnormal or negative.

• Food Science and Biotechnology
• /
• v.15 no.2
• /
• pp.183-188
• /
• 2006

The tocopherol and tocotrienol contents of 39 vegetable oils, margarines, butters, and peanut butters typically consumed in the Korea diet were determined by direct solvent extraction method followed by normal phase liquid chromatography. All samples were locally obtained in the Cheongju area in 2003 and 2004. The study examined data on 19 vegetable oils, 10 margarines, 6 butters, and 4 peanut butters. ${\gamma}$-Tocopherol (${\gamma}$-T) and ${\alpha}$-tocopherol (${\alpha}$-T) were detectable in all products except butters and were usually present in the vitamin E form in greater quantity than the other isomers. Usually, ${\gamma}$-T content was higher than ${\alpha}$-T content in many samples. Tocotrienols were measurable in some samples but usually at levels less than the corresponding tocopherols. Three analytical method validation parameters, accuracy, precision, and specificity, were calculated to ensure the method's validity and were all confirmed to be reliable and satisfactory.